1,2-Dimethoxyethane

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  • Identifiers

    CAS number
    110-71-4

    Molecular formula
    C4H10O2

    SMILES
    COCCOC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 85.91%
    Sweet 74.36%
    Alcoholic 53.56%
    Solvent 51.1%
    Rummy 38.23%
    Fermented 38.05%
    Fruity 33.93%
    Winey 31.82%
    Musty 29.37%
    Pungent 28.06%

     

    Flavor
    Sweet 65.45%
    Green 52.23%
    Alcohol 46.52%
    Alcoholic 46.33%
    Ether 46.07%
    Earthy 39.02%
    Ethereal 37.24%
    Vegetable 36.41%
    Musty 34.27%
    Bitter 32.67%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.2

    pKa est.
    6.59 (neutral)

    Molecular weight
    90.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -72 °F (NTP, 1992)
    • -58 °C
    • -58 °C; ALSO REPORTED AS -71 °C

    Boiling point

    • 185 °F at 760 mmHg (NTP, 1992)
    • 85 °C
    • 82-83 °C @ 760 MM HG
    • 82-83 °C

    Flash point

    • 3.84 ˚C est.
    • 32 °F (NTP, 1992)
    • -2 °C
    • 29 °F(-2 °C) (CLOSED CUP)
    • -2 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
    • 1000000 mg/L (at 20 °C)
    • MISCIBLE WITH WATER, ALCOHOL; SOL IN HYDROCARBON SOLVENTS
    • SOL IN CHLOROFORM, ETHER, ACETONE, BENZENE
    • water solubility = 1.00X10+6 mg/l @ 25 °C
    • Solubility in water: miscible

  • Synonyms

    • 1,2-DIMETHOXYETHANE
    • 110-71-4
    • Ethylene glycol dimethyl ether
    • Monoglyme
    • Glyme
    • Dimethyl Cellosolve
    • Dimethoxyethane
    • Ethane, 1,2-dimethoxy-
    • 2,5-Dioxahexane
    • Egdme
    • 24991-55-7
    • Glycol dimethyl ether
    • Hisolve MMM
    • Ethylene dimethyl ether
    • Dimethylglycol
    • Ansul ether 121
    • 1,2-Dimethoxyethan
    • DME (glycol ether)
    • Dimethylcellosolve
    • Monoethylene glycol dimethyl ether
    • 1,2-Ethanediol dimethyl ether
    • CH3OCH2CH2OCH3
    • Dimethyl Glycol
    • mono-Glyme
    • Ethylenglycoldimethylether
    • Ethylenglykoldimethylether
    • .alpha.,.beta.-Dimethoxyethane
    • HSDB 73
    • NSC 60542
    • alpha,beta-Dimethoxyethane
    • UNII-GXS24JF5IW
    • GXS24JF5IW
    • EINECS 203-794-9
    • MFCD00008502
    • UN2252
    • BRN 1209237
    • DTXSID0025286
    • CHEBI:42263
    • 1,2-dimethoxy-ethane
    • AI3-61007
    • NSC-60542
    • DTXCID705286
    • DIMETHYOXYETHANE, 1,2-
    • EC 203-794-9
    • 1,2-DIMETHOXYETHANE [MI]
    • 4-01-00-02376 (Beilstein Handbook Reference)
    • 1,2-DIMETHOXYETHANE [HSDB]
    • 1,2-DIMETHOXYETHANE [USP-RS]
    • UN 2252
    • 1,2-DIMETHOXYETHANE (USP-RS)
    • 1,2-dimethoxy ethane
    • Ethane-1,1,2,2-d4, 1,2-dimethoxy-
    • 1, 2-Dimethoxyethane
    • ASTM Method D4815/D5599 1,2-Dimethoxyethane IS
    • dimetoxyethane
    • ethyleneglycol dimethyl ether
    • Dimethoxyethan
    • Selexol
    • 2,5Dioxahexane
    • 1,2dimethoxyethane
    • 1,2 dimethoxyethan
    • 1,2-dimethoxyetane
    • 1,2-dimetoxyethane
    • Genosorb 175
    • Genosorb 300
    • 1,2 dimethoxyethane
    • 1,2-dimethoxiethane
    • 1,2~dimethoxyethane
    • 1.2-dimethoxyethane
    • Varonic DM 55
    • Ethane,2-dimethoxy-
    • 1,2 dimethoxyetharie
    • 1,2 dimethoxylethane
    • 1,2-dimethoxylethane
    • 1,2-dimethyoxyethane
    • Glyme-23
    • Sanfine DM 200
    • Sanfine DM 400
    • 1,2-dimethyloxyethane
    • 1,2 -dimethoxyethane
    • 1,2,-dimethoxyethane
    • 1,2- dimethoxyethane
    • 1,2-di-methoxyethane
    • 1,2-dimethoxye-thane
    • PEG-6 dimethyl ether
    • PEG-7 dimethyl ether
    • PEG-8 dimethyl ether
    • PEG-9 dimethyl ether
    • Ethane, 1,2dimethoxy
    • Sanfine DM 1000
    • Carpol CLE 1000
    • 1,2 -dimethoxy ethane
    • PEG-10 dimethyl ether
    • DME (SOLVENT)
    • UNII-OMW34MPM4E
    • Nissan Unisafe MM 400
    • OMW34MPM4E
    • 1,2-bis(methyloxy)ethane
    • ANSUL ETHER 12'
    • UNII-O5E08Z8AEA
    • UNII-W83S1I1CJE
    • Nissan Unisafe MM 1000
    • ethylene glycol dimethylether
    • U-Nox DM 200
    • O5E08Z8AEA
    • UNII-7GSD980LF9
    • UNII-9I2Z48JZJ5
    • W83S1I1CJE
    • (2-methoxy)ethylmethyl ether
    • 1,2Ethanediol dimethyl ether
    • U-Nox DM 1000
    • ethylene-glycol dimethyl ether
    • 7GSD980LF9
    • 9I2Z48JZJ5
    • PEG-DME 2000
    • 1,2-Dimethoxyethane, anhydrous
    • monoethylene glycol dimethylether
    • CHEMBL1232411
    • dimethylene glycol dimethyl ether
    • DIMETHYL CELLOSOLVE SOLVENT
    • BCP30022
    • NSC60542
    • Tox21_200420
    • STL282726
    • AKOS009029143
    • DB01749
    • SB13076
    • 1,2-Dimethoxyethane, purification grade

  • Applications

    1,2-Dimethoxyethane (CAS 110-71-4) is a polar aprotic solvent used as a general solvent and reaction medium in organic synthesis, where it can coordinate to metal centers and stabilize organometallic reagents such as Grignard and lithium species. It is also employed as a co-solvent in lithium-based battery electrolytes, contributing high donor strength and compatibility with salts. In industry, it serves as a processing solvent for polymers, resins, coatings, and adhesives, aiding dissolution, film casting, and formulation. It may be used as a solvent in pharmaceutical synthesis and formulation development under appropriate regulatory controls. Additionally, it can be used as a cleaning or degreasing solvent for lab equipment and precision parts where compatible with materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 166.1
    methanol 226.29
    isopropanol 116.56
    water 24.34
    ethyl acetate 66.93
    n-propanol 138.53
    acetone 107.21
    n-butanol 90.62
    acetonitrile 117.83
    DMF 237.43
    toluene 13.15
    isobutanol 88.04
    1,4-dioxane 154.63
    methyl acetate 112.77
    THF 175.12
    2-butanone 85.44
    n-pentanol 37.96
    sec-butanol 107.76
    n-hexane 7.24
    ethylene glycol 171.35
    NMP 242.24
    cyclohexane 25.0
    DMSO 222.58
    n-butyl acetate 37.51
    n-octanol 30.67
    chloroform 364.18
    n-propyl acetate 32.04
    acetic acid 531.85
    dichloromethane 272.22
    cyclohexanone 114.39
    propylene glycol 167.38
    isopropyl acetate 27.47
    DMAc 164.24
    2-ethoxyethanol 98.43
    isopentanol 46.75
    n-heptane 12.91
    ethyl formate 78.86
    1,2-dichloroethane 118.31
    n-hexanol 49.8
    2-methoxyethanol 258.74
    isobutyl acetate 17.93
    tetrachloromethane 89.71
    n-pentyl acetate 27.56
    transcutol 148.7
    n-heptanol 31.01
    ethylbenzene 9.08
    MIBK 18.05
    2-propoxyethanol 97.32
    tert-butanol 117.29
    MTBE 40.26
    2-butoxyethanol 62.97
    propionic acid 255.65
    o-xylene 17.92
    formic acid 260.58
    diethyl ether 39.99
    m-xylene 10.27
    p-xylene 14.91
    chlorobenzene 46.49
    dimethyl carbonate 30.01
    n-octane 4.73
    formamide 227.61
    cyclopentanone 163.04
    2-pentanone 39.99
    anisole 28.04
    cyclopentyl methyl ether 62.5
    gamma-butyrolactone 232.21
    1-methoxy-2-propanol 145.2
    pyridine 126.75
    3-pentanone 43.74
    furfural 245.72
    n-dodecane 4.03
    diethylene glycol 120.48
    diisopropyl ether 9.04
    tert-amyl alcohol 100.04
    acetylacetone 48.06
    n-hexadecane 4.34
    acetophenone 35.32
    methyl propionate 69.92
    isopentyl acetate 29.02
    trichloroethylene 288.71
    n-nonanol 27.15
    cyclohexanol 107.35
    benzyl alcohol 42.96
    2-ethylhexanol 30.39
    isooctanol 24.64
    dipropyl ether 31.42
    1,2-dichlorobenzene 53.58
    ethyl lactate 43.11
    propylene carbonate 112.26
    n-methylformamide 190.51
    2-pentanol 52.11
    n-pentane 9.98
    1-propoxy-2-propanol 73.22
    1-methoxy-2-propyl acetate 40.79
    2-(2-methoxypropoxy) propanol 60.33
    mesitylene 8.07
    ε-caprolactone 117.58
    p-cymene 15.24
    epichlorohydrin 164.18
    1,1,1-trichloroethane 131.04
    2-aminoethanol 197.3
    morpholine-4-carbaldehyde 196.03
    sulfolane 280.48
    2,2,4-trimethylpentane 6.89
    2-methyltetrahydrofuran 122.63
    n-hexyl acetate 40.82
    isooctane 2.85
    2-(2-butoxyethoxy)ethanol 67.53
    sec-butyl acetate 18.25
    tert-butyl acetate 25.79
    decalin 7.97
    glycerin 267.53
    diglyme 126.61
    acrylic acid 296.05
    isopropyl myristate 16.63
    n-butyric acid 176.13
    acetyl acetate 53.52
    di(2-ethylhexyl) phthalate 24.63
    ethyl propionate 33.68
    nitromethane 396.87
    1,2-diethoxyethane 34.92
    benzonitrile 52.98
    trioctyl phosphate 17.88
    1-bromopropane 55.58
    gamma-valerolactone 191.64
    n-decanol 19.74
    triethyl phosphate 30.67
    4-methyl-2-pentanol 19.44
    propionitrile 89.18
    vinylene carbonate 114.3
    1,1,2-trichlorotrifluoroethane 299.08
    DMS 42.31
    cumene 9.25
    2-octanol 20.38
    2-hexanone 24.18
    octyl acetate 23.88
    limonene 26.66
    1,2-dimethoxyethane 101.86
    ethyl orthosilicate 26.46
    tributyl phosphate 21.75
    diacetone alcohol 54.86
    N,N-dimethylaniline 24.15
    acrylonitrile 152.31
    aniline 65.27
    1,3-propanediol 174.53
    bromobenzene 36.92
    dibromomethane 167.66
    1,1,2,2-tetrachloroethane 230.94
    2-methyl-cyclohexyl acetate 34.18
    tetrabutyl urea 28.48
    diisobutyl methanol 17.61
    2-phenylethanol 39.93
    styrene 12.44
    dioctyl adipate 30.97
    dimethyl sulfate 72.01
    ethyl butyrate 36.29
    methyl lactate 81.45
    butyl lactate 39.44
    diethyl carbonate 30.35
    propanediol butyl ether 66.78
    triethyl orthoformate 33.05
    p-tert-butyltoluene 15.54
    methyl 4-tert-butylbenzoate 51.69
    morpholine 196.42
    tert-butylamine 73.25
    n-dodecanol 15.4
    dimethoxymethane 69.64
    ethylene carbonate 82.61
    cyrene 70.87
    2-ethoxyethyl acetate 37.06
    2-ethylhexyl acetate 25.0
    1,2,4-trichlorobenzene 80.45
    4-methylpyridine 73.17
    dibutyl ether 21.84
    2,6-dimethyl-4-heptanol 17.61
    DEF 82.91
    dimethyl isosorbide 84.8
    tetrachloroethylene 198.93
    eugenol 54.49
    triacetin 58.89
    span 80 69.7
    1,4-butanediol 58.91
    1,1-dichloroethane 123.2
    2-methyl-1-pentanol 24.79
    methyl formate 121.57
    2-methyl-1-butanol 64.36
    n-decane 6.07
    butyronitrile 62.71
    3,7-dimethyl-1-octanol 24.99
    1-chlorooctane 18.78
    1-chlorotetradecane 8.67
    n-nonane 6.07
    undecane 4.76
    tert-butylcyclohexane 7.12
    cyclooctane 6.3
    cyclopentanol 154.61
    tetrahydropyran 107.81
    tert-amyl methyl ether 35.02
    2,5,8-trioxanonane 88.95
    1-hexene 16.67
    2-isopropoxyethanol 52.52
    2,2,2-trifluoroethanol 228.23
    methyl butyrate 48.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction