1-((1,1'-Biphenyl)-2-yl)ethan-1-one

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  • Identifiers

    CAS number
    2142-66-7

    Molecular formula
    C14H12O

    SMILES
    CC(=O)C1=CC=CC=C1C2=CC=CC=C2

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Floral 93.76%
    Sweet 74.5%
    Neroli 58.59%
    Powdery 58.2%
    Honey 51.33%
    Hawthorn 46.84%
    Balsamic 45.81%
    Orange 42.39%
    Rose 40.02%
    Cherry 39.83%

     

    Flavor
    Sweet 59.87%
    Balsam 46.72%
    Floral 42.68%
    Honey 41.29%
    Bitter 40.64%
    Cherry 38.45%
    Hawthorn 38.07%
    Rose 36.89%
    Phenolic 34.73%
    Powdery 34.32%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.45 (neutral)

    Molecular weight
    196.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    311°C

    Flash point

    • 150.22 ˚C est.

  • Synonyms

    • 2-Acetylbiphenyl
    • 2142-66-7
    • 1-([1,1'-Biphenyl]-2-yl)ethanone
    • 1-(2-phenylphenyl)ethanone
    • 2-Phenylbenzoyl methide
    • 29932-58-9
    • 1-[1,1'-biphenyl]ylethan-1-one
    • 1-(1,1'-Biphenyl)ylethan-1-one
    • 1-[1,1'-Biphenyl]-2-ylethanone
    • 1-{[1,1'-biphenyl]-2-yl}ethan-1-one
    • 1-(1,1'-Biphenyl)-2-ylethanone
    • 1-((1,1'-Biphenyl)-2-yl)ethan-1-one
    • 2'-phenylacetophenone
    • 1-([1,1'-BIPHENYL]-2-YL)ETHAN-1-ONE
    • MFCD00053707
    • O-PHENYLACETOPHENONE
    • acetylbiphenyl
    • 2-acetyl-biphenyl
    • EINECS 249-962-5
    • Ethanone, 1-[1,1'-biphenyl]yl-
    • 2-acetyl-1,1'-biphenyl
    • SCHEMBL294730
    • 1-(2-phenylphenyl)ethan-1-one
    • DTXSID90184040
    • CAA14266
    • AKOS000125022
    • AS-58065
    • CS-0155085
    • NS00028807
    • EN300-60094
    • Y11685
    • Z363994832
    • 869-778-4

  • Applications

    1-((1,1'-Biphenyl)-2-yl)ethan-1-one (CAS 2142-66-7) primarily serves as a synthetic building block in organic synthesis, enabling the preparation of more complex diaryl ketones and related intermediates used in pharmaceutical and fine-chemical manufacturing. In perfumery and cosmetics, it may be employed as an odorant precursor or fragrance intermediate, contributing to woody, floral, or amber notes when transformed or integrated into formulations. In coatings, inks, and adhesives, it is used as a specialty intermediate or dye precursor for pigment synthesis and UV-curable resin formulations. In polymers and materials science, it can function as a building block for liquid-crystal materials or as a component of specialty polymers and optoelectronic materials. In electronics and related fields, diaryl ketone cores are explored as organic semiconductor or dopant candidates for organic electronics and display technologies, with this compound serving as a potential precursor. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 256.28
    methanol 275.31
    isopropanol 153.67
    water 0.64
    ethyl acetate 745.51
    n-propanol 231.29
    acetone 1348.44
    n-butanol 184.09
    acetonitrile 875.96
    DMF 2265.77
    toluene 444.32
    isobutanol 149.22
    1,4-dioxane 1513.33
    methyl acetate 831.36
    THF 1470.34
    2-butanone 914.57
    n-pentanol 126.06
    sec-butanol 131.93
    n-hexane 52.24
    ethylene glycol 91.47
    NMP 1320.68
    cyclohexane 91.8
    DMSO 1362.83
    n-butyl acetate 380.4
    n-octanol 119.56
    chloroform 2454.43
    n-propyl acetate 395.47
    acetic acid 290.39
    dichloromethane 2881.44
    cyclohexanone 1381.88
    propylene glycol 84.41
    isopropyl acetate 309.35
    DMAc 1104.44
    2-ethoxyethanol 217.26
    isopentanol 132.87
    n-heptane 42.78
    ethyl formate 558.78
    1,2-dichloroethane 2181.37
    n-hexanol 164.99
    2-methoxyethanol 470.59
    isobutyl acetate 218.82
    tetrachloromethane 210.13
    n-pentyl acetate 222.9
    transcutol 683.95
    n-heptanol 97.02
    ethylbenzene 238.44
    MIBK 279.87
    2-propoxyethanol 274.85
    tert-butanol 158.34
    MTBE 218.15
    2-butoxyethanol 168.67
    propionic acid 327.69
    o-xylene 203.71
    formic acid 68.76
    diethyl ether 587.39
    m-xylene 215.23
    p-xylene 232.2
    chlorobenzene 635.1
    dimethyl carbonate 432.04
    n-octane 24.73
    formamide 283.25
    cyclopentanone 1815.88
    2-pentanone 718.73
    anisole 455.75
    cyclopentyl methyl ether 617.69
    gamma-butyrolactone 1793.02
    1-methoxy-2-propanol 288.02
    pyridine 1344.35
    3-pentanone 627.57
    furfural 1020.84
    n-dodecane 18.93
    diethylene glycol 217.78
    diisopropyl ether 107.85
    tert-amyl alcohol 129.95
    acetylacetone 716.17
    n-hexadecane 22.77
    acetophenone 403.28
    methyl propionate 732.66
    isopentyl acetate 271.21
    trichloroethylene 3019.69
    n-nonanol 104.74
    cyclohexanol 238.37
    benzyl alcohol 253.88
    2-ethylhexanol 120.0
    isooctanol 81.52
    dipropyl ether 251.07
    1,2-dichlorobenzene 504.35
    ethyl lactate 146.6
    propylene carbonate 743.55
    n-methylformamide 969.78
    2-pentanol 107.41
    n-pentane 29.46
    1-propoxy-2-propanol 189.62
    1-methoxy-2-propyl acetate 295.66
    2-(2-methoxypropoxy) propanol 161.88
    mesitylene 119.33
    ε-caprolactone 903.35
    p-cymene 95.49
    epichlorohydrin 1959.37
    1,1,1-trichloroethane 1010.45
    2-aminoethanol 138.07
    morpholine-4-carbaldehyde 1010.81
    sulfolane 1410.75
    2,2,4-trimethylpentane 15.38
    2-methyltetrahydrofuran 917.85
    n-hexyl acetate 330.83
    isooctane 13.1
    2-(2-butoxyethoxy)ethanol 231.17
    sec-butyl acetate 216.39
    tert-butyl acetate 253.9
    decalin 50.68
    glycerin 125.83
    diglyme 573.68
    acrylic acid 325.71
    isopropyl myristate 117.25
    n-butyric acid 380.58
    acetyl acetate 382.68
    di(2-ethylhexyl) phthalate 92.0
    ethyl propionate 379.5
    nitromethane 1080.58
    1,2-diethoxyethane 331.39
    benzonitrile 459.99
    trioctyl phosphate 71.07
    1-bromopropane 728.78
    gamma-valerolactone 1477.24
    n-decanol 79.47
    triethyl phosphate 126.33
    4-methyl-2-pentanol 65.53
    propionitrile 637.78
    vinylene carbonate 701.19
    1,1,2-trichlorotrifluoroethane 627.46
    DMS 367.5
    cumene 122.7
    2-octanol 76.42
    2-hexanone 393.69
    octyl acetate 152.01
    limonene 134.22
    1,2-dimethoxyethane 686.18
    ethyl orthosilicate 111.06
    tributyl phosphate 87.78
    diacetone alcohol 259.88
    N,N-dimethylaniline 245.64
    acrylonitrile 890.85
    aniline 415.15
    1,3-propanediol 182.59
    bromobenzene 699.56
    dibromomethane 1668.58
    1,1,2,2-tetrachloroethane 1917.77
    2-methyl-cyclohexyl acetate 177.85
    tetrabutyl urea 132.67
    diisobutyl methanol 73.86
    2-phenylethanol 206.28
    styrene 330.71
    dioctyl adipate 162.11
    dimethyl sulfate 560.07
    ethyl butyrate 282.73
    methyl lactate 219.68
    butyl lactate 140.2
    diethyl carbonate 207.62
    propanediol butyl ether 143.33
    triethyl orthoformate 160.42
    p-tert-butyltoluene 86.78
    methyl 4-tert-butylbenzoate 227.05
    morpholine 1243.99
    tert-butylamine 103.62
    n-dodecanol 62.72
    dimethoxymethane 970.25
    ethylene carbonate 615.74
    cyrene 211.36
    2-ethoxyethyl acetate 294.1
    2-ethylhexyl acetate 222.6
    1,2,4-trichlorobenzene 548.52
    4-methylpyridine 1048.97
    dibutyl ether 223.38
    2,6-dimethyl-4-heptanol 73.86
    DEF 834.85
    dimethyl isosorbide 326.82
    tetrachloroethylene 1134.97
    eugenol 201.47
    triacetin 275.43
    span 80 136.72
    1,4-butanediol 77.23
    1,1-dichloroethane 1447.52
    2-methyl-1-pentanol 117.46
    methyl formate 797.55
    2-methyl-1-butanol 132.82
    n-decane 32.74
    butyronitrile 492.84
    3,7-dimethyl-1-octanol 94.18
    1-chlorooctane 140.25
    1-chlorotetradecane 54.5
    n-nonane 34.28
    undecane 24.18
    tert-butylcyclohexane 39.69
    cyclooctane 32.32
    cyclopentanol 309.68
    tetrahydropyran 1135.59
    tert-amyl methyl ether 173.31
    2,5,8-trioxanonane 332.17
    1-hexene 185.34
    2-isopropoxyethanol 160.83
    2,2,2-trifluoroethanol 151.59
    methyl butyrate 537.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction