1-Bromo-2-Chloroethane

Overview IFRA Request a quote

  • Identifiers

    CAS number
    107-04-0

    Molecular formula
    C2H4BrCl

    SMILES
    C(CBr)Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fishy 67.02%
    Cheesy 57.36%
    Ripe 42.39%
    Oily 27.59%
    Fresh 25.22%
    Musty 23.83%
    Meaty 23.49%
    Odorless 23.37%
    Fatty 22.68%
    Sweet 21.42%

     

    Flavor
    Fishy 39.92%
    Meaty 37.19%
    Sulfurous 36.42%
    Ammoniacal 34.74%
    Sulfury 30.05%
    Onion 26.92%
    Roasted 21.99%
    Ammonia 20.7%
    Garlic 20.42%
    Bloody 20.01%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.93 (weak acid)

    Molecular weight
    143.41 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 2.1 °F (NTP, 1992)
    • -16.7 °C

    Boiling point

    • 225 °F at 760 mmHg (NTP, 1992)
    • 107 °C

    Flash point

    • 25.48 ˚C est.
    • none

    Solubility expt.

    • 5 to 10 mg/mL at 70 °F (NTP, 1992)
    • Soluble in ethanol, ethyl ether, chloroform.
    • 0.69 g/100 g water @ 30 °C; 0.7 g/100 g water @ 80 °C
    • In water, 6,900 mg/l @ 25 °C

  • Synonyms

    • 1-BROMO-2-CHLOROETHANE
    • 107-04-0
    • Ethylene chlorobromide
    • 2-Chloroethyl bromide
    • 1-Chloro-2-bromoethane
    • Ethane, 1-bromo-2-chloro-
    • 2-Bromo-1-chloroethane
    • 2-Bromoethyl chloride
    • s-Chlorobromoethane
    • 1,2-Bromochloroethane
    • 1,2-Chlorobromoethane
    • beta-Chloroethyl bromide
    • sym-Chlorobromoethane
    • Caswell No. 436B
    • Ethylene bromochloride
    • CCRIS 816
    • NSC 60186
    • HSDB 6121
    • UNII-B2PDN2XO5U
    • B2PDN2XO5U
    • .beta.-Chloroethyl bromide
    • EINECS 203-456-0
    • EPA Pesticide Chemical Code 042001
    • BRN 0605265
    • CH2BrCH2Cl
    • DTXSID4024775
    • CHEBI:19032
    • AI3-52297
    • NSC-60186
    • SYN-CHLOROBROMOETHANE
    • DTXCID904775
    • 4-01-00-00155 (Beilstein Handbook Reference)
    • 1-BROMO-2-CHLOROETHANE [HSDB]
    • C2H4BrCl
    • CAS-107-04-0
    • sChlorobromoethane
    • symChlorobromoethane
    • 2-bromochloroethane
    • 2-chlorobromoethane
    • 1Chloro2bromoethane
    • 2Bromo1chloroethane
    • 2-chloroethylbromide
    • 2Bromoethyl chloride
    • 2Chloroethyl bromide
    • bromo 2 chloroethane
    • bromo-2-chloroethane
    • MFCD00000962
    • betaChloroethyl bromide
    • BrCH2CH2Cl
    • Ethane, 1bromo2chloro
    • 2-bromo-l-chloroethane
    • 1-bromo 2-chloroethane
    • 2-chloro-1-bromoethane
    • 1-bromo 2-chloro ethane
    • 1-bromo-2-chloro ethane
    • 1-bromo-2-chloro-ethane
    • 1-chloro-2-bromo-ethane
    • 2-bromo-1-chloro-ethane
    • WLN: G2E
    • Pesticide Code: 042001
    • SCHEMBL117238
    • CHEMBL160255
    • 1-Bromo-2-chloroethane, 98%
    • NSC60186
    • Tox21_201726
    • Tox21_303193
    • BBL011345
    • BR1051
    • STL146435
    • AKOS005720772
    • FB33230
    • FS-4503
    • NCGC00091170-01
    • NCGC00091170-02
    • NCGC00257128-01
    • NCGC00259275-01
    • B0572
    • NS00021486
    • EN300-31848
    • D95298
    • 1-Bromo-2-Chloroethane 1000 microg/mL in Methanol
    • Q27109104
    • F0001-0135
    • 203-456-0

  • Applications

    1-Bromo-2-Chloroethane (CAS 107-04-0) is primarily used as a reactive organic intermediate in industrial manufacturing. It serves as a building block for downstream halogenated ethyl motifs, enabling installation of both bromine and chlorine functionalities in target molecules. In pharmaceuticals and agrochemicals, it is commonly evaluated as a precursor for synthesis routes to complex intermediates bearing 2-haloethyl groups. In polymers and plastics, it is used to prepare halogenated monomers or crosslinking agents that modify polymer properties. In coatings, inks, and adhesives, it acts as a reactive precursor for halogenated crosslinkers and specialty additives. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 60.47
    methanol 56.86
    isopropanol 54.72
    water 2.54
    ethyl acetate 120.6
    n-propanol 59.17
    acetone 261.77
    n-butanol 65.38
    acetonitrile 144.27
    DMF 255.33
    toluene 157.49
    isobutanol 53.18
    1,4-dioxane 287.33
    methyl acetate 136.4
    THF 340.18
    2-butanone 173.37
    n-pentanol 66.45
    sec-butanol 60.03
    n-hexane 32.16
    ethylene glycol 29.96
    NMP 369.27
    cyclohexane 100.73
    DMSO 358.46
    n-butyl acetate 182.64
    n-octanol 74.37
    chloroform 382.74
    n-propyl acetate 125.16
    acetic acid 163.63
    dichloromethane 353.3
    cyclohexanone 331.17
    propylene glycol 25.78
    isopropyl acetate 93.33
    DMAc 247.17
    2-ethoxyethanol 115.93
    isopentanol 65.71
    n-heptane 80.95
    ethyl formate 93.18
    1,2-dichloroethane 239.78
    n-hexanol 88.26
    2-methoxyethanol 126.09
    isobutyl acetate 95.91
    tetrachloromethane 118.06
    n-pentyl acetate 121.32
    transcutol 416.75
    n-heptanol 61.67
    ethylbenzene 86.46
    MIBK 104.97
    2-propoxyethanol 140.13
    tert-butanol 77.52
    MTBE 98.69
    2-butoxyethanol 101.24
    propionic acid 75.65
    o-xylene 127.73
    formic acid 49.14
    diethyl ether 123.94
    m-xylene 110.73
    p-xylene 125.05
    chlorobenzene 201.84
    dimethyl carbonate 62.04
    n-octane 31.85
    formamide 77.54
    cyclopentanone 327.77
    2-pentanone 152.21
    anisole 154.0
    cyclopentyl methyl ether 198.8
    gamma-butyrolactone 259.46
    1-methoxy-2-propanol 95.07
    pyridine 310.37
    3-pentanone 145.73
    furfural 323.11
    n-dodecane 24.04
    diethylene glycol 114.14
    diisopropyl ether 67.21
    tert-amyl alcohol 71.6
    acetylacetone 196.17
    n-hexadecane 27.76
    acetophenone 183.98
    methyl propionate 99.19
    isopentyl acetate 151.24
    trichloroethylene 450.07
    n-nonanol 69.8
    cyclohexanol 124.31
    benzyl alcohol 114.29
    2-ethylhexanol 96.31
    isooctanol 60.09
    dipropyl ether 166.61
    1,2-dichlorobenzene 191.0
    ethyl lactate 62.31
    propylene carbonate 147.18
    n-methylformamide 100.93
    2-pentanol 59.57
    n-pentane 36.53
    1-propoxy-2-propanol 137.65
    1-methoxy-2-propyl acetate 149.33
    2-(2-methoxypropoxy) propanol 135.83
    mesitylene 82.65
    ε-caprolactone 227.04
    p-cymene 107.22
    epichlorohydrin 271.85
    1,1,1-trichloroethane 256.46
    2-aminoethanol 38.29
    morpholine-4-carbaldehyde 335.74
    sulfolane 342.19
    2,2,4-trimethylpentane 26.39
    2-methyltetrahydrofuran 258.29
    n-hexyl acetate 132.71
    isooctane 18.92
    2-(2-butoxyethoxy)ethanol 163.26
    sec-butyl acetate 94.45
    tert-butyl acetate 111.34
    decalin 45.48
    glycerin 47.05
    diglyme 319.53
    acrylic acid 89.85
    isopropyl myristate 77.31
    n-butyric acid 98.75
    acetyl acetate 105.48
    di(2-ethylhexyl) phthalate 74.4
    ethyl propionate 101.15
    nitromethane 257.39
    1,2-diethoxyethane 220.85
    benzonitrile 185.9
    trioctyl phosphate 56.35
    1-bromopropane 139.06
    gamma-valerolactone 333.55
    n-decanol 58.46
    triethyl phosphate 89.52
    4-methyl-2-pentanol 46.06
    propionitrile 95.73
    vinylene carbonate 151.85
    1,1,2-trichlorotrifluoroethane 215.82
    DMS 115.28
    cumene 69.6
    2-octanol 55.55
    2-hexanone 146.91
    octyl acetate 88.68
    limonene 157.06
    1,2-dimethoxyethane 240.37
    ethyl orthosilicate 91.26
    tributyl phosphate 71.43
    diacetone alcohol 111.18
    N,N-dimethylaniline 139.12
    acrylonitrile 118.91
    aniline 132.35
    1,3-propanediol 56.42
    bromobenzene 221.39
    dibromomethane 261.2
    1,1,2,2-tetrachloroethane 342.43
    2-methyl-cyclohexyl acetate 131.65
    tetrabutyl urea 113.84
    diisobutyl methanol 79.86
    2-phenylethanol 122.79
    styrene 115.7
    dioctyl adipate 110.01
    dimethyl sulfate 114.84
    ethyl butyrate 154.73
    methyl lactate 57.55
    butyl lactate 87.46
    diethyl carbonate 101.8
    propanediol butyl ether 94.82
    triethyl orthoformate 127.66
    p-tert-butyltoluene 99.27
    methyl 4-tert-butylbenzoate 143.53
    morpholine 244.27
    tert-butylamine 58.41
    n-dodecanol 53.04
    dimethoxymethane 137.32
    ethylene carbonate 121.72
    cyrene 155.58
    2-ethoxyethyl acetate 149.33
    2-ethylhexyl acetate 147.81
    1,2,4-trichlorobenzene 239.67
    4-methylpyridine 259.45
    dibutyl ether 125.52
    2,6-dimethyl-4-heptanol 79.86
    DEF 186.65
    dimethyl isosorbide 252.07
    tetrachloroethylene 268.34
    eugenol 140.26
    triacetin 154.85
    span 80 132.78
    1,4-butanediol 39.09
    1,1-dichloroethane 198.35
    2-methyl-1-pentanol 66.27
    methyl formate 96.64
    2-methyl-1-butanol 60.54
    n-decane 35.73
    butyronitrile 110.75
    3,7-dimethyl-1-octanol 81.6
    1-chlorooctane 84.4
    1-chlorotetradecane 46.47
    n-nonane 37.05
    undecane 28.29
    tert-butylcyclohexane 36.54
    cyclooctane 48.15
    cyclopentanol 121.03
    tetrahydropyran 263.14
    tert-amyl methyl ether 99.08
    2,5,8-trioxanonane 251.2
    1-hexene 66.47
    2-isopropoxyethanol 103.87
    2,2,2-trifluoroethanol 81.66
    methyl butyrate 132.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction