1,1,1,3,3-Pentafluoropropane

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  • Identifiers

    CAS number
    460-73-1

    Molecular formula
    C3H3F5

    SMILES
    C(C(F)F)C(F)(F)F

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 47.23%
    Fishy 31.32%
    Cooling 22.54%
    Sweet 22.33%
    Savory 20.59%
    Animal 20.06%
    Oily 19.48%
    Ripe 18.98%
    Meaty 18.78%
    Balsamic 17.15%

     

    Flavor
    Odorless 30.19%
    Sulfurous 27.56%
    Sulfury 22.05%
    Meaty 21.96%
    Mild 19.42%
    Bloody 18.77%
    Bland 18.77%
    Glue 18.7%
    Bouillon 18.23%
    Skunky 18.14%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    7.82 (neutral)

    Molecular weight
    134.05 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    14°C

    Flash point

    • 7.8 ˚C est.

  • Synonyms

    • 1,1,1,3,3-Pentafluoropropane
    • 460-73-1
    • HFC-245fa
    • pentafluoropropane
    • HFC 245fa
    • F 245fa
    • R 245fa
    • Enovate 3000
    • TA9UOF49CY
    • HFC-245A
    • Propane, 1,1,1,3,3-pentafluoro-
    • HFC245A
    • HFC 245A
    • DTXSID6052110
    • RefChem:70833
    • DTXCID4030679
    • 419-170-6
    • 610-280-1
    • MFCD00236696
    • UNII-TA9UOF49CY
    • 1,1,1,3,3,3-Pentafluoropropane
    • Propane, 1,1,1,3,3,3-pentafluoro-
    • CF3CH2CHF2
    • SCHEMBL18764
    • SCHEMBL537376
    • SCHEMBL615601
    • SCHEMBL7171909
    • SCHEMBL16144924
    • PENTAFLUOROPROPANE [VANDF]
    • 1,1,1,3,3-pentafluoro-propane
    • PENTAFLUOROPROPANE [MART.]
    • PENTAFLUOROPROPANE [WHO-DD]
    • AKOS006229271
    • DB13117
    • FP78764
    • 1,1,1,3,3-Pentafluoropropane (R245fa)
    • NS00010196
    • 460P731
    • Q7164959
    • 460-73-1

  • Applications

    1,1,1,3,3-Pentafluoropropane (CAS 460-73-1) may be used as a specialty solvent and processing aid in industrial manufacturing, serving as a fluorinated solvent and carrier in certain processing steps. In the fluorinated materials space, it is commonly employed as an intermediate in the synthesis of fluoropolymers and other organofluorine compounds. In electronics and precision cleaning, it may be used as a cleaning solvent for components that require chemical stability and low reactivity. It can also function as a reagent in fluorination or halogenation reactions to prepare related fluorinated chemicals. It may be evaluated as a solvent or carrier in fragrance or cosmetic formulations, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 785.33
    methanol 1546.85
    isopropanol 613.12
    water 573.74
    ethyl acetate 351.0
    n-propanol 486.45
    acetone 1220.94
    n-butanol 339.78
    acetonitrile 940.6
    DMF 2821.8
    toluene 115.73
    isobutanol 382.45
    1,4-dioxane 756.1
    methyl acetate 578.9
    THF 994.24
    2-butanone 632.38
    n-pentanol 260.21
    sec-butanol 427.06
    n-hexane 60.44
    ethylene glycol 517.51
    NMP 1845.03
    cyclohexane 46.06
    DMSO 2319.6
    n-butyl acetate 144.77
    n-octanol 127.86
    chloroform 234.07
    n-propyl acetate 290.85
    acetic acid 683.12
    dichloromethane 345.6
    cyclohexanone 425.49
    propylene glycol 419.73
    isopropyl acetate 233.47
    DMAc 2450.14
    2-ethoxyethanol 759.96
    isopentanol 299.11
    n-heptane 35.48
    ethyl formate 446.24
    1,2-dichloroethane 307.99
    n-hexanol 135.55
    2-methoxyethanol 1182.71
    isobutyl acetate 156.41
    tetrachloromethane 55.87
    n-pentyl acetate 107.24
    transcutol 780.65
    n-heptanol 80.97
    ethylbenzene 98.5
    MIBK 283.46
    2-propoxyethanol 467.09
    tert-butanol 682.21
    MTBE 426.15
    2-butoxyethanol 222.94
    propionic acid 411.01
    o-xylene 139.39
    formic acid 754.88
    diethyl ether 434.66
    m-xylene 109.47
    p-xylene 118.25
    chlorobenzene 85.92
    dimethyl carbonate 433.47
    n-octane 17.74
    formamide 1297.09
    cyclopentanone 589.5
    2-pentanone 411.69
    anisole 321.16
    cyclopentyl methyl ether 389.93
    gamma-butyrolactone 752.36
    1-methoxy-2-propanol 841.36
    pyridine 391.05
    3-pentanone 368.72
    furfural 738.8
    n-dodecane 19.77
    diethylene glycol 483.6
    diisopropyl ether 139.33
    tert-amyl alcohol 475.72
    acetylacetone 491.15
    n-hexadecane 20.04
    acetophenone 318.81
    methyl propionate 450.53
    isopentyl acetate 119.91
    trichloroethylene 301.49
    n-nonanol 116.75
    cyclohexanol 255.58
    benzyl alcohol 251.58
    2-ethylhexanol 88.65
    isooctanol 72.27
    dipropyl ether 203.79
    1,2-dichlorobenzene 90.67
    ethyl lactate 252.98
    propylene carbonate 372.71
    n-methylformamide 1387.26
    2-pentanol 246.37
    n-pentane 69.16
    1-propoxy-2-propanol 293.66
    1-methoxy-2-propyl acetate 222.78
    2-(2-methoxypropoxy) propanol 372.21
    mesitylene 86.03
    ε-caprolactone 380.32
    p-cymene 61.43
    epichlorohydrin 688.53
    1,1,1-trichloroethane 175.52
    2-aminoethanol 634.9
    morpholine-4-carbaldehyde 1413.99
    sulfolane 853.09
    2,2,4-trimethylpentane 32.89
    2-methyltetrahydrofuran 536.25
    n-hexyl acetate 170.32
    isooctane 24.68
    2-(2-butoxyethoxy)ethanol 368.91
    sec-butyl acetate 172.18
    tert-butyl acetate 243.99
    decalin 34.35
    glycerin 551.38
    diglyme 704.82
    acrylic acid 448.91
    isopropyl myristate 92.44
    n-butyric acid 285.79
    acetyl acetate 229.29
    di(2-ethylhexyl) phthalate 100.76
    ethyl propionate 305.99
    nitromethane 1530.06
    1,2-diethoxyethane 264.7
    benzonitrile 223.9
    trioctyl phosphate 76.32
    1-bromopropane 189.26
    gamma-valerolactone 923.7
    n-decanol 94.3
    triethyl phosphate 108.56
    4-methyl-2-pentanol 159.35
    propionitrile 488.5
    vinylene carbonate 351.97
    1,1,2-trichlorotrifluoroethane 475.24
    DMS 205.57
    cumene 86.62
    2-octanol 67.62
    2-hexanone 317.9
    octyl acetate 119.86
    limonene 83.96
    1,2-dimethoxyethane 1302.34
    ethyl orthosilicate 101.03
    tributyl phosphate 91.7
    diacetone alcohol 395.97
    N,N-dimethylaniline 341.79
    acrylonitrile 610.61
    aniline 219.48
    1,3-propanediol 511.7
    bromobenzene 64.75
    dibromomethane 206.1
    1,1,2,2-tetrachloroethane 270.76
    2-methyl-cyclohexyl acetate 130.01
    tetrabutyl urea 176.79
    diisobutyl methanol 75.7
    2-phenylethanol 144.31
    styrene 108.13
    dioctyl adipate 155.87
    dimethyl sulfate 607.55
    ethyl butyrate 175.76
    methyl lactate 424.19
    butyl lactate 129.32
    diethyl carbonate 137.81
    propanediol butyl ether 263.9
    triethyl orthoformate 135.52
    p-tert-butyltoluene 59.32
    methyl 4-tert-butylbenzoate 244.71
    morpholine 872.26
    tert-butylamine 429.7
    n-dodecanol 78.79
    dimethoxymethane 1293.76
    ethylene carbonate 297.32
    cyrene 403.6
    2-ethoxyethyl acetate 171.03
    2-ethylhexyl acetate 91.82
    1,2,4-trichlorobenzene 109.72
    4-methylpyridine 437.77
    dibutyl ether 140.01
    2,6-dimethyl-4-heptanol 75.7
    DEF 725.92
    dimethyl isosorbide 475.37
    tetrachloroethylene 175.86
    eugenol 241.56
    triacetin 257.72
    span 80 215.92
    1,4-butanediol 310.22
    1,1-dichloroethane 240.99
    2-methyl-1-pentanol 214.55
    methyl formate 1092.01
    2-methyl-1-butanol 298.54
    n-decane 26.96
    butyronitrile 349.37
    3,7-dimethyl-1-octanol 119.85
    1-chlorooctane 66.29
    1-chlorotetradecane 39.65
    n-nonane 25.9
    undecane 22.3
    tert-butylcyclohexane 36.47
    cyclooctane 21.95
    cyclopentanol 341.5
    tetrahydropyran 415.9
    tert-amyl methyl ether 345.11
    2,5,8-trioxanonane 577.86
    1-hexene 139.84
    2-isopropoxyethanol 469.61
    2,2,2-trifluoroethanol 436.84
    methyl butyrate 377.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction