11,12-Dimethoxydihydrokawain

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  • Identifiers

    CAS number
    38146-60-0

    Molecular formula
    C16H20O5

    SMILES
    COC1=CC(=O)OC(C1)CCC2=CC(=C(C=C2)OC)OC

    Safety labels

  • Odor profile

    Fragrance
    Sweet 63.07%
    Spicy 51.19%
    Vanilla 47.25%
    Floral 44.87%
    Creamy 37.11%
    Powdery 31.48%
    Lactonic 30.38%
    Herbal 29.2%
    Warm 29.09%
    Woody 28.63%

     

    Flavor
    Bitter 44.64%
    Spice 29.62%
    Herbal 26.15%
    Floral 25.0%
    Balsam 24.59%
    Sweet 24.19%
    Parsley 22.5%
    Celery 22.42%
    Coconut 22.03%
    Lovage 21.78%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    6.84 (neutral)

    Molecular weight
    292.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    712°C

    Melting point expt.

    • 124 - 125 °C

    Flash point

    • 157.77 ˚C est.

  • Synonyms

    • 11,12-DIMETHOXYDIHYDROKAWAIN
    • 6-[2-(3,4-Dimethoxyphenyl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
    • 6-(2-(3,4-dimethoxyphenyl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
    • RefChem:935222
    • GlyTouCan:G58048UA
    • G58048UA
    • 2-[2-(3,4-dimethoxyphenyl)ethyl]-4-methoxy-2,3-dihydropyran-6-one
    • 38146-60-0
    • 93159-88-7
    • KBio1_001340
    • SpecPlus_000300
    • Spectrum2_001958
    • Spectrum3_001058
    • Spectrum4_001198
    • Spectrum5_001756
    • Compound NP-015089
    • 11-Methoxytetrahydroyangonin
    • BSPBio_002616
    • KBioGR_001895
    • orb320789
    • DivK1c_006396
    • SPBio_002055
    • SCHEMBL29059594
    • SCHEMBL30555672
    • KBio3_001836
    • TETRAHYDROTRIMETHYLHISPIDIN
    • CHEBI:110179
    • CCG-39496
    • 7,8-Dihydro-11,12-dimethoxykawain
    • AKOS040738802
    • 5,6,7,8-Tetrahydro-11-methoxyyangonin
    • NCGC00178573-01
    • BRD-A86977540-001-02-6
    • Q27189559
    • 6-[(3,4-Dimethoxyphenyl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
    • 38146-60-0

  • Applications

    11,12-Dimethoxydihydrokawain, CAS 38146-60-0, is a derivative of kavalactones commonly used as an intermediate in the synthesis of related kavalactone compounds. In industry, it is often employed as a building block to prepare complex organic derivatives for pharmaceutical research and functional chemicals. Given the characteristic aroma associated with kavalactones, it may be used as a fragrance ingredient or fixative in cosmetics and perfumery, subject to regulatory constraints and formulation limits. It is also considered a research chemical in medicinal chemistry and a precursor for synthetic routes related to kavalactones in R&D applications. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.72
    methanol 27.36
    isopropanol 16.58
    water 0.03
    ethyl acetate 86.53
    n-propanol 18.32
    acetone 122.36
    n-butanol 15.4
    acetonitrile 92.73
    DMF 104.68
    toluene 28.22
    isobutanol 13.05
    1,4-dioxane 142.08
    methyl acetate 85.21
    THF 244.63
    2-butanone 83.03
    n-pentanol 15.49
    sec-butanol 15.74
    n-hexane 0.77
    ethylene glycol 10.96
    NMP 75.13
    cyclohexane 3.03
    DMSO 455.7
    n-butyl acetate 31.6
    n-octanol 8.49
    chloroform 343.34
    n-propyl acetate 42.95
    acetic acid 74.55
    dichloromethane 429.15
    cyclohexanone 103.18
    propylene glycol 12.12
    isopropyl acetate 36.88
    DMAc 168.34
    2-ethoxyethanol 74.5
    isopentanol 15.03
    n-heptane 0.88
    ethyl formate 51.61
    1,2-dichloroethane 252.09
    n-hexanol 13.74
    2-methoxyethanol 106.15
    isobutyl acetate 23.92
    tetrachloromethane 20.71
    n-pentyl acetate 18.12
    transcutol 122.76
    n-heptanol 7.99
    ethylbenzene 14.78
    MIBK 30.97
    2-propoxyethanol 58.1
    tert-butanol 28.05
    MTBE 19.52
    2-butoxyethanol 29.46
    propionic acid 36.64
    o-xylene 18.62
    formic acid 26.87
    diethyl ether 30.25
    m-xylene 15.23
    p-xylene 18.9
    chlorobenzene 57.1
    dimethyl carbonate 39.0
    n-octane 0.69
    formamide 54.62
    cyclopentanone 144.33
    2-pentanone 55.01
    anisole 43.95
    cyclopentyl methyl ether 47.73
    gamma-butyrolactone 166.58
    1-methoxy-2-propanol 57.49
    pyridine 112.05
    3-pentanone 48.08
    furfural 147.07
    n-dodecane 0.93
    diethylene glycol 61.93
    diisopropyl ether 6.56
    tert-amyl alcohol 19.32
    acetylacetone 102.8
    n-hexadecane 1.12
    acetophenone 52.48
    methyl propionate 67.57
    isopentyl acetate 30.16
    trichloroethylene 373.34
    n-nonanol 9.5
    cyclohexanol 24.39
    benzyl alcohol 40.67
    2-ethylhexanol 11.96
    isooctanol 8.14
    dipropyl ether 15.06
    1,2-dichlorobenzene 57.02
    ethyl lactate 28.24
    propylene carbonate 72.05
    n-methylformamide 52.88
    2-pentanol 9.21
    n-pentane 0.62
    1-propoxy-2-propanol 33.97
    1-methoxy-2-propyl acetate 48.0
    2-(2-methoxypropoxy) propanol 41.68
    mesitylene 9.4
    ε-caprolactone 82.34
    p-cymene 10.21
    epichlorohydrin 290.93
    1,1,1-trichloroethane 123.06
    2-aminoethanol 16.96
    morpholine-4-carbaldehyde 106.3
    sulfolane 186.86
    2,2,4-trimethylpentane 0.88
    2-methyltetrahydrofuran 83.93
    n-hexyl acetate 23.71
    isooctane 0.62
    2-(2-butoxyethoxy)ethanol 46.49
    sec-butyl acetate 25.97
    tert-butyl acetate 37.12
    decalin 2.28
    glycerin 29.82
    diglyme 103.35
    acrylic acid 41.13
    isopropyl myristate 12.42
    n-butyric acid 46.82
    acetyl acetate 61.62
    di(2-ethylhexyl) phthalate 17.31
    ethyl propionate 42.34
    nitromethane 194.71
    1,2-diethoxyethane 39.93
    benzonitrile 51.05
    trioctyl phosphate 10.55
    1-bromopropane 58.5
    gamma-valerolactone 159.42
    n-decanol 7.66
    triethyl phosphate 27.1
    4-methyl-2-pentanol 7.51
    propionitrile 54.67
    vinylene carbonate 74.32
    1,1,2-trichlorotrifluoroethane 144.07
    DMS 41.82
    cumene 10.56
    2-octanol 5.54
    2-hexanone 38.17
    octyl acetate 15.26
    limonene 12.71
    1,2-dimethoxyethane 118.34
    ethyl orthosilicate 22.96
    tributyl phosphate 15.7
    diacetone alcohol 43.92
    N,N-dimethylaniline 26.52
    acrylonitrile 81.35
    aniline 42.25
    1,3-propanediol 34.72
    bromobenzene 59.69
    dibromomethane 220.51
    1,1,2,2-tetrachloroethane 265.89
    2-methyl-cyclohexyl acetate 31.36
    tetrabutyl urea 21.83
    diisobutyl methanol 8.29
    2-phenylethanol 32.28
    styrene 19.33
    dioctyl adipate 25.75
    dimethyl sulfate 73.63
    ethyl butyrate 32.27
    methyl lactate 36.38
    butyl lactate 19.11
    diethyl carbonate 29.41
    propanediol butyl ether 22.63
    triethyl orthoformate 25.99
    p-tert-butyltoluene 8.8
    methyl 4-tert-butylbenzoate 35.92
    morpholine 137.39
    tert-butylamine 11.03
    n-dodecanol 6.34
    dimethoxymethane 107.78
    ethylene carbonate 63.53
    cyrene 53.6
    2-ethoxyethyl acetate 37.97
    2-ethylhexyl acetate 23.95
    1,2,4-trichlorobenzene 68.4
    4-methylpyridine 77.52
    dibutyl ether 13.57
    2,6-dimethyl-4-heptanol 8.29
    DEF 58.23
    dimethyl isosorbide 73.97
    tetrachloroethylene 137.46
    eugenol 38.78
    triacetin 41.12
    span 80 25.59
    1,4-butanediol 15.57
    1,1-dichloroethane 148.75
    2-methyl-1-pentanol 15.46
    methyl formate 57.18
    2-methyl-1-butanol 13.0
    n-decane 1.39
    butyronitrile 43.03
    3,7-dimethyl-1-octanol 10.88
    1-chlorooctane 7.6
    1-chlorotetradecane 3.99
    n-nonane 1.1
    undecane 1.11
    tert-butylcyclohexane 1.63
    cyclooctane 0.96
    cyclopentanol 29.12
    tetrahydropyran 88.14
    tert-amyl methyl ether 16.96
    2,5,8-trioxanonane 78.42
    1-hexene 4.79
    2-isopropoxyethanol 42.66
    2,2,2-trifluoroethanol 39.73
    methyl butyrate 51.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction