12-Aminododecanoic Acid

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  • Identifiers

    CAS number
    693-57-2

    Molecular formula
    C12H25NO2

    SMILES
    C(CCCCCC(=O)O)CCCCCN

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Waxy 44.79%
    Fatty 43.48%
    Fishy 41.74%
    Meaty 37.59%
    Cheesy 36.75%
    Odorless 33.88%
    Savory 29.45%
    Citrus 28.99%
    Animal 28.79%
    Fresh 23.72%

     

    Flavor
    Fatty 60.7%
    Waxy 49.08%
    Mild 37.04%
    Fat 34.26%
    Odorless 33.88%
    Coconut 30.89%
    Faint 27.83%
    Soapy 27.49%
    Oily 27.18%
    Bland 26.31%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.5

    pKa est.
    6.5 (neutral)

    Molecular weight
    215.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    331°C

    Flash point

    • 171.58 ˚C est.

  • Synonyms

    • 12-Aminododecanoic acid
    • 693-57-2
    • 12-Aminolauric acid
    • 12-AMINO-DODECANOIC ACID
    • Dodecanoic acid, 12-amino-
    • Omega-Aminododecanoic acid
    • omega-Aminolauric acid
    • 9042RP777G
    • CHEBI:42025
    • DTXSID90883480
    • RefChem:437322
    • 12-amino-n-dodecanoic acid
    • DTXCID1020803
    • 211-754-7
    • MFCD00008153
    • 12-aminododecanic acid
    • .omega.-Aminolauric acid
    • 25768-33-6
    • CCRIS 6171
    • EINECS 211-754-7
    • UNII-9042RP777G
    • 12-Aminododecanoicacid
    • 12-Ado-OH
    • EC 211-754-7
    • SCHEMBL35594
    • CHEMBL371701
    • SCHEMBL1536473
    • 12-Aminododecanoic acid, 95%
    • NH2-(CH2)11-COOH
    • .LAMBDA.-AMINOLAURIC ACID
    • .OMEGA.-AMINODODECANOIC ACID
    • AMINODODECANOIC ACID, OMEGA-
    • LMFA01100005
    • MSK166329
    • SBB058890
    • AKOS000121401
    • FA49092
    • HY-W105740
    • MSK166329-1000M
    • NCGC00164406-01
    • AS-16036
    • BP-28234
    • SY008929
    • DB-055258
    • A0932
    • CS-0158382
    • NS00006072
    • ST50825650
    • EN300-21176
    • E76112
    • F493048
    • Q27271277
    • 12-Aminododecanic acid Solution in Methanol, 1000ug/mL
    • 12-Aminododecanoic acid 100 microg/mL in Acetonitrile:Acetic acid
    • 693-57-2

  • Applications

    12-Aminododecanoic acid (CAS 693-57-2) is typically used as a bifunctional monomer and building block in polymer chemistry, notably for nylon-12 type polyamides and related specialty resins used in engineering plastics, films, and coatings. It serves as a feedstock for lactamization to laurolactam, the key precursor to nylon-12, placing it at the core of nylon-12 production. The molecule is also employed as an intermediate in the synthesis of specialty surfactants and polymer additives, including amphoteric or zwitterionic surfactants used in cleaners and personal-care or industrial formulations. In addition, it functions as a building block in polyurethane and epoxy resin systems, enabling crosslinking and surface modification through its amine and carboxyl groups. It is encountered as a chemical intermediate in pharmaceutical and agrochemical synthesis. Finally, its long hydrophobic chain and polar head group allow it to act as or contribute to corrosion-inhibiting additives in metalworking fluids and coatings, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 151.43
    methanol 354.4
    isopropanol 79.04
    water 0.34
    ethyl acetate 30.37
    n-propanol 100.7
    acetone 48.97
    n-butanol 88.73
    acetonitrile 13.46
    DMF 144.53
    toluene 10.68
    isobutanol 76.25
    1,4-dioxane 55.39
    methyl acetate 18.95
    THF 247.59
    2-butanone 30.74
    n-pentanol 78.67
    sec-butanol 51.96
    n-hexane 7.09
    ethylene glycol 43.95
    NMP 207.03
    cyclohexane 7.02
    DMSO 589.25
    n-butyl acetate 62.45
    n-octanol 24.85
    chloroform 49.17
    n-propyl acetate 57.12
    acetic acid 122.77
    dichloromethane 39.76
    cyclohexanone 140.32
    propylene glycol 82.36
    isopropyl acetate 39.6
    DMAc 115.48
    2-ethoxyethanol 157.59
    isopentanol 94.75
    n-heptane 4.5
    ethyl formate 37.56
    1,2-dichloroethane 41.91
    n-hexanol 75.0
    2-methoxyethanol 237.27
    isobutyl acetate 45.57
    tetrachloromethane 15.29
    n-pentyl acetate 44.59
    transcutol 351.57
    n-heptanol 38.97
    ethylbenzene 11.31
    MIBK 53.55
    2-propoxyethanol 157.57
    tert-butanol 119.26
    MTBE 36.55
    2-butoxyethanol 107.32
    propionic acid 79.63
    o-xylene 15.97
    formic acid 84.89
    diethyl ether 18.01
    m-xylene 16.38
    p-xylene 15.6
    chlorobenzene 20.43
    dimethyl carbonate 14.58
    n-octane 1.89
    formamide 95.22
    cyclopentanone 186.8
    2-pentanone 46.88
    anisole 27.56
    cyclopentyl methyl ether 97.66
    gamma-butyrolactone 201.49
    1-methoxy-2-propanol 180.91
    pyridine 48.56
    3-pentanone 27.29
    furfural 167.3
    n-dodecane 1.23
    diethylene glycol 125.0
    diisopropyl ether 13.01
    tert-amyl alcohol 78.43
    acetylacetone 77.16
    n-hexadecane 1.39
    acetophenone 45.43
    methyl propionate 30.55
    isopentyl acetate 68.82
    trichloroethylene 82.43
    n-nonanol 24.53
    cyclohexanol 86.59
    benzyl alcohol 43.66
    2-ethylhexanol 44.23
    isooctanol 35.89
    dipropyl ether 36.91
    1,2-dichlorobenzene 27.82
    ethyl lactate 46.09
    propylene carbonate 106.76
    n-methylformamide 92.1
    2-pentanol 45.71
    n-pentane 3.03
    1-propoxy-2-propanol 117.91
    1-methoxy-2-propyl acetate 76.03
    2-(2-methoxypropoxy) propanol 76.08
    mesitylene 14.51
    ε-caprolactone 124.24
    p-cymene 13.81
    epichlorohydrin 139.55
    1,1,1-trichloroethane 32.22
    2-aminoethanol 127.98
    morpholine-4-carbaldehyde 156.18
    sulfolane 401.71
    2,2,4-trimethylpentane 3.61
    2-methyltetrahydrofuran 111.28
    n-hexyl acetate 49.67
    isooctane 3.07
    2-(2-butoxyethoxy)ethanol 121.3
    sec-butyl acetate 37.93
    tert-butyl acetate 63.77
    decalin 5.96
    glycerin 139.21
    diglyme 211.78
    acrylic acid 64.58
    isopropyl myristate 18.36
    n-butyric acid 145.67
    acetyl acetate 29.64
    di(2-ethylhexyl) phthalate 29.84
    ethyl propionate 37.31
    nitromethane 108.08
    1,2-diethoxyethane 62.59
    benzonitrile 34.03
    trioctyl phosphate 22.83
    1-bromopropane 17.64
    gamma-valerolactone 253.88
    n-decanol 16.93
    triethyl phosphate 32.07
    4-methyl-2-pentanol 38.86
    propionitrile 19.94
    vinylene carbonate 69.85
    1,1,2-trichlorotrifluoroethane 186.45
    DMS 32.63
    cumene 13.21
    2-octanol 20.76
    2-hexanone 56.62
    octyl acetate 24.21
    limonene 20.99
    1,2-dimethoxyethane 157.37
    ethyl orthosilicate 33.97
    tributyl phosphate 28.06
    diacetone alcohol 118.23
    N,N-dimethylaniline 28.36
    acrylonitrile 26.29
    aniline 30.42
    1,3-propanediol 169.19
    bromobenzene 17.8
    dibromomethane 27.33
    1,1,2,2-tetrachloroethane 91.02
    2-methyl-cyclohexyl acetate 57.37
    tetrabutyl urea 37.28
    diisobutyl methanol 25.01
    2-phenylethanol 46.07
    styrene 11.51
    dioctyl adipate 36.61
    dimethyl sulfate 50.09
    ethyl butyrate 49.92
    methyl lactate 49.72
    butyl lactate 64.01
    diethyl carbonate 29.05
    propanediol butyl ether 97.33
    triethyl orthoformate 45.89
    p-tert-butyltoluene 14.21
    methyl 4-tert-butylbenzoate 60.36
    morpholine 114.91
    tert-butylamine 56.04
    n-dodecanol 12.03
    dimethoxymethane 72.48
    ethylene carbonate 61.3
    cyrene 92.46
    2-ethoxyethyl acetate 57.46
    2-ethylhexyl acetate 47.64
    1,2,4-trichlorobenzene 35.81
    4-methylpyridine 41.57
    dibutyl ether 23.8
    2,6-dimethyl-4-heptanol 25.01
    DEF 71.83
    dimethyl isosorbide 142.21
    tetrachloroethylene 74.82
    eugenol 64.49
    triacetin 66.14
    span 80 76.19
    1,4-butanediol 68.71
    1,1-dichloroethane 22.97
    2-methyl-1-pentanol 67.05
    methyl formate 45.47
    2-methyl-1-butanol 70.37
    n-decane 2.32
    butyronitrile 31.35
    3,7-dimethyl-1-octanol 30.01
    1-chlorooctane 11.09
    1-chlorotetradecane 4.07
    n-nonane 2.1
    undecane 1.6
    tert-butylcyclohexane 5.73
    cyclooctane 2.8
    cyclopentanol 119.48
    tetrahydropyran 70.12
    tert-amyl methyl ether 34.46
    2,5,8-trioxanonane 137.71
    1-hexene 19.74
    2-isopropoxyethanol 106.02
    2,2,2-trifluoroethanol 46.65
    methyl butyrate 64.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction