1-Acetylcyclohexanol

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  • Identifiers

    CAS number
    1123-27-9

    Molecular formula
    C8H14O2

    SMILES
    CC(=O)C1(CCCCC1)O

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Sweet 55.25%
    Caramellic 45.23%
    Mint 36.55%
    Nutty 36.07%
    Buttery 33.14%
    Creamy 32.95%
    Musty 31.2%
    Earthy 29.5%
    Camphoreous 29.5%
    Hay 28.94%

     

    Flavor
    Sweet 53.69%
    Caramel 39.26%
    Minty 30.53%
    Musty 29.33%
    Fruity 26.96%
    Coumarin 23.05%
    Herbal 22.54%
    Buttery 22.25%
    Maple 21.75%
    Tobacco 21.61%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    9.24 (weak base)

    Molecular weight
    142.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    215°C

    Flash point

    • 92.97 ˚C est.

  • Synonyms

    • 1-ACETYLCYCLOHEXANOL
    • 1123-27-9
    • 1-(1-Hydroxycyclohexyl)ethanone
    • Ethanone, 1-(1-hydroxycyclohexyl)-
    • 1-(1-Hydroxycyclohexyl)ethan-1-one
    • 1-(1-hydroxy-cyclohexyl)-ethanone
    • 6RXC23D3LC
    • NSC 31427
    • HYDROXYCYCLOHEXYL METHYL KETONE
    • EINECS 214-372-9
    • MFCD00019352
    • NSC 37640
    • NSC-31427
    • NSC-37640
    • AI3-13216
    • DTXSID5061536
    • 1-ACETYL-1-HYDROXYCYCLOHEXANE
    • 1-HYDROXYCYCLOHEXYL METHYL KETONE
    • KETONE, 1-HYDROXYCYCLOHEXYL METHYL
    • Ethanone, 1-(hydroxycyclohexyl)-
    • Ethanone,1-(1-hydroxycyclohexyl)-
    • 1-acetyl-1-cyclohexanol
    • UNII-6RXC23D3LC
    • SCHEMBL1674452
    • DTXCID6033293
    • NSC31427
    • NSC37640
    • AKOS006281251
    • AS-30245
    • SY031489
    • DB-041077
    • CS-0206078
    • NS00012636
    • EN300-245344

  • Applications

    1-Acetylcyclohexanol (CAS 1123-27-9) is primarily used as an intermediate in the synthesis of fragrance ingredients and as a precursor for aromatic compounds in perfumery. It can serve as a fragrance constituent or precursor to form complex odorants. In cosmetics and personal care, it may be included in formulations as a fragrance ingredient or aroma-building block for products such as lotions, creams, and shampoos. In household cleaning products, it may appear as a fragrance additive to provide a pleasant scent. In coatings and inks, it can be used as an intermediate to synthesize resins or as a scent-bearing additive in formulations. In the polymers/plastics sector, it may act as a building block for specialty polymers or resins, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 595.94
    methanol 1033.21
    isopropanol 529.6
    water 7.56
    ethyl acetate 342.6
    n-propanol 468.86
    acetone 521.96
    n-butanol 348.07
    acetonitrile 511.01
    DMF 726.0
    toluene 126.3
    isobutanol 335.77
    1,4-dioxane 984.42
    methyl acetate 420.9
    THF 923.51
    2-butanone 407.13
    n-pentanol 257.87
    sec-butanol 360.03
    n-hexane 39.78
    ethylene glycol 169.86
    NMP 561.42
    cyclohexane 43.7
    DMSO 759.75
    n-butyl acetate 234.5
    n-octanol 197.74
    chloroform 1004.44
    n-propyl acetate 229.87
    acetic acid 472.32
    dichloromethane 694.3
    cyclohexanone 539.79
    propylene glycol 199.31
    isopropyl acetate 248.09
    DMAc 440.71
    2-ethoxyethanol 431.44
    isopentanol 293.49
    n-heptane 28.54
    ethyl formate 282.8
    1,2-dichloroethane 439.25
    n-hexanol 278.14
    2-methoxyethanol 680.16
    isobutyl acetate 162.23
    tetrachloromethane 202.01
    n-pentyl acetate 212.65
    transcutol 1078.83
    n-heptanol 189.89
    ethylbenzene 102.05
    MIBK 242.24
    2-propoxyethanol 480.53
    tert-butanol 549.98
    MTBE 357.81
    2-butoxyethanol 328.59
    propionic acid 438.21
    o-xylene 122.38
    formic acid 256.67
    diethyl ether 323.67
    m-xylene 119.02
    p-xylene 142.71
    chlorobenzene 243.02
    dimethyl carbonate 135.67
    n-octane 19.61
    formamide 329.39
    cyclopentanone 693.91
    2-pentanone 315.02
    anisole 258.31
    cyclopentyl methyl ether 336.47
    gamma-butyrolactone 807.79
    1-methoxy-2-propanol 493.2
    pyridine 417.22
    3-pentanone 224.35
    furfural 647.23
    n-dodecane 18.71
    diethylene glycol 385.25
    diisopropyl ether 124.42
    tert-amyl alcohol 377.82
    acetylacetone 396.52
    n-hexadecane 20.95
    acetophenone 231.97
    methyl propionate 254.64
    isopentyl acetate 224.62
    trichloroethylene 792.54
    n-nonanol 166.09
    cyclohexanol 273.31
    benzyl alcohol 210.23
    2-ethylhexanol 153.69
    isooctanol 160.2
    dipropyl ether 162.32
    1,2-dichlorobenzene 251.83
    ethyl lactate 144.5
    propylene carbonate 413.51
    n-methylformamide 494.87
    2-pentanol 245.72
    n-pentane 35.84
    1-propoxy-2-propanol 301.64
    1-methoxy-2-propyl acetate 252.52
    2-(2-methoxypropoxy) propanol 253.5
    mesitylene 98.69
    ε-caprolactone 461.36
    p-cymene 80.38
    epichlorohydrin 682.34
    1,1,1-trichloroethane 492.61
    2-aminoethanol 323.89
    morpholine-4-carbaldehyde 676.14
    sulfolane 833.51
    2,2,4-trimethylpentane 29.83
    2-methyltetrahydrofuran 538.81
    n-hexyl acetate 303.04
    isooctane 28.75
    2-(2-butoxyethoxy)ethanol 380.47
    sec-butyl acetate 167.81
    tert-butyl acetate 301.68
    decalin 36.59
    glycerin 295.99
    diglyme 660.17
    acrylic acid 363.23
    isopropyl myristate 116.62
    n-butyric acid 450.7
    acetyl acetate 237.36
    di(2-ethylhexyl) phthalate 109.62
    ethyl propionate 192.77
    nitromethane 768.33
    1,2-diethoxyethane 327.71
    benzonitrile 293.65
    trioctyl phosphate 90.77
    1-bromopropane 255.85
    gamma-valerolactone 833.02
    n-decanol 118.67
    triethyl phosphate 101.48
    4-methyl-2-pentanol 164.69
    propionitrile 408.59
    vinylene carbonate 395.95
    1,1,2-trichlorotrifluoroethane 484.97
    DMS 226.01
    cumene 91.7
    2-octanol 143.6
    2-hexanone 254.22
    octyl acetate 143.79
    limonene 108.48
    1,2-dimethoxyethane 628.27
    ethyl orthosilicate 99.82
    tributyl phosphate 104.16
    diacetone alcohol 327.75
    N,N-dimethylaniline 177.52
    acrylonitrile 515.1
    aniline 222.61
    1,3-propanediol 410.99
    bromobenzene 239.17
    dibromomethane 475.94
    1,1,2,2-tetrachloroethane 679.99
    2-methyl-cyclohexyl acetate 156.7
    tetrabutyl urea 120.16
    diisobutyl methanol 114.03
    2-phenylethanol 203.08
    styrene 120.85
    dioctyl adipate 149.7
    dimethyl sulfate 250.6
    ethyl butyrate 184.45
    methyl lactate 196.35
    butyl lactate 176.88
    diethyl carbonate 126.71
    propanediol butyl ether 300.74
    triethyl orthoformate 138.11
    p-tert-butyltoluene 84.53
    methyl 4-tert-butylbenzoate 241.66
    morpholine 806.47
    tert-butylamine 341.59
    n-dodecanol 89.44
    dimethoxymethane 411.04
    ethylene carbonate 332.81
    cyrene 218.24
    2-ethoxyethyl acetate 261.13
    2-ethylhexyl acetate 165.68
    1,2,4-trichlorobenzene 293.55
    4-methylpyridine 381.77
    dibutyl ether 171.27
    2,6-dimethyl-4-heptanol 114.03
    DEF 320.43
    dimethyl isosorbide 364.37
    tetrachloroethylene 502.53
    eugenol 229.49
    triacetin 256.41
    span 80 221.69
    1,4-butanediol 193.56
    1,1-dichloroethane 503.16
    2-methyl-1-pentanol 205.96
    methyl formate 375.13
    2-methyl-1-butanol 258.67
    n-decane 31.42
    butyronitrile 365.99
    3,7-dimethyl-1-octanol 166.31
    1-chlorooctane 120.24
    1-chlorotetradecane 48.64
    n-nonane 29.92
    undecane 23.42
    tert-butylcyclohexane 39.51
    cyclooctane 18.82
    cyclopentanol 367.54
    tetrahydropyran 529.98
    tert-amyl methyl ether 234.82
    2,5,8-trioxanonane 429.48
    1-hexene 128.68
    2-isopropoxyethanol 303.79
    2,2,2-trifluoroethanol 213.04
    methyl butyrate 259.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction