1,1-Dichloro-1,2,2,2-tetrafluoroethane

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  • Identifiers

    CAS number
    374-07-2

    Molecular formula
    C2Cl2F4

    SMILES
    C(C(F)(Cl)Cl)(F)(F)F

  • Odor profile

    Fragrance
    Odorless 54.89%
    Sweet 24.38%
    Fishy 24.28%
    Woody 23.38%
    Balsamic 19.67%
    Cooling 18.85%
    Clean 16.98%
    Dry 16.81%
    Animal 16.49%
    Amber 14.39%

     

    Flavor
    Odorless 33.05%
    Sulfurous 21.42%
    Bland 20.33%
    Mild 18.68%
    Sulfury 18.17%
    Glue 17.87%
    Bloody 17.86%
    Sweet-like 17.71%
    Bouillon 17.6%
    Skunky 17.45%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.9

    pKa est.
    3.04 (weak acid)

    Molecular weight
    170.92 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -56.6 °C

    Boiling point

    • 3.4 °C

    Flash point

    • -14.04 ˚C est.

    Solubility expt.

    • In water,137 mg/L at 25 °C
    • Very soluble in benzene, diethyl ether, ethanol

  • Synonyms

    • 1,1-Dichlorotetrafluoroethane
    • 1,1-DICHLORO-1,2,2,2-TETRAFLUOROETHANE
    • 374-07-2
    • Frigen 114A
    • CFC-114a
    • Ethane, 1,1-dichloro-1,2,2,2-tetrafluoro-
    • Dichlorotetrafluroethane
    • 1320-37-2
    • Ethane, 1,1-dichlorotetrafluoro-
    • HSDB 5564
    • UNII-8AWA8IET6R
    • 8AWA8IET6R
    • 1,1,1,2-Tetrafluoro-2,2-dichloroethane
    • EINECS 206-774-8
    • FREON 114A
    • FREON-114A
    • DTXSID9027150
    • R-114A
    • 1,1-DICHLORO-1,2,2,2-TETRAFLUOROETHANE [HSDB]
    • SCHEMBL866
    • 1,1Dichlorotetrafluoroethane
    • Ethane, 1,1dichlorotetrafluoro
    • DTXCID407150
    • 1,1,1,2Tetrafluoro2,2dichloroethane
    • Ethane, 1,1dichloro1,2,2,2tetrafluoro
    • NS00041744
    • Q161277
    • 206-774-8

  • Applications

    1,1-Dichloro-1,2,2,2-tetrafluoroethane (CAS 374-07-2) is a halogenated hydrofluoroethane with industrial relevance across several applications. Common uses include as a refrigerant in HVAC/R systems; a specialty solvent for electronics cleaning and precision degreasing; a blowing agent in polymer foam production; and an intermediate in the synthesis of other fluorinated organics or fluorinated polymers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 224.4
    methanol 383.87
    isopropanol 154.74
    water 82.37
    ethyl acetate 75.4
    n-propanol 143.08
    acetone 239.04
    n-butanol 117.77
    acetonitrile 144.23
    DMF 670.53
    toluene 29.91
    isobutanol 99.42
    1,4-dioxane 138.5
    methyl acetate 95.07
    THF 286.73
    2-butanone 128.09
    n-pentanol 93.31
    sec-butanol 124.45
    n-hexane 24.81
    ethylene glycol 129.33
    NMP 440.08
    cyclohexane 31.0
    DMSO 966.11
    n-butyl acetate 48.83
    n-octanol 59.07
    chloroform 56.07
    n-propyl acetate 67.32
    acetic acid 117.24
    dichloromethane 84.68
    cyclohexanone 110.92
    propylene glycol 82.84
    isopropyl acetate 58.05
    DMAc 506.39
    2-ethoxyethanol 228.62
    isopentanol 91.61
    n-heptane 34.86
    ethyl formate 77.94
    1,2-dichloroethane 79.44
    n-hexanol 69.92
    2-methoxyethanol 331.3
    isobutyl acetate 30.31
    tetrachloromethane 15.16
    n-pentyl acetate 44.94
    transcutol 236.53
    n-heptanol 51.23
    ethylbenzene 24.27
    MIBK 78.86
    2-propoxyethanol 153.71
    tert-butanol 165.08
    MTBE 112.05
    2-butoxyethanol 94.35
    propionic acid 67.97
    o-xylene 36.91
    formic acid 156.62
    diethyl ether 146.06
    m-xylene 29.19
    p-xylene 26.06
    chlorobenzene 14.58
    dimethyl carbonate 73.12
    n-octane 15.21
    formamide 295.02
    cyclopentanone 159.64
    2-pentanone 121.46
    anisole 65.83
    cyclopentyl methyl ether 132.6
    gamma-butyrolactone 148.04
    1-methoxy-2-propanol 245.69
    pyridine 98.78
    3-pentanone 97.26
    furfural 125.28
    n-dodecane 9.09
    diethylene glycol 150.26
    diisopropyl ether 49.48
    tert-amyl alcohol 132.33
    acetylacetone 107.5
    n-hexadecane 9.44
    acetophenone 72.1
    methyl propionate 96.61
    isopentyl acetate 36.85
    trichloroethylene 67.61
    n-nonanol 54.58
    cyclohexanol 87.26
    benzyl alcohol 66.24
    2-ethylhexanol 45.28
    isooctanol 41.18
    dipropyl ether 92.69
    1,2-dichlorobenzene 15.48
    ethyl lactate 63.94
    propylene carbonate 58.17
    n-methylformamide 276.45
    2-pentanol 98.97
    n-pentane 44.82
    1-propoxy-2-propanol 115.85
    1-methoxy-2-propyl acetate 69.65
    2-(2-methoxypropoxy) propanol 100.0
    mesitylene 25.45
    ε-caprolactone 87.92
    p-cymene 27.51
    epichlorohydrin 140.86
    1,1,1-trichloroethane 32.09
    2-aminoethanol 156.95
    morpholine-4-carbaldehyde 309.3
    sulfolane 253.57
    2,2,4-trimethylpentane 15.21
    2-methyltetrahydrofuran 149.36
    n-hexyl acetate 53.53
    isooctane 11.24
    2-(2-butoxyethoxy)ethanol 116.6
    sec-butyl acetate 41.29
    tert-butyl acetate 60.65
    decalin 11.05
    glycerin 121.31
    diglyme 212.38
    acrylic acid 69.83
    isopropyl myristate 31.87
    n-butyric acid 66.73
    acetyl acetate 39.89
    di(2-ethylhexyl) phthalate 28.4
    ethyl propionate 65.18
    nitromethane 247.71
    1,2-diethoxyethane 92.82
    benzonitrile 40.03
    trioctyl phosphate 26.67
    1-bromopropane 67.91
    gamma-valerolactone 176.08
    n-decanol 42.8
    triethyl phosphate 33.76
    4-methyl-2-pentanol 60.7
    propionitrile 93.13
    vinylene carbonate 49.33
    1,1,2-trichlorotrifluoroethane 108.08
    DMS 43.46
    cumene 22.01
    2-octanol 42.71
    2-hexanone 83.64
    octyl acetate 38.94
    limonene 40.78
    1,2-dimethoxyethane 311.48
    ethyl orthosilicate 34.05
    tributyl phosphate 26.49
    diacetone alcohol 107.01
    N,N-dimethylaniline 91.7
    acrylonitrile 105.98
    aniline 56.45
    1,3-propanediol 138.47
    bromobenzene 11.73
    dibromomethane 69.28
    1,1,2,2-tetrachloroethane 69.26
    2-methyl-cyclohexyl acetate 41.38
    tetrabutyl urea 59.72
    diisobutyl methanol 37.94
    2-phenylethanol 49.48
    styrene 25.24
    dioctyl adipate 43.7
    dimethyl sulfate 124.53
    ethyl butyrate 55.94
    methyl lactate 91.85
    butyl lactate 47.38
    diethyl carbonate 35.03
    propanediol butyl ether 79.36
    triethyl orthoformate 47.1
    p-tert-butyltoluene 27.57
    methyl 4-tert-butylbenzoate 72.17
    morpholine 205.84
    tert-butylamine 119.88
    n-dodecanol 33.82
    dimethoxymethane 345.32
    ethylene carbonate 44.84
    cyrene 105.79
    2-ethoxyethyl acetate 53.55
    2-ethylhexyl acetate 30.01
    1,2,4-trichlorobenzene 19.49
    4-methylpyridine 89.15
    dibutyl ether 55.03
    2,6-dimethyl-4-heptanol 37.94
    DEF 207.31
    dimethyl isosorbide 132.55
    tetrachloroethylene 49.22
    eugenol 72.89
    triacetin 55.36
    span 80 66.1
    1,4-butanediol 85.39
    1,1-dichloroethane 52.11
    2-methyl-1-pentanol 67.62
    methyl formate 177.44
    2-methyl-1-butanol 91.2
    n-decane 15.11
    butyronitrile 82.67
    3,7-dimethyl-1-octanol 46.45
    1-chlorooctane 27.98
    1-chlorotetradecane 14.61
    n-nonane 16.03
    undecane 11.24
    tert-butylcyclohexane 10.33
    cyclooctane 17.5
    cyclopentanol 109.96
    tetrahydropyran 117.13
    tert-amyl methyl ether 108.71
    2,5,8-trioxanonane 168.52
    1-hexene 48.62
    2-isopropoxyethanol 137.99
    2,2,2-trifluoroethanol 73.24
    methyl butyrate 83.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction