1,2-Dimethylpropylamine, (S)-

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  • Identifiers

    CAS number
    22526-46-1

    Molecular formula
    C5H13N

    SMILES
    C[C@@H](C(C)C)N

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fishy 58.52%
    Cheesy 56.34%
    Ripe 41.04%
    Mint 30.66%
    Cooling 24.5%
    Sweaty 20.63%
    Musty 20.51%
    Fermented 20.5%
    Odorless 20.44%
    Savory 19.24%

     

    Flavor
    Fishy 35.2%
    Ammoniacal 30.71%
    Ammonia 25.42%
    Meaty 22.63%
    Glue 22.39%
    Bloody 22.2%
    Yeasty 21.2%
    Skunky 20.97%
    Sulfurous 20.9%
    Leathery 20.17%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    7.91 (neutral)

    Molecular weight
    87.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    86°C

    Flash point

    • 2.18 ˚C est.

  • Synonyms

    • 22526-46-1
    • (S)-(+)-2-Amino-3-methylbutane
    • (2S)-3-methylbutan-2-amine
    • (S)-(+)-3-Methyl-2-butylamine
    • (S)-3-methyl-2-butylamine
    • (S)-3-Methylbutane-2-amine
    • 2-Butanamine, 3-methyl-, (2S)-
    • 32QJA2ZJ2A
    • (s)-2-amino-3-methylbutane
    • 1,2-Dimethylpropylamine, (S)-
    • 3-Methyl-2-butylamine, (2S)-
    • Propylamine, 1,2-dimethyl-, (S)-
    • UNII-32QJA2ZJ2A
    • J60.644H
    • (S)-1,2-dimethylpropylamine
    • DTXSID80426446
    • MFCD01075732
    • (S)-3-methylbutan-2-amine
    • (2S)-3-methyl-2-butanamine
    • (1S)-1,2-Dimethylpropylamine
    • DTXCID60377280
    • JOZZAIIGWFLONA-YFKPBYRVSA-N
    • (s)-(+)-3-methyl-2-butyl-amine
    • AKOS015841166
    • FA29655
    • EN300-89230
    • A12293
    • (S)-(+)-2-Amino-3-methylbutane, 98+%, ee 99%
    • Q27256184
    • (S)-(+)-2-Amino-3-methylbutane, ChiPros(R), produced by BASF
    • (S)-(+)-3-Methyl-2-butylamine; (2S)-3-Methylbut-2-ylamine; (2S)-3-Methylbutan-2-amine
    • 627-253-5

  • Applications

    Applications of 1,2-Dimethylpropylamine, (S)- (CAS 22526-46-1) include its use as a chiral building block and intermediate for enantioenriched amines in pharmaceutical and agrochemical synthesis; a precursor to chiral ligands and catalysts for asymmetric transformations; a reactive amine used as a curing agent for epoxy resins in coatings and adhesives; and a versatile building block in polymer technology for functionalized polymers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 251.84
    methanol 328.58
    isopropanol 168.04
    water 12.04
    ethyl acetate 109.94
    n-propanol 227.78
    acetone 102.72
    n-butanol 238.5
    acetonitrile 124.02
    DMF 103.55
    toluene 32.6
    isobutanol 144.09
    1,4-dioxane 128.76
    methyl acetate 110.54
    THF 291.4
    2-butanone 116.0
    n-pentanol 121.28
    sec-butanol 170.73
    n-hexane 25.98
    ethylene glycol 81.87
    NMP 170.16
    cyclohexane 26.62
    DMSO 109.5
    n-butyl acetate 177.88
    n-octanol 82.44
    chloroform 292.66
    n-propyl acetate 64.49
    acetic acid 280.58
    dichloromethane 140.01
    cyclohexanone 149.65
    propylene glycol 128.23
    isopropyl acetate 63.23
    DMAc 118.0
    2-ethoxyethanol 126.32
    isopentanol 147.91
    n-heptane 43.47
    ethyl formate 106.4
    1,2-dichloroethane 70.9
    n-hexanol 240.93
    2-methoxyethanol 232.04
    isobutyl acetate 45.56
    tetrachloromethane 101.74
    n-pentyl acetate 84.25
    transcutol 252.25
    n-heptanol 127.68
    ethylbenzene 16.21
    MIBK 48.29
    2-propoxyethanol 253.9
    tert-butanol 173.58
    MTBE 103.54
    2-butoxyethanol 170.96
    propionic acid 229.79
    o-xylene 27.78
    formic acid 130.28
    diethyl ether 94.95
    m-xylene 23.45
    p-xylene 26.38
    chlorobenzene 60.83
    dimethyl carbonate 26.16
    n-octane 12.84
    formamide 106.74
    cyclopentanone 218.79
    2-pentanone 90.1
    anisole 37.85
    cyclopentyl methyl ether 115.76
    gamma-butyrolactone 240.98
    1-methoxy-2-propanol 161.43
    pyridine 124.37
    3-pentanone 73.6
    furfural 204.32
    n-dodecane 7.68
    diethylene glycol 163.18
    diisopropyl ether 29.55
    tert-amyl alcohol 179.04
    acetylacetone 70.7
    n-hexadecane 7.88
    acetophenone 41.15
    methyl propionate 83.8
    isopentyl acetate 123.76
    trichloroethylene 149.75
    n-nonanol 71.83
    cyclohexanol 127.92
    benzyl alcohol 52.67
    2-ethylhexanol 144.55
    isooctanol 83.79
    dipropyl ether 114.4
    1,2-dichlorobenzene 52.33
    ethyl lactate 51.86
    propylene carbonate 150.11
    n-methylformamide 127.51
    2-pentanol 130.44
    n-pentane 29.87
    1-propoxy-2-propanol 225.75
    1-methoxy-2-propyl acetate 103.21
    2-(2-methoxypropoxy) propanol 91.49
    mesitylene 15.28
    ε-caprolactone 149.14
    p-cymene 32.88
    epichlorohydrin 142.52
    1,1,1-trichloroethane 121.77
    2-aminoethanol 168.22
    morpholine-4-carbaldehyde 134.91
    sulfolane 207.73
    2,2,4-trimethylpentane 20.0
    2-methyltetrahydrofuran 195.74
    n-hexyl acetate 87.54
    isooctane 10.73
    2-(2-butoxyethoxy)ethanol 136.53
    sec-butyl acetate 45.92
    tert-butyl acetate 64.37
    decalin 10.94
    glycerin 154.54
    diglyme 177.64
    acrylic acid 182.12
    isopropyl myristate 34.94
    n-butyric acid 308.43
    acetyl acetate 68.9
    di(2-ethylhexyl) phthalate 42.35
    ethyl propionate 53.39
    nitromethane 195.27
    1,2-diethoxyethane 90.3
    benzonitrile 72.93
    trioctyl phosphate 36.18
    1-bromopropane 71.06
    gamma-valerolactone 205.77
    n-decanol 51.13
    triethyl phosphate 46.26
    4-methyl-2-pentanol 65.94
    propionitrile 128.86
    vinylene carbonate 107.92
    1,1,2-trichlorotrifluoroethane 181.23
    DMS 42.2
    cumene 16.44
    2-octanol 70.75
    2-hexanone 65.56
    octyl acetate 53.27
    limonene 55.08
    1,2-dimethoxyethane 122.45
    ethyl orthosilicate 50.14
    tributyl phosphate 41.94
    diacetone alcohol 96.81
    N,N-dimethylaniline 27.99
    acrylonitrile 124.78
    aniline 91.46
    1,3-propanediol 205.13
    bromobenzene 45.87
    dibromomethane 110.72
    1,1,2,2-tetrachloroethane 148.94
    2-methyl-cyclohexyl acetate 71.69
    tetrabutyl urea 45.68
    diisobutyl methanol 65.08
    2-phenylethanol 78.86
    styrene 20.05
    dioctyl adipate 43.67
    dimethyl sulfate 42.06
    ethyl butyrate 108.01
    methyl lactate 72.03
    butyl lactate 89.54
    diethyl carbonate 60.57
    propanediol butyl ether 112.46
    triethyl orthoformate 89.21
    p-tert-butyltoluene 31.74
    methyl 4-tert-butylbenzoate 63.64
    morpholine 176.49
    tert-butylamine 130.86
    n-dodecanol 38.71
    dimethoxymethane 59.72
    ethylene carbonate 100.02
    cyrene 66.53
    2-ethoxyethyl acetate 78.76
    2-ethylhexyl acetate 101.26
    1,2,4-trichlorobenzene 64.18
    4-methylpyridine 101.09
    dibutyl ether 64.45
    2,6-dimethyl-4-heptanol 65.08
    DEF 91.32
    dimethyl isosorbide 119.79
    tetrachloroethylene 133.55
    eugenol 71.04
    triacetin 69.0
    span 80 115.41
    1,4-butanediol 73.94
    1,1-dichloroethane 105.03
    2-methyl-1-pentanol 93.53
    methyl formate 78.64
    2-methyl-1-butanol 151.15
    n-decane 13.36
    butyronitrile 143.01
    3,7-dimethyl-1-octanol 72.68
    1-chlorooctane 37.12
    1-chlorotetradecane 14.95
    n-nonane 13.59
    undecane 9.66
    tert-butylcyclohexane 13.6
    cyclooctane 10.79
    cyclopentanol 166.04
    tetrahydropyran 153.8
    tert-amyl methyl ether 86.36
    2,5,8-trioxanonane 121.28
    1-hexene 55.39
    2-isopropoxyethanol 87.59
    2,2,2-trifluoroethanol 112.62
    methyl butyrate 76.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction