10-Hydroxy-2-decenoic acid

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  • Identifiers

    CAS number
    765-01-5

    Molecular formula
    C10H18O3

    SMILES
    C(CCC/C=C/C(=O)O)CCCO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fatty 54.45%
    Sweet 36.98%
    Fruity 33.95%
    Waxy 32.92%
    Dairy 32.82%
    Milky 32.8%
    Oily 32.44%
    Citrus 31.4%
    Buttery 31.23%
    Fresh 30.78%

     

    Flavor
    Waxy 52.82%
    Fatty 49.85%
    Fruity 45.23%
    Green 45.18%
    Oily 40.8%
    Sweet 35.59%
    Cheese 30.52%
    Sour 27.98%
    Fresh 27.27%
    Fat 26.96%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    7.18 (neutral)

    Molecular weight
    186.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    339°C

    Flash point

    • 179.53 ˚C est.

  • Synonyms

    • 10-Hydroxy-2-decenoic acid
    • 765-01-5
    • 76B519G7TJ
    • DTXSID601045504
    • 10-Hdec
    • RefChem:437035
    • DTXCID301527430
    • 14113-05-4
    • Royal jelly acid
    • (E)-10-hydroxydec-2-enoic acid
    • (E)-10-Hydroxy-2-decenoic acid
    • trans-10-Hydroxy-2-decenoic acid
    • 2-Decenoic acid, 10-hydroxy-, (2E)-
    • 10-Hydroxydecenoic acid
    • MFCD00204506
    • 10-HDA
    • 10-hydroxy-trans-2-decenoic acid
    • 10-hydroxy-2E-decenoic acid
    • (2E)-10-hydroxydec-2-enoic acid
    • CHEMBL5630743
    • NSC-87516
    • 10-Hydroxy-2-decylenic acid
    • Royaljellyacid
    • UNII-76B519G7TJ
    • NSC87516
    • NSC 87516
    • 2-Decenoic acid, 10-hydroxy-, (E)-
    • Queen Bee Acid;(E)-10-Hydroxy-2-decenoic acid
    • SCHEMBL285440
    • 10-HAD
    • orb1304383
    • orb3025110
    • SCHEMBL8040564
    • CHEBI:78668
    • 10-Hydroxy-2(E)-decenoic acid
    • trans-10-hydroxydec-2-enoic acid
    • (E)-10-oxidanyldec-2-enoic acid
    • HY-N1363
    • MSK40115
    • LMFA01050157
    • MSK157411
    • s3827
    • AKOS006282270
    • AKOS025310134
    • (2E)-10-Hydroxy-2-decenoic acid #
    • CCG-266478
    • EBC-153136
    • FH65555
    • FH74146
    • HY-W592871
    • AC-15652
    • AC-34577
    • AS-13924
    • AS-58742
    • SY053098
    • 10-HYDROXY-DEC-(E)-2-ENOIC ACID
    • CS-0016772
    • CS-0648816
    • H1337
    • NS00096511
    • O10366
    • EN300-1704333
    • 113H054
    • A838726
    • F861872
    • Q16908844
    • Z1198152019
    • 10-hydroxy-2E-decenoic acid; (E)-10-hydroxydec-2-enoic acid
    • 765-01-5

  • Applications

    10-Hydroxy-2-decenoic acid (CAS 765-01-5) is an unsaturated fatty acid bearing a terminal hydroxyl group, a biologically active component of royal jelly; in cosmetics and personal care it is explored as a bioactive ingredient from royal jelly extracts with interest in antimicrobial and anti-inflammatory effects and potential skin-conditioning benefits; in pharmaceutical and medicinal chemistry it serves as a lipophilic intermediate for lipid-derived compounds and is evaluated as a model substrate in research; in agriculture it has been studied for antimicrobial/ antifungal activity with potential crop-protection applications; in analytical chemistry it is used as a reference standard for lipid analyses of royal jelly and related products; in industrial manufacturing it is investigated as a building block for ester derivatives and specialty polymers.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 543.05
    methanol 1121.82
    isopropanol 240.72
    water 0.67
    ethyl acetate 116.11
    n-propanol 288.9
    acetone 241.62
    n-butanol 244.9
    acetonitrile 36.08
    DMF 620.26
    toluene 17.94
    isobutanol 189.52
    1,4-dioxane 137.66
    methyl acetate 59.53
    THF 584.56
    2-butanone 121.18
    n-pentanol 189.58
    sec-butanol 150.45
    n-hexane 11.24
    ethylene glycol 193.94
    NMP 401.43
    cyclohexane 7.86
    DMSO 1699.31
    n-butyl acetate 112.81
    n-octanol 47.57
    chloroform 33.38
    n-propyl acetate 96.49
    acetic acid 279.3
    dichloromethane 36.66
    cyclohexanone 247.12
    propylene glycol 266.64
    isopropyl acetate 96.09
    DMAc 329.99
    2-ethoxyethanol 385.29
    isopentanol 229.09
    n-heptane 5.56
    ethyl formate 68.08
    1,2-dichloroethane 63.71
    n-hexanol 163.33
    2-methoxyethanol 757.11
    isobutyl acetate 68.99
    tetrachloromethane 10.79
    n-pentyl acetate 54.65
    transcutol 823.0
    n-heptanol 62.74
    ethylbenzene 18.09
    MIBK 141.9
    2-propoxyethanol 324.25
    tert-butanol 352.43
    MTBE 104.31
    2-butoxyethanol 160.15
    propionic acid 174.42
    o-xylene 26.48
    formic acid 214.33
    diethyl ether 61.63
    m-xylene 31.14
    p-xylene 21.59
    chlorobenzene 22.74
    dimethyl carbonate 41.58
    n-octane 2.28
    formamide 281.6
    cyclopentanone 380.39
    2-pentanone 174.72
    anisole 53.44
    cyclopentyl methyl ether 225.94
    gamma-butyrolactone 356.2
    1-methoxy-2-propanol 536.41
    pyridine 74.39
    3-pentanone 73.72
    furfural 219.02
    n-dodecane 1.92
    diethylene glycol 318.87
    diisopropyl ether 33.1
    tert-amyl alcohol 209.73
    acetylacetone 208.47
    n-hexadecane 2.12
    acetophenone 70.55
    methyl propionate 104.48
    isopentyl acetate 112.26
    trichloroethylene 97.5
    n-nonanol 41.66
    cyclohexanol 170.58
    benzyl alcohol 79.11
    2-ethylhexanol 74.92
    isooctanol 51.07
    dipropyl ether 58.85
    1,2-dichlorobenzene 29.01
    ethyl lactate 77.96
    propylene carbonate 142.92
    n-methylformamide 284.28
    2-pentanol 136.51
    n-pentane 5.78
    1-propoxy-2-propanol 222.67
    1-methoxy-2-propyl acetate 141.08
    2-(2-methoxypropoxy) propanol 147.63
    mesitylene 25.46
    ε-caprolactone 188.26
    p-cymene 17.41
    epichlorohydrin 276.51
    1,1,1-trichloroethane 34.62
    2-aminoethanol 435.52
    morpholine-4-carbaldehyde 310.37
    sulfolane 581.78
    2,2,4-trimethylpentane 6.23
    2-methyltetrahydrofuran 274.47
    n-hexyl acetate 79.25
    isooctane 6.69
    2-(2-butoxyethoxy)ethanol 234.58
    sec-butyl acetate 66.01
    tert-butyl acetate 143.77
    decalin 7.27
    glycerin 388.88
    diglyme 353.49
    acrylic acid 133.47
    isopropyl myristate 29.87
    n-butyric acid 253.26
    acetyl acetate 56.02
    di(2-ethylhexyl) phthalate 40.66
    ethyl propionate 73.8
    nitromethane 267.25
    1,2-diethoxyethane 117.42
    benzonitrile 48.87
    trioctyl phosphate 31.39
    1-bromopropane 25.22
    gamma-valerolactone 395.84
    n-decanol 30.59
    triethyl phosphate 37.67
    4-methyl-2-pentanol 95.58
    propionitrile 46.05
    vinylene carbonate 86.34
    1,1,2-trichlorotrifluoroethane 261.31
    DMS 56.31
    cumene 19.0
    2-octanol 33.31
    2-hexanone 119.62
    octyl acetate 40.01
    limonene 27.9
    1,2-dimethoxyethane 348.42
    ethyl orthosilicate 38.91
    tributyl phosphate 38.32
    diacetone alcohol 277.54
    N,N-dimethylaniline 52.0
    acrylonitrile 65.6
    aniline 57.22
    1,3-propanediol 458.13
    bromobenzene 18.22
    dibromomethane 26.21
    1,1,2,2-tetrachloroethane 102.8
    2-methyl-cyclohexyl acetate 70.1
    tetrabutyl urea 56.45
    diisobutyl methanol 44.42
    2-phenylethanol 78.44
    styrene 17.71
    dioctyl adipate 57.8
    dimethyl sulfate 103.93
    ethyl butyrate 73.38
    methyl lactate 121.72
    butyl lactate 81.32
    diethyl carbonate 40.34
    propanediol butyl ether 183.37
    triethyl orthoformate 55.47
    p-tert-butyltoluene 18.63
    methyl 4-tert-butylbenzoate 79.43
    morpholine 300.17
    tert-butylamine 152.17
    n-dodecanol 22.17
    dimethoxymethane 296.48
    ethylene carbonate 77.57
    cyrene 141.53
    2-ethoxyethyl acetate 85.27
    2-ethylhexyl acetate 73.13
    1,2,4-trichlorobenzene 37.79
    4-methylpyridine 73.5
    dibutyl ether 37.83
    2,6-dimethyl-4-heptanol 44.42
    DEF 190.98
    dimethyl isosorbide 218.63
    tetrachloroethylene 78.51
    eugenol 92.23
    triacetin 88.07
    span 80 130.6
    1,4-butanediol 179.18
    1,1-dichloroethane 30.7
    2-methyl-1-pentanol 151.84
    methyl formate 124.12
    2-methyl-1-butanol 173.09
    n-decane 3.05
    butyronitrile 70.78
    3,7-dimethyl-1-octanol 52.86
    1-chlorooctane 15.04
    1-chlorotetradecane 6.28
    n-nonane 2.79
    undecane 2.34
    tert-butylcyclohexane 7.81
    cyclooctane 3.82
    cyclopentanol 238.55
    tetrahydropyran 148.08
    tert-amyl methyl ether 90.18
    2,5,8-trioxanonane 249.98
    1-hexene 38.92
    2-isopropoxyethanol 233.47
    2,2,2-trifluoroethanol 67.59
    methyl butyrate 112.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction