1-(Acetyloxy)-2-hydroxy-16-heptadecyn-4-one

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  • Identifiers

    CAS number
    24607-10-1

    Molecular formula
    C19H32O4

    SMILES
    CC(=O)OCC(CC(=O)CCCCCCCCCCCC#C)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 37.85%
    Fatty 36.14%
    Fresh 35.02%
    Sweet 30.39%
    Citrus 30.28%
    Odorless 27.53%
    Milky 27.33%
    Lactonic 26.94%
    Floral 25.25%
    Oily 24.98%

     

    Flavor
    Mild 32.92%
    Odorless 32.51%
    Bland 29.28%
    Fruity 28.24%
    Woody 27.49%
    Waxy 26.04%
    Oily 25.51%
    Fatty 24.26%
    Floral 22.32%
    Slightly waxy 21.29%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.4

    pKa est.
    7.46 (neutral)

    Molecular weight
    324.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    434°C

    Melting point expt.

    • 47 °C

    Flash point

    • 185.18 ˚C est.

  • Synonyms

    • DTXSID601263196
    • 1-(Acetyloxy)-2-hydroxy-16-heptadecyn-4-one
    • RefChem:426911
    • DTXCID501693873
    • 1-Acetoxy-2-hydroxy-16-heptadecyn-4-one
    • AVOCADYNONE ACETATE
    • 24607-10-1
    • (2-hydroxy-4-oxoheptadec-16-ynyl) acetate
    • 74D1OHC38H
    • 2-hydroxy-4-oxoheptadec-16-yn-1-yl acetate
    • UNII-74D1OHC38H
    • 1,2-Dihydroxy-16-heptadecyne-4-one 1-acetate
    • 16-Heptadecyn-4-one, 1-(acetyloxy)-2-hydroxy-
    • 16-Heptadecyn-4-one, 1,2-dihydroxy-, 1-acetate
    • KBio3_002773
    • Spectrum2_000300
    • Spectrum3_001856
    • Spectrum4_001264
    • Spectrum5_001604
    • BSPBio_003272
    • KBioGR_001848
    • SPECTRUM1505235
    • SPBio_000240
    • SCHEMBL4951546
    • CHEMBL1488011
    • CHEBI:171783
    • CCG-39858
    • LMFA05000595
    • SDCCGMLS-0066756.P001
    • NCGC00095831-01
    • NCGC00095831-02
    • Q27266273
    • 24607-10-1

  • Applications

    For 1-(Acetyloxy)-2-hydroxy-16-heptadecyn-4-one (CAS 24607-10-1), practical applications are primarily as an organic-synthesis intermediate; the alkyne, ketone and hydroxyl groups, with the acetoxy protection, enable it to serve as a building block for more complex specialty chemicals. It may be used as a functionalized alkyne precursor for polymer and monomer syntheses, enabling later crosslinking or modification. In coatings and inks, it can act as a reactive intermediate or functional additive in systems requiring protected or selectively activated groups. Its protecting-group functionality and reactive sites also make it useful in protecting-group strategies in multi-step synthesis. Additionally, it may be evaluated as a fragrance intermediate in fragrance chemistry or as a flavor precursor in the food-related sector, depending on downstream transformations, and subject to formulation limits and regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 35.07
    methanol 106.83
    isopropanol 15.7
    water 0.46
    ethyl acetate 22.84
    n-propanol 22.97
    acetone 67.15
    n-butanol 17.45
    acetonitrile 25.87
    DMF 234.99
    toluene 6.06
    isobutanol 16.17
    1,4-dioxane 52.58
    methyl acetate 31.62
    THF 140.71
    2-butanone 40.8
    n-pentanol 19.48
    sec-butanol 14.4
    n-hexane 0.71
    ethylene glycol 21.53
    NMP 204.52
    cyclohexane 1.4
    DMSO 562.43
    n-butyl acetate 24.8
    n-octanol 11.12
    chloroform 82.77
    n-propyl acetate 32.9
    acetic acid 105.83
    dichloromethane 99.12
    cyclohexanone 94.55
    propylene glycol 24.48
    isopropyl acetate 19.6
    DMAc 266.97
    2-ethoxyethanol 84.1
    isopentanol 18.76
    n-heptane 0.62
    ethyl formate 35.84
    1,2-dichloroethane 62.1
    n-hexanol 12.77
    2-methoxyethanol 111.98
    isobutyl acetate 21.67
    tetrachloromethane 10.69
    n-pentyl acetate 24.21
    transcutol 242.1
    n-heptanol 10.26
    ethylbenzene 6.92
    MIBK 27.02
    2-propoxyethanol 56.53
    tert-butanol 24.94
    MTBE 12.56
    2-butoxyethanol 46.12
    propionic acid 45.0
    o-xylene 7.89
    formic acid 92.9
    diethyl ether 9.45
    m-xylene 5.85
    p-xylene 9.07
    chlorobenzene 16.03
    dimethyl carbonate 22.23
    n-octane 0.46
    formamide 134.85
    cyclopentanone 138.24
    2-pentanone 32.02
    anisole 25.42
    cyclopentyl methyl ether 32.3
    gamma-butyrolactone 144.86
    1-methoxy-2-propanol 65.91
    pyridine 43.52
    3-pentanone 24.45
    furfural 159.19
    n-dodecane 0.51
    diethylene glycol 62.36
    diisopropyl ether 3.23
    tert-amyl alcohol 21.39
    acetylacetone 72.52
    n-hexadecane 0.59
    acetophenone 42.83
    methyl propionate 27.02
    isopentyl acetate 25.77
    trichloroethylene 118.68
    n-nonanol 10.94
    cyclohexanol 21.18
    benzyl alcohol 29.67
    2-ethylhexanol 10.19
    isooctanol 9.67
    dipropyl ether 10.04
    1,2-dichlorobenzene 23.52
    ethyl lactate 31.49
    propylene carbonate 74.98
    n-methylformamide 91.82
    2-pentanol 8.85
    n-pentane 0.37
    1-propoxy-2-propanol 36.51
    1-methoxy-2-propyl acetate 37.99
    2-(2-methoxypropoxy) propanol 56.7
    mesitylene 4.51
    ε-caprolactone 78.86
    p-cymene 5.6
    epichlorohydrin 136.24
    1,1,1-trichloroethane 36.04
    2-aminoethanol 38.61
    morpholine-4-carbaldehyde 155.72
    sulfolane 298.71
    2,2,4-trimethylpentane 0.75
    2-methyltetrahydrofuran 49.36
    n-hexyl acetate 29.35
    isooctane 0.39
    2-(2-butoxyethoxy)ethanol 71.27
    sec-butyl acetate 19.15
    tert-butyl acetate 29.81
    decalin 1.6
    glycerin 63.84
    diglyme 165.8
    acrylic acid 50.91
    isopropyl myristate 10.94
    n-butyric acid 52.49
    acetyl acetate 27.97
    di(2-ethylhexyl) phthalate 19.32
    ethyl propionate 25.23
    nitromethane 188.42
    1,2-diethoxyethane 34.31
    benzonitrile 27.52
    trioctyl phosphate 12.24
    1-bromopropane 15.55
    gamma-valerolactone 198.25
    n-decanol 7.5
    triethyl phosphate 20.97
    4-methyl-2-pentanol 7.74
    propionitrile 18.82
    vinylene carbonate 71.11
    1,1,2-trichlorotrifluoroethane 164.38
    DMS 31.02
    cumene 6.54
    2-octanol 6.38
    2-hexanone 33.28
    octyl acetate 14.59
    limonene 8.14
    1,2-dimethoxyethane 131.0
    ethyl orthosilicate 19.18
    tributyl phosphate 17.13
    diacetone alcohol 53.08
    N,N-dimethylaniline 23.04
    acrylonitrile 32.23
    aniline 16.52
    1,3-propanediol 42.67
    bromobenzene 14.13
    dibromomethane 46.26
    1,1,2,2-tetrachloroethane 112.12
    2-methyl-cyclohexyl acetate 28.1
    tetrabutyl urea 26.89
    diisobutyl methanol 6.69
    2-phenylethanol 22.88
    styrene 8.14
    dioctyl adipate 28.22
    dimethyl sulfate 72.7
    ethyl butyrate 23.9
    methyl lactate 40.27
    butyl lactate 34.47
    diethyl carbonate 19.79
    propanediol butyl ether 53.37
    triethyl orthoformate 22.82
    p-tert-butyltoluene 5.34
    methyl 4-tert-butylbenzoate 44.48
    morpholine 76.27
    tert-butylamine 10.5
    n-dodecanol 5.31
    dimethoxymethane 70.35
    ethylene carbonate 54.06
    cyrene 73.79
    2-ethoxyethyl acetate 43.99
    2-ethylhexyl acetate 19.16
    1,2,4-trichlorobenzene 30.28
    4-methylpyridine 36.6
    dibutyl ether 12.81
    2,6-dimethyl-4-heptanol 6.69
    DEF 59.65
    dimethyl isosorbide 99.08
    tetrachloroethylene 68.78
    eugenol 50.05
    triacetin 59.26
    span 80 42.29
    1,4-butanediol 23.31
    1,1-dichloroethane 30.56
    2-methyl-1-pentanol 19.67
    methyl formate 66.24
    2-methyl-1-butanol 17.25
    n-decane 0.93
    butyronitrile 20.09
    3,7-dimethyl-1-octanol 11.2
    1-chlorooctane 5.95
    1-chlorotetradecane 2.1
    n-nonane 0.78
    undecane 0.66
    tert-butylcyclohexane 1.27
    cyclooctane 0.49
    cyclopentanol 30.09
    tetrahydropyran 35.66
    tert-amyl methyl ether 13.42
    2,5,8-trioxanonane 109.27
    1-hexene 3.85
    2-isopropoxyethanol 46.79
    2,2,2-trifluoroethanol 52.42
    methyl butyrate 44.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction