Capryloyl Glycine

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  • Identifiers

    CAS number
    14246-53-8

    Molecular formula
    C10H19NO3

    SMILES
    CCCCCCCC(=O)NCC(=O)O

    Safety labels

    Corrosive
    Corrosive

  • Odor profile

    Fragrance
    Odorless 41.29%
    Savory 37.44%
    Meaty 34.84%
    Fatty 30.43%
    Milky 25.64%
    Cheesy 24.96%
    Herbal 24.33%
    Cooling 23.31%
    Oily 22.37%
    Lactonic 22.22%

     

    Flavor
    Odorless 44.0%
    Mild 30.03%
    Fatty 29.56%
    Bland 26.34%
    Cheese 24.29%
    Oily 23.4%
    Sour 22.89%
    Waxy 21.92%
    Cultured dairy 21.6%
    Bay oil 21.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    7.45 (neutral)

    Molecular weight
    201.26 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    328°C

    Flash point

    • 191.16 ˚C est.

  • Synonyms

    • 14246-53-8
    • Capryloyl glycine
    • capryloylglycine
    • N-(1-Oxooctyl)glycine
    • Glycine, N-(1-oxooctyl)-
    • 8TY5YO42NJ
    • EINECS 238-122-3
    • DTXSID9065736
    • EC 238-122-3
    • CAPRYLOYL GLYCINE [WHO-DD]
    • RefChem:573777
    • CAPRYLOYL GLYCINE [INCI]
    • DTXCID1034638
    • 238-122-3
    • 2-octanamidoacetic acid
    • Caprylylglycine
    • N-Octanoylglycine
    • 2-(octanoylamino)acetic acid
    • MFCD00154701
    • UNII-8TY5YO42NJ
    • octanoylglycine
    • N-octanoyl-Glycine
    • Lipacide C 8G
    • N-(1-oxooctyl)-Glycine
    • 2-Octanoylaminoacetic acid
    • SCHEMBL125481
    • CHEBI:74099
    • MSK170011
    • AKOS009254081
    • FC15595
    • BS-24906
    • DB-021980
    • CS-0152288
    • NS00002293
    • ST50976868
    • E75778
    • EN300-114896
    • N-Octanoylglycine, analytical reference material
    • 246C538
    • F689659
    • Q27144409
    • Z362780008
    • 14246-53-8

  • Applications

    Capryloyl Glycine (CAS 14246-53-8) is used in cosmetics and personal care as a conditioning agent and humectant that helps soften skin and hair and supports formulation stability, and it can function as a mild buffering or functional additive due to its amino acid caprylate structure. In industrial manufacturing, it serves as a specialty chemical intermediate for the synthesis of more complex glycine-caprylate derivatives. In coatings and inks, it acts as a processing aid/additive to improve formulation compatibility, flow, and leveling. In cleaning formulations, it can function as a mild surfactant or co-solvent to aid wetting and soil dispersion. In polymers and plastics, it may act as a processing aid or compatibility modifier to improve interactions with other components.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 353.35
    methanol 735.53
    isopropanol 140.44
    water 1.67
    ethyl acetate 55.04
    n-propanol 161.17
    acetone 138.39
    n-butanol 113.49
    acetonitrile 34.03
    DMF 657.98
    toluene 6.56
    isobutanol 99.2
    1,4-dioxane 63.92
    methyl acetate 42.46
    THF 210.41
    2-butanone 71.68
    n-pentanol 95.26
    sec-butanol 92.53
    n-hexane 2.05
    ethylene glycol 126.22
    NMP 304.71
    cyclohexane 1.14
    DMSO 1073.28
    n-butyl acetate 67.79
    n-octanol 17.6
    chloroform 22.74
    n-propyl acetate 51.4
    acetic acid 253.39
    dichloromethane 26.38
    cyclohexanone 123.02
    propylene glycol 167.43
    isopropyl acetate 51.63
    DMAc 460.31
    2-ethoxyethanol 272.81
    isopentanol 113.24
    n-heptane 0.76
    ethyl formate 64.95
    1,2-dichloroethane 34.42
    n-hexanol 59.89
    2-methoxyethanol 454.94
    isobutyl acetate 39.89
    tetrachloromethane 5.17
    n-pentyl acetate 29.81
    transcutol 497.87
    n-heptanol 22.67
    ethylbenzene 8.7
    MIBK 63.14
    2-propoxyethanol 181.81
    tert-butanol 198.36
    MTBE 59.36
    2-butoxyethanol 83.39
    propionic acid 107.24
    o-xylene 11.98
    formic acid 228.43
    diethyl ether 21.45
    m-xylene 10.84
    p-xylene 13.51
    chlorobenzene 12.03
    dimethyl carbonate 25.3
    n-octane 0.52
    formamide 298.08
    cyclopentanone 178.22
    2-pentanone 73.69
    anisole 31.81
    cyclopentyl methyl ether 60.73
    gamma-butyrolactone 189.1
    1-methoxy-2-propanol 281.93
    pyridine 43.54
    3-pentanone 32.44
    furfural 176.96
    n-dodecane 0.52
    diethylene glycol 199.04
    diisopropyl ether 9.91
    tert-amyl alcohol 142.2
    acetylacetone 118.16
    n-hexadecane 0.58
    acetophenone 49.58
    methyl propionate 46.63
    isopentyl acetate 78.77
    trichloroethylene 59.43
    n-nonanol 16.15
    cyclohexanol 56.51
    benzyl alcohol 57.59
    2-ethylhexanol 29.73
    isooctanol 21.27
    dipropyl ether 13.78
    1,2-dichlorobenzene 16.78
    ethyl lactate 46.1
    propylene carbonate 103.53
    n-methylformamide 248.66
    2-pentanol 49.41
    n-pentane 1.02
    1-propoxy-2-propanol 109.26
    1-methoxy-2-propyl acetate 89.85
    2-(2-methoxypropoxy) propanol 100.8
    mesitylene 8.84
    ε-caprolactone 115.58
    p-cymene 7.92
    epichlorohydrin 153.73
    1,1,1-trichloroethane 20.07
    2-aminoethanol 266.38
    morpholine-4-carbaldehyde 252.06
    sulfolane 333.46
    2,2,4-trimethylpentane 1.92
    2-methyltetrahydrofuran 103.53
    n-hexyl acetate 38.42
    isooctane 1.35
    2-(2-butoxyethoxy)ethanol 142.22
    sec-butyl acetate 38.19
    tert-butyl acetate 75.5
    decalin 2.19
    glycerin 227.05
    diglyme 218.3
    acrylic acid 91.24
    isopropyl myristate 14.42
    n-butyric acid 152.94
    acetyl acetate 38.94
    di(2-ethylhexyl) phthalate 27.86
    ethyl propionate 37.11
    nitromethane 252.1
    1,2-diethoxyethane 62.64
    benzonitrile 36.74
    trioctyl phosphate 17.25
    1-bromopropane 12.55
    gamma-valerolactone 268.27
    n-decanol 11.5
    triethyl phosphate 24.46
    4-methyl-2-pentanol 37.93
    propionitrile 29.49
    vinylene carbonate 71.52
    1,1,2-trichlorotrifluoroethane 182.04
    DMS 38.15
    cumene 9.59
    2-octanol 13.04
    2-hexanone 60.32
    octyl acetate 18.37
    limonene 10.48
    1,2-dimethoxyethane 255.16
    ethyl orthosilicate 24.52
    tributyl phosphate 23.53
    diacetone alcohol 159.02
    N,N-dimethylaniline 33.03
    acrylonitrile 46.72
    aniline 27.82
    1,3-propanediol 269.8
    bromobenzene 9.9
    dibromomethane 16.38
    1,1,2,2-tetrachloroethane 58.12
    2-methyl-cyclohexyl acetate 42.53
    tetrabutyl urea 35.31
    diisobutyl methanol 17.07
    2-phenylethanol 44.34
    styrene 9.22
    dioctyl adipate 31.7
    dimethyl sulfate 75.2
    ethyl butyrate 38.64
    methyl lactate 71.63
    butyl lactate 49.62
    diethyl carbonate 25.61
    propanediol butyl ether 108.88
    triethyl orthoformate 30.24
    p-tert-butyltoluene 8.17
    methyl 4-tert-butylbenzoate 52.12
    morpholine 146.44
    tert-butylamine 67.07
    n-dodecanol 8.38
    dimethoxymethane 132.28
    ethylene carbonate 60.15
    cyrene 98.0
    2-ethoxyethyl acetate 55.19
    2-ethylhexyl acetate 47.25
    1,2,4-trichlorobenzene 22.77
    4-methylpyridine 54.83
    dibutyl ether 14.58
    2,6-dimethyl-4-heptanol 17.07
    DEF 118.53
    dimethyl isosorbide 141.7
    tetrachloroethylene 38.14
    eugenol 60.96
    triacetin 51.77
    span 80 70.64
    1,4-butanediol 121.49
    1,1-dichloroethane 19.1
    2-methyl-1-pentanol 92.98
    methyl formate 114.49
    2-methyl-1-butanol 95.93
    n-decane 0.78
    butyronitrile 43.28
    3,7-dimethyl-1-octanol 24.95
    1-chlorooctane 4.75
    1-chlorotetradecane 2.19
    n-nonane 0.67
    undecane 0.61
    tert-butylcyclohexane 2.48
    cyclooctane 0.56
    cyclopentanol 92.53
    tetrahydropyran 44.72
    tert-amyl methyl ether 47.8
    2,5,8-trioxanonane 160.17
    1-hexene 11.29
    2-isopropoxyethanol 155.22
    2,2,2-trifluoroethanol 68.82
    methyl butyrate 71.79

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction