Diethylene glycol

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  • Identifiers

    CAS number
    111-46-6

    Molecular formula
    C4H10O3

    SMILES
    C(COCCO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 65.6%
    Alcoholic 40.23%
    Ethereal 27.84%
    Fishy 22.24%
    Solvent 19.69%
    Sweet 16.39%
    Oily 15.76%
    Clean 15.22%
    Fresh 12.56%
    Musty 12.32%

     

    Flavor
    Odorless 54.54%
    Sweet 53.01%
    Alcoholic 43.86%
    Bitter 40.93%
    Musty 34.44%
    Sweet-like 27.71%
    Pungent 27.26%
    Very slight 25.8%
    Cauliflower 22.58%
    Fruit 22.48%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.3

    pKa est.
    7.23 (neutral)

    Molecular weight
    106.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 14 °F (NTP, 1992)
    • -10.4 °C
    • -6.5 °C

    Boiling point

    • 473 °F at 760 mmHg (NTP, 1992)
    • 245.8 °C
    • 245 °C

    Flash point

    • 125.21 ˚C est.
    • 290 °F (NTP, 1992)
    • 124 °C
    • 280 to 290 °F (open cup) /from table/
    • 124 °C c.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
    • Immiscible with toluene, petroleum, linseed or castor oil
    • Soluble in chloroform
    • Soluble in ethanol, ethyl ether
    • Miscible with alcohol, ether, acetone, ethylene glycol; practically insoluble in benzene, carbon tetrachloride
    • Solubility in water: miscible

  • Synonyms

    • DIETHYLENE GLYCOL
    • 111-46-6
    • 2,2'-Oxydiethanol
    • Diglycol
    • 2-(2-Hydroxyethoxy)ethanol
    • 2,2'-Oxybisethanol
    • Diethylenglykol
    • Digol
    • 2-Hydroxyethyl ether
    • Bis(2-hydroxyethyl) ether
    • DI(HYDROXYETHYL)ETHER
    • Ethanol, 2,2'-oxybis-
    • Digenos
    • Dicol
    • Brecolane ndg
    • Glycol ether
    • Deactivator E
    • Dissolvant APV
    • Ethylene diglycol
    • 2,2'-Oxyethanol
    • 2,2'-Oxybis(ethan-1-ol)
    • 1,5-Dihydroxy-3-oxapentane
    • Diethyleneglycol
    • TL4N
    • 3-Oxapentane-1,5-diol
    • Dihydroxydiethyl ether
    • 2,2'-0xydiethanol
    • Bis(beta-hydroxyethyl) ether
    • 2,2'-Dihydroxydiethyl ether
    • Ethanol, 2,2'-oxydi-
    • 2-(2-hydroxyethoxy)ethan-1-ol
    • 2,2'-Dihydroxyethyl ether
    • beta,beta'-Dihydroxydiethyl ether
    • Deactivator H
    • Caswell No. 338A
    • 3-Oxapentamethylene-1,5-diol
    • 3-Oxa-1,5-pentanediol
    • DEG
    • HSDB 69
    • MFCD00002882
    • NSC 36391
    • CCRIS 2193
    • DTXSID8020462
    • bis(2-hydroxyethyl)ether
    • EINECS 203-872-2
    • EPA Pesticide Chemical Code 338200
    • BRN 0969209
    • CHEBI:46807
    • AI3-08416
    • UNII-61BR964293
    • 2,2'-Oxybis[Ethanol]
    • Diethylene Glycol (DEG)
    • NSC-36391
    • bis-(2-hydroxyethyl)ether
    • 2,2-Di(hydroxyethyl) ether
    • DTXCID20462
    • DIETHYLENE GLYCOL ETHER
    • Bis(.beta.-hydroxyethyl) ether
    • 61BR964293
    • EC 203-872-2
    • 2,2-OXYDI(ETHAN-1-OL)
    • 4-01-00-02390 (Beilstein Handbook Reference)
    • .beta.,.beta.'-Dihydroxydiethyl ether
    • 2,2'-oxybis(ethanol)
    • 105400-04-2
    • 149626-00-6
    • Diethylenglykol [Czech]
    • DIETHYLENE GLYCOL (USP-RS)
    • DIETHYLENE GLYCOL [USP-RS]
    • diethylene-glycol
    • 1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, 7,16-bis(1-oxodecyl)-
    • CAS-111-46-6
    • Chromate(2-), 2-5-(2,5-dichlorophenyl)azo-2-(hydroxy-.kappa.O)phenylmethyleneamino-.kappa.Nbenzoato(
    • GLYCEROL IMPURITY A (EP IMPURITY)
    • GLYCEROL IMPURITY A [EP IMPURITY]
    • OH-PEG2-OH
    • diehyleneglycol
    • Diglykol
    • Diethyleneglykol
    • diethyene glycol
    • 2,2'-Oxydiethanol; Etofenamate Imp. F (EP); Etofenamate Impurity F; Glycerol Impurity A
    • di-ethylene glycol
    • PEG2000
    • Glicole dietilenico
    • 2-hydroxyethylether
    • 1KA
    • Diethylenglykol rein
    • Ethanol,2'-oxydi-
    • 2,2'-Ossidietanolo
    • 2,2'-Oxibesethanol
    • Ethanol,2'-oxybis-
    • Glycol hydroxyethyl ether
    • Diethylene glycol, 99%
    • 3-Oxypentane-1,5-diol
    • 2,2-OXYBISETHANOL
    • SCHEMBL1462
    • HO(CH2CH2O)2H
    • 2,2-Oxybis(ethan-1-ol)
    • WLN: Q2O2Q
    • 2-HYDROXYETHOXYETHANOL
    • MLS001055330
    • BIDD:ER0301
    • DIETHYLENE GLYCOL [MI]
    • 2-(2-Hydroxy-ethoxy)-ethanol
    • PEG600
    • CHEMBL1235226
    • DIETHYLENE GLYCOL [HSDB]
    • HO(CH2)2O(CH2)2OH
    • 2-(2-hydroxyethoxyl)ethan-1-ol
    • MSK9049
    • PEG4000
    • PEG6000
    • Diethylene glycol, LR, >=99%
    • 3-OXA-1, 5-PENTANEDIOL
    • HMS2270G18
    • NSC32855
    • NSC32856
    • NSC35744
    • NSC35745
    • NSC35746
    • NSC36391
    • PEG35000
    • Tox21_201616
    • Tox21_300064
    • .beta.,.beta.'-Dihydroxyethyl ether
    • NSC-32855
    • NSC-32856
    • NSC-35744

  • Applications

    Diethylene glycol (CAS 111-46-6) is a diol widely used as a solvent and processing aid in various industries. Common applications include acting as a solvent for coatings, inks, dyes, and cleaners; functioning as a plasticizer for polymers such as polyvinyl chloride and cellulose-based resins; serving as a chemical intermediate for the production of polyesters, alkyd resins, and glycol ethers; acting as a humectant and processing solvent in cosmetics and personal care products; and supplying raw materials for the synthesis of glycol ethers and other polyol derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 154.53
    methanol 416.92
    isopropanol 65.8
    water 171.65
    ethyl acetate 18.75
    n-propanol 92.23
    acetone 36.51
    n-butanol 55.45
    acetonitrile 46.37
    DMF 330.81
    toluene 2.26
    isobutanol 41.2
    1,4-dioxane 96.07
    methyl acetate 30.61
    THF 93.07
    2-butanone 22.27
    n-pentanol 25.88
    sec-butanol 41.96
    n-hexane 1.58
    ethylene glycol 296.09
    NMP 296.02
    cyclohexane 5.92
    DMSO 461.99
    n-butyl acetate 13.39
    n-octanol 16.21
    chloroform 43.75
    n-propyl acetate 12.33
    acetic acid 324.13
    dichloromethane 65.13
    cyclohexanone 60.77
    propylene glycol 148.93
    isopropyl acetate 7.69
    DMAc 167.46
    2-ethoxyethanol 91.1
    isopentanol 21.73
    n-heptane 4.5
    ethyl formate 42.91
    1,2-dichloroethane 37.53
    n-hexanol 24.06
    2-methoxyethanol 241.77
    isobutyl acetate 6.14
    tetrachloromethane 8.88
    n-pentyl acetate 10.54
    transcutol 127.82
    n-heptanol 15.05
    ethylbenzene 1.93
    MIBK 5.15
    2-propoxyethanol 72.02
    tert-butanol 44.76
    MTBE 10.7
    2-butoxyethanol 41.53
    propionic acid 145.78
    o-xylene 3.96
    formic acid 462.98
    diethyl ether 14.54
    m-xylene 2.18
    p-xylene 2.82
    chlorobenzene 8.73
    dimethyl carbonate 16.69
    n-octane 1.68
    formamide 352.47
    cyclopentanone 77.44
    2-pentanone 12.59
    anisole 9.25
    cyclopentyl methyl ether 24.63
    gamma-butyrolactone 145.55
    1-methoxy-2-propanol 95.03
    pyridine 44.78
    3-pentanone 13.36
    furfural 145.21
    n-dodecane 1.42
    diethylene glycol 126.84
    diisopropyl ether 2.86
    tert-amyl alcohol 30.46
    acetylacetone 16.59
    n-hexadecane 1.49
    acetophenone 13.92
    methyl propionate 27.2
    isopentyl acetate 9.08
    trichloroethylene 47.89
    n-nonanol 14.34
    cyclohexanol 50.69
    benzyl alcohol 21.09
    2-ethylhexanol 12.45
    isooctanol 10.6
    dipropyl ether 14.73
    1,2-dichlorobenzene 12.45
    ethyl lactate 25.46
    propylene carbonate 57.2
    n-methylformamide 225.61
    2-pentanol 18.71
    n-pentane 2.57
    1-propoxy-2-propanol 44.01
    1-methoxy-2-propyl acetate 18.93
    2-(2-methoxypropoxy) propanol 38.92
    mesitylene 2.25
    ε-caprolactone 65.27
    p-cymene 4.43
    epichlorohydrin 73.61
    1,1,1-trichloroethane 11.9
    2-aminoethanol 251.16
    morpholine-4-carbaldehyde 231.41
    sulfolane 234.6
    2,2,4-trimethylpentane 1.4
    2-methyltetrahydrofuran 42.97
    n-hexyl acetate 15.41
    isooctane 0.69
    2-(2-butoxyethoxy)ethanol 50.84
    sec-butyl acetate 5.7
    tert-butyl acetate 7.64
    decalin 1.87
    glycerin 281.2
    diglyme 93.28
    acrylic acid 179.06
    isopropyl myristate 7.04
    n-butyric acid 86.24
    acetyl acetate 14.68
    di(2-ethylhexyl) phthalate 13.84
    ethyl propionate 12.34
    nitromethane 219.9
    1,2-diethoxyethane 20.21
    benzonitrile 18.84
    trioctyl phosphate 11.07
    1-bromopropane 12.66
    gamma-valerolactone 141.65
    n-decanol 10.66
    triethyl phosphate 14.76
    4-methyl-2-pentanol 6.74
    propionitrile 34.82
    vinylene carbonate 62.85
    1,1,2-trichlorotrifluoroethane 150.58
    DMS 19.74
    cumene 2.31
    2-octanol 8.67
    2-hexanone 9.08
    octyl acetate 10.45
    limonene 7.69
    1,2-dimethoxyethane 83.15
    ethyl orthosilicate 12.71
    tributyl phosphate 12.1
    diacetone alcohol 19.99
    N,N-dimethylaniline 10.85
    acrylonitrile 62.66
    aniline 18.12
    1,3-propanediol 182.03
    bromobenzene 5.33
    dibromomethane 31.95
    1,1,2,2-tetrachloroethane 46.07
    2-methyl-cyclohexyl acetate 13.83
    tetrabutyl urea 21.34
    diisobutyl methanol 7.37
    2-phenylethanol 17.18
    styrene 2.81
    dioctyl adipate 17.43
    dimethyl sulfate 49.41
    ethyl butyrate 14.78
    methyl lactate 50.79
    butyl lactate 21.62
    diethyl carbonate 12.44
    propanediol butyl ether 47.53
    triethyl orthoformate 15.72
    p-tert-butyltoluene 4.5
    methyl 4-tert-butylbenzoate 22.83
    morpholine 129.7
    tert-butylamine 23.17
    n-dodecanol 8.55
    dimethoxymethane 63.05
    ethylene carbonate 48.68
    cyrene 54.46
    2-ethoxyethyl acetate 16.29
    2-ethylhexyl acetate 7.84
    1,2,4-trichlorobenzene 17.27
    4-methylpyridine 22.51
    dibutyl ether 10.42
    2,6-dimethyl-4-heptanol 7.37
    DEF 54.91
    dimethyl isosorbide 58.3
    tetrachloroethylene 40.95
    eugenol 31.74
    triacetin 27.94
    span 80 45.14
    1,4-butanediol 75.58
    1,1-dichloroethane 15.5
    2-methyl-1-pentanol 13.11
    methyl formate 113.96
    2-methyl-1-butanol 26.49
    n-decane 2.13
    butyronitrile 24.46
    3,7-dimethyl-1-octanol 11.5
    1-chlorooctane 6.11
    1-chlorotetradecane 2.96
    n-nonane 2.09
    undecane 1.64
    tert-butylcyclohexane 1.43
    cyclooctane 1.88
    cyclopentanol 76.98
    tetrahydropyran 45.48
    tert-amyl methyl ether 9.95
    2,5,8-trioxanonane 75.25
    1-hexene 3.57
    2-isopropoxyethanol 36.99
    2,2,2-trifluoroethanol 141.32
    methyl butyrate 20.78

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction