1-Ethoxy-2-methoxy-4-methylbenzene

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  • Identifiers

    CAS number
    33963-27-8

    Molecular formula
    C10H14O2

    SMILES
    CCOC1=C(C=C(C=C1)C)OC

  • Odor profile

    Fragrance
    Phenolic 63.23%
    Spicy 61.96%
    Vanilla 59.95%
    Sweet 55.91%
    Smoky 50.62%
    Woody 45.5%
    Earthy 41.05%
    Nutty 39.37%
    Powdery 37.43%
    Anisic 36.38%

     

    Flavor
    Phenolic 45.94%
    Vanilla 41.49%
    Sweet 40.98%
    Spice 39.81%
    Bitter 38.78%
    Musty 38.77%
    Smoky 37.97%
    Spicy 33.36%
    Earthy 32.91%
    Woody 32.26%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    7.95 (neutral)

    Molecular weight
    166.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    236°C

    Flash point

    • 79.91 ˚C est.

  • Synonyms

    • 1-Ethoxy-2-methoxy-4-methylbenzene
    • 33963-27-8
    • 4-Ethoxy-3-methoxytoluene
    • Benzene, 1-ethoxy-2-methoxy-4-methyl-
    • SCHEMBL7634998
    • QOFRRWWZQIIACS-UHFFFAOYSA-
    • DTXSID30343018
    • QOFRRWWZQIIACS-UHFFFAOYSA-N
    • MFCD00210457
    • AKOS006242922
    • 1-Ethoxy-2-methoxy-4-methylbenzene #
    • FE67179
    • InChI=1/C10H14O2/c1-4-12-9-6-5-8(2)7-10(9)11-3/h5-7H,4H2,1-3H3

  • Applications

    1-Ethoxy-2-methoxy-4-methylbenzene (CAS 33963-27-8) is used primarily as a fragrance-related ingredient and chemical intermediate; in perfumery it functions as an odorant and can be incorporated as a component in fragrance formulations; in cosmetics and personal care it may serve as a fragrance ingredient; in household products such as cleaners and air fresheners it acts as a scent component; in industrial manufacturing it serves as an intermediate for the synthesis of other aromatic compounds and aroma-related materials; in coatings, inks, and adhesives it can be used as a fragrance additive to impart scent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 939.96
    methanol 936.96
    isopropanol 702.92
    water 3.11
    ethyl acetate 896.35
    n-propanol 762.69
    acetone 1289.82
    n-butanol 669.45
    acetonitrile 1262.56
    DMF 1187.53
    toluene 422.27
    isobutanol 570.2
    1,4-dioxane 1967.79
    methyl acetate 995.21
    THF 1480.41
    2-butanone 765.19
    n-pentanol 511.84
    sec-butanol 623.1
    n-hexane 175.51
    ethylene glycol 418.81
    NMP 728.43
    cyclohexane 453.75
    DMSO 1204.09
    n-butyl acetate 686.92
    n-octanol 359.78
    chloroform 3758.27
    n-propyl acetate 580.51
    acetic acid 1221.55
    dichloromethane 3771.17
    cyclohexanone 1170.28
    propylene glycol 361.6
    isopropyl acetate 405.34
    DMAc 693.68
    2-ethoxyethanol 833.55
    isopentanol 473.11
    n-heptane 185.17
    ethyl formate 967.11
    1,2-dichloroethane 2127.16
    n-hexanol 615.26
    2-methoxyethanol 1222.12
    isobutyl acetate 344.24
    tetrachloromethane 815.34
    n-pentyl acetate 375.81
    transcutol 1028.5
    n-heptanol 300.11
    ethylbenzene 299.38
    MIBK 324.92
    2-propoxyethanol 799.81
    tert-butanol 901.31
    MTBE 668.18
    2-butoxyethanol 436.49
    propionic acid 773.47
    o-xylene 294.98
    formic acid 325.23
    diethyl ether 872.78
    m-xylene 297.47
    p-xylene 399.65
    chlorobenzene 798.93
    dimethyl carbonate 370.74
    n-octane 91.81
    formamide 493.19
    cyclopentanone 1123.44
    2-pentanone 589.15
    anisole 587.1
    cyclopentyl methyl ether 682.51
    gamma-butyrolactone 1357.01
    1-methoxy-2-propanol 740.45
    pyridine 1215.92
    3-pentanone 465.75
    furfural 1238.6
    n-dodecane 71.41
    diethylene glycol 694.53
    diisopropyl ether 229.74
    tert-amyl alcohol 648.64
    acetylacetone 671.46
    n-hexadecane 80.75
    acetophenone 469.17
    methyl propionate 633.67
    isopentyl acetate 499.81
    trichloroethylene 3165.23
    n-nonanol 294.92
    cyclohexanol 743.84
    benzyl alcohol 486.86
    2-ethylhexanol 375.53
    isooctanol 242.32
    dipropyl ether 465.0
    1,2-dichlorobenzene 748.1
    ethyl lactate 326.33
    propylene carbonate 917.2
    n-methylformamide 770.31
    2-pentanol 429.19
    n-pentane 163.27
    1-propoxy-2-propanol 524.41
    1-methoxy-2-propyl acetate 449.02
    2-(2-methoxypropoxy) propanol 351.84
    mesitylene 219.35
    ε-caprolactone 923.38
    p-cymene 220.54
    epichlorohydrin 1690.49
    1,1,1-trichloroethane 1954.22
    2-aminoethanol 513.2
    morpholine-4-carbaldehyde 1002.48
    sulfolane 1266.03
    2,2,4-trimethylpentane 84.69
    2-methyltetrahydrofuran 1049.39
    n-hexyl acetate 548.29
    isooctane 66.82
    2-(2-butoxyethoxy)ethanol 494.4
    sec-butyl acetate 326.8
    tert-butyl acetate 389.86
    decalin 158.31
    glycerin 484.18
    diglyme 1030.67
    acrylic acid 705.58
    isopropyl myristate 231.59
    n-butyric acid 904.62
    acetyl acetate 613.04
    di(2-ethylhexyl) phthalate 196.58
    ethyl propionate 468.2
    nitromethane 1666.31
    1,2-diethoxyethane 562.93
    benzonitrile 730.07
    trioctyl phosphate 168.84
    1-bromopropane 1029.57
    gamma-valerolactone 1189.58
    n-decanol 227.09
    triethyl phosphate 262.29
    4-methyl-2-pentanol 216.6
    propionitrile 864.22
    vinylene carbonate 956.75
    1,1,2-trichlorotrifluoroethane 1156.91
    DMS 414.37
    cumene 217.63
    2-octanol 241.16
    2-hexanone 490.6
    octyl acetate 305.72
    limonene 317.13
    1,2-dimethoxyethane 1415.44
    ethyl orthosilicate 246.82
    tributyl phosphate 198.76
    diacetone alcohol 426.64
    N,N-dimethylaniline 340.3
    acrylonitrile 1029.2
    aniline 527.3
    1,3-propanediol 696.92
    bromobenzene 904.69
    dibromomethane 2436.61
    1,1,2,2-tetrachloroethane 2539.25
    2-methyl-cyclohexyl acetate 354.12
    tetrabutyl urea 245.0
    diisobutyl methanol 210.14
    2-phenylethanol 442.59
    styrene 410.7
    dioctyl adipate 311.5
    dimethyl sulfate 470.13
    ethyl butyrate 498.97
    methyl lactate 340.08
    butyl lactate 269.15
    diethyl carbonate 416.76
    propanediol butyl ether 380.44
    triethyl orthoformate 348.95
    p-tert-butyltoluene 216.09
    methyl 4-tert-butylbenzoate 375.43
    morpholine 1621.47
    tert-butylamine 591.35
    n-dodecanol 183.95
    dimethoxymethane 908.84
    ethylene carbonate 829.3
    cyrene 364.09
    2-ethoxyethyl acetate 432.01
    2-ethylhexyl acetate 403.82
    1,2,4-trichlorobenzene 792.61
    4-methylpyridine 954.4
    dibutyl ether 404.86
    2,6-dimethyl-4-heptanol 210.14
    DEF 675.54
    dimethyl isosorbide 551.62
    tetrachloroethylene 1790.93
    eugenol 367.67
    triacetin 432.99
    span 80 331.41
    1,4-butanediol 375.95
    1,1-dichloroethane 1874.5
    2-methyl-1-pentanol 383.42
    methyl formate 871.8
    2-methyl-1-butanol 487.08
    n-decane 112.09
    butyronitrile 935.84
    3,7-dimethyl-1-octanol 285.59
    1-chlorooctane 333.46
    1-chlorotetradecane 141.18
    n-nonane 121.93
    undecane 87.01
    tert-butylcyclohexane 132.83
    cyclooctane 140.79
    cyclopentanol 717.56
    tetrahydropyran 1439.79
    tert-amyl methyl ether 431.25
    2,5,8-trioxanonane 649.02
    1-hexene 406.89
    2-isopropoxyethanol 528.94
    2,2,2-trifluoroethanol 414.21
    methyl butyrate 679.84

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction