Cyanoguanidine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    461-58-5

    Molecular formula
    C2H4N4

    SMILES
    C(#N)N=C(N)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 51.11%
    Fishy 31.43%
    Pungent 25.94%
    Meaty 20.47%
    Savory 18.06%
    Cooked 17.31%
    Cheesy 15.84%
    Ripe 14.8%
    Sulfurous 14.64%
    Radish 14.51%

     

    Flavor
    Bitter 56.76%
    Odorless 36.43%
    Nitrile 20.03%
    Bland 19.28%
    Mild 18.83%
    Formyl 18.8%
    Taco 18.67%
    Rotten 18.66%
    Bread crust 18.45%
    Mousy 18.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    7.54 (neutral)

    Molecular weight
    84.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    298°C

    Melting point expt.

    • 209.5 °C
    • 211 °C

    Flash point

    • 115.47 ˚C est.

    Solubility expt.

    • SOLUBILITY IN H2O @ 13 °C: 2.26%; MORE SOL IN HOT H2O; SOLUBILITY IN ABS ETHANOL @ 13 °C: 1.26%, IN ETHER @ 13 °C: 0.01%; SOL IN LIQUID AMMONIA, INSOL IN BENZENE & CHLOROFORM
    • Solubility in water, g/100ml at 25 °C: 4.13

  • Synonyms

    • Dicyandiamide
    • CYANOGUANIDINE
    • 461-58-5
    • Dicyanodiamide
    • 2-Cyanoguanidine
    • N-Cyanoguanidine
    • 1-Cyanoguanidine
    • Guanidine, cyano-
    • Dicyandiamido
    • Pyroset DO
    • Dicyandiamin
    • Epicure DICY 7
    • Epicure DICY 15
    • Araldite HT 986
    • Bakelite VE 2560
    • Araldite XB 2879B
    • Araldite XB 2979B
    • Dicy
    • ACR-H 3636
    • XB 2879B
    • Dicyanediamide
    • CCRIS 3478
    • Guanidine-1-carbonitrile
    • HSDB 2126
    • AI3-14632
    • NSC 2031
    • EINECS 207-312-8
    • UNII-M9B1R0C16H
    • MFCD00008066
    • Guanidine, N-cyano-
    • DTXSID1020354
    • Dyhard 100S
    • Adeka EH 3636AS
    • NSC-2031
    • Adeka EH 3636
    • CYANOGUANIDINE [HSDB]
    • DTXCID50354
    • NCN=C(NH2)2
    • M9B1R0C16H
    • 3-cyanoguanidine
    • CHEBI:147423
    • NSC2031
    • EC 207-312-8
    • J3.635H
    • METFORMIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]
    • Dicyandiamin [German]
    • guanidine, cyano
    • CAS-461-58-5
    • DCD
    • Metformin impurity A
    • Cyanoguanidine Metformin Related Compound A USP
    • METFORMIN HYDROCHLORIDE IMPURITY A (EP IMPURITY)
    • Dicyanadiamide
    • NCyanoguanidine
    • cyano-guanidine
    • 1Cyanoguanidine
    • 2Cyanoguanidine
    • 1-cyano-guanidine
    • Cyanamide metabolite
    • Dicyandiamide, 99%
    • DICYANODIAMIDE [MI]
    • CHEMBL3183942
    • ACRH 3636
    • Tox21_201513
    • Tox21_302730
    • BBL009709
    • STL141074
    • STL483054
    • AKOS000118777
    • AKOS005208673
    • CCG-214839
    • FC20647
    • NCGC00249058-01
    • NCGC00256355-01
    • NCGC00259063-01
    • 157480-33-6
    • BP-31003
    • CS-0015691
    • NS00003801
    • EN300-21430
    • D78355
    • Q905401
    • Dicyanodiamide (210 degrees C) Melting Point Standard
    • F0001-1248
    • Z203045078
    • Cyanoguanidine, >=95.0% (HPLC), pharmaceutical impurity standard
    • Metformin impurity A, European Pharmacopoeia (EP) Reference Standard
    • N-Cyanoguanidine;1-Cyanoguanidine;2-Cyanoguanidine;Dicyandiamide
    • 26591-10-6

  • Applications

    Cyanoguanidine, CAS 461-58-5, is used primarily as an intermediate in the synthesis of guanidine derivatives and heterocyclic compounds; it also serves as a precursor in melamine production. In agriculture, it is used as a nitrogen fertilizer with slow-release characteristics. In the materials sector, it acts as a latent curing agent for epoxy resins, coatings, adhesives, and composites. It also serves as a raw material for the manufacture of nitrogen-rich guanidine polymers and related derivatives for specialized applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 11.58
    methanol 33.98
    isopropanol 4.82
    water 38.18
    ethyl acetate 4.35
    n-propanol 5.66
    acetone 9.43
    n-butanol 2.97
    acetonitrile 4.62
    DMF 330.36
    toluene 0.47
    isobutanol 3.1
    1,4-dioxane 9.81
    methyl acetate 9.6
    THF 13.03
    2-butanone 5.39
    n-pentanol 2.17
    sec-butanol 2.68
    n-hexane 0.13
    ethylene glycol 41.68
    NMP 75.16
    cyclohexane 0.11
    DMSO 87.28
    n-butyl acetate 2.89
    n-octanol 1.29
    chloroform 1.41
    n-propyl acetate 3.35
    acetic acid 29.51
    dichloromethane 1.36
    cyclohexanone 4.84
    propylene glycol 29.35
    isopropyl acetate 2.39
    DMAc 122.73
    2-ethoxyethanol 15.37
    isopentanol 1.69
    n-heptane 0.15
    ethyl formate 9.68
    1,2-dichloroethane 1.19
    n-hexanol 1.77
    2-methoxyethanol 45.82
    isobutyl acetate 2.06
    tetrachloromethane 0.52
    n-pentyl acetate 2.28
    transcutol 13.13
    n-heptanol 1.44
    ethylbenzene 0.21
    MIBK 1.94
    2-propoxyethanol 13.67
    tert-butanol 3.38
    MTBE 1.57
    2-butoxyethanol 7.94
    propionic acid 16.17
    o-xylene 0.47
    formic acid 64.42
    diethyl ether 1.69
    m-xylene 0.45
    p-xylene 0.39
    chlorobenzene 0.52
    dimethyl carbonate 21.13
    n-octane 0.07
    formamide 62.01
    cyclopentanone 11.9
    2-pentanone 3.49
    anisole 1.44
    cyclopentyl methyl ether 3.38
    gamma-butyrolactone 24.16
    1-methoxy-2-propanol 25.63
    pyridine 4.43
    3-pentanone 3.16
    furfural 27.8
    n-dodecane 0.07
    diethylene glycol 27.36
    diisopropyl ether 0.48
    tert-amyl alcohol 2.44
    acetylacetone 7.51
    n-hexadecane 0.08
    acetophenone 2.57
    methyl propionate 10.86
    isopentyl acetate 1.97
    trichloroethylene 2.37
    n-nonanol 1.22
    cyclohexanol 1.67
    benzyl alcohol 2.44
    2-ethylhexanol 0.88
    isooctanol 1.0
    dipropyl ether 1.47
    1,2-dichlorobenzene 0.63
    ethyl lactate 8.98
    propylene carbonate 11.89
    n-methylformamide 80.67
    2-pentanol 1.35
    n-pentane 0.13
    1-propoxy-2-propanol 7.9
    1-methoxy-2-propyl acetate 6.63
    2-(2-methoxypropoxy) propanol 7.69
    mesitylene 0.32
    ε-caprolactone 6.61
    p-cymene 0.36
    epichlorohydrin 9.99
    1,1,1-trichloroethane 0.89
    2-aminoethanol 27.24
    morpholine-4-carbaldehyde 64.87
    sulfolane 40.65
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 3.87
    n-hexyl acetate 2.51
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 8.28
    sec-butyl acetate 1.55
    tert-butyl acetate 2.28
    decalin 0.08
    glycerin 67.72
    diglyme 16.07
    acrylic acid 27.7
    isopropyl myristate 0.95
    n-butyric acid 8.16
    acetyl acetate 4.28
    di(2-ethylhexyl) phthalate 2.62
    ethyl propionate 3.36
    nitromethane 63.97
    1,2-diethoxyethane 2.4
    benzonitrile 1.91
    trioctyl phosphate 1.83
    1-bromopropane 0.47
    gamma-valerolactone 29.15
    n-decanol 0.93
    triethyl phosphate 2.24
    4-methyl-2-pentanol 0.84
    propionitrile 2.88
    vinylene carbonate 13.7
    1,1,2-trichlorotrifluoroethane 33.41
    DMS 6.26
    cumene 0.24
    2-octanol 0.78
    2-hexanone 2.35
    octyl acetate 1.69
    limonene 0.49
    1,2-dimethoxyethane 17.25
    ethyl orthosilicate 1.7
    tributyl phosphate 2.05
    diacetone alcohol 5.79
    N,N-dimethylaniline 1.64
    acrylonitrile 7.11
    aniline 1.9
    1,3-propanediol 17.32
    bromobenzene 0.31
    dibromomethane 0.68
    1,1,2,2-tetrachloroethane 2.65
    2-methyl-cyclohexyl acetate 1.83
    tetrabutyl urea 3.34
    diisobutyl methanol 0.57
    2-phenylethanol 2.1
    styrene 0.26
    dioctyl adipate 2.4
    dimethyl sulfate 50.17
    ethyl butyrate 2.45
    methyl lactate 28.47
    butyl lactate 5.36
    diethyl carbonate 2.4
    propanediol butyl ether 10.25
    triethyl orthoformate 2.25
    p-tert-butyltoluene 0.38
    methyl 4-tert-butylbenzoate 4.54
    morpholine 13.45
    tert-butylamine 1.26
    n-dodecanol 0.7
    dimethoxymethane 41.59
    ethylene carbonate 9.05
    cyrene 12.29
    2-ethoxyethyl acetate 4.6
    2-ethylhexyl acetate 1.52
    1,2,4-trichlorobenzene 1.12
    4-methylpyridine 3.25
    dibutyl ether 0.73
    2,6-dimethyl-4-heptanol 0.57
    DEF 13.07
    dimethyl isosorbide 10.02
    tetrachloroethylene 2.0
    eugenol 6.02
    triacetin 5.81
    span 80 6.64
    1,4-butanediol 8.92
    1,1-dichloroethane 0.9
    2-methyl-1-pentanol 1.24
    methyl formate 64.12
    2-methyl-1-butanol 1.9
    n-decane 0.1
    butyronitrile 2.12
    3,7-dimethyl-1-octanol 0.91
    1-chlorooctane 0.31
    1-chlorotetradecane 0.18
    n-nonane 0.09
    undecane 0.08
    tert-butylcyclohexane 0.08
    cyclooctane 0.06
    cyclopentanol 3.91
    tetrahydropyran 2.57
    tert-amyl methyl ether 1.51
    2,5,8-trioxanonane 12.11
    1-hexene 0.35
    2-isopropoxyethanol 6.84
    2,2,2-trifluoroethanol 26.98
    methyl butyrate 4.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction