Edetate Disodium

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  • Identifiers

    CAS number
    6381-92-6

    Molecular formula
    C10H18N2Na2O10

    SMILES
    C(CN(CC(=O)O)CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].O.O.[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 67.07%
    Sweet 37.22%
    Savory 26.45%
    Fishy 18.93%
    Alcoholic 18.3%
    Meaty 15.95%
    Clean 15.5%
    Cooked 14.67%
    Oily 14.61%
    Milky 14.32%

     

    Flavor
    Odorless 65.26%
    Bitter 34.9%
    Mild 34.38%
    Bland 32.75%
    Very mild 26.3%
    Yeast 22.35%
    Sweet-like 22.06%
    Faint 20.42%
    Bread crust 19.31%
    Nitrile 19.22%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    0.83 (strong acid)

    Molecular weight
    372.24 g/mol

    Melting point expt.

    • 240 undefined
    • MP: 242 °C /EDTA disodium dihydrate/

    Boiling point

    • 252 undefined

    Flash point

    • 282.81 ˚C est.
    • Flash point is> 100 °C,

  • Synonyms

    • Disodium edetate dihydrate
    • Edetate disodium
    • 6381-92-6
    • Endrate
    • EDTA disodium salt
    • Disodium edetate
    • Sodium versenate
    • Chelest f-na
    • Disodium EDTA dihydrate
    • Edetate disodium dihydrate
    • Ins no.386
    • Disodium ethylenediaminetetraacetate dihydrate
    • Ins-386
    • UNII-7FLD91C86K
    • EDTA disodium dihydrate
    • Edta disodium
    • 7FLD91C86K
    • Titriplex III
    • Disodium EDTA
    • EDTA DISODIUM SALT DIHYDRATE
    • Disodium edetate hydrate
    • Edetate disodium (USP)
    • Edetate disodium [USP]
    • Disodium (ethylenedinitrilo)tetraacetate dihydrate
    • NSC-759604
    • E-386
    • Ethylenediaminetetraacetic acid disoium salt dihydrate
    • NSC 759604
    • Versene NA
    • Endrate (TN)
    • disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate;dihydrate
    • EDTA-Na2
    • EDETATE DISODIUM (II)
    • EDETATE DISODIUM [II]
    • Ethylenediaminetetraacetate
    • Na2H2EDTA.2H2O
    • EDETATE DISODIUM (USP-RS)
    • EDETATE DISODIUM [USP-RS]
    • Disotate
    • Edta disodium salt anhydrous
    • (ETHYLENEDINITRILO) TETRAACETIC ACID DISODIUM SALT DIHYDRATE
    • DISODIUM EDETATE (EP IMPURITY)
    • DISODIUM EDETATE [EP IMPURITY]
    • Edetate disodium salt dihydrate
    • DISODIUM EDETATE (EP MONOGRAPH)
    • DISODIUM EDETATE [EP MONOGRAPH]
    • EDETATE DISODIUM (USP MONOGRAPH)
    • EDETATE DISODIUM [USP MONOGRAPH]
    • GLYCINE, N,N'-1,2-ETHANEDIYLBIS N-(CARBOXYMETHYL)-, DISODIUM SALT, DIHYDRATE
    • CHEBI:64734
    • CHEBI:64758
    • Disodium ethylenediaminetetraacetate
    • NSC-2760
    • EDETATE DISODIUM ANHYDROUS (II)
    • Clinplant
    • Ethylenediamine-N,N,N',N'-tetraacetic Acid Disodium Dihydrate
    • Dinatrii edetas
    • Edeta BD
    • Disodium edetate; Disodium dihydrogen (ethylenedinitrilo)tetraacetate dihydrate: EDTA disodium hydrate
    • Dissolvine NA2-P
    • disodium 2,2',2'',2'''-(ethane-1,2-diyldiammonio)tetraacetate--water (1/2)
    • VERSENE NA2 Crystals
    • disodium edetate, dihydrate
    • DISODIUM EDTA [FCC]
    • DISODIUM EDTA [VANDF]
    • CHEMBL3989507
    • Disodium dihydrogen ethylenediaminetetraacetate dihydrate
    • DTXSID5049576
    • EDETATE DISODIUM [VANDF]
    • DISODIUM EDETATE [WHO-IP]
    • Disodium edetate hydrate (JP17)
    • Ethylenedinitrilotetraacetate Disodium
    • ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT, DIHYDRATE
    • AKOS024386277
    • DISODIUM EDETATE HYDRATE [JAN]
    • EDETATE DISODIUM [ORANGE BOOK]
    • DISODIUM EDETATE DIHYDRATE [WHO-DD]
    • Disodium ethylenediaminetetraacetatedihydrate
    • D01802
    • EN300-103508
    • EDTA, disodium salt, dihydrate, for molecular biology
    • ethylene-diaminetetraacetic acid disodium salt dihydrate
    • ethylenediamine-tetraacetic acid disodium salt dihydrate
    • ethylenediaminetetra-acetic acid disodium salt dihydrate
    • Ethylenediaminetetraacetic acid, disodium salt dihydrate, ACS reagent
    • disodium 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate dihydrate
    • Ethylenediaminetetraacetic acid disodium salt dihydrate, Molecular biology grade
    • Ethylenediaminetetraacetic acid, disodium salt dihydrate, biochemical grade 98.5% - 101.5%
    • Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt, dihydrate
    • 205-358-3

  • Applications

    Edetate Disodium (CAS 6381-92-6) is a chelating agent widely used across industries to stabilize formulations by binding metal ions. In detergents and household cleaners, it improves cleaning performance and prevents scale formation; in cosmetics and personal care, it acts as a stabilizer and extends shelf life; in food processing, it is used as a sequestrant to limit metal-catalyzed changes and help preserve color; in polymers/plastics, it helps prevent metal-catalyzed oxidation and color degradation; in pharmaceutical formulations, it serves as a chelating/stabilizing aid to improve solution properties and durability; and in coatings/inks, it reduces unwanted metal interactions with pigments and binders.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.33
    methanol 2.75
    isopropanol 0.06
    water 3.43
    ethyl acetate 0.04
    n-propanol 0.16
    acetone 0.1
    n-butanol 0.07
    acetonitrile 0.04
    DMF 22.71
    toluene 0.03
    isobutanol 0.06
    1,4-dioxane 0.02
    methyl acetate 0.08
    THF 0.16
    2-butanone 0.13
    n-pentanol 0.02
    sec-butanol 0.07
    n-hexane 0.0
    ethylene glycol 1.68
    NMP 45.73
    cyclohexane 0.0
    DMSO 32.14
    n-butyl acetate 0.05
    n-octanol 0.02
    chloroform 0.04
    n-propyl acetate 0.03
    acetic acid 1.31
    dichloromethane 0.08
    cyclohexanone 0.23
    propylene glycol 1.48
    isopropyl acetate 0.02
    DMAc 16.06
    2-ethoxyethanol 0.33
    isopentanol 0.03
    n-heptane 0.01
    ethyl formate 0.16
    1,2-dichloroethane 0.06
    n-hexanol 0.04
    2-methoxyethanol 2.46
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.02
    transcutol 0.74
    n-heptanol 0.03
    ethylbenzene 0.02
    MIBK 0.04
    2-propoxyethanol 0.52
    tert-butanol 0.05
    MTBE 0.01
    2-butoxyethanol 0.2
    propionic acid 0.62
    o-xylene 0.07
    formic acid 16.42
    diethyl ether 0.02
    m-xylene 0.04
    p-xylene 0.02
    chlorobenzene 0.02
    dimethyl carbonate 0.33
    n-octane 0.0
    formamide 16.54
    cyclopentanone 0.55
    2-pentanone 0.08
    anisole 0.04
    cyclopentyl methyl ether 0.1
    gamma-butyrolactone 1.13
    1-methoxy-2-propanol 1.12
    pyridine 0.18
    3-pentanone 0.13
    furfural 2.31
    n-dodecane 0.0
    diethylene glycol 1.08
    diisopropyl ether 0.0
    tert-amyl alcohol 0.08
    acetylacetone 0.13
    n-hexadecane 0.0
    acetophenone 0.16
    methyl propionate 0.25
    isopentyl acetate 0.04
    trichloroethylene 0.15
    n-nonanol 0.02
    cyclohexanol 0.05
    benzyl alcohol 0.09
    2-ethylhexanol 0.03
    isooctanol 0.02
    dipropyl ether 0.05
    1,2-dichlorobenzene 0.03
    ethyl lactate 0.27
    propylene carbonate 0.32
    n-methylformamide 7.56
    2-pentanol 0.03
    n-pentane 0.0
    1-propoxy-2-propanol 0.39
    1-methoxy-2-propyl acetate 0.23
    2-(2-methoxypropoxy) propanol 0.46
    mesitylene 0.02
    ε-caprolactone 0.28
    p-cymene 0.03
    epichlorohydrin 0.3
    1,1,1-trichloroethane 0.02
    2-aminoethanol 2.34
    morpholine-4-carbaldehyde 5.06
    sulfolane 13.84
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.05
    n-hexyl acetate 0.03
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.29
    sec-butyl acetate 0.02
    tert-butyl acetate 0.04
    decalin 0.0
    glycerin 7.13
    diglyme 0.6
    acrylic acid 1.61
    isopropyl myristate 0.01
    n-butyric acid 0.28
    acetyl acetate 0.03
    di(2-ethylhexyl) phthalate 0.05
    ethyl propionate 0.06
    nitromethane 1.63
    1,2-diethoxyethane 0.03
    benzonitrile 0.04
    trioctyl phosphate 0.03
    1-bromopropane 0.02
    gamma-valerolactone 1.78
    n-decanol 0.01
    triethyl phosphate 0.14
    4-methyl-2-pentanol 0.01
    propionitrile 0.06
    vinylene carbonate 0.46
    1,1,2-trichlorotrifluoroethane 2.71
    DMS 0.1
    cumene 0.02
    2-octanol 0.01
    2-hexanone 0.03
    octyl acetate 0.02
    limonene 0.04
    1,2-dimethoxyethane 0.27
    ethyl orthosilicate 0.09
    tributyl phosphate 0.05
    diacetone alcohol 0.28
    N,N-dimethylaniline 0.15
    acrylonitrile 0.22
    aniline 0.11
    1,3-propanediol 0.67
    bromobenzene 0.01
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.13
    2-methyl-cyclohexyl acetate 0.06
    tetrabutyl urea 0.15
    diisobutyl methanol 0.02
    2-phenylethanol 0.07
    styrene 0.02
    dioctyl adipate 0.03
    dimethyl sulfate 2.93
    ethyl butyrate 0.08
    methyl lactate 1.57
    butyl lactate 0.19
    diethyl carbonate 0.05
    propanediol butyl ether 0.33
    triethyl orthoformate 0.08
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.26
    morpholine 0.12
    tert-butylamine 0.02
    n-dodecanol 0.01
    dimethoxymethane 0.94
    ethylene carbonate 0.16
    cyrene 1.3
    2-ethoxyethyl acetate 0.05
    2-ethylhexyl acetate 0.03
    1,2,4-trichlorobenzene 0.05
    4-methylpyridine 0.17
    dibutyl ether 0.01
    2,6-dimethyl-4-heptanol 0.02
    DEF 0.77
    dimethyl isosorbide 0.92
    tetrachloroethylene 0.13
    eugenol 0.29
    triacetin 0.12
    span 80 0.25
    1,4-butanediol 0.13
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.02
    methyl formate 2.46
    2-methyl-1-butanol 0.06
    n-decane 0.0
    butyronitrile 0.03
    3,7-dimethyl-1-octanol 0.02
    1-chlorooctane 0.01
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.08
    tetrahydropyran 0.02
    tert-amyl methyl ether 0.04
    2,5,8-trioxanonane 0.5
    1-hexene 0.01
    2-isopropoxyethanol 0.08
    2,2,2-trifluoroethanol 1.07
    methyl butyrate 0.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction