1-O-Hexadecylglycerol

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  • Identifiers

    CAS number
    6145-69-3

    Molecular formula
    C19H40O3

    SMILES
    CCCCCCCCCCCCCCCCOCC(CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Waxy 63.79%
    Fatty 50.55%
    Oily 47.83%
    Fruity 32.45%
    Odorless 32.05%
    Sweet 26.82%
    Clean 26.65%
    Fresh 26.5%
    Citrus 24.97%
    Soapy 22.08%

     

    Flavor
    Waxy 54.79%
    Fatty 44.3%
    Mild 39.31%
    Oily 35.11%
    Floral 31.97%
    Fat 30.25%
    Soapy 29.84%
    Bland 27.73%
    Flower 27.31%
    Coconut 26.91%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.5

    pKa est.
    6.49 (neutral)

    Molecular weight
    316.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    406°C

    Flash point

    • 189.34 ˚C est.

  • Synonyms

    • 6145-69-3
    • 1-O-Hexadecylglycerol
    • cetyl glyceryl ether
    • Glyceryl-1-hexadecyl ether
    • P9FNL3D0MN
    • 1,2-Propanediol, 3-(hexadecyloxy)-
    • (1)-3-(Hexadecyloxy)propane-1,2-diol
    • NSC-59269
    • RefChem:575383
    • GlyTouCan:G85884UN
    • G85884UN
    • 228-149-9
    • 1-O-Hexadecyl-Rac-Glycerol
    • 3-(hexadecyloxy)propane-1,2-diol
    • 1-O-Palmityl-rac-glycerol
    • 3-(Hexadecyloxy)-1,2-propanediol
    • 1-O-palmitylglycerol
    • 1-Hexadecylglycerol
    • MFCD00042736
    • NSC59269
    • rac-1-O-hexadecylglycerol
    • CHEMBL142186
    • C19H40O3
    • rac-1-Hexadecyl-glycerol
    • UNII-P9FNL3D0MN
    • NSC 59269
    • BRN 1724517
    • Chimylalkohol
    • DL-Testriol
    • 1-palmitylglycerol
    • (R)-3-(hexadecyloxy)-1,2-propanediol
    • EINECS 228-149-9
    • 1-hexadecyl glycerol
    • 1-hexadecyl-glycerol
    • HXDG
    • 3-O-Palmityl-sn-glycerol
    • DL-alpha-Hexadecylglycerol
    • 1-hexadecyl-glyceryl ether
    • NCIMech_000208
    • SCHEMBL38241
    • 3-01-00-02322 (Beilstein Handbook Reference)
    • orb1296819
    • SCHEMBL9851874
    • (+/-)-1-O-Hexadecylglycerol
    • CHEBI:76061
    • DTXSID80862067
    • 3-Hexadecyloxy-propane-1,2-diol
    • 1-O-Palmityl-rac-glycerol, ~99%
    • EINECS 234-133-2
    • BDBM50121670
    • (+/-)-1-HEXADECYL GLYCEROL
    • 3-hHxadecoxypropane-1,2-diolIaaEIaaE
    • AKOS017343245
    • CS-W012025
    • FH49389
    • HY-W011309
    • 3-HEXADECYLOXYPROPANE-1,2-DIOL
    • BS-28926
    • NCI60_004445
    • SY247930
    • (+/-)-3-(hexadecyloxy)propane-1,2-diol
    • L-(-)-3-(Hexadecyloxy)-1,2-propanediol
    • NS00013442
    • 1-O-Palmityl-rac-glycerol, >=99.0% (GC)
    • E77697
    • H-1805
    • H-1807
    • rac 1-O-N-Hexadecylglycerol (DL-Chimyl alcohol)
    • Q27887159
    • 1,2-PROPANEDIOL, 3-(HEXADECYLOXY)-, (+/-)-
    • 6145-69-3

  • Applications

    1-O-Hexadecylglycerol (CAS 6145-69-3) is a glycerol ether bearing a hexadecyl group at position 1, functioning as a nonionic surfactant and emollient in cosmetic and personal care formulations to improve feel and stabilize oil–water emulsions; it can act as a solvent or co-surfactant in household cleaning products and other industrial formulations; it is also used as an intermediate or stabilizing additive in polymer processing and in coatings/inks; additionally, it may be employed as a synthetic intermediate for lipid-like additives and specialty surfactants designed for formulation engineering.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 31.8
    methanol 41.28
    isopropanol 40.55
    water 0.06
    ethyl acetate 160.69
    n-propanol 46.0
    acetone 102.77
    n-butanol 64.1
    acetonitrile 36.59
    DMF 138.97
    toluene 42.93
    isobutanol 53.9
    1,4-dioxane 191.4
    methyl acetate 90.49
    THF 529.43
    2-butanone 127.13
    n-pentanol 54.01
    sec-butanol 61.31
    n-hexane 20.11
    ethylene glycol 4.99
    NMP 333.66
    cyclohexane 123.65
    DMSO 415.57
    n-butyl acetate 248.45
    n-octanol 81.32
    chloroform 362.72
    n-propyl acetate 260.37
    acetic acid 78.96
    dichloromethane 353.59
    cyclohexanone 480.66
    propylene glycol 14.81
    isopropyl acetate 183.84
    DMAc 233.03
    2-ethoxyethanol 137.31
    isopentanol 98.74
    n-heptane 44.24
    ethyl formate 81.31
    1,2-dichloroethane 283.53
    n-hexanol 60.67
    2-methoxyethanol 134.54
    isobutyl acetate 175.89
    tetrachloromethane 116.22
    n-pentyl acetate 342.75
    transcutol 682.98
    n-heptanol 81.58
    ethylbenzene 45.72
    MIBK 190.42
    2-propoxyethanol 133.79
    tert-butanol 115.74
    MTBE 138.84
    2-butoxyethanol 200.5
    propionic acid 70.36
    o-xylene 56.69
    formic acid 16.29
    diethyl ether 102.74
    m-xylene 46.57
    p-xylene 66.96
    chlorobenzene 86.71
    dimethyl carbonate 42.15
    n-octane 17.87
    formamide 33.13
    cyclopentanone 449.87
    2-pentanone 169.42
    anisole 97.25
    cyclopentyl methyl ether 284.54
    gamma-butyrolactone 414.19
    1-methoxy-2-propanol 151.31
    pyridine 139.47
    3-pentanone 131.72
    furfural 279.46
    n-dodecane 8.87
    diethylene glycol 59.57
    diisopropyl ether 71.03
    tert-amyl alcohol 120.62
    acetylacetone 231.98
    n-hexadecane 11.0
    acetophenone 154.35
    methyl propionate 112.42
    isopentyl acetate 247.66
    trichloroethylene 432.42
    n-nonanol 81.46
    cyclohexanol 180.02
    benzyl alcohol 68.09
    2-ethylhexanol 91.43
    isooctanol 96.71
    dipropyl ether 205.2
    1,2-dichlorobenzene 131.34
    ethyl lactate 101.13
    propylene carbonate 249.64
    n-methylformamide 54.5
    2-pentanol 67.73
    n-pentane 14.94
    1-propoxy-2-propanol 192.92
    1-methoxy-2-propyl acetate 220.03
    2-(2-methoxypropoxy) propanol 146.22
    mesitylene 49.02
    ε-caprolactone 407.57
    p-cymene 65.31
    epichlorohydrin 397.46
    1,1,1-trichloroethane 320.34
    2-aminoethanol 19.3
    morpholine-4-carbaldehyde 279.46
    sulfolane 794.75
    2,2,4-trimethylpentane 21.99
    2-methyltetrahydrofuran 348.45
    n-hexyl acetate 276.62
    isooctane 13.3
    2-(2-butoxyethoxy)ethanol 217.09
    sec-butyl acetate 201.25
    tert-butyl acetate 294.27
    decalin 38.65
    glycerin 33.97
    diglyme 552.73
    acrylic acid 46.45
    isopropyl myristate 91.78
    n-butyric acid 195.17
    acetyl acetate 124.61
    di(2-ethylhexyl) phthalate 68.09
    ethyl propionate 192.7
    nitromethane 166.07
    1,2-diethoxyethane 280.67
    benzonitrile 92.66
    trioctyl phosphate 62.97
    1-bromopropane 152.15
    gamma-valerolactone 542.72
    n-decanol 50.31
    triethyl phosphate 138.15
    4-methyl-2-pentanol 64.98
    propionitrile 47.7
    vinylene carbonate 172.63
    1,1,2-trichlorotrifluoroethane 327.57
    DMS 119.72
    cumene 44.28
    2-octanol 78.37
    2-hexanone 192.94
    octyl acetate 109.41
    limonene 125.15
    1,2-dimethoxyethane 326.4
    ethyl orthosilicate 146.25
    tributyl phosphate 85.53
    diacetone alcohol 270.76
    N,N-dimethylaniline 84.19
    acrylonitrile 48.2
    aniline 54.94
    1,3-propanediol 50.39
    bromobenzene 102.64
    dibromomethane 243.41
    1,1,2,2-tetrachloroethane 496.21
    2-methyl-cyclohexyl acetate 211.21
    tetrabutyl urea 122.59
    diisobutyl methanol 89.42
    2-phenylethanol 69.45
    styrene 48.21
    dioctyl adipate 153.68
    dimethyl sulfate 118.52
    ethyl butyrate 271.12
    methyl lactate 66.57
    butyl lactate 213.65
    diethyl carbonate 135.97
    propanediol butyl ether 145.61
    triethyl orthoformate 232.09
    p-tert-butyltoluene 63.01
    methyl 4-tert-butylbenzoate 203.32
    morpholine 269.95
    tert-butylamine 78.44
    n-dodecanol 35.21
    dimethoxymethane 118.63
    ethylene carbonate 182.66
    cyrene 166.38
    2-ethoxyethyl acetate 297.7
    2-ethylhexyl acetate 212.66
    1,2,4-trichlorobenzene 152.63
    4-methylpyridine 123.61
    dibutyl ether 199.24
    2,6-dimethyl-4-heptanol 89.42
    DEF 223.98
    dimethyl isosorbide 319.95
    tetrachloroethylene 341.97
    eugenol 148.61
    triacetin 282.2
    span 80 147.7
    1,4-butanediol 21.52
    1,1-dichloroethane 196.33
    2-methyl-1-pentanol 76.95
    methyl formate 44.14
    2-methyl-1-butanol 83.0
    n-decane 22.89
    butyronitrile 71.55
    3,7-dimethyl-1-octanol 93.47
    1-chlorooctane 95.19
    1-chlorotetradecane 27.07
    n-nonane 23.34
    undecane 12.98
    tert-butylcyclohexane 29.69
    cyclooctane 34.18
    cyclopentanol 159.79
    tetrahydropyran 343.94
    tert-amyl methyl ether 137.62
    2,5,8-trioxanonane 296.88
    1-hexene 44.31
    2-isopropoxyethanol 125.98
    2,2,2-trifluoroethanol 47.35
    methyl butyrate 287.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction