1-Cyclobutylethan-1-one

Overview IFRA Request a quote

  • Identifiers

    CAS number
    3019-25-8

    Molecular formula
    C6H10O

    SMILES
    CC(=O)C1CCC1

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Mint 63.79%
    Herbal 60.56%
    Ketonic 54.87%
    Fruity 53.29%
    Camphoreous 47.43%
    Woody 39.1%
    Ethereal 34.11%
    Fresh 32.84%
    Musty 32.57%
    Solvent 31.0%

     

    Flavor
    Fruity 57.28%
    Minty 39.44%
    Sweet 34.21%
    Fruit 27.61%
    Berry 26.31%
    Mint 24.6%
    Ethereal 24.48%
    Pungent 22.91%
    Caramel 22.62%
    Camphor 22.46%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    7.93 (neutral)

    Molecular weight
    98.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    134°C

    Flash point

    • 23.01 ˚C est.

  • Synonyms

    • Cyclobutyl methyl ketone
    • 3019-25-8
    • 1-Cyclobutylethan-1-one
    • EINECS 221-163-6
    • DTXSID50184263
    • RefChem:431599
    • DTXCID60106754
    • 221-163-6
    • 1-Cyclobutylethanone
    • Acetylcyclobutane
    • Ethanone, 1-cyclobutyl-
    • MFCD00037148
    • Cyclobutylmethylketone
    • Ketone, cyclobutyl methyl
    • 1-cyclobutyl-ethanone
    • Methyl cyclobutyl ketone
    • Acetylcyclobutan
    • Cyclobutylethanone
    • Cyclobutane, acetyl-
    • cyclobutylmethyl ketone
    • 1-Cyclobutylethanone #
    • SCHEMBL93225
    • Cyclobutyl methyl ketone, 98%
    • SCHEMBL2047608
    • SCHEMBL3869687
    • SCHEMBL6238749
    • SCHEMBL28058416
    • GEO-00006
    • AKOS005257570
    • GS-0681
    • PB42491
    • SY049680
    • DB-068244
    • NS00028875
    • EN300-85446
    • P15299
    • F0001-0928
    • 3019-25-8

  • Applications

    1-Cyclobutylethan-1-one (CAS 3019-25-8) is a cyclobutyl-substituted ketone that is primarily used as an organic synthesis intermediate. It serves as a precursor to cyclobutyl-containing compounds in pharmaceutical and agrochemical development, and is evaluated for fragrance and flavor applications as an odor-active intermediate. It can be used in cosmetics and personal care formulations as a building block for aroma ingredients. In coatings and inks, it is employed as a specialty chemical intermediate for ketone-containing additives; in polymers and plastics, it provides a building block for cyclobutyl-containing monomers and resins. It may also be used in industrial manufacturing as a reagent or intermediate in multi-step syntheses, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 803.47
    methanol 1068.35
    isopropanol 484.69
    water 4.34
    ethyl acetate 486.35
    n-propanol 513.63
    acetone 575.17
    n-butanol 455.91
    acetonitrile 756.4
    DMF 506.6
    toluene 227.28
    isobutanol 332.1
    1,4-dioxane 842.4
    methyl acetate 447.26
    THF 1000.57
    2-butanone 469.44
    n-pentanol 338.67
    sec-butanol 370.95
    n-hexane 117.42
    ethylene glycol 124.5
    NMP 581.63
    cyclohexane 111.6
    DMSO 520.31
    n-butyl acetate 481.71
    n-octanol 202.71
    chloroform 2178.39
    n-propyl acetate 304.96
    acetic acid 814.72
    dichloromethane 1496.91
    cyclohexanone 626.99
    propylene glycol 155.86
    isopropyl acetate 270.84
    DMAc 354.51
    2-ethoxyethanol 360.37
    isopentanol 355.05
    n-heptane 68.94
    ethyl formate 334.16
    1,2-dichloroethane 638.84
    n-hexanol 388.91
    2-methoxyethanol 533.57
    isobutyl acetate 198.09
    tetrachloromethane 376.88
    n-pentyl acetate 310.85
    transcutol 1730.95
    n-heptanol 186.17
    ethylbenzene 135.62
    MIBK 233.42
    2-propoxyethanol 510.57
    tert-butanol 463.28
    MTBE 363.92
    2-butoxyethanol 313.96
    propionic acid 523.07
    o-xylene 144.26
    formic acid 312.37
    diethyl ether 470.37
    m-xylene 150.67
    p-xylene 185.86
    chlorobenzene 459.53
    dimethyl carbonate 107.68
    n-octane 30.36
    formamide 349.46
    cyclopentanone 753.88
    2-pentanone 362.98
    anisole 271.55
    cyclopentyl methyl ether 387.6
    gamma-butyrolactone 894.63
    1-methoxy-2-propanol 376.65
    pyridine 727.22
    3-pentanone 266.44
    furfural 794.28
    n-dodecane 22.24
    diethylene glycol 348.93
    diisopropyl ether 133.47
    tert-amyl alcohol 342.28
    acetylacetone 384.57
    n-hexadecane 24.97
    acetophenone 250.5
    methyl propionate 283.88
    isopentyl acetate 363.34
    trichloroethylene 1329.98
    n-nonanol 172.84
    cyclohexanol 351.45
    benzyl alcohol 246.24
    2-ethylhexanol 211.73
    isooctanol 149.31
    dipropyl ether 266.08
    1,2-dichlorobenzene 391.42
    ethyl lactate 126.34
    propylene carbonate 465.2
    n-methylformamide 411.96
    2-pentanol 286.98
    n-pentane 90.56
    1-propoxy-2-propanol 364.65
    1-methoxy-2-propyl acetate 316.92
    2-(2-methoxypropoxy) propanol 286.12
    mesitylene 101.06
    ε-caprolactone 587.35
    p-cymene 102.26
    epichlorohydrin 833.07
    1,1,1-trichloroethane 739.67
    2-aminoethanol 276.85
    morpholine-4-carbaldehyde 606.9
    sulfolane 716.16
    2,2,4-trimethylpentane 41.64
    2-methyltetrahydrofuran 713.73
    n-hexyl acetate 405.49
    isooctane 34.92
    2-(2-butoxyethoxy)ethanol 446.74
    sec-butyl acetate 205.19
    tert-butyl acetate 260.55
    decalin 56.73
    glycerin 208.04
    diglyme 719.06
    acrylic acid 447.96
    isopropyl myristate 135.92
    n-butyric acid 646.69
    acetyl acetate 319.11
    di(2-ethylhexyl) phthalate 124.36
    ethyl propionate 229.76
    nitromethane 901.63
    1,2-diethoxyethane 578.39
    benzonitrile 467.13
    trioctyl phosphate 89.17
    1-bromopropane 464.52
    gamma-valerolactone 839.06
    n-decanol 116.89
    triethyl phosphate 111.3
    4-methyl-2-pentanol 161.53
    propionitrile 509.45
    vinylene carbonate 468.02
    1,1,2-trichlorotrifluoroethane 550.41
    DMS 273.76
    cumene 104.74
    2-octanol 136.26
    2-hexanone 333.2
    octyl acetate 175.82
    limonene 145.11
    1,2-dimethoxyethane 549.06
    ethyl orthosilicate 113.95
    tributyl phosphate 128.15
    diacetone alcohol 284.8
    N,N-dimethylaniline 166.08
    acrylonitrile 618.76
    aniline 327.46
    1,3-propanediol 359.82
    bromobenzene 468.3
    dibromomethane 1008.27
    1,1,2,2-tetrachloroethane 947.68
    2-methyl-cyclohexyl acetate 197.17
    tetrabutyl urea 134.49
    diisobutyl methanol 124.48
    2-phenylethanol 272.87
    styrene 190.32
    dioctyl adipate 182.08
    dimethyl sulfate 160.84
    ethyl butyrate 280.12
    methyl lactate 141.88
    butyl lactate 213.14
    diethyl carbonate 171.12
    propanediol butyl ether 295.75
    triethyl orthoformate 184.11
    p-tert-butyltoluene 93.77
    methyl 4-tert-butylbenzoate 207.9
    morpholine 824.7
    tert-butylamine 337.96
    n-dodecanol 84.39
    dimethoxymethane 300.38
    ethylene carbonate 379.39
    cyrene 193.33
    2-ethoxyethyl acetate 397.81
    2-ethylhexyl acetate 280.88
    1,2,4-trichlorobenzene 434.68
    4-methylpyridine 613.89
    dibutyl ether 282.53
    2,6-dimethyl-4-heptanol 124.48
    DEF 357.65
    dimethyl isosorbide 411.63
    tetrachloroethylene 725.67
    eugenol 219.81
    triacetin 319.41
    span 80 265.91
    1,4-butanediol 156.95
    1,1-dichloroethane 813.29
    2-methyl-1-pentanol 275.65
    methyl formate 277.49
    2-methyl-1-butanol 319.57
    n-decane 40.37
    butyronitrile 510.17
    3,7-dimethyl-1-octanol 196.27
    1-chlorooctane 148.52
    1-chlorotetradecane 54.97
    n-nonane 41.0
    undecane 28.17
    tert-butylcyclohexane 58.65
    cyclooctane 37.26
    cyclopentanol 415.99
    tetrahydropyran 691.55
    tert-amyl methyl ether 244.03
    2,5,8-trioxanonane 445.83
    1-hexene 297.12
    2-isopropoxyethanol 272.59
    2,2,2-trifluoroethanol 232.38
    methyl butyrate 316.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction