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Isobutyl Quinoline Aroma Chemical
CAS# 65442-31-1 / 67634-06-4

Earthy, Green, Animal, Leathery, Herbal

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Isobutyl Quinoline (and its isomer variations such as Pyralone or Butyl Quinoline Secondary) is a premium and iconic synthetic raw material in the perfumery industry. This compound is renowned for its ability to create extremely powerful leather, dry tobacco, and woody notes. Historically, Isobutyl Quinoline was the core ingredient in the famous Mousse de Saxe base created by the De Laire house, which shaped the golden era of classic leather and Chypre fragrances.

The product delivers a complex scent profile with high diffusion and vibrancy. The characteristic odor of Isobutyl Quinoline is described as a blend of tanned leather, damp earthy roots (similar to vetiver), oakmoss, and tobacco. Depending on the specific isomer, the olfactory nuances can vary slightly; for instance, Pyralone is generally finer, more aromatic, and more tobacco-like, with a less dry and earthy character compared to Butyl Quinoline Secondary. In the dry-down (base notes), this compound leaves a resinous layer and sometimes exhibits animalic or tarry facets.

One of the greatest advantages of Isobutyl Quinoline is its exceptionally high substantivity and its ability to act as an outstanding fixative. Its odor can last on a smelling blotter from 5 days up to over 160 hours. Due to its extreme odor strength, perfumers are often recommended to evaluate and use this product in a diluted form (such as 10% or 1% in DPG solvent) to fully appreciate its scent structure without being overwhelmed.
This chemical is a perfect choice for building depth in Chypre, Fougère, and Oriental perfume formulas, especially in premium masculine fragrances. The typical usage rate in fine fragrances usually ranges from minute traces up to a maximum of about 1% to 2% of the total composition.

Beyond fine fragrances, Isobutyl Quinoline is highly favored in consumer goods and home care products thanks to its excellent chemical stability. Due to its pyridine ring structure, which is highly resistant to hydrolysis and oxidation, this compound retains its scent exceptionally well across various harsh pH environments. The product demonstrates excellent performance in application bases such as acid cleaners, fabric conditioners, shampoos, antiperspirants, and bar soaps. It also provides great scent diffusion when used in candles or spatial diffusers.

Technical standards

Solubility @25˚C

Solvent Solubility (g/L)
ethanol 549.56
methanol 399.23
isopropanol 252.38
water 0.04
ethyl acetate 2054.81
n-propanol 543.81
acetone 1916.98
n-butanol 479.54
acetonitrile 984.08
DMF 2358.01
toluene 1456.18
isobutanol 338.78
1,4-dioxane 2452.23
methyl acetate 1469.12
THF 2461.37
2-butanone 1845.79
n-pentanol 288.02
sec-butanol 264.32
n-hexane 62.45
ethylene glycol 35.4
NMP 956.97
cyclohexane 99.44
DMSO 1068.29
n-butyl acetate 1492.7
n-octanol 58.61
chloroform 2808.58
n-propyl acetate 762.07
acetic acid 300.21
dichloromethane 4957.76
cyclohexanone 1885.03
propylene glycol 42.59
isopropyl acetate 779.03
DMAc 1205.08
2-ethoxyethanol 542.5
isopentanol 373.07
n-heptane 29.02
ethyl formate 710.77
1,2-dichloroethane 4768.8
n-hexanol 402.11
2-methoxyethanol 1098.19
isobutyl acetate 451.92
tetrachloromethane 271.45
n-pentyl acetate 391.47
transcutol 2884.0
n-heptanol 90.42
ethylbenzene 380.38
MIBK 537.52
2-propoxyethanol 985.67
tert-butanol 289.58
MTBE 956.76
2-butoxyethanol 259.09
propionic acid 321.79
o-xylene 440.29
formic acid 62.83
diethyl ether 2302.45
m-xylene 569.01
p-xylene 414.77
chlorobenzene 1277.88
dimethyl carbonate 503.22
n-octane 9.65
formamide 225.24
cyclopentanone 1982.84
2-pentanone 1448.51
anisole 789.32
cyclopentyl methyl ether 1241.89
gamma-butyrolactone 1849.09
1-methoxy-2-propanol 548.51
pyridine 3165.36
3-pentanone 1357.83
furfural 1326.4
n-dodecane 6.48
diethylene glycol 366.27
diisopropyl ether 299.66
tert-amyl alcohol 264.47
acetylacetone 1308.08
n-hexadecane 8.24
acetophenone 545.26
methyl propionate 1573.15
isopentyl acetate 1105.61
trichloroethylene 5655.81
n-nonanol 59.64
cyclohexanol 330.59
benzyl alcohol 376.02
2-ethylhexanol 238.82
isooctanol 77.36
dipropyl ether 588.77
1,2-dichlorobenzene 808.57
ethyl lactate 122.95
propylene carbonate 698.47
n-methylformamide 867.1
2-pentanol 246.33
n-pentane 51.71
1-propoxy-2-propanol 503.77
1-methoxy-2-propyl acetate 1026.05
2-(2-methoxypropoxy) propanol 261.32
mesitylene 236.46
ε-caprolactone 1250.93
p-cymene 150.0
epichlorohydrin 3627.14
1,1,1-trichloroethane 1619.6
2-aminoethanol 121.24
morpholine-4-carbaldehyde 1440.13
sulfolane 1242.6
2,2,4-trimethylpentane 27.37
2-methyltetrahydrofuran 1800.15
n-hexyl acetate 396.62
isooctane 21.7
2-(2-butoxyethoxy)ethanol 440.65
sec-butyl acetate 458.56
tert-butyl acetate 681.47
decalin 50.78
glycerin 69.53
diglyme 1215.18
acrylic acid 245.88
isopropyl myristate 122.8
n-butyric acid 604.4
acetyl acetate 669.73
di(2-ethylhexyl) phthalate 116.16
ethyl propionate 665.28
nitromethane 1253.98
1,2-diethoxyethane 1695.23
benzonitrile 626.76
trioctyl phosphate 67.56
1-bromopropane 1784.53
gamma-valerolactone 2399.74
n-decanol 44.98
triethyl phosphate 175.32
4-methyl-2-pentanol 136.65
propionitrile 835.69
vinylene carbonate 734.78
1,1,2-trichlorotrifluoroethane 757.51
DMS 580.36
cumene 172.58
2-octanol 50.41
2-hexanone 687.28
octyl acetate 152.83
limonene 229.12
1,2-dimethoxyethane 1525.25
ethyl orthosilicate 188.53
tributyl phosphate 121.38
diacetone alcohol 446.16
N,N-dimethylaniline 351.01
acrylonitrile 1046.73
aniline 1035.65
1,3-propanediol 283.22
bromobenzene 1543.46
dibromomethane 2633.34
1,1,2,2-tetrachloroethane 2948.39
2-methyl-cyclohexyl acetate 358.79
tetrabutyl urea 148.27
diisobutyl methanol 115.66
2-phenylethanol 478.19
styrene 623.12
dioctyl adipate 182.91
dimethyl sulfate 495.53
ethyl butyrate 688.44
methyl lactate 169.06
butyl lactate 184.87
diethyl carbonate 387.44
propanediol butyl ether 138.25
triethyl orthoformate 360.11
p-tert-butyltoluene 138.76
methyl 4-tert-butylbenzoate 223.57
morpholine 2749.49
tert-butylamine 197.2
n-dodecanol 36.45
dimethoxymethane 2143.29
ethylene carbonate 645.12
cyrene 213.72
2-ethoxyethyl acetate 848.95
2-ethylhexyl acetate 876.72
1,2,4-trichlorobenzene 887.93
4-methylpyridine 2771.98
dibutyl ether 322.88
2,6-dimethyl-4-heptanol 115.66
DEF 1847.1
dimethyl isosorbide 645.36
tetrachloroethylene 1877.06
eugenol 235.22
triacetin 292.55
span 80 168.16
1,4-butanediol 73.88
1,1-dichloroethane 2232.56
2-methyl-1-pentanol 303.79
methyl formate 619.6
2-methyl-1-butanol 392.61
n-decane 10.96
butyronitrile 768.43
3,7-dimethyl-1-octanol 100.06
1-chlorooctane 88.76
1-chlorotetradecane 32.98
n-nonane 10.07
undecane 8.18
tert-butylcyclohexane 44.68
cyclooctane 30.08
cyclopentanol 277.34
tetrahydropyran 2477.55
tert-amyl methyl ether 574.07
2,5,8-trioxanonane 566.32
1-hexene 370.06
2-isopropoxyethanol 353.2
2,2,2-trifluoroethanol 86.35
methyl butyrate 880.81

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  • CAS NUMBER

    65442-31-1
    67634-06-4

  • FAMILIES

    Animalic

  • BRAND

    Scent.vn

  • EVAPORATION RATE

    Very slow

  • Odor impact

    High est.

  • FLASH POINT

    132.3 ˚C est.

Olfactory Pyramid

base

Notes

Earthy
Green
Animal
Leathery
Herbal

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Shipping & Returns

  • All orders will be processed within 1-2 business days from the time the order is confirmed.
  • Free shipping is available for international retail orders valued at 500 USD or more.
  • Delivery time is 1-3 business days for local areas, 3-7 days for suburban and nationwide deliveries, and 1-4 weeks for international orders.
  • You have 30 days from the date of receipt to initiate the return process.
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Certificates of Quality

  • Certificate of Analysis (COA)

    Provides information on the physical and chemical properties of the product.
    Download  

  • IFRA Certificate of Conformity

    Sets safety standards and guidelines for the product in manufacturing.
    Download  

  • Safety Data Sheet (SDS)

    Provides important safety guidelines for transporting, storing, and using the product.
    Download  
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