1-Benzyloxy-1-(2-methoxyethoxy)ethane

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  • Identifiers

    CAS number
    7492-39-9

    Molecular formula
    C12H18O3

    SMILES
    CC(OCCOC)OCC1=CC=CC=C1

  • Odor profile

    Fragrance
    Fruity 83.85%
    Green 77.33%
    Sweet 74.88%
    Almond 55.53%
    Bitter 44.14%
    Earthy 36.76%
    Fresh 33.99%
    Cherry 32.77%
    Hyacinth 31.9%
    Floral 31.13%

     

    Flavor
    Green 65.7%
    Fruity 61.01%
    Floral 59.41%
    Earthy 47.55%
    Bitter 36.08%
    Rose 33.56%
    Mushroom 33.19%
    Sweet 31.28%
    Wine 31.16%
    Vegetable 30.95%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    5.64 (weak acid)

    Molecular weight
    210.27 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    265°C

    Flash point

    • 104.69 ˚C est.

    Solubility expt.

    • insoluble in water; soluble in organic solvents, oils
    • miscible at room temperature (in ethanol)

  • Synonyms

    • Benzyl methoxyethyl acetal
    • 7492-39-9
    • Benzyl 2-methoxyethyl acetal
    • Acetaldehyde benzyl 2-methoxyethyl acetal
    • FEMA No. 2148
    • UNII-94BT9GZ4KT
    • 94BT9GZ4KT
    • 1-Benzoxy-1-(2-methoxyethoxy)ethane
    • 1-Benzyloxy-1-(2-methoxyethoxy)ethane
    • 1-Benzyloxy-1-(beta-methoxy)ethoxyethane
    • Acetaldehyde, benzyl 2-methoxyethyl acetal
    • {[1-(2-METHOXYETHOXY)ETHOXY]METHYL}BENZENE
    • Acetaldehyde benzyl beta-methoxyethyl acetal
    • ((1-(2-Methoxyethoxy)ethoxy)methyl)benzene
    • DTXSID50996404
    • Benzene, ((1-(2-methoxyethoxy)ethoxy)methyl)-
    • BENZYL 2-METHOXYETHYL ACETAL [FHFI]
    • ACETALDEHYDE BENZYL .BETA.-METHOXYETHYL ACETAL
    • [[1-(2-Methoxyethoxy)ethoxy]methyl]benzene
    • SCHEMBL3275844
    • FEMA 2148
    • CNGTXGHYZBQUQS-UHFFFAOYSA-N
    • DTXCID301423422
    • Acetaldehyde benzyl b-methoxyethyl acetal
    • Q27271668

  • Applications

    1-Benzyloxy-1-(2-methoxyethoxy)ethane (CAS 7492-39-9) is primarily used as a protecting group for alcohols in organic synthesis, notably for diols and carbohydrate derivatives, because the benzyl and 2-methoxyethoxy substituents can be selectively removed later. It often serves as a building block to prepare protected sugar derivatives and glycosides, enabling selective transformations at other functional groups. The compound can function as an intermediate in pharmaceutical and fine chemical syntheses, providing a masked hydroxyl functionality during multi-step sequences. Additionally, due to its ether linkages, it can be used as a specialty solvent or co-solvent in certain organic reactions and polymer-related processes, offering a compatible medium for reactive substrates. It is typically handled as a reagent or intermediate in synthetic workflows, with use governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 768.22
    methanol 866.92
    isopropanol 395.64
    water 6.46
    ethyl acetate 753.51
    n-propanol 509.84
    acetone 245.6
    n-butanol 415.66
    acetonitrile 623.27
    DMF 171.28
    toluene 199.55
    isobutanol 279.31
    1,4-dioxane 1299.98
    methyl acetate 449.21
    THF 611.42
    2-butanone 272.7
    n-pentanol 282.18
    sec-butanol 356.93
    n-hexane 28.42
    ethylene glycol 222.3
    NMP 117.83
    cyclohexane 132.65
    DMSO 678.18
    n-butyl acetate 210.97
    n-octanol 72.86
    chloroform 2219.2
    n-propyl acetate 260.55
    acetic acid 924.57
    dichloromethane 2250.3
    cyclohexanone 365.65
    propylene glycol 253.67
    isopropyl acetate 234.44
    DMAc 280.52
    2-ethoxyethanol 705.03
    isopentanol 257.08
    n-heptane 32.65
    ethyl formate 327.92
    1,2-dichloroethane 1096.92
    n-hexanol 221.04
    2-methoxyethanol 843.72
    isobutyl acetate 145.77
    tetrachloromethane 217.63
    n-pentyl acetate 97.16
    transcutol 1159.82
    n-heptanol 75.3
    ethylbenzene 99.01
    MIBK 112.28
    2-propoxyethanol 387.46
    tert-butanol 435.88
    MTBE 282.21
    2-butoxyethanol 184.01
    propionic acid 416.21
    o-xylene 127.76
    formic acid 366.34
    diethyl ether 510.62
    m-xylene 105.95
    p-xylene 133.43
    chlorobenzene 273.81
    dimethyl carbonate 114.13
    n-octane 11.56
    formamide 393.81
    cyclopentanone 232.94
    2-pentanone 190.18
    anisole 238.14
    cyclopentyl methyl ether 274.18
    gamma-butyrolactone 379.95
    1-methoxy-2-propanol 433.53
    pyridine 687.3
    3-pentanone 193.27
    furfural 457.92
    n-dodecane 10.39
    diethylene glycol 396.55
    diisopropyl ether 83.75
    tert-amyl alcohol 312.83
    acetylacetone 270.55
    n-hexadecane 11.57
    acetophenone 198.28
    methyl propionate 317.87
    isopentyl acetate 171.18
    trichloroethylene 1612.22
    n-nonanol 71.47
    cyclohexanol 350.95
    benzyl alcohol 220.66
    2-ethylhexanol 119.45
    isooctanol 59.59
    dipropyl ether 192.39
    1,2-dichlorobenzene 259.75
    ethyl lactate 140.87
    propylene carbonate 274.38
    n-methylformamide 200.63
    2-pentanol 212.91
    n-pentane 36.2
    1-propoxy-2-propanol 228.25
    1-methoxy-2-propyl acetate 205.39
    2-(2-methoxypropoxy) propanol 186.91
    mesitylene 68.55
    ε-caprolactone 391.51
    p-cymene 62.44
    epichlorohydrin 750.97
    1,1,1-trichloroethane 745.31
    2-aminoethanol 371.29
    morpholine-4-carbaldehyde 389.71
    sulfolane 336.3
    2,2,4-trimethylpentane 20.17
    2-methyltetrahydrofuran 464.78
    n-hexyl acetate 127.63
    isooctane 11.31
    2-(2-butoxyethoxy)ethanol 268.74
    sec-butyl acetate 158.78
    tert-butyl acetate 187.87
    decalin 37.43
    glycerin 316.28
    diglyme 591.46
    acrylic acid 360.12
    isopropyl myristate 60.62
    n-butyric acid 527.82
    acetyl acetate 415.77
    di(2-ethylhexyl) phthalate 66.75
    ethyl propionate 233.27
    nitromethane 847.29
    1,2-diethoxyethane 360.59
    benzonitrile 234.02
    trioctyl phosphate 41.47
    1-bromopropane 516.26
    gamma-valerolactone 422.7
    n-decanol 52.95
    triethyl phosphate 116.7
    4-methyl-2-pentanol 87.78
    propionitrile 388.02
    vinylene carbonate 311.64
    1,1,2-trichlorotrifluoroethane 624.02
    DMS 150.96
    cumene 67.08
    2-octanol 43.28
    2-hexanone 167.1
    octyl acetate 72.07
    limonene 92.66
    1,2-dimethoxyethane 736.14
    ethyl orthosilicate 117.78
    tributyl phosphate 60.83
    diacetone alcohol 175.59
    N,N-dimethylaniline 136.62
    acrylonitrile 389.78
    aniline 288.82
    1,3-propanediol 479.22
    bromobenzene 295.71
    dibromomethane 1276.98
    1,1,2,2-tetrachloroethane 1336.44
    2-methyl-cyclohexyl acetate 147.33
    tetrabutyl urea 72.81
    diisobutyl methanol 67.18
    2-phenylethanol 161.72
    styrene 140.96
    dioctyl adipate 110.52
    dimethyl sulfate 154.22
    ethyl butyrate 211.63
    methyl lactate 140.43
    butyl lactate 91.28
    diethyl carbonate 176.04
    propanediol butyl ether 141.41
    triethyl orthoformate 164.67
    p-tert-butyltoluene 58.28
    methyl 4-tert-butylbenzoate 135.83
    morpholine 1301.21
    tert-butylamine 261.42
    n-dodecanol 44.01
    dimethoxymethane 301.7
    ethylene carbonate 284.18
    cyrene 162.36
    2-ethoxyethyl acetate 174.19
    2-ethylhexyl acetate 136.07
    1,2,4-trichlorobenzene 313.62
    4-methylpyridine 396.67
    dibutyl ether 130.96
    2,6-dimethyl-4-heptanol 67.18
    DEF 297.67
    dimethyl isosorbide 256.43
    tetrachloroethylene 882.7
    eugenol 144.97
    triacetin 196.93
    span 80 152.11
    1,4-butanediol 218.73
    1,1-dichloroethane 868.85
    2-methyl-1-pentanol 206.96
    methyl formate 165.44
    2-methyl-1-butanol 249.48
    n-decane 16.96
    butyronitrile 346.54
    3,7-dimethyl-1-octanol 75.01
    1-chlorooctane 62.26
    1-chlorotetradecane 27.14
    n-nonane 16.0
    undecane 12.46
    tert-butylcyclohexane 27.66
    cyclooctane 31.44
    cyclopentanol 245.29
    tetrahydropyran 954.42
    tert-amyl methyl ether 193.96
    2,5,8-trioxanonane 395.59
    1-hexene 113.71
    2-isopropoxyethanol 348.72
    2,2,2-trifluoroethanol 285.59
    methyl butyrate 295.52

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction