1,1,1,2,3,3,3-Heptafluoropropane

Overview IFRA Request a quote

  • Identifiers

    CAS number
    431-89-0

    Molecular formula
    C3HF7

    SMILES
    C(C(F)(F)F)(C(F)(F)F)F

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 48.87%
    Fishy 25.3%
    Sweet 24.36%
    Cooling 23.28%
    Woody 22.12%
    Balsamic 18.81%
    Savory 18.51%
    Animal 17.16%
    Oily 16.65%
    Mint 16.04%

     

    Flavor
    Odorless 32.69%
    Sulfurous 22.81%
    Bland 20.47%
    Mild 18.82%
    Sulfury 18.73%
    Bloody 17.96%
    Glue 17.79%
    Bouillon 17.73%
    Sweet-like 17.68%
    Skunky 17.29%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    7.27 (neutral)

    Molecular weight
    170.03 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -126.8 °C

    Boiling point

    • -16.34 °C

    Flash point

    • -15.33 ˚C est.

  • Synonyms

    • 1,1,1,2,3,3,3-Heptafluoropropane
    • 431-89-0
    • Apaflurane
    • 2H-Heptafluoropropane
    • HFC-227ea
    • Solkane 227
    • 2-Hydroheptafluoropropane
    • HFA-227
    • Propane, 1,1,1,2,3,3,3-heptafluoro-
    • Khladon 227
    • HFC-227
    • 2-Hydroperfluoropropane
    • HFC 227
    • Apaflurano
    • FM 200
    • HFA-227EA
    • R40P36GDK6
    • HYDROFLUOROCARBON 227EA
    • R-227
    • apafluranum
    • RefChem:558391
    • 207-079-2
    • MFCD00043834
    • Apaflurane [INN:BAN]
    • CCRIS 7786
    • HFA 227
    • EINECS 207-079-2
    • UNII-R40P36GDK6
    • DTXSID4042048
    • HSDB 7830
    • 2h-perfluoropropane
    • Hfa 227ea
    • Hfc 227ea
    • APAFLURANE [II]
    • Apaflurane (INN/BAN)
    • CF3CHFCF3
    • APAFLURANE [INN]
    • HC-227ea
    • EC 207-079-2
    • APAFLURANE [MART.]
    • SCHEMBL19860
    • SCHEMBL99135
    • CHEMBL2104472
    • SBB088355
    • 1,1,1,2,3,3,3 heptafluoropropane
    • AKOS006229361
    • FH97716
    • 1,1,1,2,3,3,3-heptafluoro-propane
    • DB-051054
    • NS00010611
    • 1,1,1,2,3,3,3-heptakis(fluoranyl)propane
    • 2-Propanyl, 1,1,1,2,3,3,3-heptafluoro-
    • D10216
    • Q2683759
    • InChI=1/C3HF7/c4-1(2(5,6)7)3(8,9)10/h1
    • 431-89-0

  • Applications

    1,1,1,2,3,3,3-Heptafluoropropane (CAS 431-89-0) is primarily used as a refrigerant for air-conditioning and cooling systems, including automotive A/C and commercial equipment, thanks to its stability and cooling performance over a wide temperature range; it is also employed as a blowing agent for rigid polyurethane and polyisocyanurate foams used in insulation; it serves as a fluorinated intermediate for the synthesis of fluoropolymers and specialty fluorochemical products; it may be evaluated as a propellant component in certain aerosol formulations; and it is considered a feedstock or processing aid in fluorochemical manufacturing. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 243.85
    methanol 558.47
    isopropanol 207.51
    water 339.6
    ethyl acetate 112.64
    n-propanol 175.31
    acetone 330.46
    n-butanol 118.04
    acetonitrile 280.66
    DMF 1093.02
    toluene 41.73
    isobutanol 141.44
    1,4-dioxane 243.26
    methyl acetate 178.2
    THF 385.24
    2-butanone 203.3
    n-pentanol 91.76
    sec-butanol 141.48
    n-hexane 32.35
    ethylene glycol 222.73
    NMP 758.34
    cyclohexane 32.9
    DMSO 1163.56
    n-butyl acetate 61.42
    n-octanol 46.58
    chloroform 86.73
    n-propyl acetate 96.41
    acetic acid 179.88
    dichloromethane 117.26
    cyclohexanone 149.03
    propylene glycol 179.17
    isopropyl acetate 81.88
    DMAc 1006.81
    2-ethoxyethanol 272.27
    isopentanol 97.29
    n-heptane 25.06
    ethyl formate 139.36
    1,2-dichloroethane 103.68
    n-hexanol 62.15
    2-methoxyethanol 427.59
    isobutyl acetate 56.28
    tetrachloromethane 27.66
    n-pentyl acetate 38.91
    transcutol 239.82
    n-heptanol 34.42
    ethylbenzene 33.44
    MIBK 97.22
    2-propoxyethanol 191.22
    tert-butanol 223.71
    MTBE 145.07
    2-butoxyethanol 90.5
    propionic acid 145.35
    o-xylene 56.57
    formic acid 249.58
    diethyl ether 179.04
    m-xylene 39.9
    p-xylene 41.26
    chlorobenzene 23.97
    dimethyl carbonate 153.05
    n-octane 11.64
    formamide 444.77
    cyclopentanone 213.94
    2-pentanone 137.68
    anisole 89.43
    cyclopentyl methyl ether 166.63
    gamma-butyrolactone 266.4
    1-methoxy-2-propanol 311.3
    pyridine 134.42
    3-pentanone 145.1
    furfural 215.37
    n-dodecane 9.5
    diethylene glycol 205.96
    diisopropyl ether 62.69
    tert-amyl alcohol 154.21
    acetylacetone 136.2
    n-hexadecane 9.68
    acetophenone 96.08
    methyl propionate 165.79
    isopentyl acetate 45.24
    trichloroethylene 89.29
    n-nonanol 43.77
    cyclohexanol 98.22
    benzyl alcohol 82.65
    2-ethylhexanol 39.56
    isooctanol 28.05
    dipropyl ether 98.51
    1,2-dichlorobenzene 24.44
    ethyl lactate 107.65
    propylene carbonate 127.39
    n-methylformamide 492.56
    2-pentanol 92.01
    n-pentane 41.51
    1-propoxy-2-propanol 132.99
    1-methoxy-2-propyl acetate 98.75
    2-(2-methoxypropoxy) propanol 126.49
    mesitylene 33.98
    ε-caprolactone 138.6
    p-cymene 29.13
    epichlorohydrin 206.71
    1,1,1-trichloroethane 56.43
    2-aminoethanol 249.52
    morpholine-4-carbaldehyde 499.66
    sulfolane 354.81
    2,2,4-trimethylpentane 17.41
    2-methyltetrahydrofuran 195.41
    n-hexyl acetate 52.65
    isooctane 12.33
    2-(2-butoxyethoxy)ethanol 127.89
    sec-butyl acetate 59.21
    tert-butyl acetate 81.98
    decalin 15.8
    glycerin 235.13
    diglyme 233.96
    acrylic acid 150.41
    isopropyl myristate 31.79
    n-butyric acid 98.17
    acetyl acetate 64.62
    di(2-ethylhexyl) phthalate 31.7
    ethyl propionate 105.17
    nitromethane 401.83
    1,2-diethoxyethane 97.79
    benzonitrile 64.09
    trioctyl phosphate 28.01
    1-bromopropane 79.44
    gamma-valerolactone 304.89
    n-decanol 36.17
    triethyl phosphate 54.28
    4-methyl-2-pentanol 62.13
    propionitrile 168.09
    vinylene carbonate 111.23
    1,1,2-trichlorotrifluoroethane 174.31
    DMS 71.69
    cumene 30.68
    2-octanol 28.13
    2-hexanone 102.63
    octyl acetate 39.86
    limonene 38.9
    1,2-dimethoxyethane 422.44
    ethyl orthosilicate 51.13
    tributyl phosphate 33.5
    diacetone alcohol 131.2
    N,N-dimethylaniline 121.05
    acrylonitrile 195.3
    aniline 77.68
    1,3-propanediol 179.76
    bromobenzene 18.48
    dibromomethane 86.18
    1,1,2,2-tetrachloroethane 95.4
    2-methyl-cyclohexyl acetate 51.21
    tetrabutyl urea 68.6
    diisobutyl methanol 34.89
    2-phenylethanol 55.01
    styrene 33.34
    dioctyl adipate 48.65
    dimethyl sulfate 233.32
    ethyl butyrate 75.97
    methyl lactate 172.15
    butyl lactate 54.87
    diethyl carbonate 58.86
    propanediol butyl ether 97.73
    triethyl orthoformate 66.05
    p-tert-butyltoluene 28.9
    methyl 4-tert-butylbenzoate 79.29
    morpholine 327.74
    tert-butylamine 170.31
    n-dodecanol 31.09
    dimethoxymethane 494.25
    ethylene carbonate 106.5
    cyrene 166.76
    2-ethoxyethyl acetate 57.97
    2-ethylhexyl acetate 36.81
    1,2,4-trichlorobenzene 32.14
    4-methylpyridine 131.27
    dibutyl ether 53.34
    2,6-dimethyl-4-heptanol 34.89
    DEF 281.33
    dimethyl isosorbide 189.56
    tetrachloroethylene 65.42
    eugenol 88.01
    triacetin 76.39
    span 80 77.66
    1,4-butanediol 117.3
    1,1-dichloroethane 81.39
    2-methyl-1-pentanol 66.99
    methyl formate 344.22
    2-methyl-1-butanol 101.19
    n-decane 14.11
    butyronitrile 117.44
    3,7-dimethyl-1-octanol 40.92
    1-chlorooctane 26.0
    1-chlorotetradecane 15.14
    n-nonane 14.03
    undecane 11.12
    tert-butylcyclohexane 15.19
    cyclooctane 16.08
    cyclopentanol 134.36
    tetrahydropyran 163.42
    tert-amyl methyl ether 132.58
    2,5,8-trioxanonane 200.33
    1-hexene 55.81
    2-isopropoxyethanol 167.96
    2,2,2-trifluoroethanol 160.64
    methyl butyrate 125.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction