1-Chloro-2-propanol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    127-00-4

    Molecular formula
    C3H7ClO

    SMILES
    CC(CCl)O

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 37.9%
    Alcoholic 36.7%
    Oily 35.85%
    Odorless 33.1%
    Fishy 32.74%
    Sweet 31.67%
    Buttery 30.78%
    Cheesy 28.32%
    Fermented 26.76%
    Nutty 24.89%

     

    Flavor
    Odorless 40.74%
    Sulfurous 33.26%
    Fishy 32.24%
    Onion 29.61%
    Mild 23.36%
    Very slight 21.75%
    Meaty 21.46%
    Sulfury 20.79%
    Sweet-like 20.11%
    Meat broth 20.05%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    7.21 (neutral)

    Molecular weight
    94.54 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point

    • 259 to 261 °F at 760 mmHg (NTP, 1992)
    • 126-127 °C

    Flash point

    • 55.1 ˚C est.
    • 125 °F (NTP, 1992)
    • 125 °F

    Solubility expt.

    • greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)
    • SOL IN WATER, ALC
    • SOL IN ETHANOL, ETHER, CARBON TETRACHLORIDE

  • Synonyms

    • 1-Chloro-2-propanol
    • 1-Chloropropan-2-ol
    • 127-00-4
    • 2-PROPANOL, 1-CHLORO-
    • Chloroisopropyl alcohol
    • Propene chlorohydrin
    • 1-Chloroisopropyl alcohol
    • sec-Propylene chlorohydrin
    • 1-Chloro-2-hydroxypropane
    • .alpha.-Propylene chlorohydrin
    • 3-chloro-2-propanol
    • CCRIS 4766
    • chloroisopropanol
    • HSDB 1341
    • UNII-ZL0FUS96WW
    • EINECS 204-819-6
    • NSC 77373
    • BRN 0773653
    • 3-chloropropan-2-ol
    • CHEBI:76260
    • PROPYLCHLOROHYDRIN
    • EINECS 268-361-9
    • NSC-77373
    • ZL0FUS96WW
    • 1-Chloro-2-propanol, technical grade (~75% 1-chloro-2-propanol; ~25% 2-chloro-1-propanol)
    • DTXSID5020285
    • (S)-1-chloropropan-2-ol
    • 1-CHLORO-2-PROPANOL, (+/-)-
    • 1-Chloro-2-propanol (70%, Technical Grade)
    • alpha-Propylene chlorohydrin
    • 1-Cloro-2-propanol, technical
    • MFCD01862132
    • 1Chloro2propanol
    • (+/-)-1-Chloro-2-propanol; 1-Chloro-2-hydroxypropane; 1-Chloroisopropyl alcohol; NSC 77373; sec-Propylene chlorohydrin; a-Propylene chlorohydrin
    • 1-chloro2-propanol
    • EINECS 269-076-2
    • EINECS 269-078-3
    • 1Chloro2hydroxypropane
    • 1 -chloro-2-propanol
    • 1-Chloro-propan-2-ol
    • 1Chloroisopropyl alcohol
    • secPropylene chlorohydrin
    • DSSTox_CID_285
    • DSSTox_RID_76444
    • DSSTox_GSID_21988
    • DTXCID30285
    • 1-Chloro-2-propanol, 70%
    • 2-PROPANOL,1-CHLORO-
    • CHEMBL1361129
    • NSC77373
    • Tox21_200998
    • BBL011446
    • MFCD00004530
    • STL146557
    • (+-)-1-CHLORO-2-PROPANOL
    • Chloropropanol, Propylene chlorohydrin
    • AKOS005720868
    • SB44665
    • SB83796
    • SEC-PROPYLENE CHLOROHYDRIN [MI]
    • (.+-.)-1-CHLORO-2-PROPANOL
    • NCGC00091542-01
    • NCGC00091542-02
    • NCGC00091542-03
    • NCGC00258551-01
    • SEC-PROPYLENE CHLOROHYDRIN [HSDB]
    • SY110717
    • DB-062559
    • C3533
    • NS00024044
    • EN300-39011
    • H11611
    • Q161602

  • Applications

    1-Chloro-2-propanol is primarily used as a reactive intermediate in organic synthesis. It is used to make glycidyl ethers and other epoxide precursors for epoxy resins that are widely employed in coatings, adhesives, and electronics; it also serves as a building block for chlorohydrin-derived intermediates in the production of specialty polymers and plasticizers. In pharmaceutical and agrochemical manufacturing, it can function as an intermediate in multi-step synthetic routes. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 723.14
    methanol 1084.59
    isopropanol 513.59
    water 311.03
    ethyl acetate 77.82
    n-propanol 459.8
    acetone 375.03
    n-butanol 356.9
    acetonitrile 205.48
    DMF 705.38
    toluene 18.1
    isobutanol 284.93
    1,4-dioxane 283.94
    methyl acetate 122.47
    THF 355.69
    2-butanone 180.2
    n-pentanol 219.35
    sec-butanol 329.65
    n-hexane 19.87
    ethylene glycol 516.11
    NMP 454.86
    cyclohexane 27.47
    DMSO 593.36
    n-butyl acetate 99.63
    n-octanol 108.44
    chloroform 133.08
    n-propyl acetate 80.78
    acetic acid 823.65
    dichloromethane 102.92
    cyclohexanone 227.49
    propylene glycol 473.53
    isopropyl acetate 49.23
    DMAc 478.82
    2-ethoxyethanol 360.66
    isopentanol 223.99
    n-heptane 28.94
    ethyl formate 106.1
    1,2-dichloroethane 71.16
    n-hexanol 216.84
    2-methoxyethanol 601.02
    isobutyl acetate 56.69
    tetrachloromethane 38.15
    n-pentyl acetate 70.22
    transcutol 609.34
    n-heptanol 108.56
    ethylbenzene 15.16
    MIBK 65.42
    2-propoxyethanol 324.66
    tert-butanol 463.4
    MTBE 130.39
    2-butoxyethanol 198.15
    propionic acid 322.45
    o-xylene 25.08
    formic acid 610.78
    diethyl ether 100.18
    m-xylene 20.76
    p-xylene 25.3
    chlorobenzene 32.23
    dimethyl carbonate 39.94
    n-octane 9.53
    formamide 466.3
    cyclopentanone 267.78
    2-pentanone 118.81
    anisole 59.87
    cyclopentyl methyl ether 126.36
    gamma-butyrolactone 230.57
    1-methoxy-2-propanol 356.16
    pyridine 124.48
    3-pentanone 86.53
    furfural 227.44
    n-dodecane 7.53
    diethylene glycol 411.96
    diisopropyl ether 30.25
    tert-amyl alcohol 306.06
    acetylacetone 112.13
    n-hexadecane 7.85
    acetophenone 74.37
    methyl propionate 83.88
    isopentyl acetate 81.87
    trichloroethylene 131.48
    n-nonanol 88.37
    cyclohexanol 241.17
    benzyl alcohol 96.27
    2-ethylhexanol 104.51
    isooctanol 79.4
    dipropyl ether 92.97
    1,2-dichlorobenzene 35.58
    ethyl lactate 81.51
    propylene carbonate 108.71
    n-methylformamide 361.43
    2-pentanol 199.02
    n-pentane 23.79
    1-propoxy-2-propanol 246.61
    1-methoxy-2-propyl acetate 93.49
    2-(2-methoxypropoxy) propanol 199.0
    mesitylene 17.55
    ε-caprolactone 163.83
    p-cymene 27.24
    epichlorohydrin 175.25
    1,1,1-trichloroethane 61.92
    2-aminoethanol 644.92
    morpholine-4-carbaldehyde 406.38
    sulfolane 322.8
    2,2,4-trimethylpentane 13.58
    2-methyltetrahydrofuran 214.61
    n-hexyl acetate 96.09
    isooctane 9.23
    2-(2-butoxyethoxy)ethanol 253.31
    sec-butyl acetate 46.81
    tert-butyl acetate 64.79
    decalin 11.2
    glycerin 580.6
    diglyme 368.4
    acrylic acid 321.9
    isopropyl myristate 41.17
    n-butyric acid 264.63
    acetyl acetate 53.62
    di(2-ethylhexyl) phthalate 61.65
    ethyl propionate 56.94
    nitromethane 448.37
    1,2-diethoxyethane 127.55
    benzonitrile 72.13
    trioctyl phosphate 46.31
    1-bromopropane 46.23
    gamma-valerolactone 313.01
    n-decanol 64.26
    triethyl phosphate 46.42
    4-methyl-2-pentanol 87.2
    propionitrile 134.56
    vinylene carbonate 98.25
    1,1,2-trichlorotrifluoroethane 289.58
    DMS 63.13
    cumene 17.68
    2-octanol 69.28
    2-hexanone 102.76
    octyl acetate 59.36
    limonene 51.76
    1,2-dimethoxyethane 342.21
    ethyl orthosilicate 47.72
    tributyl phosphate 53.38
    diacetone alcohol 157.31
    N,N-dimethylaniline 62.51
    acrylonitrile 166.53
    aniline 83.58
    1,3-propanediol 538.52
    bromobenzene 20.67
    dibromomethane 65.95
    1,1,2,2-tetrachloroethane 127.58
    2-methyl-cyclohexyl acetate 74.0
    tetrabutyl urea 82.28
    diisobutyl methanol 55.0
    2-phenylethanol 93.88
    styrene 19.41
    dioctyl adipate 78.05
    dimethyl sulfate 76.76
    ethyl butyrate 75.03
    methyl lactate 112.25
    butyl lactate 93.51
    diethyl carbonate 46.8
    propanediol butyl ether 234.89
    triethyl orthoformate 66.05
    p-tert-butyltoluene 29.56
    methyl 4-tert-butylbenzoate 101.34
    morpholine 385.7
    tert-butylamine 248.07
    n-dodecanol 50.0
    dimethoxymethane 187.16
    ethylene carbonate 80.91
    cyrene 161.7
    2-ethoxyethyl acetate 83.79
    2-ethylhexyl acetate 65.41
    1,2,4-trichlorobenzene 50.77
    4-methylpyridine 103.37
    dibutyl ether 65.1
    2,6-dimethyl-4-heptanol 55.0
    DEF 179.66
    dimethyl isosorbide 203.72
    tetrachloroethylene 107.71
    eugenol 121.84
    triacetin 112.33
    span 80 186.62
    1,4-butanediol 274.45
    1,1-dichloroethane 68.72
    2-methyl-1-pentanol 153.18
    methyl formate 203.1
    2-methyl-1-butanol 228.58
    n-decane 12.07
    butyronitrile 122.04
    3,7-dimethyl-1-octanol 88.1
    1-chlorooctane 34.6
    1-chlorotetradecane 15.95
    n-nonane 12.25
    undecane 8.92
    tert-butylcyclohexane 12.95
    cyclooctane 8.84
    cyclopentanol 314.72
    tetrahydropyran 217.13
    tert-amyl methyl ether 101.14
    2,5,8-trioxanonane 303.08
    1-hexene 50.18
    2-isopropoxyethanol 224.19
    2,2,2-trifluoroethanol 269.8
    methyl butyrate 88.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction