1-(2-(N,N-Dimethylamino)ethyl)-4-methylpiperazine

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  • Identifiers

    CAS number
    104-19-8

    Molecular formula
    C9H21N3

    SMILES
    CN1CCN(CC1)CCN(C)C

    Safety labels

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 75.38%
    Cheesy 44.03%
    Odorless 41.67%
    Ripe 40.53%
    Animal 28.09%
    Nutty 19.48%
    Popcorn 18.07%
    Cooling 17.97%
    Oily 17.9%
    Meaty 17.83%

     

    Flavor
    Bitter 28.84%
    Roasted 24.84%
    Odorless 22.65%
    Alkaline 21.73%
    Bouillon 20.43%
    Sweet-like 20.42%
    Shrimp 20.37%
    Cedarleaf 20.3%
    Bland 20.18%
    Bloody 20.12%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    7.36 (neutral)

    Molecular weight
    171.28 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    222°C

    Flash point

    • 84.56 ˚C est.

  • Synonyms

    • 1-Piperazineethanamine, N,N,4-trimethyl-
    • Toyocat NP
    • Kaolizer 8
    • 1-(2-(N,N-Dimethylamino)ethyl)-4-methylpiperazine
    • NSC 79879
    • S 36081-3
    • 1-(2-(Dimethylamino)ethyl)-4-methylpiperazine
    • N,N,4-Trimethylpiperazine-1-ethylamine
    • EINECS 203-183-7
    • N-Methyl-N'-(beta-dimethylaminoethyl)piperazine
    • BRN 0106624
    • N-Methyl-N'-(.beta.-dimethylaminoethyl)piperazine
    • 384CK0D21R
    • NSC-79879
    • JEFFCAT TR 52
    • Piperazine, 1-(2-(dimethylamino)ethyl)-4-methyl-
    • DTXSID5059292
    • 1-[2-(Dimethylamino)ethyl]-4-methylpiperazine
    • 5-23-01-00270 (Beilstein Handbook Reference)
    • n,n,n'-trimethylaminoethylpiperazine
    • Piperazine, 1-[2-(dimethylamino)ethyl]-4-methyl-
    • RefChem:421304
    • DTXCID7032840
    • 203-183-7
    • 104-19-8
    • N,N-dimethyl-2-(4-methylpiperazin-1-yl)ethanamine
    • 1-(2-Dimethylaminoethyl)-4-methylpiperazine
    • dimethyl[2-(4-methylpiperazin-1-yl)ethyl]amine
    • N,N-Dimethyl-2-(4-methylpiperazin-1-yl)ethan-1-amine
    • MFCD00059773
    • N-Methyl-N'-(dimethylaminoethyl)piperazine
    • 1-Piperazineethanamine,N,N,4-trimethyl-
    • UNII-384CK0D21R
    • NSC79879
    • SCHEMBL134397
    • KL 8
    • SCHEMBL2074528
    • 1-Piperazineethanamine,N,4-trimethyl-
    • AKOS022300257
    • FD75435
    • n-methyl-n'-dimethylaminoethylpiperazine
    • WLN: T6N DNTJ A2N1 & 1 D1
    • CS-0325410
    • D1766
    • N-methyl-4-(2 dimethylaminoethyl)piperazine
    • NS00019584
    • A800920
    • N,N-Dimethyl-2-(4-methyl-1-piperazinyl)ethanamine
    • N,N-Dimethyl-2-(4-methyl-1-piperazinyl)ethanamine #
    • Q27256736
    • ETHANAMINE,N,N-DIMETHYL(4-METHYL-1-PIPERAZINYL)-
    • 104-19-8

  • Applications

    1-(2-(N,N-Dimethylamino)ethyl)-4-methylpiperazine (CAS 104-19-8) is a versatile building block in chemical synthesis. In pharmaceuticals, it is commonly used as an intermediate for the preparation of piperazine-containing drug candidates and as a scaffold in medicinal chemistry programs. In coatings, polymers and adhesives, its secondary and tertiary amine functionalities can serve as reactive centers or curing aids for epoxy resin formulations, enhancing curing performance and adhesion. In chemical research, it is employed as a reactive amine building block for developing more complex piperazine-containing compounds and for library synthesis. It may also function as a ligand or precursor in coordination chemistry and catalysis studies; actual applications depend on regulatory requirements and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 63.79
    methanol 141.07
    isopropanol 21.22
    water 65.7
    ethyl acetate 16.81
    n-propanol 49.82
    acetone 8.27
    n-butanol 30.0
    acetonitrile 17.39
    DMF 36.96
    toluene 6.04
    isobutanol 28.98
    1,4-dioxane 35.22
    methyl acetate 24.44
    THF 35.12
    2-butanone 12.26
    n-pentanol 12.35
    sec-butanol 23.27
    n-hexane 1.28
    ethylene glycol 112.07
    NMP 104.36
    cyclohexane 6.49
    DMSO 51.55
    n-butyl acetate 21.43
    n-octanol 10.7
    chloroform 185.84
    n-propyl acetate 9.8
    acetic acid 295.84
    dichloromethane 122.69
    cyclohexanone 40.76
    propylene glycol 89.83
    isopropyl acetate 6.34
    DMAc 42.3
    2-ethoxyethanol 38.85
    isopentanol 13.3
    n-heptane 3.98
    ethyl formate 43.63
    1,2-dichloroethane 37.7
    n-hexanol 31.18
    2-methoxyethanol 106.54
    isobutyl acetate 6.84
    tetrachloromethane 55.02
    n-pentyl acetate 11.25
    transcutol 79.43
    n-heptanol 17.1
    ethylbenzene 3.31
    MIBK 2.87
    2-propoxyethanol 65.06
    tert-butanol 16.32
    MTBE 4.4
    2-butoxyethanol 40.26
    propionic acid 143.81
    o-xylene 7.96
    formic acid 343.14
    diethyl ether 4.87
    m-xylene 4.64
    p-xylene 5.34
    chlorobenzene 22.76
    dimethyl carbonate 10.21
    n-octane 1.33
    formamide 183.34
    cyclopentanone 42.93
    2-pentanone 5.37
    anisole 6.84
    cyclopentyl methyl ether 16.52
    gamma-butyrolactone 105.04
    1-methoxy-2-propanol 39.23
    pyridine 45.78
    3-pentanone 7.89
    furfural 149.45
    n-dodecane 1.01
    diethylene glycol 97.25
    diisopropyl ether 1.47
    tert-amyl alcohol 20.69
    acetylacetone 9.98
    n-hexadecane 1.07
    acetophenone 12.8
    methyl propionate 18.77
    isopentyl acetate 16.23
    trichloroethylene 112.56
    n-nonanol 10.17
    cyclohexanol 39.69
    benzyl alcohol 21.16
    2-ethylhexanol 19.03
    isooctanol 11.81
    dipropyl ether 8.85
    1,2-dichlorobenzene 32.2
    ethyl lactate 21.36
    propylene carbonate 70.74
    n-methylformamide 79.93
    2-pentanol 9.24
    n-pentane 1.76
    1-propoxy-2-propanol 42.46
    1-methoxy-2-propyl acetate 24.19
    2-(2-methoxypropoxy) propanol 31.75
    mesitylene 3.2
    ε-caprolactone 58.01
    p-cymene 9.13
    epichlorohydrin 59.23
    1,1,1-trichloroethane 38.54
    2-aminoethanol 132.7
    morpholine-4-carbaldehyde 83.83
    sulfolane 139.77
    2,2,4-trimethylpentane 1.71
    2-methyltetrahydrofuran 28.84
    n-hexyl acetate 14.34
    isooctane 0.57
    2-(2-butoxyethoxy)ethanol 39.36
    sec-butyl acetate 5.14
    tert-butyl acetate 5.95
    decalin 2.38
    glycerin 157.88
    diglyme 54.07
    acrylic acid 187.91
    isopropyl myristate 5.0
    n-butyric acid 99.83
    acetyl acetate 20.54
    di(2-ethylhexyl) phthalate 15.54
    ethyl propionate 9.67
    nitromethane 139.88
    1,2-diethoxyethane 9.38
    benzonitrile 23.88
    trioctyl phosphate 9.99
    1-bromopropane 14.18
    gamma-valerolactone 86.92
    n-decanol 7.76
    triethyl phosphate 18.72
    4-methyl-2-pentanol 4.33
    propionitrile 21.01
    vinylene carbonate 85.73
    1,1,2-trichlorotrifluoroethane 215.19
    DMS 19.68
    cumene 3.77
    2-octanol 6.84
    2-hexanone 4.66
    octyl acetate 8.91
    limonene 12.19
    1,2-dimethoxyethane 20.76
    ethyl orthosilicate 16.39
    tributyl phosphate 12.67
    diacetone alcohol 13.8
    N,N-dimethylaniline 6.8
    acrylonitrile 36.93
    aniline 29.79
    1,3-propanediol 95.84
    bromobenzene 17.7
    dibromomethane 67.98
    1,1,2,2-tetrachloroethane 107.77
    2-methyl-cyclohexyl acetate 20.09
    tetrabutyl urea 13.69
    diisobutyl methanol 7.4
    2-phenylethanol 27.91
    styrene 3.99
    dioctyl adipate 12.05
    dimethyl sulfate 26.63
    ethyl butyrate 15.6
    methyl lactate 35.13
    butyl lactate 26.2
    diethyl carbonate 15.7
    propanediol butyl ether 36.72
    triethyl orthoformate 17.99
    p-tert-butyltoluene 8.92
    methyl 4-tert-butylbenzoate 22.85
    morpholine 53.1
    tert-butylamine 10.33
    n-dodecanol 5.91
    dimethoxymethane 12.68
    ethylene carbonate 57.47
    cyrene 42.11
    2-ethoxyethyl acetate 17.68
    2-ethylhexyl acetate 15.39
    1,2,4-trichlorobenzene 47.99
    4-methylpyridine 25.25
    dibutyl ether 5.08
    2,6-dimethyl-4-heptanol 7.4
    DEF 17.26
    dimethyl isosorbide 53.52
    tetrachloroethylene 123.82
    eugenol 29.84
    triacetin 27.57
    span 80 38.24
    1,4-butanediol 34.05
    1,1-dichloroethane 27.1
    2-methyl-1-pentanol 8.67
    methyl formate 55.81
    2-methyl-1-butanol 21.91
    n-decane 1.51
    butyronitrile 14.88
    3,7-dimethyl-1-octanol 10.21
    1-chlorooctane 5.24
    1-chlorotetradecane 2.45
    n-nonane 1.41
    undecane 1.2
    tert-butylcyclohexane 1.88
    cyclooctane 2.03
    cyclopentanol 55.86
    tetrahydropyran 24.38
    tert-amyl methyl ether 5.76
    2,5,8-trioxanonane 43.44
    1-hexene 2.66
    2-isopropoxyethanol 18.69
    2,2,2-trifluoroethanol 177.26
    methyl butyrate 13.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction