1-Ethoxy-2-methoxybenzene

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  • Identifiers

    CAS number
    17600-72-5

    Molecular formula
    C9H12O2

    SMILES
    CCOC1=CC=CC=C1OC

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Sweet 83.74%
    Vanilla 69.55%
    Phenolic 67.8%
    Nutty 58.43%
    Earthy 50.84%
    Anisic 50.52%
    Smoky 48.65%
    Spicy 43.84%
    Creamy 39.11%
    Musty 38.22%

     

    Flavor
    Sweet 74.07%
    Vanilla 52.54%
    Phenolic 46.67%
    Musty 45.34%
    Creamy 42.04%
    Bitter 41.68%
    Earthy 37.82%
    Powdery 36.44%
    Anise 35.66%
    Green 33.84%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    7.41 (neutral)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    222°C

    Flash point

    • 70.67 ˚C est.

  • Synonyms

    • 1-Ethoxy-2-methoxybenzene
    • 17600-72-5
    • 2-Ethoxyanisole
    • Benzene, 1-ethoxy-2-methoxy-
    • 2-Methoxyphenetole
    • W6Y3DDU3ZP
    • EINECS 241-571-8
    • AI3-20935
    • DTXSID10170066
    • ETHYL O-METHOXYPHENYL ETHER
    • UNII-W6Y3DDU3ZP
    • ethyl guaiacol
    • methoxy-phenetole
    • Guajacol-athylather
    • MFCD00043552
    • 1-methoxy-2-ethoxybenzene
    • SCHEMBL194473
    • CHEMBL2252472
    • DTXCID3092557
    • AKOS015890124
    • FE70943
    • BS-15594
    • CS-0151455
    • NS00021756
    • Q27292410
    • 241-571-8

  • Applications

    1-Ethoxy-2-methoxybenzene is a di-alkoxybenzene that serves primarily as a chemical intermediate and building block in organic synthesis. In fragrance and flavor applications, it may act as a precursor to aroma compounds and contribute to scent profiles in perfumery. It is also evaluated as a specialty solvent or processing aid in coatings, inks, and cleaning formulations. In polymer and plastics manufacturing, it can function as a starting material for the synthesis of other anisole derivatives, and it may be used as an intermediate in pharmaceutical chemistry for further transformations. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1152.46
    methanol 1231.22
    isopropanol 751.68
    water 5.23
    ethyl acetate 1754.7
    n-propanol 832.9
    acetone 2461.32
    n-butanol 713.0
    acetonitrile 3040.49
    DMF 2021.33
    toluene 674.07
    isobutanol 598.46
    1,4-dioxane 2831.8
    methyl acetate 2000.59
    THF 2126.33
    2-butanone 1361.61
    n-pentanol 576.79
    sec-butanol 648.65
    n-hexane 248.15
    ethylene glycol 480.66
    NMP 1454.62
    cyclohexane 700.13
    DMSO 2716.42
    n-butyl acetate 1359.16
    n-octanol 505.34
    chloroform 7196.84
    n-propyl acetate 1242.33
    acetic acid 2048.3
    dichloromethane 9799.82
    cyclohexanone 2056.44
    propylene glycol 344.27
    isopropyl acetate 703.32
    DMAc 1223.7
    2-ethoxyethanol 1098.31
    isopentanol 486.16
    n-heptane 348.71
    ethyl formate 1840.97
    1,2-dichloroethane 4804.89
    n-hexanol 625.99
    2-methoxyethanol 1531.68
    isobutyl acetate 599.68
    tetrachloromethane 1636.37
    n-pentyl acetate 683.84
    transcutol 1633.23
    n-heptanol 363.63
    ethylbenzene 487.54
    MIBK 483.36
    2-propoxyethanol 955.82
    tert-butanol 883.47
    MTBE 702.16
    2-butoxyethanol 567.71
    propionic acid 1215.26
    o-xylene 468.96
    formic acid 531.84
    diethyl ether 1217.61
    m-xylene 413.21
    p-xylene 703.49
    chlorobenzene 1590.37
    dimethyl carbonate 754.17
    n-octane 157.23
    formamide 1056.58
    cyclopentanone 2082.18
    2-pentanone 1000.64
    anisole 1001.36
    cyclopentyl methyl ether 955.04
    gamma-butyrolactone 2651.18
    1-methoxy-2-propanol 832.4
    pyridine 2434.41
    3-pentanone 934.67
    furfural 2420.21
    n-dodecane 124.22
    diethylene glycol 804.09
    diisopropyl ether 319.7
    tert-amyl alcohol 657.21
    acetylacetone 1254.87
    n-hexadecane 140.45
    acetophenone 882.83
    methyl propionate 1259.96
    isopentyl acetate 820.48
    trichloroethylene 7265.22
    n-nonanol 413.67
    cyclohexanol 840.56
    benzyl alcohol 724.33
    2-ethylhexanol 492.9
    isooctanol 298.9
    dipropyl ether 868.8
    1,2-dichlorobenzene 1574.23
    ethyl lactate 533.25
    propylene carbonate 1738.26
    n-methylformamide 1529.49
    2-pentanol 430.42
    n-pentane 232.5
    1-propoxy-2-propanol 693.78
    1-methoxy-2-propyl acetate 768.82
    2-(2-methoxypropoxy) propanol 475.0
    mesitylene 321.17
    ε-caprolactone 1750.64
    p-cymene 399.82
    epichlorohydrin 3229.37
    1,1,1-trichloroethane 3788.83
    2-aminoethanol 593.09
    morpholine-4-carbaldehyde 1742.41
    sulfolane 2773.81
    2,2,4-trimethylpentane 107.54
    2-methyltetrahydrofuran 1553.92
    n-hexyl acetate 977.94
    isooctane 79.37
    2-(2-butoxyethoxy)ethanol 653.93
    sec-butyl acetate 573.92
    tert-butyl acetate 589.91
    decalin 239.5
    glycerin 497.15
    diglyme 1775.21
    acrylic acid 1210.38
    isopropyl myristate 395.88
    n-butyric acid 1332.05
    acetyl acetate 1161.28
    di(2-ethylhexyl) phthalate 297.38
    ethyl propionate 996.04
    nitromethane 3935.4
    1,2-diethoxyethane 987.63
    benzonitrile 1426.93
    trioctyl phosphate 258.39
    1-bromopropane 1922.17
    gamma-valerolactone 2160.44
    n-decanol 314.7
    triethyl phosphate 495.27
    4-methyl-2-pentanol 215.86
    propionitrile 1751.38
    vinylene carbonate 2017.92
    1,1,2-trichlorotrifluoroethane 1968.13
    DMS 784.89
    cumene 343.82
    2-octanol 308.78
    2-hexanone 880.87
    octyl acetate 510.56
    limonene 555.09
    1,2-dimethoxyethane 2236.34
    ethyl orthosilicate 426.66
    tributyl phosphate 344.45
    diacetone alcohol 555.61
    N,N-dimethylaniline 566.1
    acrylonitrile 2260.4
    aniline 780.48
    1,3-propanediol 750.93
    bromobenzene 1934.04
    dibromomethane 5801.18
    1,1,2,2-tetrachloroethane 4915.06
    2-methyl-cyclohexyl acetate 615.93
    tetrabutyl urea 423.72
    diisobutyl methanol 289.44
    2-phenylethanol 595.66
    styrene 736.39
    dioctyl adipate 556.92
    dimethyl sulfate 972.14
    ethyl butyrate 1131.63
    methyl lactate 511.68
    butyl lactate 454.55
    diethyl carbonate 964.86
    propanediol butyl ether 459.68
    triethyl orthoformate 706.31
    p-tert-butyltoluene 348.34
    methyl 4-tert-butylbenzoate 592.26
    morpholine 2179.06
    tert-butylamine 620.18
    n-dodecanol 260.2
    dimethoxymethane 1439.41
    ethylene carbonate 1712.01
    cyrene 505.3
    2-ethoxyethyl acetate 799.38
    2-ethylhexyl acetate 695.23
    1,2,4-trichlorobenzene 1579.06
    4-methylpyridine 1791.21
    dibutyl ether 765.7
    2,6-dimethyl-4-heptanol 289.44
    DEF 1289.71
    dimethyl isosorbide 862.17
    tetrachloroethylene 3773.1
    eugenol 549.8
    triacetin 827.17
    span 80 450.45
    1,4-butanediol 417.68
    1,1-dichloroethane 3892.67
    2-methyl-1-pentanol 416.7
    methyl formate 1736.1
    2-methyl-1-butanol 498.73
    n-decane 190.33
    butyronitrile 1629.32
    3,7-dimethyl-1-octanol 392.39
    1-chlorooctane 596.34
    1-chlorotetradecane 251.67
    n-nonane 210.89
    undecane 147.54
    tert-butylcyclohexane 180.45
    cyclooctane 226.61
    cyclopentanol 931.6
    tetrahydropyran 1916.82
    tert-amyl methyl ether 490.11
    2,5,8-trioxanonane 994.86
    1-hexene 547.64
    2-isopropoxyethanol 665.24
    2,2,2-trifluoroethanol 732.06
    methyl butyrate 1426.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction