Difluoromethane

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  • Identifiers

    CAS number
    75-10-5

    Molecular formula
    CH2F2

    SMILES
    C(F)F

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fishy 53.69%
    Cheesy 45.56%
    Odorless 41.81%
    Ripe 38.77%
    Meaty 29.44%
    Sulfurous 26.38%
    Pungent 22.58%
    Fermented 21.68%
    Alcoholic 21.53%
    Oily 21.23%

     

    Flavor
    Fishy 38.12%
    Sulfurous 29.7%
    Ammoniacal 29.02%
    Odorless 26.71%
    Meaty 26.52%
    Sulfury 25.71%
    Egg 22.44%
    Onion 22.12%
    Rotten 20.46%
    Roasted 19.64%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    4.18 (weak acid)

    Molecular weight
    52.023 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -136.8 °C

    Boiling point

    • -51.65 °C

    Flash point

    • -19.62 ˚C est.

    Solubility expt.

    • In water, 0.44% at 25 °C
    • Soluble in ethanol

  • Synonyms

    • DIFLUOROMETHANE
    • 75-10-5
    • Methane, difluoro-
    • Methylene difluoride
    • Freon 32
    • Methylene fluoride
    • Genetron 32
    • Carbon fluoride hydride
    • CH2F2
    • HFC-32
    • R 32 (refrigerant)
    • Difluormethan
    • Khladon 32 [Russian]
    • HFC 32
    • Khladon 32
    • Freon-32
    • Difluoro-Methane
    • EINECS 200-839-4
    • CF2H2
    • UN3252
    • UNII-77JW9K722X
    • CHEBI:47855
    • 77JW9K722X
    • GENETRON-32
    • ECOLO ACE-32
    • DIFLUOROMETHANE [MI]
    • 2154-59-8
    • DTXSID6029597
    • HSDB 8300
    • EC 200-839-4
    • Khladon 32 (Russian)
    • Methane, difluoro
    • MFCD00039283
    • bis(fluoranyl)methane
    • Carbon fluoride (CF2)
    • Difluoromethane, 99.7%
    • Difluoromethane (FC-32)
    • ECOLO ACE 32
    • HFC32
    • REFRIGERANT GAS R-32
    • CHEMBL115186
    • DTXCID409597
    • DTXSID901045808
    • AKOS009075807
    • Difluoromethane or Refrigerant gas R 32
    • METHYL, DIFLUORO-(7CI,8CI,9CI)
    • R 32
    • R-32
    • NS00003559
    • A838325
    • Q421742
    • Difluoromethane or Refrigerant gas R 32 [UN3252] [Flammable gas]
    • 200-839-4

  • Applications

    Difluoromethane (CAS 75-10-5) is primarily used as a refrigerant in air conditioning and heat pump systems (commonly sold as R-32). It also serves as a blowing agent for rigid polyurethane and polyisocyanurate foams, contributing to insulation performance with a relatively low global warming potential compared with some traditional blowing agents. Additionally, it is employed as a component in low-GWP refrigerant blends to meet regulatory targets and reduce environmental impact. In specialized fluorinated formulations, it may be evaluated as a processing solvent or cleaning medium, although such uses are limited and depend on formulation requirements and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 215.48
    methanol 419.06
    isopropanol 143.37
    water 308.71
    ethyl acetate 77.88
    n-propanol 114.07
    acetone 279.74
    n-butanol 81.78
    acetonitrile 410.69
    DMF 736.64
    toluene 16.23
    isobutanol 75.09
    1,4-dioxane 149.57
    methyl acetate 152.17
    THF 141.99
    2-butanone 128.58
    n-pentanol 42.28
    sec-butanol 83.13
    n-hexane 7.35
    ethylene glycol 174.48
    NMP 445.0
    cyclohexane 15.71
    DMSO 691.23
    n-butyl acetate 29.66
    n-octanol 25.63
    chloroform 125.9
    n-propyl acetate 42.23
    acetic acid 449.78
    dichloromethane 186.86
    cyclohexanone 107.14
    propylene glycol 85.14
    isopropyl acetate 33.8
    DMAc 530.13
    2-ethoxyethanol 126.08
    isopentanol 54.21
    n-heptane 10.0
    ethyl formate 92.82
    1,2-dichloroethane 121.29
    n-hexanol 27.04
    2-methoxyethanol 287.07
    isobutyl acetate 18.2
    tetrachloromethane 32.88
    n-pentyl acetate 22.51
    transcutol 183.95
    n-heptanol 18.37
    ethylbenzene 10.84
    MIBK 31.58
    2-propoxyethanol 69.21
    tert-butanol 139.71
    MTBE 63.4
    2-butoxyethanol 43.83
    propionic acid 156.1
    o-xylene 22.66
    formic acid 446.26
    diethyl ether 80.52
    m-xylene 14.0
    p-xylene 17.2
    chlorobenzene 29.68
    dimethyl carbonate 57.93
    n-octane 4.18
    formamide 633.32
    cyclopentanone 138.22
    2-pentanone 69.73
    anisole 41.1
    cyclopentyl methyl ether 58.04
    gamma-butyrolactone 173.85
    1-methoxy-2-propanol 144.96
    pyridine 138.19
    3-pentanone 73.09
    furfural 193.81
    n-dodecane 3.44
    diethylene glycol 101.18
    diisopropyl ether 17.48
    tert-amyl alcohol 87.25
    acetylacetone 76.94
    n-hexadecane 3.65
    acetophenone 47.33
    methyl propionate 90.8
    isopentyl acetate 22.42
    trichloroethylene 168.24
    n-nonanol 21.26
    cyclohexanol 65.71
    benzyl alcohol 44.59
    2-ethylhexanol 18.2
    isooctanol 15.4
    dipropyl ether 33.75
    1,2-dichlorobenzene 34.49
    ethyl lactate 35.24
    propylene carbonate 66.13
    n-methylformamide 408.1
    2-pentanol 47.89
    n-pentane 13.05
    1-propoxy-2-propanol 46.58
    1-methoxy-2-propyl acetate 34.41
    2-(2-methoxypropoxy) propanol 58.54
    mesitylene 12.14
    ε-caprolactone 85.5
    p-cymene 13.15
    epichlorohydrin 146.48
    1,1,1-trichloroethane 68.69
    2-aminoethanol 171.48
    morpholine-4-carbaldehyde 316.16
    sulfolane 217.52
    2,2,4-trimethylpentane 6.16
    2-methyltetrahydrofuran 94.68
    n-hexyl acetate 30.48
    isooctane 3.26
    2-(2-butoxyethoxy)ethanol 59.9
    sec-butyl acetate 20.5
    tert-butyl acetate 30.07
    decalin 5.2
    glycerin 156.13
    diglyme 141.74
    acrylic acid 199.85
    isopropyl myristate 13.89
    n-butyric acid 104.7
    acetyl acetate 46.7
    di(2-ethylhexyl) phthalate 18.25
    ethyl propionate 40.04
    nitromethane 644.5
    1,2-diethoxyethane 46.41
    benzonitrile 58.64
    trioctyl phosphate 13.3
    1-bromopropane 53.99
    gamma-valerolactone 187.4
    n-decanol 16.24
    triethyl phosphate 22.64
    4-methyl-2-pentanol 21.2
    propionitrile 140.93
    vinylene carbonate 75.21
    1,1,2-trichlorotrifluoroethane 157.03
    DMS 38.94
    cumene 9.94
    2-octanol 14.07
    2-hexanone 39.06
    octyl acetate 19.28
    limonene 20.95
    1,2-dimethoxyethane 181.57
    ethyl orthosilicate 20.17
    tributyl phosphate 16.56
    diacetone alcohol 54.11
    N,N-dimethylaniline 42.51
    acrylonitrile 218.04
    aniline 54.82
    1,3-propanediol 157.91
    bromobenzene 22.92
    dibromomethane 105.94
    1,1,2,2-tetrachloroethane 116.68
    2-methyl-cyclohexyl acetate 21.99
    tetrabutyl urea 32.17
    diisobutyl methanol 14.48
    2-phenylethanol 27.63
    styrene 15.72
    dioctyl adipate 25.26
    dimethyl sulfate 116.88
    ethyl butyrate 32.23
    methyl lactate 72.64
    butyl lactate 25.11
    diethyl carbonate 25.7
    propanediol butyl ether 45.84
    triethyl orthoformate 25.25
    p-tert-butyltoluene 12.8
    methyl 4-tert-butylbenzoate 45.99
    morpholine 203.57
    tert-butylamine 84.94
    n-dodecanol 13.48
    dimethoxymethane 186.8
    ethylene carbonate 56.17
    cyrene 59.33
    2-ethoxyethyl acetate 33.73
    2-ethylhexyl acetate 17.9
    1,2,4-trichlorobenzene 43.97
    4-methylpyridine 96.05
    dibutyl ether 22.99
    2,6-dimethyl-4-heptanol 14.48
    DEF 162.38
    dimethyl isosorbide 72.65
    tetrachloroethylene 98.23
    eugenol 46.23
    triacetin 47.55
    span 80 41.87
    1,4-butanediol 60.57
    1,1-dichloroethane 94.19
    2-methyl-1-pentanol 31.64
    methyl formate 245.79
    2-methyl-1-butanol 56.79
    n-decane 5.19
    butyronitrile 96.13
    3,7-dimethyl-1-octanol 22.14
    1-chlorooctane 14.82
    1-chlorotetradecane 7.11
    n-nonane 5.42
    undecane 3.98
    tert-butylcyclohexane 4.49
    cyclooctane 5.01
    cyclopentanol 83.32
    tetrahydropyran 86.55
    tert-amyl methyl ether 49.48
    2,5,8-trioxanonane 102.8
    1-hexene 17.39
    2-isopropoxyethanol 66.11
    2,2,2-trifluoroethanol 216.22
    methyl butyrate 57.35

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction