1,1-Dimethoxyethane

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  • Identifiers

    CAS number
    534-15-6

    Molecular formula
    C4H10O2

    SMILES
    CC(OC)OC

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Ethereal 89.78%
    Green 65.15%
    Alcoholic 65.06%
    Cognac 53.55%
    Sweet 45.94%
    Fresh 45.55%
    Fruity 42.99%
    Rummy 40.97%
    Nutty 40.72%
    Fermented 38.32%

     

    Flavor
    Sweet 81.32%
    Green 81.08%
    Ether 57.52%
    Earthy 49.09%
    Alcohol 49.07%
    Vegetable 42.79%
    Fruit 39.03%
    Ethereal 38.06%
    Sharp 37.66%
    Alcoholic 36.45%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.5

    pKa est.
    7.15 (neutral)

    Molecular weight
    90.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -113.2 °C

    Boiling point

    • 64.5 °C
    • 64.00 to 65.00 °C. @ 760.00 mm Hg

    Flash point

    • -16.88 ˚C est.
    • BELOW 80 °F

    Solubility expt.

    • ETHER; VERY SOL IN ACETONE
    • Miscible with water, alcohol, chloroform, ether.
    • 1000 mg/mL at 25 °C
    • miscible with water, organic solvent, oils
    • miscible (in ethanol)

  • Synonyms

    • 1,1-DIMETHOXYETHANE
    • 534-15-6
    • Dimethyl acetal
    • Acetaldehyde dimethyl acetal
    • Dimethylacetal
    • Ethane, 1,1-dimethoxy-
    • Dimethyl aldehyde
    • Ethylidene dimethyl ether
    • Methyl formyl
    • Acetaldehyde methyl acetal
    • 3-Methyl-2,4-dioxapentane
    • Acetaldehyde, dimethyl acetal
    • FEMA No. 3426
    • dimethoxy-ethane
    • HSDB 5427
    • ZO2AW8UR5T
    • EINECS 208-589-8
    • UN2377
    • BRN 1697039
    • DTXSID7027178
    • AI3-24137
    • 1,1-Dimethoxy-Ethane
    • acetaldehyde dimethyl acetal-d10
    • MFCD00008493
    • 1219798-83-0
    • DIMETHYLACETAL [MI]
    • CH3CH(OCH3)2
    • AcetaldehydeDimethylAcetal-d10
    • DTXCID207178
    • DIMETHOXYETHANE, 1,1-
    • 1,1-DIMETHOXYETHANE [FHFI]
    • 1,1-DIMETHOXYETHANE [HSDB]
    • 25154-53-4
    • Ethane, dimethoxy-
    • UNII-ZO2AW8UR5T
    • dimethoxylethane
    • dimethyoxyethane
    • dimethyloxyethane
    • 2-dimethoxyethane
    • Acetaldehyde, dimethyl acetal (6CI,8CI); 3-Methyl-2,4-dioxapentane; Acetaldehyde methyl acetal; Dimethyl acetal; Ethylidene dimethyl ether
    • 2,2-dimethoxyethane
    • 2,2-dimethoxy ethane
    • 1,1'-Dimethoxyetiane
    • Ethane, 1,1dimethoxy
    • 3Methyl2,4dioxapentane
    • acetaldehyde dimethylacetal
    • acetaldehyde-dimethylacetal
    • 1,1-Dimethoxyethane, 9CI
    • 1,1-Dimethoxyethane [UN2377] [Flammable liquid]
    • CHEMBL3183607
    • FEMA 3426
    • CHEBI:178404
    • Acetaldehyde dimethyl acetal, 95%
    • Tox21_200713
    • 1,1-Dimethoxyethane, >=97%, FG
    • AKOS000269040
    • UN 2377
    • NCGC00248807-01
    • NCGC00258267-01
    • CAS-534-15-6
    • FD166483
    • D0633
    • NS00021194
    • D89692
    • EN300-100625
    • 1,1-Dimethoxyethane [UN2377] [Flammable liquid]
    • Q27295796
    • 208-589-8

  • Applications

    1,1-Dimethoxyethane (DME) is a volatile, aprotic ether solvent with high polarity and low viscosity that finds extensive use in both laboratory and industrial settings: it serves as an excellent reaction medium for Grignard, lithiation, and anionic/cationic polymerization processes, and as a diluent or co-solvent in lithium-ion and lithium-metal battery electrolytes where it boosts ionic conductivity and thermal stability; in pharmaceutical and agrochemical synthesis DME can replace THF or diethyl ether to enhance metal-salt solubility and shorten reaction times; in natural-product extraction it delivers high yields of essential oils, flavors, and pigments while being easy to recover by distillation; additionally, it is employed in coatings, inks, and adhesives, and as a semiconductor micro-cleaner because it dissolves epoxy, polyacrylate, polyvinyl, and other stubborn organics, allowing lower VOC formulations thanks to its rapid evaporation, relatively low toxicity, and good recyclability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1393.48
    methanol 1806.1
    isopropanol 1102.83
    water 139.69
    ethyl acetate 611.49
    n-propanol 1007.31
    acetone 771.83
    n-butanol 854.46
    acetonitrile 1184.61
    DMF 858.59
    toluene 283.66
    isobutanol 719.32
    1,4-dioxane 1102.41
    methyl acetate 707.9
    THF 1162.96
    2-butanone 669.33
    n-pentanol 474.22
    sec-butanol 963.82
    n-hexane 195.48
    ethylene glycol 408.55
    NMP 908.7
    cyclohexane 313.6
    DMSO 768.71
    n-butyl acetate 195.96
    n-octanol 174.97
    chloroform 2369.66
    n-propyl acetate 238.49
    acetic acid 1779.41
    dichloromethane 2106.46
    cyclohexanone 668.49
    propylene glycol 426.89
    isopropyl acetate 273.45
    DMAc 902.82
    2-ethoxyethanol 752.29
    isopentanol 558.16
    n-heptane 120.86
    ethyl formate 460.64
    1,2-dichloroethane 923.92
    n-hexanol 319.43
    2-methoxyethanol 1297.05
    isobutyl acetate 126.16
    tetrachloromethane 832.89
    n-pentyl acetate 172.57
    transcutol 735.4
    n-heptanol 171.38
    ethylbenzene 128.62
    MIBK 177.05
    2-propoxyethanol 481.58
    tert-butanol 1143.3
    MTBE 728.57
    2-butoxyethanol 271.15
    propionic acid 924.45
    o-xylene 201.75
    formic acid 1067.72
    diethyl ether 920.55
    m-xylene 140.78
    p-xylene 182.18
    chlorobenzene 347.37
    dimethyl carbonate 111.55
    n-octane 44.02
    formamide 1076.87
    cyclopentanone 689.91
    2-pentanone 413.38
    anisole 271.41
    cyclopentyl methyl ether 572.14
    gamma-butyrolactone 790.13
    1-methoxy-2-propanol 702.92
    pyridine 859.09
    3-pentanone 383.82
    furfural 775.45
    n-dodecane 26.39
    diethylene glycol 388.44
    diisopropyl ether 175.22
    tert-amyl alcohol 1046.85
    acetylacetone 304.22
    n-hexadecane 28.43
    acetophenone 197.91
    methyl propionate 407.74
    isopentyl acetate 157.54
    trichloroethylene 1517.12
    n-nonanol 156.87
    cyclohexanol 748.69
    benzyl alcohol 278.52
    2-ethylhexanol 184.92
    isooctanol 134.74
    dipropyl ether 250.0
    1,2-dichlorobenzene 308.91
    ethyl lactate 129.63
    propylene carbonate 341.89
    n-methylformamide 707.99
    2-pentanol 564.64
    n-pentane 252.58
    1-propoxy-2-propanol 306.14
    1-methoxy-2-propyl acetate 169.75
    2-(2-methoxypropoxy) propanol 192.2
    mesitylene 82.05
    ε-caprolactone 604.98
    p-cymene 91.4
    epichlorohydrin 912.54
    1,1,1-trichloroethane 1103.06
    2-aminoethanol 789.62
    morpholine-4-carbaldehyde 820.31
    sulfolane 743.44
    2,2,4-trimethylpentane 104.62
    2-methyltetrahydrofuran 1149.48
    n-hexyl acetate 215.73
    isooctane 40.48
    2-(2-butoxyethoxy)ethanol 255.49
    sec-butyl acetate 165.51
    tert-butyl acetate 233.3
    decalin 83.93
    glycerin 524.45
    diglyme 497.67
    acrylic acid 781.17
    isopropyl myristate 81.15
    n-butyric acid 877.49
    acetyl acetate 334.93
    di(2-ethylhexyl) phthalate 77.03
    ethyl propionate 235.15
    nitromethane 1449.05
    1,2-diethoxyethane 321.98
    benzonitrile 302.77
    trioctyl phosphate 54.42
    1-bromopropane 751.0
    gamma-valerolactone 815.03
    n-decanol 104.92
    triethyl phosphate 106.31
    4-methyl-2-pentanol 198.71
    propionitrile 738.84
    vinylene carbonate 310.11
    1,1,2-trichlorotrifluoroethane 852.88
    DMS 131.58
    cumene 95.58
    2-octanol 128.47
    2-hexanone 244.01
    octyl acetate 107.95
    limonene 158.55
    1,2-dimethoxyethane 814.22
    ethyl orthosilicate 114.91
    tributyl phosphate 69.63
    diacetone alcohol 297.18
    N,N-dimethylaniline 192.14
    acrylonitrile 773.6
    aniline 498.7
    1,3-propanediol 839.99
    bromobenzene 309.65
    dibromomethane 1452.27
    1,1,2,2-tetrachloroethane 1210.07
    2-methyl-cyclohexyl acetate 144.87
    tetrabutyl urea 88.61
    diisobutyl methanol 98.29
    2-phenylethanol 196.45
    styrene 172.96
    dioctyl adipate 113.86
    dimethyl sulfate 184.19
    ethyl butyrate 188.55
    methyl lactate 200.29
    butyl lactate 119.95
    diethyl carbonate 127.08
    propanediol butyl ether 186.65
    triethyl orthoformate 157.63
    p-tert-butyltoluene 90.69
    methyl 4-tert-butylbenzoate 169.03
    morpholine 1343.15
    tert-butylamine 879.28
    n-dodecanol 79.26
    dimethoxymethane 433.55
    ethylene carbonate 271.67
    cyrene 196.56
    2-ethoxyethyl acetate 197.84
    2-ethylhexyl acetate 137.04
    1,2,4-trichlorobenzene 389.21
    4-methylpyridine 643.33
    dibutyl ether 206.02
    2,6-dimethyl-4-heptanol 98.29
    DEF 612.71
    dimethyl isosorbide 261.35
    tetrachloroethylene 977.03
    eugenol 164.06
    triacetin 185.3
    span 80 178.04
    1,4-butanediol 325.03
    1,1-dichloroethane 1158.55
    2-methyl-1-pentanol 381.08
    methyl formate 401.14
    2-methyl-1-butanol 664.47
    n-decane 49.67
    butyronitrile 664.25
    3,7-dimethyl-1-octanol 159.64
    1-chlorooctane 136.77
    1-chlorotetradecane 53.03
    n-nonane 53.52
    undecane 33.71
    tert-butylcyclohexane 81.96
    cyclooctane 89.33
    cyclopentanol 814.59
    tetrahydropyran 1041.8
    tert-amyl methyl ether 561.74
    2,5,8-trioxanonane 306.41
    1-hexene 348.18
    2-isopropoxyethanol 422.78
    2,2,2-trifluoroethanol 698.48
    methyl butyrate 311.87

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.2%