1-Chloro-1,1,2,2-tetrafluoroethane

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  • Identifiers

    CAS number
    354-25-6

    Molecular formula
    C2HClF4

    SMILES
    C(C(F)(F)Cl)(F)F

  • Odor profile

    Fragrance
    Odorless 59.43%
    Fishy 30.64%
    Sweet 22.44%
    Cooling 21.4%
    Woody 17.76%
    Savory 17.09%
    Animal 16.55%
    Ripe 16.01%
    Balsamic 15.37%
    Oily 15.12%

     

    Flavor
    Odorless 34.33%
    Sulfurous 24.98%
    Sulfury 20.73%
    Mild 19.77%
    Bland 19.63%
    Meaty 18.96%
    Bloody 18.53%
    Glue 18.46%
    Bouillon 18.08%
    Skunky 17.9%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.4

    pKa est.
    3.51 (weak acid)

    Molecular weight
    136.47 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -117 °C

    Boiling point

    • -11.7 °C

    Flash point

    • -4.26 ˚C est.

  • Synonyms

    • 1-Chloro-1,1,2,2-tetrafluoroethane
    • 354-25-6
    • HCFC-124A
    • Ethane, 1-chloro-1,1,2,2-tetrafluoro-
    • F 124a
    • R 124a
    • 1,1,2,2-Tetrafluoro-1-chloroethane
    • HSDB 6872
    • EINECS 206-552-0
    • BRN 1736683
    • monochlorotetrafluoroethane
    • HCFC-124A [HSDB]
    • 4X1142270I
    • DTXSID1042023
    • 1,1,2,2-Tetrafluorochloroethane
    • HCFC 124a
    • UNII-4X1142270I
    • CHF2CClF2
    • SCHEMBL246615
    • DTXCID9022023
    • 1Chloro1,1,2,2tetrafluoroethane
    • Ethane, 1chloro1,1,2,2tetrafluoro
    • MFCD00069099
    • AKOS006227826
    • 1-chloro-1,1,2,2-tetrafluoro-ethane
    • DB-048805
    • NS00041653
    • 1-chloranyl-1,1,2,2-tetrakis(fluoranyl)ethane
    • A822791
    • 206-552-0

  • Applications

    1-Chloro-1,1,2,2-tetrafluoroethane (CAS 354-25-6) is a fluorinated compound used mainly as an intermediate in the synthesis of fluorinated polymers and specialty materials; it may also function as a process solvent or cleaning agent in electronics manufacturing and other precision production settings. In coatings and inks formulations, it can act as a fluorinated solvent or processing aid; it may be used as a blowing agent for polyurethane foam production; and it is sometimes evaluated as a refrigerant or heat-transfer fluid in niche systems, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 267.87
    methanol 570.06
    isopropanol 161.14
    water 256.89
    ethyl acetate 99.46
    n-propanol 150.83
    acetone 418.79
    n-butanol 115.22
    acetonitrile 290.61
    DMF 1184.97
    toluene 34.42
    isobutanol 97.35
    1,4-dioxane 204.65
    methyl acetate 158.46
    THF 280.26
    2-butanone 185.64
    n-pentanol 89.52
    sec-butanol 118.44
    n-hexane 14.7
    ethylene glycol 213.25
    NMP 674.22
    cyclohexane 32.41
    DMSO 1966.4
    n-butyl acetate 51.17
    n-octanol 49.27
    chloroform 69.88
    n-propyl acetate 78.35
    acetic acid 226.33
    dichloromethane 140.09
    cyclohexanone 150.15
    propylene glycol 101.11
    isopropyl acetate 61.76
    DMAc 828.95
    2-ethoxyethanol 295.04
    isopentanol 84.9
    n-heptane 27.32
    ethyl formate 120.97
    1,2-dichloroethane 134.95
    n-hexanol 54.95
    2-methoxyethanol 475.97
    isobutyl acetate 33.94
    tetrachloromethane 16.23
    n-pentyl acetate 39.99
    transcutol 375.43
    n-heptanol 37.54
    ethylbenzene 23.04
    MIBK 71.84
    2-propoxyethanol 150.44
    tert-butanol 158.65
    MTBE 111.1
    2-butoxyethanol 89.48
    propionic acid 103.49
    o-xylene 46.34
    formic acid 374.82
    diethyl ether 145.22
    m-xylene 29.65
    p-xylene 28.44
    chlorobenzene 22.9
    dimethyl carbonate 105.29
    n-octane 10.78
    formamide 665.38
    cyclopentanone 194.27
    2-pentanone 131.99
    anisole 77.72
    cyclopentyl methyl ether 118.55
    gamma-butyrolactone 200.42
    1-methoxy-2-propanol 254.03
    pyridine 156.79
    3-pentanone 123.36
    furfural 227.35
    n-dodecane 7.69
    diethylene glycol 188.41
    diisopropyl ether 40.67
    tert-amyl alcohol 124.41
    acetylacetone 163.97
    n-hexadecane 8.01
    acetophenone 98.02
    methyl propionate 125.24
    isopentyl acetate 36.23
    trichloroethylene 123.82
    n-nonanol 45.58
    cyclohexanol 95.05
    benzyl alcohol 85.04
    2-ethylhexanol 36.47
    isooctanol 29.25
    dipropyl ether 79.29
    1,2-dichlorobenzene 25.37
    ethyl lactate 72.7
    propylene carbonate 73.93
    n-methylformamide 529.97
    2-pentanol 82.98
    n-pentane 29.37
    1-propoxy-2-propanol 103.29
    1-methoxy-2-propyl acetate 74.12
    2-(2-methoxypropoxy) propanol 126.27
    mesitylene 24.89
    ε-caprolactone 117.15
    p-cymene 27.38
    epichlorohydrin 192.54
    1,1,1-trichloroethane 42.31
    2-aminoethanol 205.52
    morpholine-4-carbaldehyde 519.84
    sulfolane 375.19
    2,2,4-trimethylpentane 11.49
    2-methyltetrahydrofuran 153.96
    n-hexyl acetate 50.45
    isooctane 7.06
    2-(2-butoxyethoxy)ethanol 138.86
    sec-butyl acetate 41.69
    tert-butyl acetate 59.82
    decalin 9.85
    glycerin 170.9
    diglyme 295.85
    acrylic acid 129.41
    isopropyl myristate 29.66
    n-butyric acid 86.87
    acetyl acetate 64.6
    di(2-ethylhexyl) phthalate 30.06
    ethyl propionate 71.02
    nitromethane 583.02
    1,2-diethoxyethane 110.17
    benzonitrile 65.53
    trioctyl phosphate 24.84
    1-bromopropane 71.01
    gamma-valerolactone 267.68
    n-decanol 36.3
    triethyl phosphate 38.7
    4-methyl-2-pentanol 43.35
    propionitrile 136.92
    vinylene carbonate 75.03
    1,1,2-trichlorotrifluoroethane 166.24
    DMS 57.53
    cumene 20.38
    2-octanol 29.2
    2-hexanone 88.07
    octyl acetate 38.53
    limonene 43.39
    1,2-dimethoxyethane 420.23
    ethyl orthosilicate 35.27
    tributyl phosphate 28.75
    diacetone alcohol 110.53
    N,N-dimethylaniline 106.58
    acrylonitrile 189.82
    aniline 70.6
    1,3-propanediol 190.5
    bromobenzene 17.78
    dibromomethane 92.97
    1,1,2,2-tetrachloroethane 103.74
    2-methyl-cyclohexyl acetate 41.79
    tetrabutyl urea 69.11
    diisobutyl methanol 29.98
    2-phenylethanol 50.98
    styrene 27.64
    dioctyl adipate 49.26
    dimethyl sulfate 204.11
    ethyl butyrate 60.96
    methyl lactate 116.97
    butyl lactate 45.53
    diethyl carbonate 42.93
    propanediol butyl ether 85.54
    triethyl orthoformate 51.09
    p-tert-butyltoluene 25.35
    methyl 4-tert-butylbenzoate 80.12
    morpholine 282.68
    tert-butylamine 103.62
    n-dodecanol 29.33
    dimethoxymethane 391.48
    ethylene carbonate 63.06
    cyrene 136.52
    2-ethoxyethyl acetate 59.31
    2-ethylhexyl acetate 29.32
    1,2,4-trichlorobenzene 32.43
    4-methylpyridine 134.67
    dibutyl ether 50.19
    2,6-dimethyl-4-heptanol 29.98
    DEF 286.53
    dimethyl isosorbide 155.35
    tetrachloroethylene 78.71
    eugenol 84.04
    triacetin 77.06
    span 80 72.33
    1,4-butanediol 111.98
    1,1-dichloroethane 67.84
    2-methyl-1-pentanol 61.2
    methyl formate 346.43
    2-methyl-1-butanol 85.74
    n-decane 11.9
    butyronitrile 105.16
    3,7-dimethyl-1-octanol 40.97
    1-chlorooctane 24.78
    1-chlorotetradecane 12.85
    n-nonane 12.27
    undecane 9.16
    tert-butylcyclohexane 7.51
    cyclooctane 14.4
    cyclopentanol 107.81
    tetrahydropyran 133.96
    tert-amyl methyl ether 100.39
    2,5,8-trioxanonane 236.41
    1-hexene 32.54
    2-isopropoxyethanol 152.04
    2,2,2-trifluoroethanol 144.94
    methyl butyrate 100.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction