1-Piperazinecarboxaldehyde

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  • Identifiers

    CAS number
    7755-92-2

    Molecular formula
    C5H10N2O

    SMILES
    C1CN(CCN1)C=O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 44.16%
    Nutty 43.45%
    Fishy 42.68%
    Popcorn 39.95%
    Roasted 32.52%
    Burnt 21.53%
    Pungent 20.67%
    Meaty 18.27%
    Animal 17.55%
    Cooked 17.17%

     

    Flavor
    Bitter 62.77%
    Roasted 29.15%
    Amine 24.11%
    Alkaline 23.78%
    Shrimp 23.03%
    Taco 21.48%
    Cereal 21.46%
    Animal 20.94%
    Clam 20.85%
    Nitrile 20.81%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.9

    pKa est.
    6.2 (neutral)

    Molecular weight
    114.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    267°C

    Flash point

    • 110.95 ˚C est.

  • Synonyms

    • 1-Formylpiperazine
    • 7755-92-2
    • 1-Piperazinecarboxaldehyde
    • EINECS 231-813-0
    • NSC 511082
    • DTXSID1064790
    • RefChem:77020
    • DTXCID8047977
    • MSSDTZLYNMFTKN-UHFFFAOYSA-N
    • Piperazine-1-carbaldehyde
    • 1-Piperazinecarbaldehyde
    • N-Formylpiperazine
    • Formylpiperazine
    • Piperazine-1-carboxaldehyde
    • MFCD00005963
    • piperazinecarbaldehyde
    • 1-formyl piperazine
    • 1-Formylpiperazine (>85%)
    • l-formylpiperazine
    • 4-formylpiperazine
    • N-formyl piperazine
    • N-formyl-piperazine
    • 4-formyl-piperazine
    • 1-Formyl-piperazine
    • NSC511082
    • piperazinecarboxaldehyde
    • piperazin-1-yl-methanone
    • 1-Piperazinecarbaldehyde #
    • SCHEMBL8466
    • SCHEMBL8467
    • SCHEMBL144676
    • SCHEMBL930605
    • SCHEMBL930606
    • SCHEMBL7231222
    • SCHEMBL27629357
    • CHEBI:151031
    • BB_SC-04847
    • Bucinnazine Hydrochloride Impurity 1
    • SBB027307
    • STK802250
    • AKOS001146173
    • CS-W016606
    • NSC-511082
    • AS-15753
    • 1-Formylpiperazine, technical grade, 85%
    • DB-019187
    • F0194
    • NS00037928
    • ST50998282
    • 1-Formylpiperazine, technical, >=90% (GC)
    • EN300-20598
    • F223849
    • Q27452019
    • F2190-0515
    • Z104479110
    • 1FP
    • 7755-92-2

  • Applications

    1-Piperazinecarboxaldehyde, CAS 7755-92-2, is primarily used as a versatile building block in organic and medicinal chemistry, serving as an aldehyde-functional starting material for the synthesis of piperazine-containing heterocycles and as an intermediate for pharmaceutical R&D. It also serves as a reactive handle in polymer chemistry to introduce piperazine moieties into polymers and resins, and can be used as a precursor in coatings, inks, and specialty materials. In addition, it may be employed as a scaffold in agrochemical research and as a starting point for library generation via Schiff base formation or reductive amination, with its use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.12
    methanol 64.08
    isopropanol 4.8
    water 247.77
    ethyl acetate 5.28
    n-propanol 10.92
    acetone 1.31
    n-butanol 6.6
    acetonitrile 3.93
    DMF 31.17
    toluene 1.02
    isobutanol 5.44
    1,4-dioxane 6.92
    methyl acetate 5.57
    THF 5.33
    2-butanone 2.09
    n-pentanol 2.81
    sec-butanol 3.65
    n-hexane 0.1
    ethylene glycol 59.69
    NMP 63.08
    cyclohexane 0.36
    DMSO 38.88
    n-butyl acetate 4.05
    n-octanol 2.0
    chloroform 23.43
    n-propyl acetate 1.74
    acetic acid 102.55
    dichloromethane 21.52
    cyclohexanone 8.37
    propylene glycol 21.52
    isopropyl acetate 1.88
    DMAc 33.29
    2-ethoxyethanol 12.75
    isopentanol 3.24
    n-heptane 0.3
    ethyl formate 12.87
    1,2-dichloroethane 7.81
    n-hexanol 4.41
    2-methoxyethanol 46.83
    isobutyl acetate 0.95
    tetrachloromethane 6.14
    n-pentyl acetate 2.53
    transcutol 29.23
    n-heptanol 3.18
    ethylbenzene 0.59
    MIBK 0.78
    2-propoxyethanol 16.37
    tert-butanol 3.3
    MTBE 0.58
    2-butoxyethanol 11.54
    propionic acid 47.69
    o-xylene 1.67
    formic acid 353.61
    diethyl ether 0.81
    m-xylene 1.15
    p-xylene 0.91
    chlorobenzene 5.09
    dimethyl carbonate 3.67
    n-octane 0.14
    formamide 220.41
    cyclopentanone 9.03
    2-pentanone 1.26
    anisole 1.69
    cyclopentyl methyl ether 2.45
    gamma-butyrolactone 33.84
    1-methoxy-2-propanol 16.17
    pyridine 15.01
    3-pentanone 1.61
    furfural 73.68
    n-dodecane 0.12
    diethylene glycol 37.45
    diisopropyl ether 0.29
    tert-amyl alcohol 3.29
    acetylacetone 3.03
    n-hexadecane 0.13
    acetophenone 3.76
    methyl propionate 6.07
    isopentyl acetate 3.02
    trichloroethylene 24.88
    n-nonanol 1.89
    cyclohexanol 5.75
    benzyl alcohol 6.07
    2-ethylhexanol 2.51
    isooctanol 2.23
    dipropyl ether 1.22
    1,2-dichlorobenzene 8.34
    ethyl lactate 5.31
    propylene carbonate 20.83
    n-methylformamide 59.44
    2-pentanol 1.93
    n-pentane 0.15
    1-propoxy-2-propanol 8.83
    1-methoxy-2-propyl acetate 6.34
    2-(2-methoxypropoxy) propanol 10.38
    mesitylene 0.9
    ε-caprolactone 17.37
    p-cymene 1.61
    epichlorohydrin 15.57
    1,1,1-trichloroethane 5.48
    2-aminoethanol 60.9
    morpholine-4-carbaldehyde 44.0
    sulfolane 47.36
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 3.64
    n-hexyl acetate 3.0
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 13.04
    sec-butyl acetate 1.04
    tert-butyl acetate 1.38
    decalin 0.22
    glycerin 68.07
    diglyme 18.52
    acrylic acid 76.76
    isopropyl myristate 1.18
    n-butyric acid 34.98
    acetyl acetate 6.51
    di(2-ethylhexyl) phthalate 4.02
    ethyl propionate 2.13
    nitromethane 56.71
    1,2-diethoxyethane 2.69
    benzonitrile 7.53
    trioctyl phosphate 2.32
    1-bromopropane 1.89
    gamma-valerolactone 30.0
    n-decanol 1.37
    triethyl phosphate 4.05
    4-methyl-2-pentanol 1.04
    propionitrile 4.62
    vinylene carbonate 29.43
    1,1,2-trichlorotrifluoroethane 67.7
    DMS 5.78
    cumene 0.74
    2-octanol 1.32
    2-hexanone 0.77
    octyl acetate 1.89
    limonene 1.79
    1,2-dimethoxyethane 6.28
    ethyl orthosilicate 3.26
    tributyl phosphate 3.06
    diacetone alcohol 4.4
    N,N-dimethylaniline 1.98
    acrylonitrile 13.13
    aniline 7.37
    1,3-propanediol 45.23
    bromobenzene 3.5
    dibromomethane 8.9
    1,1,2,2-tetrachloroethane 19.27
    2-methyl-cyclohexyl acetate 3.21
    tetrabutyl urea 4.27
    diisobutyl methanol 1.47
    2-phenylethanol 7.05
    styrene 0.78
    dioctyl adipate 2.64
    dimethyl sulfate 12.62
    ethyl butyrate 3.39
    methyl lactate 15.71
    butyl lactate 6.28
    diethyl carbonate 3.25
    propanediol butyl ether 10.43
    triethyl orthoformate 3.23
    p-tert-butyltoluene 1.5
    methyl 4-tert-butylbenzoate 6.88
    morpholine 12.39
    tert-butylamine 1.56
    n-dodecanol 1.05
    dimethoxymethane 5.08
    ethylene carbonate 16.8
    cyrene 13.78
    2-ethoxyethyl acetate 4.72
    2-ethylhexyl acetate 2.66
    1,2,4-trichlorobenzene 10.7
    4-methylpyridine 7.51
    dibutyl ether 0.82
    2,6-dimethyl-4-heptanol 1.47
    DEF 8.21
    dimethyl isosorbide 15.98
    tetrachloroethylene 25.62
    eugenol 10.18
    triacetin 5.69
    span 80 10.03
    1,4-butanediol 12.65
    1,1-dichloroethane 3.86
    2-methyl-1-pentanol 2.04
    methyl formate 26.49
    2-methyl-1-butanol 4.05
    n-decane 0.16
    butyronitrile 3.29
    3,7-dimethyl-1-octanol 1.86
    1-chlorooctane 0.69
    1-chlorotetradecane 0.36
    n-nonane 0.15
    undecane 0.14
    tert-butylcyclohexane 0.16
    cyclooctane 0.17
    cyclopentanol 9.53
    tetrahydropyran 2.86
    tert-amyl methyl ether 0.84
    2,5,8-trioxanonane 16.69
    1-hexene 0.3
    2-isopropoxyethanol 4.63
    2,2,2-trifluoroethanol 95.45
    methyl butyrate 3.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction