1-Methoxy-2-propyl acetate

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  • Identifiers

    CAS number
    108-65-6

    Molecular formula
    C6H12O3

    SMILES
    CC(COC)OC(=O)C

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Fruity 93.63%
    Ethereal 67.45%
    Sweet 62.96%
    Buttery 37.29%
    Rummy 35.83%
    Pineapple 35.76%
    Solvent 33.56%
    Winey 32.75%
    Banana 31.51%
    Fermented 31.07%

     

    Flavor
    Fruity 69.81%
    Bitter 58.0%
    Sweet 54.34%
    Ethereal 44.28%
    Tropical 40.03%
    Banana 36.08%
    Fruit 36.03%
    Ether 34.67%
    Solvent 31.38%
    Musty 30.05%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    6.44 (neutral)

    Molecular weight
    132.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -66 °C

    Boiling point

    • 302 °F at 760 mmHg (USCG, 1999)
    • 145-146 °C
    • BP: 145.8 °C at 101.325 kPa
    • BP: 302 °F = 150 °C = 423 K at 1 atm
    • 146 °C
    • 302 °F

    Flash point

    • 48.52 ˚C est.
    • 114 °F (USCG, 1999)
    • 42 °C
    • 45.5 °C (113.9 °F) - closed cup
    • 108 °F (42 °C) - closed cup
    • 42 °C c.c.

    Solubility expt.

    • In water, 1.98X10+5 mg/L at 25 °C
    • In water, 198 g/L at 20 °C, pH 6.8
    • Solubility in water, g/100ml: 19.8

  • Synonyms

    • 1-Methoxy-2-propyl acetate
    • 108-65-6
    • Propylene glycol monomethyl ether acetate
    • 1-methoxypropan-2-yl acetate
    • Propylene glycol methyl ether acetate
    • PGMEA
    • 2-Acetoxy-1-methoxypropane
    • 1-Methoxy-2-acetoxypropane
    • METHOXYISOPROPYL ACETATE
    • 2-Methoxy-1-methylethyl acetate
    • 2-Propanol, 1-methoxy-, acetate
    • 1-METHOXY-2-PROPANOL ACETATE
    • Propyleneglycol monomethyl ether acetate
    • NSC 2207
    • 2-Propanol, 1-methoxy-, 2-acetate
    • Acetic acid, 2-methoxy-1-methylethyl ester
    • Dowanol (R) PMA glycol ether acetate
    • EINECS 203-603-9
    • Propylene glycol 1-methyl ether 2-acetate
    • PA7O2U6S2Q
    • BRN 1751656
    • DTXSID1026796
    • AI3-18548
    • NSC-2207
    • SU 8 DEVELOPER
    • Propylene Glycol 1-Monomethyl Ether 2-Acetate
    • MFCD00038500
    • PROPYLENEGLYCOLMETHYLETHERACETATE
    • 1,2-Propanediol monomethyl ether acetate
    • DTXCID106796
    • HSDB 8443
    • EC 203-603-9
    • UNII-PA7O2U6S2Q
    • 2-(1-Methoxy)propyl acetate
    • Arcosolv PMA
    • Dowanol PMA
    • PGMEA cpd
    • 2-Propanol, acetate
    • Ektasolve PM Acetate
    • propylene glycol monomethylether acetate
    • 1Methoxy2acetoxypropane
    • 2Acetoxy1methoxypropane
    • 1Methoxy2propanol acetate
    • 2Methoxy1methylethyl acetate
    • 1-methoxy-2-acetoxy propane
    • SCHEMBL15667
    • 2Propanol, 1methoxy, acetate
    • 2Propanol, 1methoxy, 2acetate
    • CHEMBL3182130
    • DTXSID3042346
    • LLHKCFNBLRBOGN-UHFFFAOYSA-
    • NSC2207
    • propyleneglycol methyl ether acetate
    • Propanol, 1(or 2)methoxy, acetate
    • Tox21_201436
    • AKOS015837930
    • Propylene glycol 1-methyl ether 2-acetate 100 microg/mL in Acetonitrile
    • HY-W133953
    • METHOXYISOPROPYL ACETATE [INCI]
    • Acetic acid, 2methoxy1methylethyl ester
    • NCGC00249046-01
    • NCGC00258987-01
    • CAS-108-65-6
    • 2-methoxy-1-methylethyl ester acetic acid
    • DB-371699
    • CS-0198137
    • NS00011490
    • P1171
    • 1,2-Propanediol 1-Monomethyl Ether 2-Acetate
    • Propylene glycol monomethyl ether acetate, 99%
    • EN300-1725866
    • Q2170375
    • Propylene glycol monomethyl ether acetate, >=99.0% (GC)
    • Propylene glycol monomethyl ether acetate, ReagentPlus(R), >=99.5%
    • Propylene glycol monomethyl ether acetate, Vetec(TM) reagent grade
    • InChI=1/C6H12O3/c1-5(4-8-3)9-6(2)7/h5H,4H2,1-3H3
    • 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; MPA
    • 203-603-9

  • Applications

    1-Methoxy-2-propyl acetate (CAS 108-65-6), commonly known as propylene glycol monomethyl ether acetate (PGMEA), is widely used as a solvent in coatings and varnishes to dissolve resin binders and promote film formation; it is also a key solvent in printing inks and adhesive formulations where it balances evaporation rate and substrate interaction; in electronics manufacturing, it serves as a processing solvent for photoresists and related resins; it is employed in industrial cleaning and degreasing formulations for equipment and components; and it may function as a carrier solvent or processing aid in various industrial formulations, subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2105.59
    methanol 3980.88
    isopropanol 1187.44
    water 415.6
    ethyl acetate 497.13
    n-propanol 1122.71
    acetone 843.2
    n-butanol 872.92
    acetonitrile 1065.69
    DMF 1338.56
    toluene 175.46
    isobutanol 619.35
    1,4-dioxane 1684.47
    methyl acetate 623.51
    THF 1423.36
    2-butanone 389.01
    n-pentanol 482.52
    sec-butanol 738.86
    n-hexane 78.81
    ethylene glycol 935.66
    NMP 1100.61
    cyclohexane 188.9
    DMSO 887.67
    n-butyl acetate 173.17
    n-octanol 208.36
    chloroform 1324.26
    n-propyl acetate 197.01
    acetic acid 3267.24
    dichloromethane 1359.74
    cyclohexanone 624.01
    propylene glycol 657.66
    isopropyl acetate 194.08
    DMAc 1063.1
    2-ethoxyethanol 981.99
    isopentanol 443.75
    n-heptane 56.99
    ethyl formate 557.75
    1,2-dichloroethane 537.62
    n-hexanol 379.71
    2-methoxyethanol 1960.08
    isobutyl acetate 107.38
    tetrachloromethane 211.59
    n-pentyl acetate 129.05
    transcutol 1165.65
    n-heptanol 139.96
    ethylbenzene 96.49
    MIBK 124.85
    2-propoxyethanol 676.48
    tert-butanol 933.07
    MTBE 377.65
    2-butoxyethanol 277.85
    propionic acid 985.0
    o-xylene 139.2
    formic acid 2431.16
    diethyl ether 566.13
    m-xylene 105.32
    p-xylene 134.7
    chlorobenzene 231.09
    dimethyl carbonate 168.74
    n-octane 21.17
    formamide 1717.67
    cyclopentanone 535.89
    2-pentanone 264.22
    anisole 239.51
    cyclopentyl methyl ether 490.49
    gamma-butyrolactone 803.57
    1-methoxy-2-propanol 864.5
    pyridine 639.91
    3-pentanone 217.4
    furfural 850.96
    n-dodecane 20.33
    diethylene glycol 695.17
    diisopropyl ether 86.91
    tert-amyl alcohol 617.05
    acetylacetone 286.22
    n-hexadecane 21.58
    acetophenone 200.19
    methyl propionate 366.96
    isopentyl acetate 133.08
    trichloroethylene 832.45
    n-nonanol 172.47
    cyclohexanol 771.66
    benzyl alcohol 304.49
    2-ethylhexanol 174.73
    isooctanol 97.05
    dipropyl ether 190.79
    1,2-dichlorobenzene 215.46
    ethyl lactate 147.47
    propylene carbonate 428.22
    n-methylformamide 1049.62
    2-pentanol 387.4
    n-pentane 102.69
    1-propoxy-2-propanol 337.85
    1-methoxy-2-propyl acetate 200.57
    2-(2-methoxypropoxy) propanol 283.73
    mesitylene 63.97
    ε-caprolactone 626.69
    p-cymene 66.32
    epichlorohydrin 810.16
    1,1,1-trichloroethane 436.26
    2-aminoethanol 1167.11
    morpholine-4-carbaldehyde 1237.84
    sulfolane 628.81
    2,2,4-trimethylpentane 36.9
    2-methyltetrahydrofuran 945.19
    n-hexyl acetate 242.55
    isooctane 17.77
    2-(2-butoxyethoxy)ethanol 400.9
    sec-butyl acetate 115.15
    tert-butyl acetate 158.33
    decalin 50.18
    glycerin 835.35
    diglyme 648.16
    acrylic acid 898.3
    isopropyl myristate 93.96
    n-butyric acid 822.78
    acetyl acetate 333.2
    di(2-ethylhexyl) phthalate 108.11
    ethyl propionate 197.85
    nitromethane 2189.2
    1,2-diethoxyethane 301.94
    benzonitrile 295.96
    trioctyl phosphate 74.24
    1-bromopropane 346.31
    gamma-valerolactone 988.26
    n-decanol 120.82
    triethyl phosphate 100.55
    4-methyl-2-pentanol 150.17
    propionitrile 548.51
    vinylene carbonate 482.89
    1,1,2-trichlorotrifluoroethane 802.24
    DMS 196.21
    cumene 70.57
    2-octanol 101.65
    2-hexanone 170.04
    octyl acetate 132.8
    limonene 113.19
    1,2-dimethoxyethane 1170.98
    ethyl orthosilicate 100.17
    tributyl phosphate 96.71
    diacetone alcohol 240.25
    N,N-dimethylaniline 174.23
    acrylonitrile 606.68
    aniline 370.9
    1,3-propanediol 1264.19
    bromobenzene 197.19
    dibromomethane 757.74
    1,1,2,2-tetrachloroethane 651.57
    2-methyl-cyclohexyl acetate 144.17
    tetrabutyl urea 133.16
    diisobutyl methanol 80.99
    2-phenylethanol 213.24
    styrene 118.37
    dioctyl adipate 164.86
    dimethyl sulfate 220.4
    ethyl butyrate 160.04
    methyl lactate 252.51
    butyl lactate 122.67
    diethyl carbonate 137.02
    propanediol butyl ether 274.8
    triethyl orthoformate 143.09
    p-tert-butyltoluene 62.98
    methyl 4-tert-butylbenzoate 177.78
    morpholine 1854.42
    tert-butylamine 585.93
    n-dodecanol 93.08
    dimethoxymethane 682.76
    ethylene carbonate 414.02
    cyrene 257.37
    2-ethoxyethyl acetate 197.36
    2-ethylhexyl acetate 109.21
    1,2,4-trichlorobenzene 267.64
    4-methylpyridine 560.65
    dibutyl ether 183.14
    2,6-dimethyl-4-heptanol 80.99
    DEF 514.87
    dimethyl isosorbide 391.58
    tetrachloroethylene 533.32
    eugenol 202.87
    triacetin 262.16
    span 80 263.11
    1,4-butanediol 490.69
    1,1-dichloroethane 536.02
    2-methyl-1-pentanol 311.88
    methyl formate 790.98
    2-methyl-1-butanol 470.68
    n-decane 33.59
    butyronitrile 530.08
    3,7-dimethyl-1-octanol 166.3
    1-chlorooctane 101.86
    1-chlorotetradecane 47.12
    n-nonane 34.79
    undecane 24.57
    tert-butylcyclohexane 42.26
    cyclooctane 44.9
    cyclopentanol 797.84
    tetrahydropyran 1099.87
    tert-amyl methyl ether 273.92
    2,5,8-trioxanonane 488.1
    1-hexene 190.34
    2-isopropoxyethanol 439.22
    2,2,2-trifluoroethanol 929.2
    methyl butyrate 273.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction