Chlorodifluoromethane

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  • Identifiers

    CAS number
    75-45-6

    Molecular formula
    CHClF2

    SMILES
    C(F)(F)Cl

    Safety labels

    Compressed Gas
    Compressed Gas

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 51.24%
    Fishy 37.45%
    Cheesy 24.56%
    Meaty 22.12%
    Ripe 21.86%
    Green 21.03%
    Savory 19.16%
    Pungent 17.49%
    Sulfurous 17.45%
    Oily 17.08%

     

    Flavor
    Odorless 36.08%
    Sulfurous 27.81%
    Fishy 26.38%
    Meaty 24.87%
    Sulfury 24.74%
    Ammoniacal 23.13%
    Glue 19.28%
    Bloody 19.13%
    Onion 18.92%
    Rotten 18.64%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    4.1 (weak acid)

    Molecular weight
    86.47 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -231 °F (NIOSH, 2024)
    • -157.42 °C
    • -146 °C
    • "-231 °F"
    • -231 °F

    Boiling point

    • -40.9 °F at 760 mmHg (USCG, 1999)
    • -40.8 °C
    • -41 °C
    • -41 °F

    Flash point

    • -7.37 ˚C est.

    Solubility expt.

    • 0.3 % at 77 °F (NIOSH, 2024)
    • Solubility: 0.14 g/L water at 122 °F at 14.7 psia
    • In water, 2770 mg/L at 25 °C
    • 0.28 g/L water at 77 °F and 14.7 psia
    • > 10% in acetone; > 10% in chloroform; > 10% in ethyl ether
    • Soluble in ether, acetone, and chloroform
    • Solubility in water, g/100ml at 25 °C: 0.3
    • (77 °F): 0.3%

  • Synonyms

    • CHLORODIFLUOROMETHANE
    • 75-45-6
    • Difluorochloromethane
    • chloro(difluoro)methane
    • Methane, chlorodifluoro-
    • Frigen
    • Fluorocarbon 22
    • Propellant 22
    • Monochlorodifluoromethane
    • HCFC-22
    • Khladon 22
    • Frigen 22
    • Freon 22
    • F 22 (halocarbon)
    • Algofrene 6
    • Fluorocarbon-22
    • Difluoromonochloromethane
    • Algofrene type 6
    • Algofrene 22
    • Arcton 4
    • Genetron 22
    • Daiflon 22
    • Eskimon 22
    • Flugene 22
    • Haltron 22
    • Isotron 22
    • Refrigerant R 22
    • Algeon 22
    • Arcton 22
    • Forane 22
    • Hydrochlorofluorocarbon 22
    • Isceon 22
    • Electro-CF 22
    • Dymel 22
    • Chlorofluorocarbon 22
    • Forane 22 B
    • HCFC 22
    • Ucon 22
    • Refrigerant 22
    • FKW 22
    • FC 22
    • CHClF2
    • CHF2Cl
    • CCRIS 858
    • Chloro-difluoro-methane
    • CFC 22
    • HFA-22
    • HSDB 143
    • UNII-ZFO627O6CN
    • FREON-22
    • EINECS 200-871-9
    • UN1018
    • BRN 1731036
    • F 22
    • R-22
    • Monochlorodifluormethane
    • Flon 22
    • SOLKANE 22
    • ZFO627O6CN
    • DTXSID6020301
    • CHEBI:82417
    • EC 200-871-9
    • 4-01-00-00032 (Beilstein Handbook Reference)
    • CHLORODIFLUOROMETHANE [HSDB]
    • CHLORODIFLUOROMETHANE [IARC]
    • UN 1018
    • Racon 22
    • R 22 (refrigerant)
    • CHLORODIFLUOROMETHANE (IARC)
    • chloro-difluoromethane
    • Fluorocarbon22
    • Genetron22
    • Diflurochloromethane
    • Khaladon 22
    • difiuorochloromethane
    • Freon22
    • ElectroCF 22
    • MFCD00000821
    • Freon R22
    • HCF2Cl
    • Difluoromethyl chloride
    • chloro-difluoro methane
    • Methane, chlorodifluoro
    • Chlorodifluoromethane 99%
    • ESKIMON-22
    • UCONN-22
    • Fluorocarbon-22, Freon22
    • HFA22
    • FRON 22
    • Chlorodifluoromethane (ACGIH)
    • DTXCID60301
    • REFRIGERANT GAS R-22
    • chloranyl-bis(fluoranyl)methane
    • CHEMBL116155
    • HFA 22
    • DTXSID90168648
    • AKOS006228558
    • R22 [UN1018] [Nonflammable gas]
    • HYDROCHLOROFLUOROCARBON 22 [INCI]
    • R 22
    • NS00011371
    • C19361
    • Chlorodifluoromethane 100 microg/mL in Methanol
    • A838420
    • Chlorodifluoromethane 1000 microg/mL in Methanol
    • Q422994
    • Chlorodifluoromethane [R22] [UN1018] [Nonflammable gas]
    • 55585-03-0

  • Applications

    Chlorodifluoromethane (CAS 75-45-6) is principally used as a refrigerant in air conditioning and industrial cooling systems; it is also employed as a blowing agent for polyurethane foams used in insulation; it serves as an intermediate or feedstock for the synthesis of fluorinated materials and polymer fluorinated; in certain manufacturing processes it can be used as a processing solvent or cleaning medium within regulatory limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 273.02
    methanol 519.98
    isopropanol 198.59
    water 512.99
    ethyl acetate 93.49
    n-propanol 165.15
    acetone 459.25
    n-butanol 121.14
    acetonitrile 357.84
    DMF 1316.92
    toluene 31.5
    isobutanol 112.94
    1,4-dioxane 217.58
    methyl acetate 163.29
    THF 262.49
    2-butanone 191.26
    n-pentanol 90.43
    sec-butanol 126.76
    n-hexane 17.87
    ethylene glycol 267.72
    NMP 764.73
    cyclohexane 30.9
    DMSO 1457.85
    n-butyl acetate 53.04
    n-octanol 52.3
    chloroform 92.1
    n-propyl acetate 78.57
    acetic acid 362.71
    dichloromethane 154.85
    cyclohexanone 168.44
    propylene glycol 119.4
    isopropyl acetate 59.94
    DMAc 887.91
    2-ethoxyethanol 245.57
    isopentanol 94.19
    n-heptane 25.51
    ethyl formate 114.34
    1,2-dichloroethane 142.52
    n-hexanol 55.74
    2-methoxyethanol 399.43
    isobutyl acetate 38.07
    tetrachloromethane 26.87
    n-pentyl acetate 44.23
    transcutol 294.91
    n-heptanol 42.48
    ethylbenzene 22.78
    MIBK 69.98
    2-propoxyethanol 138.17
    tert-butanol 205.46
    MTBE 112.65
    2-butoxyethanol 92.8
    propionic acid 139.31
    o-xylene 45.58
    formic acid 431.43
    diethyl ether 136.99
    m-xylene 30.77
    p-xylene 31.51
    chlorobenzene 32.07
    dimethyl carbonate 100.75
    n-octane 10.35
    formamide 696.07
    cyclopentanone 224.6
    2-pentanone 131.87
    anisole 77.11
    cyclopentyl methyl ether 118.33
    gamma-butyrolactone 215.54
    1-methoxy-2-propanol 239.97
    pyridine 172.39
    3-pentanone 129.22
    furfural 248.13
    n-dodecane 8.59
    diethylene glycol 190.44
    diisopropyl ether 40.04
    tert-amyl alcohol 131.89
    acetylacetone 153.29
    n-hexadecane 9.08
    acetophenone 96.84
    methyl propionate 125.74
    isopentyl acetate 40.5
    trichloroethylene 149.42
    n-nonanol 46.75
    cyclohexanol 100.75
    benzyl alcohol 80.55
    2-ethylhexanol 38.52
    isooctanol 33.93
    dipropyl ether 78.21
    1,2-dichlorobenzene 35.31
    ethyl lactate 65.09
    propylene carbonate 85.19
    n-methylformamide 541.57
    2-pentanol 85.45
    n-pentane 31.21
    1-propoxy-2-propanol 98.21
    1-methoxy-2-propyl acetate 66.98
    2-(2-methoxypropoxy) propanol 113.7
    mesitylene 27.98
    ε-caprolactone 122.6
    p-cymene 28.05
    epichlorohydrin 184.32
    1,1,1-trichloroethane 62.11
    2-aminoethanol 248.21
    morpholine-4-carbaldehyde 521.02
    sulfolane 353.2
    2,2,4-trimethylpentane 13.4
    2-methyltetrahydrofuran 152.47
    n-hexyl acetate 54.93
    isooctane 9.14
    2-(2-butoxyethoxy)ethanol 120.3
    sec-butyl acetate 42.55
    tert-butyl acetate 59.8
    decalin 11.1
    glycerin 201.12
    diglyme 267.72
    acrylic acid 175.8
    isopropyl myristate 30.48
    n-butyric acid 104.34
    acetyl acetate 68.24
    di(2-ethylhexyl) phthalate 35.75
    ethyl propionate 71.43
    nitromethane 626.12
    1,2-diethoxyethane 95.69
    benzonitrile 76.76
    trioctyl phosphate 28.13
    1-bromopropane 71.42
    gamma-valerolactone 271.41
    n-decanol 37.73
    triethyl phosphate 41.94
    4-methyl-2-pentanol 46.72
    propionitrile 159.67
    vinylene carbonate 88.54
    1,1,2-trichlorotrifluoroethane 184.36
    DMS 60.75
    cumene 22.52
    2-octanol 32.15
    2-hexanone 89.59
    octyl acetate 40.24
    limonene 43.61
    1,2-dimethoxyethane 374.97
    ethyl orthosilicate 38.39
    tributyl phosphate 31.18
    diacetone alcohol 103.39
    N,N-dimethylaniline 105.76
    acrylonitrile 220.44
    aniline 75.2
    1,3-propanediol 194.41
    bromobenzene 24.13
    dibromomethane 100.46
    1,1,2,2-tetrachloroethane 120.28
    2-methyl-cyclohexyl acetate 44.43
    tetrabutyl urea 67.12
    diisobutyl methanol 33.32
    2-phenylethanol 51.91
    styrene 29.39
    dioctyl adipate 48.02
    dimethyl sulfate 195.94
    ethyl butyrate 60.95
    methyl lactate 111.74
    butyl lactate 48.99
    diethyl carbonate 43.28
    propanediol butyl ether 94.86
    triethyl orthoformate 49.6
    p-tert-butyltoluene 27.49
    methyl 4-tert-butylbenzoate 86.15
    morpholine 296.29
    tert-butylamine 137.95
    n-dodecanol 32.32
    dimethoxymethane 370.67
    ethylene carbonate 72.26
    cyrene 128.66
    2-ethoxyethyl acetate 59.3
    2-ethylhexyl acetate 33.4
    1,2,4-trichlorobenzene 44.08
    4-methylpyridine 141.94
    dibutyl ether 48.89
    2,6-dimethyl-4-heptanol 33.32
    DEF 287.68
    dimethyl isosorbide 143.74
    tetrachloroethylene 101.5
    eugenol 92.79
    triacetin 74.58
    span 80 82.39
    1,4-butanediol 118.54
    1,1-dichloroethane 86.87
    2-methyl-1-pentanol 65.89
    methyl formate 344.36
    2-methyl-1-butanol 91.46
    n-decane 12.47
    butyronitrile 122.86
    3,7-dimethyl-1-octanol 45.96
    1-chlorooctane 28.94
    1-chlorotetradecane 15.68
    n-nonane 12.41
    undecane 9.94
    tert-butylcyclohexane 9.76
    cyclooctane 12.79
    cyclopentanol 130.05
    tetrahydropyran 141.36
    tert-amyl methyl ether 95.63
    2,5,8-trioxanonane 208.18
    1-hexene 38.4
    2-isopropoxyethanol 143.65
    2,2,2-trifluoroethanol 214.06
    methyl butyrate 100.7

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction