1,2-Dichloro-1,1,2-trifluoroethane

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  • Identifiers

    CAS number
    354-23-4

    Molecular formula
    C2HCl2F3

    SMILES
    C(C(F)(F)Cl)(F)Cl

  • Odor profile

    Fragrance
    Odorless 56.78%
    Fishy 29.11%
    Sweet 23.4%
    Woody 21.41%
    Cooling 20.98%
    Balsamic 17.78%
    Animal 17.46%
    Savory 16.01%
    Ripe 15.67%
    Oily 15.5%

     

    Flavor
    Odorless 34.13%
    Sulfurous 24.23%
    Sulfury 20.13%
    Mild 19.51%
    Bland 19.5%
    Meaty 18.49%
    Bloody 18.48%
    Glue 18.4%
    Bouillon 17.96%
    Skunky 17.87%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    3.99 (weak acid)

    Molecular weight
    152.93 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -78 °C

    Boiling point

    • 29.5 °C

    Flash point

    • -4.35 ˚C est.

  • Synonyms

    • 1,2-Dichloro-1,1,2-trifluoroethane
    • 1,2-Dichlorotrifluoroethane
    • 354-23-4
    • HCFC 123a
    • HCFC-123A
    • Ethane, 1,2-dichloro-1,1,2-trifluoro-
    • 1,1,2-Trifluoro-1,2-dichloroethane
    • HSDB 6871
    • UNII-K8CR1MEG1D
    • K8CR1MEG1D
    • 90454-18-5
    • EINECS 206-549-4
    • CF2ClCHFCl
    • BRN 1698496
    • DICHLORO-1,1,2-TRIFLUOROETHANE
    • DTXSID1042021
    • 4-01-00-00136 (Beilstein Handbook Reference)
    • 1,2-dichloro-1,2,2-trifluoroethane
    • 1,2-DICHLORO-1,1,2-TRIFLUOROETHANE [HSDB]
    • CFC 123a
    • F 123a
    • R 123a
    • SCHEMBL166828
    • 1,2-Dichlorotrifluoroethane 100 microg/mL in Methanol
    • DTXCID9022021
    • 1,1,2Trifluoro1,2dichloroethane
    • Ethane, 1,2dichloro1,1,2trifluoro
    • AKOS006345010
    • FD78405
    • 1,2-Dichlorotrifluoroethane, high purity
    • DB-048801
    • NS00042120
    • Q27282088
    • 206-549-4

  • Applications

    1,2-Dichloro-1,1,2-trifluoroethane (CAS 354-23-4) is a halogenated small molecule used primarily as an intermediate in the synthesis of fluorinated organic compounds and can function as a specialty solvent in industrial processes; it is also considered a precursor for the production of fluorinated polymers and coatings, or as a component in refrigerant and blowing-agent formulations in plastics; in electronics manufacturing, it may be used for surface cleaning and conditioning of components under controlled conditions; its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 442.95
    methanol 826.85
    isopropanol 290.43
    water 233.75
    ethyl acetate 209.82
    n-propanol 266.39
    acetone 857.59
    n-butanol 200.81
    acetonitrile 579.37
    DMF 1926.83
    toluene 91.01
    isobutanol 179.7
    1,4-dioxane 440.67
    methyl acetate 292.55
    THF 571.48
    2-butanone 381.05
    n-pentanol 183.8
    sec-butanol 207.73
    n-hexane 43.74
    ethylene glycol 305.99
    NMP 1037.84
    cyclohexane 79.68
    DMSO 2627.08
    n-butyl acetate 111.86
    n-octanol 105.98
    chloroform 158.65
    n-propyl acetate 181.74
    acetic acid 353.68
    dichloromethane 287.32
    cyclohexanone 311.59
    propylene glycol 143.86
    isopropyl acetate 133.31
    DMAc 1279.38
    2-ethoxyethanol 517.02
    isopentanol 159.32
    n-heptane 60.93
    ethyl formate 226.1
    1,2-dichloroethane 286.27
    n-hexanol 108.21
    2-methoxyethanol 735.36
    isobutyl acetate 82.58
    tetrachloromethane 37.69
    n-pentyl acetate 91.04
    transcutol 771.03
    n-heptanol 72.78
    ethylbenzene 70.02
    MIBK 169.37
    2-propoxyethanol 276.22
    tert-butanol 285.3
    MTBE 218.86
    2-butoxyethanol 164.06
    propionic acid 163.7
    o-xylene 112.76
    formic acid 464.52
    diethyl ether 309.77
    m-xylene 78.44
    p-xylene 79.45
    chlorobenzene 55.21
    dimethyl carbonate 182.3
    n-octane 25.9
    formamide 960.84
    cyclopentanone 389.88
    2-pentanone 292.7
    anisole 201.82
    cyclopentyl methyl ether 269.15
    gamma-butyrolactone 369.93
    1-methoxy-2-propanol 432.52
    pyridine 327.77
    3-pentanone 266.71
    furfural 405.03
    n-dodecane 18.24
    diethylene glycol 332.36
    diisopropyl ether 95.1
    tert-amyl alcohol 212.67
    acetylacetone 361.39
    n-hexadecane 19.41
    acetophenone 229.63
    methyl propionate 249.28
    isopentyl acetate 78.9
    trichloroethylene 261.17
    n-nonanol 96.84
    cyclohexanol 178.31
    benzyl alcohol 171.11
    2-ethylhexanol 76.68
    isooctanol 59.33
    dipropyl ether 179.38
    1,2-dichlorobenzene 57.08
    ethyl lactate 129.56
    propylene carbonate 136.38
    n-methylformamide 800.9
    2-pentanol 158.25
    n-pentane 73.52
    1-propoxy-2-propanol 190.7
    1-methoxy-2-propyl acetate 144.7
    2-(2-methoxypropoxy) propanol 227.16
    mesitylene 65.11
    ε-caprolactone 228.8
    p-cymene 60.33
    epichlorohydrin 386.19
    1,1,1-trichloroethane 102.65
    2-aminoethanol 309.2
    morpholine-4-carbaldehyde 933.83
    sulfolane 601.46
    2,2,4-trimethylpentane 25.32
    2-methyltetrahydrofuran 317.4
    n-hexyl acetate 114.58
    isooctane 16.61
    2-(2-butoxyethoxy)ethanol 259.34
    sec-butyl acetate 99.85
    tert-butyl acetate 132.09
    decalin 25.78
    glycerin 229.8
    diglyme 568.38
    acrylic acid 190.28
    isopropyl myristate 66.21
    n-butyric acid 147.43
    acetyl acetate 136.89
    di(2-ethylhexyl) phthalate 59.86
    ethyl propionate 162.93
    nitromethane 928.27
    1,2-diethoxyethane 257.0
    benzonitrile 147.24
    trioctyl phosphate 49.29
    1-bromopropane 167.65
    gamma-valerolactone 500.26
    n-decanol 78.69
    triethyl phosphate 77.1
    4-methyl-2-pentanol 90.5
    propionitrile 278.34
    vinylene carbonate 135.91
    1,1,2-trichlorotrifluoroethane 284.12
    DMS 122.28
    cumene 58.18
    2-octanol 62.34
    2-hexanone 223.89
    octyl acetate 83.29
    limonene 92.83
    1,2-dimethoxyethane 850.19
    ethyl orthosilicate 72.59
    tributyl phosphate 56.98
    diacetone alcohol 210.26
    N,N-dimethylaniline 249.13
    acrylonitrile 347.72
    aniline 140.61
    1,3-propanediol 290.14
    bromobenzene 44.5
    dibromomethane 204.91
    1,1,2,2-tetrachloroethane 210.56
    2-methyl-cyclohexyl acetate 90.75
    tetrabutyl urea 136.95
    diisobutyl methanol 62.32
    2-phenylethanol 101.39
    styrene 82.3
    dioctyl adipate 105.62
    dimethyl sulfate 323.26
    ethyl butyrate 136.25
    methyl lactate 187.87
    butyl lactate 88.71
    diethyl carbonate 90.04
    propanediol butyl ether 157.47
    triethyl orthoformate 104.85
    p-tert-butyltoluene 55.58
    methyl 4-tert-butylbenzoate 153.69
    morpholine 556.6
    tert-butylamine 195.67
    n-dodecanol 64.4
    dimethoxymethane 756.41
    ethylene carbonate 117.28
    cyrene 247.66
    2-ethoxyethyl acetate 130.78
    2-ethylhexyl acetate 66.11
    1,2,4-trichlorobenzene 71.26
    4-methylpyridine 283.99
    dibutyl ether 126.28
    2,6-dimethyl-4-heptanol 62.32
    DEF 536.36
    dimethyl isosorbide 295.6
    tetrachloroethylene 170.82
    eugenol 163.95
    triacetin 150.28
    span 80 135.13
    1,4-butanediol 185.09
    1,1-dichloroethane 158.51
    2-methyl-1-pentanol 135.83
    methyl formate 567.66
    2-methyl-1-butanol 160.81
    n-decane 29.38
    butyronitrile 225.23
    3,7-dimethyl-1-octanol 86.86
    1-chlorooctane 63.24
    1-chlorotetradecane 32.34
    n-nonane 30.72
    undecane 22.32
    tert-butylcyclohexane 19.53
    cyclooctane 34.96
    cyclopentanol 204.81
    tetrahydropyran 291.95
    tert-amyl methyl ether 201.69
    2,5,8-trioxanonane 440.16
    1-hexene 94.58
    2-isopropoxyethanol 294.43
    2,2,2-trifluoroethanol 221.78
    methyl butyrate 224.38

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction