1,2-Dimethylhydrazine

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  • Identifiers

    CAS number
    540-73-8

    Molecular formula
    C2H8N2

    SMILES
    CNNC

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Fishy 81.75%
    Cheesy 48.32%
    Ripe 43.15%
    Odorless 42.67%
    Animal 20.98%
    Pungent 17.74%
    Meaty 17.35%
    Savory 14.81%
    Cooked 12.61%
    Oily 12.59%

     

    Flavor
    Fishy 39.74%
    Odorless 32.49%
    Ammoniacal 32.46%
    Sulfurous 28.68%
    Meaty 24.92%
    Sulfury 22.85%
    Onion 22.45%
    Rotten 19.36%
    Ammonia 19.22%
    Glue 19.1%

     

    Odor impact est.
    High

    Odor threshold

    • The warning properties (irritation & odor) of the hydrazines are probably sufficient to prevent acute poisoning from short exposures. However, in view of the chronic toxicity properties, the warning properties should not be considered adequate for prolonged exposures. /Hydrazines/

  • Properties

    XLogP3-AA
    -0.4

    pKa est.
    6.5 (neutral)

    Molecular weight
    60.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -9 °C

    Boiling point

    • 177.8 °F at 760 mmHg (USCG, 1999)
    • 81 °C @ 753 mm Hg
    • 81 °C

    Flash point

    • 21.67 ˚C est.
    • 5 °F
    • Less than 23 °C (Closed cup)

    Solubility expt.

    • Miscible with alcohol, ether, dimethylformamide, hydrocarbons
    • Miscible with water: 1X10+6 mg/l at 25 °C
    • Solubility in water, g/100ml at 25 °C: 100

  • Synonyms

    • 1,2-DIMETHYLHYDRAZINE
    • Hydrazomethane
    • 540-73-8
    • N,N'-Dimethylhydrazine
    • sym-Dimethylhydrazine
    • SDMH
    • Hydrazine, 1,2-dimethyl-
    • 1,2-Dimethylhydrazin
    • 1,2-Dimethyl-hydrazine
    • Symmetrical-dimethylhydrazine
    • MeNHNHMe
    • RCRA waste number U099
    • 1,2-DMH
    • s-Dimethylhydrazine
    • Symetryczna dwumetylohydrazyna
    • CCRIS 259
    • (CH3NH)2
    • 1,2-Dimethylhydrazin [German]
    • HSDB 4039
    • (MeNH)2
    • UN2382
    • Dimethylhydrazine, symmetrical
    • Symetryczna dwumetylohydrazyna [Polish]
    • BRN 1730826
    • DMH
    • UNII-IX068S9745
    • CHEBI:73755
    • 12-Dimethyl hydrazine
    • IX068S9745
    • DTXSID0041228
    • 4-04-00-03323 (Beilstein Handbook Reference)
    • 1,2-DIMETHYLHYDRAZINE [MI]
    • 1,2-DIMETHYLHYDRAZINE [HSDB]
    • 1,2-DIMETHYLHYDRAZINE [IARC]
    • UN 2382
    • 1,2-DIMETHYLHYDRAZINE (IARC)
    • 1,2-DIMETHYLHYDRAZIN (GERMAN)
    • SYMETRYCZNA DWUMETYLOHYDRAZYNA (POLISH)
    • 1,2 Dimethylhydrazine
    • N,N' Dimethylhydrazine
    • 1,2 Dimethyl hydrazine
    • RCRA waste no. U099
    • dimethyl hydrazine
    • symDimethylhydrazine
    • 1,2Dimethylhydrazin
    • 1,2dimethylhydrazine
    • 1,2-dimethyldiazane
    • n,n'dimethylhydrazine
    • Spectrum_001942
    • SpecPlus_000706
    • Hydrazine, 1,2dimethyl
    • Spectrum2_000777
    • Spectrum4_000928
    • Spectrum5_001838
    • Symmetricaldimethylhydrazine
    • hydrazine, N,N'-dimethyl-
    • KBioGR_001456
    • KBioSS_002496
    • DivK1c_006802
    • SPBio_000854
    • 1,2DMH
    • CHEMBL162921
    • DTXCID8021228
    • KBio1_001746
    • KBio2_002488
    • KBio2_005056
    • KBio2_007624
    • ALBB-017785
    • AKOS006228693
    • NCGC00248953-01
    • LS-05888
    • PD075291
    • NS00075365
    • C19176
    • H32404
    • A829943
    • Q161484
    • Dimethylhydrazine, symmetrical [UN2382] [Poison]

  • Applications

    1,2-Dimethylhydrazine is primarily used as an organic synthesis intermediate and building block across several industries, and is identified by CAS 540-73-8. It serves as a precursor for pharmaceutical and agrochemical intermediates containing hydrazine or hydrazone motifs; in polymer and coatings chemistry it can function as a curing or crosslinking reagent to form hydrazide linkages in specialty resins and coatings; in analytical chemistry it is used as a derivatization reagent to form hydrazones with carbonyl compounds for detection or separation; it also participates in dye and pigment chemistry as a reactive intermediate for hydrazide- or hydrazone-based dye synthesis; and it may be evaluated as a reagent or building block in other specialty syntheses, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 94.77
    methanol 244.83
    isopropanol 37.57
    water 91.77
    ethyl acetate 15.93
    n-propanol 61.89
    acetone 27.07
    n-butanol 39.03
    acetonitrile 43.82
    DMF 101.83
    toluene 3.24
    isobutanol 28.83
    1,4-dioxane 33.89
    methyl acetate 30.54
    THF 51.13
    2-butanone 24.48
    n-pentanol 18.7
    sec-butanol 29.36
    n-hexane 1.88
    ethylene glycol 112.09
    NMP 119.94
    cyclohexane 4.05
    DMSO 81.16
    n-butyl acetate 10.28
    n-octanol 7.51
    chloroform 73.44
    n-propyl acetate 6.96
    acetic acid 191.44
    dichloromethane 61.57
    cyclohexanone 30.68
    propylene glycol 78.75
    isopropyl acetate 5.12
    DMAc 73.36
    2-ethoxyethanol 41.01
    isopentanol 15.52
    n-heptane 3.2
    ethyl formate 30.55
    1,2-dichloroethane 24.93
    n-hexanol 18.74
    2-methoxyethanol 118.62
    isobutyl acetate 3.56
    tetrachloromethane 26.03
    n-pentyl acetate 6.72
    transcutol 47.21
    n-heptanol 10.2
    ethylbenzene 1.55
    MIBK 3.26
    2-propoxyethanol 38.39
    tert-butanol 23.93
    MTBE 8.0
    2-butoxyethanol 23.15
    propionic acid 99.51
    o-xylene 3.48
    formic acid 246.58
    diethyl ether 11.22
    m-xylene 1.81
    p-xylene 2.49
    chlorobenzene 10.19
    dimethyl carbonate 6.46
    n-octane 1.03
    formamide 175.1
    cyclopentanone 49.23
    2-pentanone 10.17
    anisole 5.05
    cyclopentyl methyl ether 13.62
    gamma-butyrolactone 71.4
    1-methoxy-2-propanol 45.23
    pyridine 39.69
    3-pentanone 11.52
    furfural 81.59
    n-dodecane 0.7
    diethylene glycol 54.21
    diisopropyl ether 1.45
    tert-amyl alcohol 22.38
    acetylacetone 8.97
    n-hexadecane 0.7
    acetophenone 6.94
    methyl propionate 18.65
    isopentyl acetate 6.35
    trichloroethylene 50.68
    n-nonanol 7.05
    cyclohexanol 24.28
    benzyl alcohol 12.71
    2-ethylhexanol 8.74
    isooctanol 6.59
    dipropyl ether 8.26
    1,2-dichlorobenzene 10.51
    ethyl lactate 9.53
    propylene carbonate 26.82
    n-methylformamide 114.61
    2-pentanol 12.39
    n-pentane 3.06
    1-propoxy-2-propanol 22.72
    1-methoxy-2-propyl acetate 9.64
    2-(2-methoxypropoxy) propanol 14.81
    mesitylene 1.1
    ε-caprolactone 30.97
    p-cymene 3.01
    epichlorohydrin 44.48
    1,1,1-trichloroethane 21.63
    2-aminoethanol 123.04
    morpholine-4-carbaldehyde 72.12
    sulfolane 86.51
    2,2,4-trimethylpentane 1.24
    2-methyltetrahydrofuran 31.39
    n-hexyl acetate 8.04
    isooctane 0.41
    2-(2-butoxyethoxy)ethanol 20.58
    sec-butyl acetate 3.12
    tert-butyl acetate 3.78
    decalin 1.06
    glycerin 128.55
    diglyme 29.82
    acrylic acid 116.37
    isopropyl myristate 2.97
    n-butyric acid 58.25
    acetyl acetate 10.82
    di(2-ethylhexyl) phthalate 6.29
    ethyl propionate 6.55
    nitromethane 121.86
    1,2-diethoxyethane 9.08
    benzonitrile 12.35
    trioctyl phosphate 4.15
    1-bromopropane 13.42
    gamma-valerolactone 63.11
    n-decanol 5.0
    triethyl phosphate 6.31
    4-methyl-2-pentanol 4.04
    propionitrile 31.79
    vinylene carbonate 28.57
    1,1,2-trichlorotrifluoroethane 91.27
    DMS 8.15
    cumene 1.56
    2-octanol 4.72
    2-hexanone 5.82
    octyl acetate 4.97
    limonene 5.25
    1,2-dimethoxyethane 25.3
    ethyl orthosilicate 5.63
    tributyl phosphate 4.99
    diacetone alcohol 10.44
    N,N-dimethylaniline 4.66
    acrylonitrile 50.14
    aniline 19.22
    1,3-propanediol 83.97
    bromobenzene 6.63
    dibromomethane 35.42
    1,1,2,2-tetrachloroethane 40.83
    2-methyl-cyclohexyl acetate 6.87
    tetrabutyl urea 7.42
    diisobutyl methanol 3.48
    2-phenylethanol 11.95
    styrene 2.37
    dioctyl adipate 5.9
    dimethyl sulfate 15.56
    ethyl butyrate 8.05
    methyl lactate 23.28
    butyl lactate 10.4
    diethyl carbonate 6.02
    propanediol butyl ether 19.52
    triethyl orthoformate 7.15
    p-tert-butyltoluene 2.96
    methyl 4-tert-butylbenzoate 9.49
    morpholine 56.26
    tert-butylamine 14.19
    n-dodecanol 3.75
    dimethoxymethane 19.57
    ethylene carbonate 19.63
    cyrene 17.84
    2-ethoxyethyl acetate 10.06
    2-ethylhexyl acetate 5.73
    1,2,4-trichlorobenzene 15.17
    4-methylpyridine 21.63
    dibutyl ether 4.88
    2,6-dimethyl-4-heptanol 3.48
    DEF 24.73
    dimethyl isosorbide 20.19
    tetrachloroethylene 46.21
    eugenol 13.14
    triacetin 11.11
    span 80 17.32
    1,4-butanediol 32.98
    1,1-dichloroethane 21.91
    2-methyl-1-pentanol 9.67
    methyl formate 55.04
    2-methyl-1-butanol 20.98
    n-decane 1.11
    butyronitrile 19.95
    3,7-dimethyl-1-octanol 5.82
    1-chlorooctane 3.34
    1-chlorotetradecane 1.47
    n-nonane 1.11
    undecane 0.83
    tert-butylcyclohexane 0.92
    cyclooctane 1.04
    cyclopentanol 46.63
    tetrahydropyran 25.88
    tert-amyl methyl ether 7.68
    2,5,8-trioxanonane 22.99
    1-hexene 4.57
    2-isopropoxyethanol 16.31
    2,2,2-trifluoroethanol 89.46
    methyl butyrate 10.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction