Dichlorodifluoromethane

Overview IFRA Request a quote

  • Identifiers

    CAS number
    75-71-8

    Molecular formula
    CCl2F2

    SMILES
    C(F)(F)(Cl)Cl

    Safety labels

    Compressed Gas
    Compressed Gas

  • Odor profile

    Fragrance
    Odorless 44.01%
    Sweet 28.48%
    Floral 27.52%
    Fishy 23.26%
    Balsamic 20.74%
    Woody 20.54%
    Fresh 18.81%
    Animal 18.12%
    Citrus 17.61%
    Clean 17.49%

     

    Flavor
    Odorless 36.22%
    Sulfurous 24.03%
    Sulfury 22.03%
    Meaty 20.51%
    Fishy 18.67%
    Bloody 18.48%
    Glue 18.43%
    Rotten 18.29%
    Mousy 17.98%
    Bouillon 17.97%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.3

    pKa est.
    3.73 (weak acid)

    Molecular weight
    120.91 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -252 °F (NTP, 1992)
    • -157.1 °C
    • -158 °C
    • -252 °F

    Boiling point

    • -21.6 °F at 760 mmHg (NTP, 1992)
    • -29.8 °C
    • -30 °C
    • -22 °F

    Flash point

    • -9.05 ˚C est.

    Solubility expt.

    • Insoluble (NTP, 1992)
    • In water, 280 mg/L at 25 °C
    • Soluble in ethanol, ether, acetic acid
    • Solubility of water in dichlorodifluoromethane, 0.009 wt% at 25 °C
    • 13.1 wt% amyl chloride; 9.0 wt% benzene; 5.0 wt% bromobenzene; 1.2 wt% bromoform; 8.5 wt% n-butyl alcohol; 13.2 wt% butyl butyrate; 5.2 wt% carbon tetrachloride; 5.5 wt% chloroform; 3.9 wt% alpha-chloronaphthalene; 8.5 wt% cyclohexanone; 6.1 wt% diacetone alcohol; 14.1 wt% dibutyl ether; 8.9 wt% dibutyl oxalate; 6.3 wt% dibutyl tartrate; 3.9 wt% dichloroethyl ether; 7.2 wt% diethyl aniline; 4.7 wt% diethyl phthalate; 6.9 wt% dioxane; 4.7 wt% ethylene dichloride; 7.2 wt% ethylene glycol butyl ether; 7.4 wt% ethylene glycol ethyl ether (all 21.1 °C at 1 atm)
    • 0.28 mg/mL at 25 °C
    • Solubility in water, g/100ml at 20 °C: 0.03
    • (77 °F): 0.03%

  • Synonyms

    • DICHLORODIFLUOROMETHANE
    • 75-71-8
    • Difluorodichloromethane
    • Genetron 12
    • Refrigerant 12
    • Freon 12
    • Halon
    • Eskimon 12
    • Frigen 12
    • dichloro(difluoro)methane
    • Electro-CF 12
    • Chlorofluorocarbon 12
    • Algofrene type 2
    • Isotron 2
    • Propellant 12
    • Arcton 6
    • Isotron 12
    • Arcton 12
    • Forane 12
    • Kaiser chemicals 12
    • Dymel 12
    • Ledon 12
    • Isceon 122
    • Methane, dichlorodifluoro-
    • Fluorocarbon-12
    • CFC-12
    • Freon F-12
    • Halon 122
    • Ucon 12
    • Refrigerant R 12
    • Ucon 12/halocarbon 12
    • Dwuchlorodwufluorometan
    • Freon-12
    • Fluorocarbon 12
    • R 12 (refrigerant)
    • Diclorodifluometano
    • Halocarbon 12
    • Rcra waste number U075
    • Caswell No. 304
    • FC 12
    • CCl2F2
    • Refrigerant R12
    • CFC 12
    • FCC 12
    • FKW 12
    • Propellent 12
    • CCRIS 3501
    • HSDB 139
    • CF2Cl2
    • UNII-OFM06SG1KO
    • F 12
    • OFM06SG1KO
    • EINECS 200-893-9
    • EPA Pesticide Chemical Code 000014
    • R 12, Refrigerant
    • AI3-01708
    • Fron 12
    • Dichlorodifluoromethane (NF)
    • Dichlorodifluoromethane [NF]
    • Chlorofluoromethane (CCl2F2)
    • METHANE, DICHLORODIFLUORO
    • DTXSID6020436
    • EC 200-893-9
    • R 12
    • khladon 12
    • DICHLORODIFLUOROMETHANE (II)
    • DICHLORODIFLUOROMETHANE [II]
    • DICHLORODIFLUOROMETHANE (MART.)
    • DICHLORODIFLUOROMETHANE [MART.]
    • Diclorodifluometano [Spanish]
    • Isot ron 2
    • Dwuchlorodwufluorometan [Polish]
    • Dichloro-difluoro-methane
    • UN1028
    • RCRA waste no. U075
    • Carbon dichloride difluoride
    • Sterethox
    • dichlorodifluormethane
    • MFCD00000781
    • R12 [UN1028] [Nonflammable gas]
    • dichlorodifluoro-methane
    • dichloro(diluoro)methane
    • CHLADONE 12
    • FRIGEN R12
    • SCHEMBL485
    • F 12 (HALOCARBON)
    • CF 12 (HALOCARBON)
    • DTXCID80436
    • REFRIGERANT GAS R-12
    • DWUCHLORODWU-FLUOROMETAN
    • SCHEMBL9459323
    • CHEMBL2106634
    • PXBRQCKWGAHEHS-UHFFFAOYSA-
    • SDD 100
    • CHEBI:229860
    • CF 12
    • Dichlorodifluoromethane [R12] [UN1028] [Nonflammable gas]
    • HC 12
    • DICHLORODIFLUOROMETHANE [MI]
    • DICHLORODIFLUOROMETHANE [HSDB]
    • AKOS006228770
    • DICHLORODIFLUOROMETHANE [VANDF]
    • UN 1028
    • DICHLORODIFLUOROMETHANE (CCL2F2)
    • DICHLORODIFLUOROMETHANE [WHO-DD]
    • R12 [UN1028] [Nonflammable gas]
    • InChI=1/CCl2F2/c2-1(3,4)5
    • F-12
    • DB-055985
    • NS00002142
    • D03789
    • Dichlorodifluoromethane 100 microg/mL in Methanol
    • Q423021
    • Dichlorodifluoromethane 5000 microg/mL in Methanol
    • Dichlorodifluoromethane [R12] [UN1028] [Nonflammable gas]
    • 200-893-9

  • Applications

    Dichlorodifluoromethane is used primarily as a refrigerant (CFC-12) in air conditioning and refrigeration equipment; it has also been employed as a blowing agent for rigid polyurethane foams used in insulation; it serves as a solvent for cleaning and degreasing in electronics, optics, and metalworking; it has historically been used as an aerosol propellant in various consumer and industrial products; and it can be considered a solvent or intermediate in select fluorochemical processes, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 387.46
    methanol 614.11
    isopropanol 325.11
    water 178.33
    ethyl acetate 138.02
    n-propanol 256.32
    acetone 433.7
    n-butanol 202.91
    acetonitrile 234.53
    DMF 1236.28
    toluene 65.32
    isobutanol 185.77
    1,4-dioxane 277.06
    methyl acetate 162.38
    THF 481.76
    2-butanone 219.26
    n-pentanol 155.29
    sec-butanol 220.67
    n-hexane 57.5
    ethylene glycol 264.27
    NMP 687.03
    cyclohexane 63.9
    DMSO 1381.28
    n-butyl acetate 88.91
    n-octanol 105.33
    chloroform 140.01
    n-propyl acetate 114.78
    acetic acid 254.49
    dichloromethane 183.85
    cyclohexanone 194.93
    propylene glycol 167.48
    isopropyl acetate 109.0
    DMAc 792.32
    2-ethoxyethanol 335.62
    isopentanol 164.06
    n-heptane 56.69
    ethyl formate 141.52
    1,2-dichloroethane 165.88
    n-hexanol 113.28
    2-methoxyethanol 513.99
    isobutyl acetate 63.45
    tetrachloromethane 46.57
    n-pentyl acetate 86.53
    transcutol 373.43
    n-heptanol 89.82
    ethylbenzene 48.45
    MIBK 138.07
    2-propoxyethanol 253.15
    tert-butanol 347.95
    MTBE 218.35
    2-butoxyethanol 160.92
    propionic acid 143.5
    o-xylene 75.31
    formic acid 278.65
    diethyl ether 253.19
    m-xylene 63.81
    p-xylene 55.8
    chlorobenzene 46.24
    dimethyl carbonate 139.42
    n-octane 28.86
    formamide 465.27
    cyclopentanone 280.78
    2-pentanone 201.26
    anisole 120.47
    cyclopentyl methyl ether 216.2
    gamma-butyrolactone 265.8
    1-methoxy-2-propanol 395.67
    pyridine 184.75
    3-pentanone 170.8
    furfural 245.58
    n-dodecane 20.78
    diethylene glycol 274.05
    diisopropyl ether 96.58
    tert-amyl alcohol 233.11
    acetylacetone 204.73
    n-hexadecane 21.65
    acetophenone 121.42
    methyl propionate 166.95
    isopentyl acetate 72.87
    trichloroethylene 149.51
    n-nonanol 95.25
    cyclohexanol 159.28
    benzyl alcohol 109.13
    2-ethylhexanol 75.07
    isooctanol 74.82
    dipropyl ether 157.54
    1,2-dichlorobenzene 48.0
    ethyl lactate 100.52
    propylene carbonate 115.05
    n-methylformamide 485.42
    2-pentanol 169.64
    n-pentane 91.81
    1-propoxy-2-propanol 191.64
    1-methoxy-2-propyl acetate 117.7
    2-(2-methoxypropoxy) propanol 149.41
    mesitylene 55.38
    ε-caprolactone 150.58
    p-cymene 50.4
    epichlorohydrin 233.65
    1,1,1-trichloroethane 92.46
    2-aminoethanol 294.97
    morpholine-4-carbaldehyde 503.46
    sulfolane 419.03
    2,2,4-trimethylpentane 34.05
    2-methyltetrahydrofuran 242.48
    n-hexyl acetate 100.33
    isooctane 27.59
    2-(2-butoxyethoxy)ethanol 184.92
    sec-butyl acetate 74.06
    tert-butyl acetate 120.73
    decalin 23.44
    glycerin 240.87
    diglyme 357.19
    acrylic acid 152.71
    isopropyl myristate 64.87
    n-butyric acid 138.89
    acetyl acetate 82.09
    di(2-ethylhexyl) phthalate 55.59
    ethyl propionate 111.57
    nitromethane 419.13
    1,2-diethoxyethane 157.93
    benzonitrile 83.75
    trioctyl phosphate 52.0
    1-bromopropane 127.87
    gamma-valerolactone 307.0
    n-decanol 79.07
    triethyl phosphate 61.44
    4-methyl-2-pentanol 107.88
    propionitrile 155.05
    vinylene carbonate 103.26
    1,1,2-trichlorotrifluoroethane 215.07
    DMS 88.3
    cumene 44.82
    2-octanol 79.37
    2-hexanone 142.25
    octyl acetate 76.92
    limonene 74.34
    1,2-dimethoxyethane 488.19
    ethyl orthosilicate 64.23
    tributyl phosphate 53.8
    diacetone alcohol 177.91
    N,N-dimethylaniline 156.92
    acrylonitrile 181.64
    aniline 107.11
    1,3-propanediol 248.66
    bromobenzene 37.63
    dibromomethane 141.52
    1,1,2,2-tetrachloroethane 153.71
    2-methyl-cyclohexyl acetate 71.16
    tetrabutyl urea 103.8
    diisobutyl methanol 71.59
    2-phenylethanol 84.16
    styrene 54.26
    dioctyl adipate 80.44
    dimethyl sulfate 228.24
    ethyl butyrate 95.15
    methyl lactate 159.94
    butyl lactate 87.65
    diethyl carbonate 63.56
    propanediol butyl ether 151.99
    triethyl orthoformate 80.24
    p-tert-butyltoluene 52.91
    methyl 4-tert-butylbenzoate 133.04
    morpholine 354.85
    tert-butylamine 259.69
    n-dodecanol 68.88
    dimethoxymethane 566.12
    ethylene carbonate 93.7
    cyrene 157.59
    2-ethoxyethyl acetate 97.93
    2-ethylhexyl acetate 60.02
    1,2,4-trichlorobenzene 56.26
    4-methylpyridine 164.28
    dibutyl ether 102.74
    2,6-dimethyl-4-heptanol 71.59
    DEF 332.31
    dimethyl isosorbide 204.99
    tetrachloroethylene 123.83
    eugenol 132.22
    triacetin 105.18
    span 80 126.46
    1,4-butanediol 145.11
    1,1-dichloroethane 132.15
    2-methyl-1-pentanol 110.41
    methyl formate 323.53
    2-methyl-1-butanol 152.45
    n-decane 31.38
    butyronitrile 141.02
    3,7-dimethyl-1-octanol 89.18
    1-chlorooctane 60.91
    1-chlorotetradecane 34.33
    n-nonane 32.76
    undecane 24.47
    tert-butylcyclohexane 22.95
    cyclooctane 31.44
    cyclopentanol 202.45
    tetrahydropyran 221.44
    tert-amyl methyl ether 190.49
    2,5,8-trioxanonane 274.54
    1-hexene 101.4
    2-isopropoxyethanol 216.33
    2,2,2-trifluoroethanol 155.89
    methyl butyrate 142.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction