Chloroform

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  • Identifiers

    CAS number
    67-66-3

    Molecular formula
    CHCl3

    SMILES
    C(Cl)(Cl)Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Odorless 42.85%
    Fishy 33.41%
    Green 25.15%
    Sweet 22.38%
    Cheesy 22.35%
    Fruity 21.96%
    Oily 21.37%
    Floral 21.04%
    Ripe 19.79%
    Musty 19.11%

    Scent© AI

    Odor threshold>

    • Odor Threshold Low: 133.0 [mmHg]. Odor Threshold High: 276.0 [mmHg]. Detection odor threshold from AIHA (mean = 192 ppm)
    • 3.30 mg/L (Detection in air; purity not specified)
    • Odor thresholds: low= 250 mg/cu m; high= 1000 mg/cu m. /From table/
    • Odor thresholds of 85 ppm and 2.4 ppm have been reported for chloroform in air and water, respectively.

  • Properties

    XLogP3-AA
    2.3

    Molecular weight
    119.37 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -82.3 °F (EPA, 1998)
    • -63.47 °C
    • -63.2 °C
    • -64 °C
    • -82 °F

    Boiling point

    • 143 °F at 760 mmHg (EPA, 1998)
    • 61.12 °C
    • 61.00 to 62.00 °C. @ 760.00 mm Hg
    • 62 °C
    • 143 °F

    Flash point est.
    24.53 ˚C

    Flash point expt.

    • None (EPA, 1998)

    Solubility expt.

    • less than 1 mg/mL at 66 °F (NTP, 1992)
    • In water, 7.95X10+3 mg/L at 25 °C
    • Highly soluble in water
    • One mL dissolves in about 200 mL water at 25 °C
    • Miscible with alcohol, benzene, ether, petroleum ether, carbon tetrachloride, carbon disulfide, oils
    • For more Solubility (Complete) data for Chloroform (6 total), please visit the HSDB record page.
    • 7.95 mg/mL at 25 °C
    • Solubility in water, g/100ml at 20 °C: 0.8 (slightly soluble)
    • (77 °F): 0.5%

  • Synonyms

    • CHLOROFORM
    • Trichloromethane
    • 67-66-3
    • Trichlormethan
    • Formyl trichloride
    • Trichloroform
    • Methane, trichloro-
    • Methenyl trichloride
    • Chloroforme
    • Methyl trichloride
    • Methane trichloride
    • CHCl3
    • R 20 (Refrigerant)
    • Triclorometano
    • Cloroformio
    • Trichloormethaan
    • Freon 20
    • 1,1,1-Trichloromethane
    • Methenyl chloride
    • RCRA waste number U044
    • NCI-C02686
    • Chloroformum
    • Caswell No. 192
    • Chloroform bp
    • Methylidyne trichloride
    • HSDB 56
    • Refrigerant R20
    • CCRIS 137
    • NSC 77361
    • trichloro-methane
    • Hcc 20
    • R 20
    • EINECS 200-663-8
    • NSC-77361
    • EPA Pesticide Chemical Code 020701
    • UNII-7V31YC746X
    • BRN 1731042
    • DTXSID1020306
    • CHEBI:35255
    • AI3-24207
    • 7V31YC746X
    • Chloroform [UN1888] [Poison]
    • chloroformium pro narcosi
    • DTXCID10306
    • EC 200-663-8
    • 4-01-00-00042 (Beilstein Handbook Reference)
    • NSC77361
    • MFCD00000826
    • NCGC00090794-01
    • chloroform CHCl3
    • CHLOROFORM (II)
    • CHLOROFORM [II]
    • CHLOROFORM (IARC)
    • CHLOROFORM [IARC]
    • CHLOROFORM (MART.)
    • CHLOROFORM [MART.]
    • CHLOROFORM (USP-RS)
    • CHLOROFORM [USP-RS]
    • Chloroform, analytical standard
    • Chloroforme [French]
    • Cloroformio [Italian]
    • Trichlormethan [Czech]
    • Chloroform [NF XVII]
    • Trichloormethaan [Dutch]
    • Triclorometano [Italian]
    • CAS-67-66-3
    • Chloroform [NF]
    • Chloroform (Stabilized with ~1% Ethanol)
    • CHLOROBUTANOL IMPURITY A (EP IMPURITY)
    • CHLOROBUTANOL IMPURITY A [EP IMPURITY]
    • CHLOROFORM, ACS
    • CHLOROFORMWith Amylene
    • CHLOROFORMWith Ethanol
    • UN1888
    • Chloroform (Anhydrous) Contains Amylenes as stabilizer
    • RCRA waste no. U044
    • chlorform
    • chloroforrn
    • cloroform
    • trichlormethane
    • chloro form
    • chloro-form
    • Chloroform-
    • Chloroform, for HPLC, >=99.8%, contains 0.5-1.0% ethanol as stabilizer
    • trichloro- methane
    • methane trichloride
    • tris(chloranyl)methane
    • CCl3H
    • HCCl3
    • Chloroform, for HPLC
    • Trichloromethane, 9CI
    • CHLOROFORM [MI]
    • Chloroform, ethanol-free
    • Chloroform, HPLC Grade
    • Trichlormethan/Chloroform
    • WLN: GYGG
    • CHLOROFORM [HSDB]
    • CHLOROFORM [VANDF]
    • CHLOROFORMUM [HPUS]
    • R 20(REFRIGERANT)
    • CHLOROFORM [WHO-DD]
    • Pesticide Code: 020701
    • CHEMBL44618
    • Chloroform, p.a., 99.8%
    • GTPL2503
    • NCI-CO2686
    • CHLOROFORM [GREEN BOOK]
    • DTXSID10953654
    • R 20 (VAN)
    • Chloroform with Amylene HPLC grade
    • Chloroform, Spectrophotometric Grade
    • Chloroform (stabilized with ethanol)
    • Tox21_111024
    • Tox21_202494
    • Chloroform, for HPLC, >=99.5%
    • Chloroform, for HPLC, >=99.8%
    • AKOS000269026
    • Chloroform 100 microg/mL in Methanol
    • DB11387
    • InChI=1/CHCl3/c2-1(3)4/h1
    • UN 1888
    • Chloroform 5000 microg/mL in Methanol
    • Chloroform, purification grade, >=99%
    • NCGC00090794-02
    • NCGC00260043-01
    • F 20
    • R-20
    • Trichloromethane 10 microg/mL in Methanol

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 110.94
    methanol 128.03
    isopropanol 101.73
    water 12.4
    ethyl acetate 137.47
    n-propanol 96.22
    acetone 303.98
    n-butanol 104.86
    acetonitrile 161.68
    DMF 553.8
    toluene 140.96
    isobutanol 77.99
    1,4-dioxane 306.48
    methyl acetate 159.66
    THF 411.0
    2-butanone 181.84
    n-pentanol 79.48
    sec-butanol 95.8
    n-hexane 52.24
    ethylene glycol 57.14
    NMP 595.24
    cyclohexane 117.95
    DMSO 572.3
    n-butyl acetate 129.54
    n-octanol 85.11
    chloroform 342.92
    n-propyl acetate 112.55
    acetic acid 196.85
    dichloromethane 316.53
    cyclohexanone 309.21
    propylene glycol 47.94
    isopropyl acetate 107.48
    DMAc 465.25
    2-ethoxyethanol 138.64
    isopentanol 89.15
    n-heptane 78.05
    ethyl formate 109.93
    1,2-dichloroethane 231.83
    n-hexanol 87.09
    2-methoxyethanol 205.07
    isobutyl acetate 79.15
    tetrachloromethane 132.78
    n-pentyl acetate 105.13
    transcutol 316.65
    n-heptanol 71.88
    ethylbenzene 77.89
    MIBK 114.76
    2-propoxyethanol 144.65
    tert-butanol 130.41
    MTBE 143.35
    2-butoxyethanol 114.83
    propionic acid 96.48
    o-xylene 125.94
    formic acid 92.76
    diethyl ether 174.61
    m-xylene 105.68
    p-xylene 113.32
    chlorobenzene 163.04
    dimethyl carbonate 105.12
    n-octane 35.14
    formamide 145.89
    cyclopentanone 360.43
    2-pentanone 171.91
    anisole 149.91
    cyclopentyl methyl ether 230.1
    gamma-butyrolactone 309.21
    1-methoxy-2-propanol 161.71
    pyridine 283.21
    3-pentanone 164.03
    furfural 329.14
    n-dodecane 25.37
    diethylene glycol 133.26
    diisopropyl ether 82.09
    tert-amyl alcohol 112.55
    acetylacetone 224.06
    n-hexadecane 28.11
    acetophenone 165.35
    methyl propionate 136.44
    isopentyl acetate 109.07
    trichloroethylene 385.14
    n-nonanol 77.45
    cyclohexanol 156.5
    benzyl alcohol 112.38
    2-ethylhexanol 79.9
    isooctanol 62.3
    dipropyl ether 150.89
    1,2-dichlorobenzene 158.28
    ethyl lactate 66.89
    propylene carbonate 163.05
    n-methylformamide 179.33
    2-pentanol 87.49
    n-pentane 64.36
    1-propoxy-2-propanol 133.43
    1-methoxy-2-propyl acetate 133.08
    2-(2-methoxypropoxy) propanol 119.94
    mesitylene 85.63
    ε-caprolactone 216.79
    p-cymene 86.44
    epichlorohydrin 274.83
    1,1,1-trichloroethane 240.58
    2-aminoethanol 72.12
    morpholine-4-carbaldehyde 429.75
    sulfolane 447.79
    2,2,4-trimethylpentane 35.58
    2-methyltetrahydrofuran 273.94
    n-hexyl acetate 118.85
    isooctane 26.3
    2-(2-butoxyethoxy)ethanol 139.84
    sec-butyl acetate 82.55
    tert-butyl acetate 124.8
    decalin 45.77
    glycerin 82.78
    diglyme 307.15
    acrylic acid 110.89
    isopropyl myristate 72.56
    n-butyric acid 118.43
    acetyl acetate 121.77
    di(2-ethylhexyl) phthalate 62.09
    ethyl propionate 103.64
    nitromethane 306.07
    1,2-diethoxyethane 171.72
    benzonitrile 145.92
    trioctyl phosphate 53.19
    1-bromopropane 150.81
    gamma-valerolactone 348.23
    n-decanol 62.65
    triethyl phosphate 80.2
    4-methyl-2-pentanol 57.28
    propionitrile 103.01
    vinylene carbonate 154.16
    1,1,2-trichlorotrifluoroethane 257.86
    DMS 110.22
    cumene 63.89
    2-octanol 63.43
    2-hexanone 130.8
    octyl acetate 81.52
    limonene 132.92
    1,2-dimethoxyethane 286.11
    ethyl orthosilicate 80.99
    tributyl phosphate 59.56
    diacetone alcohol 138.84
    N,N-dimethylaniline 157.81
    acrylonitrile 135.99
    aniline 140.36
    1,3-propanediol 93.82
    bromobenzene 168.66
    dibromomethane 244.79
    1,1,2,2-tetrachloroethane 313.81
    2-methyl-cyclohexyl acetate 101.52
    tetrabutyl urea 101.59
    diisobutyl methanol 72.67
    2-phenylethanol 107.43
    styrene 102.67
    dioctyl adipate 96.06
    dimethyl sulfate 202.24
    ethyl butyrate 124.22
    methyl lactate 92.64
    butyl lactate 80.72
    diethyl carbonate 87.7
    propanediol butyl ether 98.79
    triethyl orthoformate 105.13
    p-tert-butyltoluene 87.88
    methyl 4-tert-butylbenzoate 149.2
    morpholine 292.67
    tert-butylamine 101.61
    n-dodecanol 55.39
    dimethoxymethane 275.56
    ethylene carbonate 125.93
    cyrene 146.12
    2-ethoxyethyl acetate 121.36
    2-ethylhexyl acetate 101.25
    1,2,4-trichlorobenzene 187.36
    4-methylpyridine 259.58
    dibutyl ether 117.23
    2,6-dimethyl-4-heptanol 72.67
    DEF 267.63
    dimethyl isosorbide 219.13
    tetrachloroethylene 265.94
    eugenol 135.58
    triacetin 133.57
    span 80 119.94
    1,4-butanediol 52.29
    1,1-dichloroethane 203.54
    2-methyl-1-pentanol 72.2
    methyl formate 153.03
    2-methyl-1-butanol 83.84
    n-decane 38.31
    butyronitrile 109.01
    3,7-dimethyl-1-octanol 77.39
    1-chlorooctane 83.05
    1-chlorotetradecane 45.64
    n-nonane 40.65
    undecane 29.7
    tert-butylcyclohexane 38.65
    cyclooctane 54.26
    cyclopentanol 169.51
    tetrahydropyran 262.69
    tert-amyl methyl ether 138.34
    2,5,8-trioxanonane 224.21
    1-hexene 85.89
    2-isopropoxyethanol 110.37
    2,2,2-trifluoroethanol 119.44
    methyl butyrate 133.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Carob bean extract 1 9000-40-2 Ceratonia siliqua L., fam. Leguminoseae 0.1%