1,1-Difluoroethane

Overview IFRA Request a quote

  • Identifiers

    CAS number
    75-37-6

    Molecular formula
    C2H4F2

    SMILES
    CC(F)F

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Fishy 44.65%
    Cheesy 37.4%
    Odorless 33.77%
    Meaty 29.68%
    Ripe 28.8%
    Sulfurous 24.11%
    Green 23.27%
    Pungent 22.18%
    Oily 22.1%
    Fruity 21.7%

     

    Flavor
    Sulfurous 36.84%
    Meaty 35.94%
    Fishy 35.52%
    Ammoniacal 29.23%
    Onion 28.33%
    Sulfury 26.42%
    Odorless 22.8%
    Glue 20.74%
    Bloody 20.37%
    Ammonia 19.83%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    7.41 (neutral)

    Molecular weight
    66.05 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -179 °F (USCG, 1999)
    • -118.6 °C
    • -117 °C

    Boiling point

    • 52.3 °F at 760 mmHg (USCG, 1999)
    • -24.05 °C
    • -24.7 °C

    Flash point

    • -44.31 ˚C est.
    • < -50 °C (open cup)
    • Flammable gas

    Solubility expt.

    • In water, 3.2X10+3 mg/L at 25 °C
    • Solubility in water, g/100ml at 25 °C: 0.02 (very poor)

  • Synonyms

    • 1,1-DIFLUOROETHANE
    • Difluoroethane
    • 75-37-6
    • Ethylidene fluoride
    • Ethane, 1,1-difluoro-
    • Ethylidene difluoride
    • HFC-152a
    • Freon 152a
    • Propellant 152a
    • Halocarbon 152A
    • Refrigerant 152a
    • Algofrene type 67
    • Genetron 152a
    • Genetron 100
    • Ethylene fluoride
    • Dymel 152A
    • Dymel 152
    • Hydrofluorocarbon 152a
    • HFC 152a
    • Fluorocarbon 152a
    • R 152a
    • FC 152a
    • 1, 1-Difluoroethane
    • CCRIS 8974
    • HSDB 5205
    • EINECS 200-866-1
    • UNII-0B1U8K2ME0
    • BRN 1696900
    • 0B1U8K2ME0
    • 1,1-Difluoro-ethane
    • R-152a
    • CH3CHF2
    • DIFLUOROETHANE [MART.]
    • DTXSID0024050
    • EC 200-866-1
    • 1,1-DIFLUOROETHANE [HSDB]
    • UN 1030
    • 25497-28-3
    • DIFLUOROETHANE (MART.)
    • MFCD00000449
    • UN1030
    • Ethane, 1,1difluoro
    • ALGOFRENE 67
    • Refrigerant gas R 152a
    • 1,1-bis(fluoranyl)ethane
    • Fr1030eon 152a
    • Ethane, 1,1,-difluoro-
    • FRON 152A
    • HCFC 152A
    • R152a
    • CHEMBL325493
    • DTXCID904050
    • FKW 152A
    • HFA 152A
    • 1,1-Difluoroethane, >=98%
    • REFRIGERANT GAS R-152A
    • DTXSID50179058
    • 1,1-Difluoroethane (FC-152a)
    • DTXSID501015758
    • F 152A
    • AKOS006221650
    • HYDROFLUOROCARBON 152A [INCI]
    • NS00011370
    • A838393
    • Q161285
    • 1,1-Difluoroethane 10% (wt/wt) in N,N-Dimethylacetamide
    • 200-866-1
    • 687-441-8

  • Applications

    1,1-Difluoroethane (CAS 75-37-6) is widely used as a refrigerant (R-152a) for small refrigeration equipment and some automotive air-conditioning systems. It is also employed as a blowing agent for polyurethane foams used in insulation and packaging applications. In aerosol products, it acts as a propellant for a range of items from cleaners and household sprays to some cosmetic formulations. It is sometimes assessed as a solvent or cleaning agent in niche electronics and precision-cleaning processes, and it can serve as an intermediate or feedstock in the synthesis of other fluorinated chemicals. Uses are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1078.18
    methanol 1977.94
    isopropanol 723.7
    water 1889.11
    ethyl acetate 364.71
    n-propanol 579.06
    acetone 1091.81
    n-butanol 408.1
    acetonitrile 1250.14
    DMF 2201.99
    toluene 158.13
    isobutanol 391.19
    1,4-dioxane 721.0
    methyl acetate 588.9
    THF 590.89
    2-butanone 494.14
    n-pentanol 247.13
    sec-butanol 458.42
    n-hexane 81.21
    ethylene glycol 815.02
    NMP 1436.69
    cyclohexane 71.3
    DMSO 1366.93
    n-butyl acetate 107.72
    n-octanol 153.84
    chloroform 530.19
    n-propyl acetate 190.58
    acetic acid 1684.42
    dichloromethane 657.82
    cyclohexanone 445.76
    propylene glycol 582.24
    isopropyl acetate 188.17
    DMAc 1719.67
    2-ethoxyethanol 629.84
    isopentanol 275.24
    n-heptane 36.92
    ethyl formate 472.21
    1,2-dichloroethane 405.55
    n-hexanol 132.16
    2-methoxyethanol 1301.28
    isobutyl acetate 92.98
    tetrachloromethane 124.82
    n-pentyl acetate 104.16
    transcutol 828.56
    n-heptanol 85.3
    ethylbenzene 102.31
    MIBK 174.09
    2-propoxyethanol 341.3
    tert-butanol 688.2
    MTBE 349.28
    2-butoxyethanol 192.24
    propionic acid 714.9
    o-xylene 162.37
    formic acid 1610.03
    diethyl ether 357.66
    m-xylene 116.7
    p-xylene 136.74
    chlorobenzene 189.52
    dimethyl carbonate 319.92
    n-octane 21.97
    formamide 1811.53
    cyclopentanone 545.98
    2-pentanone 313.47
    anisole 277.08
    cyclopentyl methyl ether 273.92
    gamma-butyrolactone 768.4
    1-methoxy-2-propanol 730.3
    pyridine 494.28
    3-pentanone 284.49
    furfural 878.72
    n-dodecane 21.48
    diethylene glycol 455.18
    diisopropyl ether 98.39
    tert-amyl alcohol 453.25
    acetylacetone 425.06
    n-hexadecane 22.15
    acetophenone 264.21
    methyl propionate 413.46
    isopentyl acetate 86.6
    trichloroethylene 590.01
    n-nonanol 125.79
    cyclohexanol 328.55
    benzyl alcohol 271.68
    2-ethylhexanol 77.6
    isooctanol 66.69
    dipropyl ether 117.86
    1,2-dichlorobenzene 185.67
    ethyl lactate 176.46
    propylene carbonate 339.91
    n-methylformamide 1399.46
    2-pentanol 251.48
    n-pentane 88.32
    1-propoxy-2-propanol 197.34
    1-methoxy-2-propyl acetate 145.71
    2-(2-methoxypropoxy) propanol 262.01
    mesitylene 79.77
    ε-caprolactone 406.09
    p-cymene 55.44
    epichlorohydrin 600.23
    1,1,1-trichloroethane 295.17
    2-aminoethanol 871.69
    morpholine-4-carbaldehyde 1328.11
    sulfolane 709.75
    2,2,4-trimethylpentane 39.34
    2-methyltetrahydrofuran 384.42
    n-hexyl acetate 191.96
    isooctane 22.87
    2-(2-butoxyethoxy)ethanol 310.82
    sec-butyl acetate 108.52
    tert-butyl acetate 173.36
    decalin 37.86
    glycerin 842.8
    diglyme 561.75
    acrylic acid 820.41
    isopropyl myristate 76.71
    n-butyric acid 470.39
    acetyl acetate 268.26
    di(2-ethylhexyl) phthalate 94.49
    ethyl propionate 222.48
    nitromethane 2177.95
    1,2-diethoxyethane 216.22
    benzonitrile 292.62
    trioctyl phosphate 64.43
    1-bromopropane 229.46
    gamma-valerolactone 899.43
    n-decanol 93.04
    triethyl phosphate 78.74
    4-methyl-2-pentanol 132.49
    propionitrile 490.07
    vinylene carbonate 398.5
    1,1,2-trichlorotrifluoroethane 630.96
    DMS 210.94
    cumene 78.95
    2-octanol 75.15
    2-hexanone 194.28
    octyl acetate 108.29
    limonene 74.01
    1,2-dimethoxyethane 884.36
    ethyl orthosilicate 73.02
    tributyl phosphate 84.7
    diacetone alcohol 264.7
    N,N-dimethylaniline 239.77
    acrylonitrile 743.16
    aniline 319.05
    1,3-propanediol 752.68
    bromobenzene 147.71
    dibromomethane 378.35
    1,1,2,2-tetrachloroethane 440.55
    2-methyl-cyclohexyl acetate 82.78
    tetrabutyl urea 138.62
    diisobutyl methanol 54.92
    2-phenylethanol 133.45
    styrene 133.23
    dioctyl adipate 124.47
    dimethyl sulfate 480.16
    ethyl butyrate 115.45
    methyl lactate 363.47
    butyl lactate 117.59
    diethyl carbonate 96.66
    propanediol butyl ether 267.69
    triethyl orthoformate 89.86
    p-tert-butyltoluene 53.99
    methyl 4-tert-butylbenzoate 189.29
    morpholine 814.67
    tert-butylamine 440.45
    n-dodecanol 73.37
    dimethoxymethane 839.75
    ethylene carbonate 309.06
    cyrene 245.57
    2-ethoxyethyl acetate 166.54
    2-ethylhexyl acetate 69.76
    1,2,4-trichlorobenzene 207.78
    4-methylpyridine 557.17
    dibutyl ether 126.11
    2,6-dimethyl-4-heptanol 54.92
    DEF 576.98
    dimethyl isosorbide 275.84
    tetrachloroethylene 356.74
    eugenol 207.18
    triacetin 244.32
    span 80 195.98
    1,4-butanediol 331.19
    1,1-dichloroethane 400.46
    2-methyl-1-pentanol 184.75
    methyl formate 1023.7
    2-methyl-1-butanol 302.84
    n-decane 31.93
    butyronitrile 362.44
    3,7-dimethyl-1-octanol 114.19
    1-chlorooctane 81.6
    1-chlorotetradecane 40.31
    n-nonane 32.83
    undecane 24.92
    tert-butylcyclohexane 36.16
    cyclooctane 27.32
    cyclopentanol 380.99
    tetrahydropyran 396.49
    tert-amyl methyl ether 269.4
    2,5,8-trioxanonane 420.51
    1-hexene 155.85
    2-isopropoxyethanol 324.58
    2,2,2-trifluoroethanol 785.06
    methyl butyrate 276.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction