Erythritol

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  • Identifiers

    CAS number
    149-32-6

    Molecular formula
    C4H10O4

    SMILES
    C([C@H]([C@H](CO)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 71.4%
    Sweet 41.56%
    Alcoholic 26.37%
    Caramellic 23.25%
    Buttery 18.52%
    Clean 17.74%
    Fishy 16.36%
    Ethereal 16.32%
    Oily 15.29%
    Sharp 15.12%

     

    Flavor
    Odorless 76.4%
    Sweet 60.46%
    Sweet-like 34.16%
    Very slight 24.09%
    Very mild 23.9%
    Cauliflower 20.32%
    Mild 19.92%
    Yeast 19.8%
    Alcoholic 19.62%
    Soup 19.53%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.3

    pKa est.
    6.64 (neutral)

    Molecular weight
    122.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 119-123 °C
    • 121.5 °C
    • Crystals. MP: 61 °C. Soluble in alcohol, ether, and glycerol; insoluble in water /Erythritol tetranitrate/

    Boiling point

    • 330.5 °C
    • 330.00 to 331.00 °C. @ 760.00 mm Hg

    Flash point

    • 189.01 ˚C est.

    Solubility expt.

    • Freely soluble in water, slightly soluble in ethanol, insoluble in diethyl ether.
    • Very soluble in water (saturated solution contains about 61% w/w); soluble in pyridine (saturated solution contains 2.5% w/w); slightly soluble in alcohol; practically insoluble in ether
    • Insoluble in ethyl ether, benzene
    • In water, 6.10X10+5 mg/L at 22 °C
    • 610 mg/mL at 22 °C

  • Synonyms

    • ERYTHRITOL
    • meso-Erythritol
    • 149-32-6
    • Phycitol
    • Erythrit
    • Mesoerythritol
    • Phycite
    • Erythrite
    • Erythrol
    • L-Erythritol
    • (2R,3S)-butane-1,2,3,4-tetrol
    • Antierythrite
    • 1,2,3,4-Butanetetrol, (2R,3S)-rel-
    • erythro-tetritol
    • Butanetetrol
    • Erythroglucin
    • Paycite
    • C*Eridex
    • 1,2,3,4-Butanetetrol
    • i-Erythritol
    • Tetrahydroxybutane
    • (2R,3S)-rel-Butane-1,2,3,4-tetraol
    • CHEBI:17113
    • NIK 242
    • Cargill Zerose 16957
    • Erythritol, meso-
    • Erythritol [NF]
    • MFCD00004710
    • (2S,3R)-butane-1,2,3,4-tetrol
    • UNII-RA96B954X6
    • CCRIS 7901
    • 1,2,3,4-Butanetetrol, (R*,S*)-
    • DTXSID6043919
    • HSDB 7968
    • meso-1,2,3,4-Tetrahydroxybutane
    • RA96B954X6
    • NSC 8099
    • NSC-8099
    • EINECS 205-737-3
    • ZEROSE TM 16957
    • INS NO.968
    • 10030-58-7
    • DTXCID4023919
    • FEMA NO. 4819
    • INS-968
    • NSC8099
    • Erythritol (NF)
    • F 8015
    • Erythrol (VAN)
    • 1,2,3,4-Butanetetrol, (theta,S)-
    • rel-(2R,3S)-butane-1,2,3,4-tetraol
    • E-968
    • ERYTHRITOL (MART.)
    • ERYTHRITOL [MART.]
    • BUTANE-1,2,3,4-TETROL, (2R,3S)-
    • ERYTHRITOL (USP-RS)
    • ERYTHRITOL [USP-RS]
    • BUTANE 1,2,3,4-TETROL (MESO-ERYTHRITOL)
    • Lichen sugar
    • ERYTHRITOL (EP IMPURITY)
    • ERYTHRITOL [EP IMPURITY]
    • ERYTHRITOL (EP MONOGRAPH)
    • ERYTHRITOL [EP MONOGRAPH]
    • C4H10O4
    • MRY
    • SMR000112220
    • meso-Eythritol
    • L-(-)-Threitol
    • D-ERYTHRITOL
    • (2R,3S)-rel-1,2,3,4-Butanetetrol
    • Erythritol [WHO-DD]
    • ERYTHRITOL [MI]
    • ERYTHRITOL [FCC]
    • WLN: Q1YQYQ1Q
    • ERYTHRITOL [VANDF]
    • 1,3,4-Tetrahydroxybutane
    • Epitope ID:114707
    • meso-Erythritol (Standard)
    • meso-Erythritol, >=99%
    • SCHEMBL17062
    • MLS001332365
    • MLS001332366
    • CHEMBL349605
    • HMS2270M08
    • Pharmakon1600-01301025
    • meso-Erythritol, analytical standard
    • Tox21_200564
    • NSC760400
    • s4224
    • 1,3,4-Butanetetrol, (R*,S*)-
    • (2r,3s)-butane-1,2,3,4-tetraol
    • AKOS006339851
    • CCG-266079
    • DB04481
    • DS-5851
    • HY-100551R
    • ME05658
    • NSC-760400
    • NCGC00247033-01
    • NCGC00258118-01
    • CAS-149-32-6
    • E968
    • E0021
    • SW219107-1
    • C00503
    • D08915
    • E70403
    • EN300-1273040
    • Q421873
    • BRD-K79315489-001-07-8
    • BRD-K79315489-001-08-6
    • F0001-2636
    • Z1203161930
    • BDF1567C-B08B-425A-B87F-15FF46328423
    • Erythritol, European Pharmacopoeia (EP) Reference Standard
    • Erythritol, United States Pharmacopeia (USP) Reference Standard
    • Erythritol, Pharmaceutical Secondary Standard; Certified Reference Material
    • 205-737-3

  • Applications

    Erythritol (CAS 149-32-6) is a sugar alcohol widely used as a low-calorie sweetener and bulking agent in food processing and flavor formulations, contributing sweetness and mouthfeel in sugar-free products. In cosmetics and personal care, erythritol serves as a humectant and texturizing agent, helping retain moisture in formulations such as creams and dental care products. In pharmaceuticals, it functions as an inert excipient and diluent in tablets and lyophilized formulations. In polymers and plastics, erythritol can be used as a diol building block for biodegradable polyesters and other specialty polymers. In coatings and inks, it may be evaluated as a polyol component to influence rheology and moisture handling.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.56
    methanol 40.51
    isopropanol 5.16
    water 1383.65
    ethyl acetate 1.24
    n-propanol 8.47
    acetone 1.87
    n-butanol 4.44
    acetonitrile 1.34
    DMF 84.96
    toluene 0.1
    isobutanol 3.78
    1,4-dioxane 5.81
    methyl acetate 1.37
    THF 4.91
    2-butanone 1.64
    n-pentanol 1.63
    sec-butanol 5.06
    n-hexane 0.13
    ethylene glycol 166.85
    NMP 83.42
    cyclohexane 0.54
    DMSO 224.13
    n-butyl acetate 0.79
    n-octanol 1.45
    chloroform 0.62
    n-propyl acetate 0.64
    acetic acid 37.83
    dichloromethane 0.75
    cyclohexanone 3.76
    propylene glycol 60.34
    isopropyl acetate 0.82
    DMAc 46.57
    2-ethoxyethanol 16.62
    isopentanol 2.28
    n-heptane 0.58
    ethyl formate 2.32
    1,2-dichloroethane 0.92
    n-hexanol 2.32
    2-methoxyethanol 54.52
    isobutyl acetate 0.29
    tetrachloromethane 0.73
    n-pentyl acetate 0.84
    transcutol 14.78
    n-heptanol 2.08
    ethylbenzene 0.12
    MIBK 0.91
    2-propoxyethanol 11.21
    tert-butanol 5.18
    MTBE 0.96
    2-butoxyethanol 7.14
    propionic acid 15.59
    o-xylene 0.33
    formic acid 346.77
    diethyl ether 0.89
    m-xylene 0.21
    p-xylene 0.16
    chlorobenzene 0.13
    dimethyl carbonate 2.33
    n-octane 0.24
    formamide 182.8
    cyclopentanone 5.04
    2-pentanone 1.32
    anisole 0.38
    cyclopentyl methyl ether 2.04
    gamma-butyrolactone 9.18
    1-methoxy-2-propanol 22.78
    pyridine 1.19
    3-pentanone 1.4
    furfural 10.98
    n-dodecane 0.13
    diethylene glycol 40.03
    diisopropyl ether 0.39
    tert-amyl alcohol 5.34
    acetylacetone 2.42
    n-hexadecane 0.14
    acetophenone 0.9
    methyl propionate 2.45
    isopentyl acetate 0.62
    trichloroethylene 1.07
    n-nonanol 1.32
    cyclohexanol 5.14
    benzyl alcohol 1.31
    2-ethylhexanol 1.29
    isooctanol 1.61
    dipropyl ether 1.29
    1,2-dichlorobenzene 0.28
    ethyl lactate 3.61
    propylene carbonate 3.74
    n-methylformamide 47.25
    2-pentanol 2.25
    n-pentane 0.22
    1-propoxy-2-propanol 6.98
    1-methoxy-2-propyl acetate 2.29
    2-(2-methoxypropoxy) propanol 6.45
    mesitylene 0.3
    ε-caprolactone 4.82
    p-cymene 0.47
    epichlorohydrin 3.16
    1,1,1-trichloroethane 0.4
    2-aminoethanol 94.57
    morpholine-4-carbaldehyde 52.17
    sulfolane 51.29
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 2.37
    n-hexyl acetate 1.04
    isooctane 0.11
    2-(2-butoxyethoxy)ethanol 8.42
    sec-butyl acetate 0.42
    tert-butyl acetate 1.1
    decalin 0.17
    glycerin 185.05
    diglyme 14.72
    acrylic acid 24.1
    isopropyl myristate 0.47
    n-butyric acid 7.81
    acetyl acetate 1.06
    di(2-ethylhexyl) phthalate 1.13
    ethyl propionate 0.84
    nitromethane 21.57
    1,2-diethoxyethane 1.2
    benzonitrile 0.51
    trioctyl phosphate 1.15
    1-bromopropane 0.32
    gamma-valerolactone 14.46
    n-decanol 1.0
    triethyl phosphate 1.42
    4-methyl-2-pentanol 1.23
    propionitrile 1.08
    vinylene carbonate 3.43
    1,1,2-trichlorotrifluoroethane 27.73
    DMS 1.25
    cumene 0.18
    2-octanol 1.16
    2-hexanone 0.59
    octyl acetate 0.72
    limonene 0.82
    1,2-dimethoxyethane 7.6
    ethyl orthosilicate 1.3
    tributyl phosphate 0.97
    diacetone alcohol 5.69
    N,N-dimethylaniline 0.85
    acrylonitrile 1.96
    aniline 0.73
    1,3-propanediol 56.86
    bromobenzene 0.09
    dibromomethane 0.48
    1,1,2,2-tetrachloroethane 1.71
    2-methyl-cyclohexyl acetate 0.95
    tetrabutyl urea 1.9
    diisobutyl methanol 1.26
    2-phenylethanol 1.24
    styrene 0.1
    dioctyl adipate 0.93
    dimethyl sulfate 10.25
    ethyl butyrate 1.02
    methyl lactate 12.85
    butyl lactate 2.9
    diethyl carbonate 0.66
    propanediol butyl ether 9.55
    triethyl orthoformate 1.31
    p-tert-butyltoluene 0.56
    methyl 4-tert-butylbenzoate 3.03
    morpholine 10.78
    tert-butylamine 1.93
    n-dodecanol 0.79
    dimethoxymethane 9.31
    ethylene carbonate 2.6
    cyrene 13.61
    2-ethoxyethyl acetate 1.26
    2-ethylhexyl acetate 0.53
    1,2,4-trichlorobenzene 0.42
    4-methylpyridine 0.64
    dibutyl ether 0.57
    2,6-dimethyl-4-heptanol 1.26
    DEF 8.44
    dimethyl isosorbide 8.74
    tetrachloroethylene 2.21
    eugenol 4.13
    triacetin 2.15
    span 80 7.19
    1,4-butanediol 19.23
    1,1-dichloroethane 0.34
    2-methyl-1-pentanol 1.19
    methyl formate 15.97
    2-methyl-1-butanol 3.09
    n-decane 0.21
    butyronitrile 0.85
    3,7-dimethyl-1-octanol 1.1
    1-chlorooctane 0.39
    1-chlorotetradecane 0.2
    n-nonane 0.22
    undecane 0.16
    tert-butylcyclohexane 0.12
    cyclooctane 0.32
    cyclopentanol 8.04
    tetrahydropyran 1.96
    tert-amyl methyl ether 1.36
    2,5,8-trioxanonane 12.53
    1-hexene 0.17
    2-isopropoxyethanol 5.9
    2,2,2-trifluoroethanol 45.29
    methyl butyrate 1.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction