10,16-Dihydroxyhexadecanoic acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    3233-90-7

    Molecular formula
    C16H32O4

    SMILES
    C(CCCCC(=O)O)CCCC(CCCCCCO)O

    Safety labels

  • Odor profile

    Fragrance
    Oily 38.22%
    Fresh 35.33%
    Sweet 35.0%
    Fatty 33.98%
    Odorless 33.18%
    Waxy 29.51%
    Fruity 28.65%
    Citrus 28.42%
    Peach 25.09%
    Lactonic 24.02%

     

    Flavor
    Fatty 48.93%
    Waxy 45.2%
    Oily 37.19%
    Green 34.73%
    Mild 33.63%
    Floral 31.91%
    Odorless 31.1%
    Mushroom 29.24%
    Fruity 29.15%
    Fat 27.39%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    6.49 (neutral)

    Molecular weight
    288.42 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    416°C

    Melting point expt.

    • 74 - 75 °C

    Flash point

    • 219.33 ˚C est.

  • Synonyms

    • 10,16-Dihydroxyhexadecanoic acid
    • 3233-90-7
    • Hexadecanoic acid, 10,16-dihydroxy-
    • DTXSID10954121
    • RefChem:907879
    • 10,16-DHHA
    • DTXCID501382153
    • 10,16-dihydroxy-palmitic acid
    • 10,16-dihydroxy-hexadecanoic acid
    • CHEBI:692
    • SCHEMBL2459399
    • LMFA01050341
    • C08285
    • Q27105328
    • 3233-90-7

  • Applications

    10,16-Dihydroxyhexadecanoic acid is a long-chain hydroxy fatty acid that serves as a biobased building block in polymer and coating chemistries. It is commonly used as a diol-containing monomer for the synthesis of polyester and polyurethane resins, enabling flexible, durable biopolymer materials. It can function as a crosslinking or chain-extending component in coatings and adhesives, contributing to performance and resilience. It is evaluated for use in specialty cosmetic polymers and ester derivatives as an emollient or conditioning ingredient in personal care products. It can be incorporated into cleaning formulations as a fatty-acid-derived surfactant precursor or functional additive, depending on formulation. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 49.69
    methanol 98.9
    isopropanol 27.92
    water 0.17
    ethyl acetate 10.16
    n-propanol 28.43
    acetone 18.31
    n-butanol 27.59
    acetonitrile 3.24
    DMF 86.19
    toluene 3.94
    isobutanol 21.59
    1,4-dioxane 38.3
    methyl acetate 7.31
    THF 167.87
    2-butanone 13.2
    n-pentanol 27.94
    sec-butanol 18.54
    n-hexane 1.73
    ethylene glycol 12.82
    NMP 129.75
    cyclohexane 3.22
    DMSO 378.96
    n-butyl acetate 25.27
    n-octanol 21.17
    chloroform 15.23
    n-propyl acetate 25.13
    acetic acid 36.84
    dichloromethane 13.64
    cyclohexanone 70.64
    propylene glycol 30.09
    isopropyl acetate 18.71
    DMAc 115.08
    2-ethoxyethanol 94.87
    isopentanol 34.75
    n-heptane 1.83
    ethyl formate 11.67
    1,2-dichloroethane 16.72
    n-hexanol 25.82
    2-methoxyethanol 124.44
    isobutyl acetate 21.89
    tetrachloromethane 4.68
    n-pentyl acetate 29.89
    transcutol 334.01
    n-heptanol 22.83
    ethylbenzene 6.43
    MIBK 32.06
    2-propoxyethanol 86.3
    tert-butanol 53.29
    MTBE 19.53
    2-butoxyethanol 71.42
    propionic acid 23.82
    o-xylene 7.8
    formic acid 28.37
    diethyl ether 8.82
    m-xylene 7.67
    p-xylene 7.81
    chlorobenzene 6.36
    dimethyl carbonate 7.72
    n-octane 1.19
    formamide 37.87
    cyclopentanone 83.92
    2-pentanone 20.02
    anisole 16.96
    cyclopentyl methyl ether 47.03
    gamma-butyrolactone 82.6
    1-methoxy-2-propanol 109.38
    pyridine 17.92
    3-pentanone 11.51
    furfural 69.94
    n-dodecane 1.01
    diethylene glycol 69.91
    diisopropyl ether 7.27
    tert-amyl alcohol 35.34
    acetylacetone 40.45
    n-hexadecane 1.12
    acetophenone 28.86
    methyl propionate 11.73
    isopentyl acetate 33.36
    trichloroethylene 26.72
    n-nonanol 21.14
    cyclohexanol 36.48
    benzyl alcohol 21.55
    2-ethylhexanol 19.66
    isooctanol 21.9
    dipropyl ether 17.72
    1,2-dichlorobenzene 10.58
    ethyl lactate 25.39
    propylene carbonate 44.88
    n-methylformamide 30.06
    2-pentanol 17.14
    n-pentane 0.88
    1-propoxy-2-propanol 70.23
    1-methoxy-2-propyl acetate 47.56
    2-(2-methoxypropoxy) propanol 70.19
    mesitylene 7.58
    ε-caprolactone 66.99
    p-cymene 7.82
    epichlorohydrin 63.24
    1,1,1-trichloroethane 11.37
    2-aminoethanol 40.16
    morpholine-4-carbaldehyde 110.82
    sulfolane 221.49
    2,2,4-trimethylpentane 1.77
    2-methyltetrahydrofuran 57.23
    n-hexyl acetate 36.77
    isooctane 1.51
    2-(2-butoxyethoxy)ethanol 109.65
    sec-butyl acetate 20.54
    tert-butyl acetate 41.67
    decalin 3.26
    glycerin 64.34
    diglyme 181.73
    acrylic acid 18.85
    isopropyl myristate 15.53
    n-butyric acid 45.35
    acetyl acetate 11.92
    di(2-ethylhexyl) phthalate 20.86
    ethyl propionate 17.61
    nitromethane 40.3
    1,2-diethoxyethane 47.74
    benzonitrile 13.66
    trioctyl phosphate 16.61
    1-bromopropane 6.7
    gamma-valerolactone 147.36
    n-decanol 14.45
    triethyl phosphate 19.41
    4-methyl-2-pentanol 19.6
    propionitrile 5.01
    vinylene carbonate 28.47
    1,1,2-trichlorotrifluoroethane 88.08
    DMS 21.22
    cumene 7.57
    2-octanol 14.25
    2-hexanone 27.36
    octyl acetate 18.98
    limonene 12.03
    1,2-dimethoxyethane 109.43
    ethyl orthosilicate 20.91
    tributyl phosphate 19.51
    diacetone alcohol 81.76
    N,N-dimethylaniline 20.09
    acrylonitrile 6.63
    aniline 10.69
    1,3-propanediol 64.54
    bromobenzene 5.62
    dibromomethane 9.35
    1,1,2,2-tetrachloroethane 35.14
    2-methyl-cyclohexyl acetate 35.3
    tetrabutyl urea 30.65
    diisobutyl methanol 15.43
    2-phenylethanol 23.36
    styrene 5.73
    dioctyl adipate 31.64
    dimethyl sulfate 28.13
    ethyl butyrate 24.1
    methyl lactate 28.89
    butyl lactate 42.02
    diethyl carbonate 14.27
    propanediol butyl ether 78.59
    triethyl orthoformate 27.63
    p-tert-butyltoluene 8.41
    methyl 4-tert-butylbenzoate 48.5
    morpholine 76.44
    tert-butylamine 22.13
    n-dodecanol 10.12
    dimethoxymethane 48.16
    ethylene carbonate 25.17
    cyrene 73.81
    2-ethoxyethyl acetate 41.25
    2-ethylhexyl acetate 24.33
    1,2,4-trichlorobenzene 14.15
    4-methylpyridine 16.35
    dibutyl ether 20.48
    2,6-dimethyl-4-heptanol 15.43
    DEF 38.32
    dimethyl isosorbide 115.58
    tetrachloroethylene 25.33
    eugenol 51.0
    triacetin 53.98
    span 80 63.97
    1,4-butanediol 24.67
    1,1-dichloroethane 7.46
    2-methyl-1-pentanol 29.35
    methyl formate 15.57
    2-methyl-1-butanol 24.4
    n-decane 1.92
    butyronitrile 8.67
    3,7-dimethyl-1-octanol 22.43
    1-chlorooctane 8.61
    1-chlorotetradecane 3.23
    n-nonane 1.66
    undecane 1.31
    tert-butylcyclohexane 2.91
    cyclooctane 1.52
    cyclopentanol 43.19
    tetrahydropyran 37.31
    tert-amyl methyl ether 21.17
    2,5,8-trioxanonane 129.15
    1-hexene 5.45
    2-isopropoxyethanol 65.42
    2,2,2-trifluoroethanol 16.88
    methyl butyrate 29.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction