Edetic Acid

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  • Identifiers

    CAS number
    60-00-4

    Molecular formula
    C10H16N2O8

    SMILES
    C(CN(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 65.87%
    Sweet 35.06%
    Savory 27.01%
    Meaty 18.37%
    Alcoholic 18.21%
    Fishy 18.02%
    Clean 17.15%
    Sour 16.1%
    Cooked 15.76%
    Milky 14.67%

     

    Flavor
    Odorless 68.44%
    Mild 37.44%
    Bland 31.99%
    Bitter 28.22%
    Very mild 27.23%
    Yeast 23.54%
    Sweet-like 21.99%
    Faint 21.16%
    Sour 20.55%
    Stinky 19.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.9

    pKa est.
    3.12 (weak acid)

    Molecular weight
    292.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    469°C

    Melting point expt.

    • 237 °C
    • 245 °C
    • MP: 240-241 °C (decomposes). The free acid tends to carboxylate when heated to temps of 150 °C. Stable on storage and on boiling in aqueous solution.
    • MP: 242 °C /EDTA disodium dihydrate/

    Flash point

    • 310.51 ˚C est.
    • Flash point is> 100 °C,

    Solubility expt.

    • 1000000 mg/L at 25 °C
    • SOL IN SOLN OF ALKALI HYDROXIDES
    • Insoluble in common organic solvents
    • In water, 1,000 mg/L at 25 °C
    • 9.26e+00 g/L
    • Solubility in water, g/100ml at 20 °C: 0.05 (very poor)

  • Synonyms

    • EDTA
    • Edetic acid
    • Ethylenediaminetetraacetic acid
    • 60-00-4
    • Edathamil
    • Sequestrol
    • Versene
    • Havidote
    • Titriplex
    • EDTA acid
    • Versene acid
    • Endrate
    • Cheelox
    • Gluma cleanser
    • Sequestrene aa
    • Sequestric acid
    • Warkeelate acid
    • Komplexon ii
    • Tetrine acid
    • Quastal Special
    • Metaquest A
    • Trilon bw
    • Titriplex II
    • Hamp-ene acid
    • Cheelox BF acid
    • Trilon BS
    • Celon A
    • Celon ATH
    • Chelest 3A
    • Questex 4H
    • (Ethylenedinitrilo)tetraacetic acid
    • Chemcolox 340
    • Acide edetique
    • Acido edetico
    • Universne acid
    • EDTA (chelating agent)
    • Dissolvine E
    • Vinkeil 100
    • Nullapon B acid
    • Nullapon bf acid
    • Nervanaid B acid
    • Perma kleer 50 acid
    • Clewat TAA
    • Ethylenedinitrilotetraacetic acid
    • Acidum edeticum
    • Caswell No. 438
    • Versenate
    • ICRF 185
    • Calcium disodium versenate
    • Ethylenebisiminodiacetic acid
    • Ethylenediamine-N,N,N',N'-tetraacetic acid
    • SEQ 100
    • YD 30
    • Disodium EDTA
    • CCRIS 946
    • Chelaton 3
    • Ethylenebis(iminodiacetic acid)
    • HSDB 809
    • Acide ethylenediaminetetracetique
    • ETHYLENEDIAMINE TETRAACETIC ACID
    • Cheladrate
    • Edetate calcium
    • Edetate disodium
    • Acide edetique [INN-French]
    • Acido edetico [INN-Spanish]
    • Acidum edeticum [INN-Latin]
    • Acetic acid, (ethylenedinitrilo)tetra-
    • EPA Pesticide Chemical Code 039101
    • Ethylenediaminetetraacetate
    • Kyselina ethylendiamintetraoctova
    • Tricon bw
    • Acid, Edetic
    • AI3-17181
    • H4edta
    • 3,6-Diazaoctanedioic acid, 3,6-bis(carboxymethyl)-
    • 470462-56-7
    • Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-
    • EINECS 200-449-4
    • 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid
    • UNII-9G34HU7RV0
    • MFCD00003541
    • Edetate
    • BRN 1716295
    • Edta disodium
    • 9G34HU7RV0
    • Disodium edetate
    • Disodium versene
    • Endrate disodium
    • Sodium versenate
    • Edetic acid disodium salt
    • Kyselina ethylendiamintetraoctova [Czech]
    • Acetic acid, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetrakis-
    • Acide ethylenediaminetetracetique [French]
    • DTXSID6022977
    • Metaquest B
    • N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine)
    • CHEBI:42191
    • Kiresuto B
    • Chelaplex III
    • Diso-Tate
    • Titriplex III
    • Chelaton III
    • Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-
    • N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)
    • Versene NA
    • Triplex III
    • Disodium versenate
    • Edathamil disodium
    • Trilon BD
    • Versene Na2
    • Disodium sequestrene
    • Disodium tetracemate
    • EDTA disodium salt
    • EDTA, ion(4-)
    • CHEMBL858
    • Sequestrene sodium 2
    • 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetic acid
    • {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
    • Disodium salt of EDTA
    • ethylenediamine tetracetic acid
    • DTXCID902977
    • Perma Kleer Di Crystals
    • (ethylenedinitrilo)tetraacetic acid, ion(4-)
    • Calcium disodium versenate (TN)
    • ethylene-diamine tetraacetic acid
    • 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid
    • EC 200-449-4
    • 2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetic acid

  • Applications

    Edetic Acid (CAS 60-00-4) is a versatile chelating agent widely used to bind metal ions and improve stability in a range of formulations. Key applications include: in household and industrial cleaning products as a water-softening and stabilizing additive; in cosmetics and personal care to preserve color and product integrity; in pharmaceuticals and laboratory formulations as a chelating agent and stabilizer; in food processing as a sequestrant to limit metal-catalyzed oxidation; in industrial manufacturing and metal finishing baths to control metal ion content; in polymers and plastics processing to stabilize formulations against metal-catalyzed degradation; in agriculture as a source of chelated micronutrients in fertilizers; and in water treatment to prevent scale and corrosion.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.08
    methanol 0.62
    isopropanol 0.02
    water 2.1
    ethyl acetate 0.01
    n-propanol 0.05
    acetone 0.01
    n-butanol 0.02
    acetonitrile 0.01
    DMF 5.54
    toluene 0.01
    isobutanol 0.02
    1,4-dioxane 0.01
    methyl acetate 0.02
    THF 0.04
    2-butanone 0.03
    n-pentanol 0.01
    sec-butanol 0.02
    n-hexane 0.0
    ethylene glycol 0.52
    NMP 17.24
    cyclohexane 0.0
    DMSO 8.84
    n-butyl acetate 0.02
    n-octanol 0.01
    chloroform 0.01
    n-propyl acetate 0.01
    acetic acid 0.29
    dichloromethane 0.02
    cyclohexanone 0.06
    propylene glycol 0.47
    isopropyl acetate 0.01
    DMAc 5.69
    2-ethoxyethanol 0.11
    isopentanol 0.01
    n-heptane 0.01
    ethyl formate 0.03
    1,2-dichloroethane 0.01
    n-hexanol 0.02
    2-methoxyethanol 0.66
    isobutyl acetate 0.0
    tetrachloromethane 0.01
    n-pentyl acetate 0.01
    transcutol 0.27
    n-heptanol 0.02
    ethylbenzene 0.01
    MIBK 0.01
    2-propoxyethanol 0.2
    tert-butanol 0.02
    MTBE 0.01
    2-butoxyethanol 0.1
    propionic acid 0.19
    o-xylene 0.02
    formic acid 5.16
    diethyl ether 0.01
    m-xylene 0.01
    p-xylene 0.01
    chlorobenzene 0.0
    dimethyl carbonate 0.1
    n-octane 0.0
    formamide 4.31
    cyclopentanone 0.13
    2-pentanone 0.02
    anisole 0.01
    cyclopentyl methyl ether 0.04
    gamma-butyrolactone 0.3
    1-methoxy-2-propanol 0.4
    pyridine 0.04
    3-pentanone 0.04
    furfural 0.57
    n-dodecane 0.0
    diethylene glycol 0.38
    diisopropyl ether 0.0
    tert-amyl alcohol 0.04
    acetylacetone 0.03
    n-hexadecane 0.0
    acetophenone 0.05
    methyl propionate 0.08
    isopentyl acetate 0.01
    trichloroethylene 0.03
    n-nonanol 0.01
    cyclohexanol 0.02
    benzyl alcohol 0.02
    2-ethylhexanol 0.01
    isooctanol 0.01
    dipropyl ether 0.02
    1,2-dichlorobenzene 0.01
    ethyl lactate 0.1
    propylene carbonate 0.1
    n-methylformamide 1.79
    2-pentanol 0.01
    n-pentane 0.0
    1-propoxy-2-propanol 0.19
    1-methoxy-2-propyl acetate 0.09
    2-(2-methoxypropoxy) propanol 0.21
    mesitylene 0.01
    ε-caprolactone 0.09
    p-cymene 0.02
    epichlorohydrin 0.07
    1,1,1-trichloroethane 0.0
    2-aminoethanol 0.77
    morpholine-4-carbaldehyde 1.64
    sulfolane 5.16
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.02
    n-hexyl acetate 0.01
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.12
    sec-butyl acetate 0.01
    tert-butyl acetate 0.01
    decalin 0.0
    glycerin 2.97
    diglyme 0.24
    acrylic acid 0.46
    isopropyl myristate 0.0
    n-butyric acid 0.08
    acetyl acetate 0.01
    di(2-ethylhexyl) phthalate 0.02
    ethyl propionate 0.02
    nitromethane 0.29
    1,2-diethoxyethane 0.01
    benzonitrile 0.01
    trioctyl phosphate 0.01
    1-bromopropane 0.01
    gamma-valerolactone 0.44
    n-decanol 0.01
    triethyl phosphate 0.07
    4-methyl-2-pentanol 0.01
    propionitrile 0.01
    vinylene carbonate 0.12
    1,1,2-trichlorotrifluoroethane 0.95
    DMS 0.04
    cumene 0.01
    2-octanol 0.01
    2-hexanone 0.01
    octyl acetate 0.01
    limonene 0.02
    1,2-dimethoxyethane 0.07
    ethyl orthosilicate 0.05
    tributyl phosphate 0.02
    diacetone alcohol 0.1
    N,N-dimethylaniline 0.06
    acrylonitrile 0.05
    aniline 0.03
    1,3-propanediol 0.19
    bromobenzene 0.0
    dibromomethane 0.01
    1,1,2,2-tetrachloroethane 0.04
    2-methyl-cyclohexyl acetate 0.03
    tetrabutyl urea 0.07
    diisobutyl methanol 0.01
    2-phenylethanol 0.02
    styrene 0.0
    dioctyl adipate 0.01
    dimethyl sulfate 1.08
    ethyl butyrate 0.03
    methyl lactate 0.58
    butyl lactate 0.09
    diethyl carbonate 0.02
    propanediol butyl ether 0.17
    triethyl orthoformate 0.04
    p-tert-butyltoluene 0.02
    methyl 4-tert-butylbenzoate 0.11
    morpholine 0.03
    tert-butylamine 0.01
    n-dodecanol 0.0
    dimethoxymethane 0.25
    ethylene carbonate 0.04
    cyrene 0.46
    2-ethoxyethyl acetate 0.02
    2-ethylhexyl acetate 0.01
    1,2,4-trichlorobenzene 0.01
    4-methylpyridine 0.04
    dibutyl ether 0.0
    2,6-dimethyl-4-heptanol 0.01
    DEF 0.25
    dimethyl isosorbide 0.41
    tetrachloroethylene 0.04
    eugenol 0.12
    triacetin 0.05
    span 80 0.11
    1,4-butanediol 0.04
    1,1-dichloroethane 0.0
    2-methyl-1-pentanol 0.01
    methyl formate 0.49
    2-methyl-1-butanol 0.02
    n-decane 0.0
    butyronitrile 0.01
    3,7-dimethyl-1-octanol 0.01
    1-chlorooctane 0.0
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.03
    tetrahydropyran 0.01
    tert-amyl methyl ether 0.02
    2,5,8-trioxanonane 0.19
    1-hexene 0.01
    2-isopropoxyethanol 0.03
    2,2,2-trifluoroethanol 0.3
    methyl butyrate 0.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction