1,1,2,2-Tetrachloro-1,2-difluoroethane

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  • Identifiers

    CAS number
    76-12-0

    Molecular formula
    C2Cl4F2

    SMILES
    C(C(F)(Cl)Cl)(F)(Cl)Cl

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 49.4%
    Woody 29.29%
    Sweet 26.78%
    Balsamic 23.66%
    Fishy 21.39%
    Dry 19.71%
    Clean 19.04%
    Animal 17.6%
    Amber 17.19%
    Waxy 17.11%

     

    Flavor
    Odorless 32.53%
    Sulfurous 20.79%
    Bland 19.95%
    Mild 18.35%
    Glue 17.83%
    Bloody 17.78%
    Sweet-like 17.63%
    Sulfury 17.53%
    Bouillon 17.48%
    Skunky 17.41%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    3.4

    pKa est.
    2.3 (strong acid)

    Molecular weight
    203.8 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 77 °F (NIOSH, 2024)
    • 26 °C
    • 77 °F

    Boiling point

    • 199 °F at 760 mmHg (NIOSH, 2024)
    • 92.8 °C
    • 93 °C
    • 199 °F

    Flash point

    • 22.67 ˚C est.

    Solubility expt.

    • 0.01 % at 77 °F (NIOSH, 2024)
    • In water, 120 mg/L at 25 °C
    • Soluble in ethanol, ethyl ether, chloroform
    • Solubility in water, g/100ml: 0.012
    • (77 °F): 0.01%

  • Synonyms

    • 76-12-0
    • 1,1,2,2-Tetrachloro-1,2-difluoroethane
    • 1,2-Difluorotetrachloroethane
    • Freon R 112
    • Daiflon 112
    • Daiflon S2
    • Refrigerant 112
    • Halocarbon 112
    • Genetron 112
    • Tetrachloro-1,2-difluoroethane
    • sym-Tetrachlorodifluoroethane
    • 1,2-Difluoro-1,1,2,2-tetrachloroethane
    • Fluorocarbon 112
    • Ucon 112
    • FREON 112
    • R 112
    • CFC-112
    • Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-
    • FC 112
    • HSDB 144
    • F-112
    • EINECS 200-935-6
    • Ethane, 1,2-difluoro-1,1,2,2-tetrachloro-
    • BRN 1740336
    • H155PU1V8F
    • DTXSID5026091
    • Ethane,1,1,2,2-tetrachloro-1,2-difluoro-
    • 1,1,2,2-Tetrachlorodifluoroethane
    • s-Tetrachlorodifluoroethane
    • DTXCID706091
    • EC 200-935-6
    • 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE [HSDB]
    • UNII-H155PU1V8F
    • Freon112
    • CFCl2CFCl2
    • Difluorotetrachloroethane
    • DAIFLON S 2
    • symTetrachlorodifluoroethane
    • Tetrachloro1,2difluoroethane
    • SCHEMBL74197
    • CFC112
    • FRON 112
    • CHEMBL3186694
    • UGCSPKPEHQEOSR-UHFFFAOYSA-
    • CFC 112
    • Tox21_200566
    • MFCD00039322
    • 1,2Difluoro1,1,2,2tetrachloroethane
    • CAS-76-12-0
    • NCGC00248707-01
    • NCGC00258120-01
    • 1,2-Difluorotetrachloroethane (CFC-112)
    • DB-056024
    • F 112
    • NS00003480
    • A838615
    • InChI=1/C2Cl4F2/c3-1(4,7)2(5,6)8
    • Q2806548
    • 1,1,2,2-Tetrachloro-1,2-difluoroethane (ACGIH:OSHA)
    • 1,1,2,2-tetrakis(chloranyl)-1,2-bis(fluoranyl)ethane
    • 200-935-6

  • Applications

    Chemical name: 1,1,2,2-Tetrachloro-1,2-difluoroethane (CAS 76-12-0) finds use as an intermediate in the synthesis of halogenated specialty chemicals; as a solvent or reaction medium in industrial processes involving halogenated substrates; as a building block for halogenated polymers, resins, and flame retardants; and as a cleaning/degassing solvent in coatings, inks, electronics, and metal-part cleaning, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 47.57
    methanol 68.56
    isopropanol 33.95
    water 9.32
    ethyl acetate 36.01
    n-propanol 35.76
    acetone 82.81
    n-butanol 28.24
    acetonitrile 47.39
    DMF 248.71
    toluene 19.08
    isobutanol 25.02
    1,4-dioxane 62.34
    methyl acetate 44.32
    THF 123.57
    2-butanone 55.93
    n-pentanol 26.05
    sec-butanol 30.88
    n-hexane 12.22
    ethylene glycol 32.81
    NMP 255.4
    cyclohexane 23.78
    DMSO 396.9
    n-butyl acetate 34.47
    n-octanol 27.24
    chloroform 55.89
    n-propyl acetate 31.5
    acetic acid 49.76
    dichloromethane 68.67
    cyclohexanone 66.49
    propylene glycol 23.11
    isopropyl acetate 28.92
    DMAc 209.22
    2-ethoxyethanol 70.27
    isopentanol 23.74
    n-heptane 22.88
    ethyl formate 35.58
    1,2-dichloroethane 55.64
    n-hexanol 29.01
    2-methoxyethanol 95.86
    isobutyl acetate 16.08
    tetrachloromethane 15.91
    n-pentyl acetate 32.07
    transcutol 131.18
    n-heptanol 23.64
    ethylbenzene 16.02
    MIBK 32.99
    2-propoxyethanol 63.16
    tert-butanol 36.59
    MTBE 36.71
    2-butoxyethanol 44.43
    propionic acid 29.46
    o-xylene 24.59
    formic acid 49.15
    diethyl ether 49.37
    m-xylene 18.03
    p-xylene 17.72
    chlorobenzene 14.77
    dimethyl carbonate 31.79
    n-octane 10.69
    formamide 103.35
    cyclopentanone 93.99
    2-pentanone 47.55
    anisole 31.6
    cyclopentyl methyl ether 61.89
    gamma-butyrolactone 94.85
    1-methoxy-2-propanol 74.37
    pyridine 61.01
    3-pentanone 47.35
    furfural 83.25
    n-dodecane 6.55
    diethylene glycol 62.58
    diisopropyl ether 21.44
    tert-amyl alcohol 34.91
    acetylacetone 56.07
    n-hexadecane 7.1
    acetophenone 44.04
    methyl propionate 45.14
    isopentyl acetate 26.36
    trichloroethylene 64.75
    n-nonanol 26.23
    cyclohexanol 36.93
    benzyl alcohol 31.33
    2-ethylhexanol 24.98
    isooctanol 19.92
    dipropyl ether 47.49
    1,2-dichlorobenzene 17.82
    ethyl lactate 27.79
    propylene carbonate 38.73
    n-methylformamide 97.95
    2-pentanol 26.1
    n-pentane 18.67
    1-propoxy-2-propanol 53.52
    1-methoxy-2-propyl acetate 44.41
    2-(2-methoxypropoxy) propanol 55.72
    mesitylene 16.49
    ε-caprolactone 53.98
    p-cymene 23.12
    epichlorohydrin 77.29
    1,1,1-trichloroethane 27.84
    2-aminoethanol 40.4
    morpholine-4-carbaldehyde 159.66
    sulfolane 169.57
    2,2,4-trimethylpentane 7.93
    2-methyltetrahydrofuran 72.24
    n-hexyl acetate 35.02
    isooctane 5.76
    2-(2-butoxyethoxy)ethanol 63.81
    sec-butyl acetate 21.69
    tert-butyl acetate 32.71
    decalin 8.31
    glycerin 39.9
    diglyme 118.34
    acrylic acid 33.34
    isopropyl myristate 20.3
    n-butyric acid 29.01
    acetyl acetate 24.23
    di(2-ethylhexyl) phthalate 18.79
    ethyl propionate 31.28
    nitromethane 107.18
    1,2-diethoxyethane 54.09
    benzonitrile 29.89
    trioctyl phosphate 17.1
    1-bromopropane 38.91
    gamma-valerolactone 96.11
    n-decanol 21.13
    triethyl phosphate 24.52
    4-methyl-2-pentanol 18.55
    propionitrile 33.46
    vinylene carbonate 32.41
    1,1,2-trichlorotrifluoroethane 74.55
    DMS 33.05
    cumene 13.98
    2-octanol 19.91
    2-hexanone 35.93
    octyl acetate 24.69
    limonene 33.63
    1,2-dimethoxyethane 107.13
    ethyl orthosilicate 23.9
    tributyl phosphate 18.38
    diacetone alcohol 46.96
    N,N-dimethylaniline 45.58
    acrylonitrile 45.68
    aniline 29.02
    1,3-propanediol 37.64
    bromobenzene 12.94
    dibromomethane 55.8
    1,1,2,2-tetrachloroethane 62.51
    2-methyl-cyclohexyl acetate 30.3
    tetrabutyl urea 39.07
    diisobutyl methanol 22.15
    2-phenylethanol 31.13
    styrene 17.48
    dioctyl adipate 30.66
    dimethyl sulfate 67.38
    ethyl butyrate 35.55
    methyl lactate 39.19
    butyl lactate 30.87
    diethyl carbonate 23.2
    propanediol butyl ether 42.8
    triethyl orthoformate 31.6
    p-tert-butyltoluene 21.94
    methyl 4-tert-butylbenzoate 49.43
    morpholine 86.62
    tert-butylamine 29.89
    n-dodecanol 17.83
    dimethoxymethane 109.93
    ethylene carbonate 26.96
    cyrene 60.65
    2-ethoxyethyl acetate 38.08
    2-ethylhexyl acetate 23.59
    1,2,4-trichlorobenzene 23.92
    4-methylpyridine 51.77
    dibutyl ether 32.3
    2,6-dimethyl-4-heptanol 22.15
    DEF 87.6
    dimethyl isosorbide 85.11
    tetrachloroethylene 49.62
    eugenol 47.04
    triacetin 42.94
    span 80 42.16
    1,4-butanediol 23.57
    1,1-dichloroethane 33.32
    2-methyl-1-pentanol 21.91
    methyl formate 70.11
    2-methyl-1-butanol 24.48
    n-decane 10.73
    butyronitrile 30.37
    3,7-dimethyl-1-octanol 25.66
    1-chlorooctane 20.76
    1-chlorotetradecane 10.77
    n-nonane 11.11
    undecane 8.08
    tert-butylcyclohexane 7.05
    cyclooctane 12.25
    cyclopentanol 45.52
    tetrahydropyran 54.72
    tert-amyl methyl ether 41.0
    2,5,8-trioxanonane 94.78
    1-hexene 20.69
    2-isopropoxyethanol 46.75
    2,2,2-trifluoroethanol 35.28
    methyl butyrate 39.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction