Calcium Gluconate

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  • Identifiers

    CAS number
    299-28-5

    Molecular formula
    C12H22CaO14

    SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Ca+2]

  • Odor profile

    Fragrance
    Odorless 72.18%
    Sweet 48.12%
    Caramellic 26.01%
    Buttery 21.5%
    Milky 17.36%
    Clean 17.28%
    Savory 16.84%
    Bitter 15.85%
    Alcoholic 15.73%
    Sharp 14.68%

     

    Flavor
    Odorless 71.97%
    Sweet 33.74%
    Sweet-like 30.88%
    Very mild 30.55%
    Bland 24.22%
    Mild 21.49%
    Very slight 20.22%
    Yeast 19.74%
    Caramellic 19.02%
    Acetoin 18.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    1.43 (strong acid)

    Molecular weight
    430.37 g/mol

    Melting point expt.

    • 120 °C
    • 178 °C

    Flash point

    • 228.83 ˚C est.

    Solubility expt.

    • Soluble in water, insoluble in ethanol
    • Slowly soluble in 5 parts boiling water; insoluble in alc or other organic solvents. Slowly soluble in 30 parts cold, about 5 parts boiling water
    • Insoluble in acetic acid
    • Sol in water 3.3 g/100 cc at 15 °C
    • In water, 3.33X10+4 mg/L at 25 °C
    • Solubility in water, g/100ml at 25 °C: 3.5 (moderate)

  • Synonyms

    • CALCIUM GLUCONATE
    • 299-28-5
    • Calcium D-gluconate
    • D-Gluconic acid, calcium salt (2:1)
    • Calglucon
    • Calcicol
    • Calcipur
    • Calglucol
    • Dragocal
    • Kalpren
    • Novocal
    • Calcarea gluconica
    • Calcium di-gluconate
    • Gluconate de calcium
    • Calcium hexagluconate
    • Calcium gluconate anhydrous
    • Gluconato di calcio
    • Calcium gluconate, anhydrous
    • CCRIS 1336
    • HSDB 994
    • Calcii gluconas
    • UNII-SQE6VB453K
    • EINECS 206-075-8
    • SQE6VB453K
    • Glucobiogen
    • Calciofon
    • INS NO.578
    • Gluconate Calcium
    • INS-578
    • Gluconic Acid Calcium Salt
    • NSC-744619
    • CHEBI:3309
    • calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • calcium;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • DTXSID2029618
    • E-578
    • Ebucin
    • MFCD00064209
    • D-Gluconic acid calcium salt
    • NSC 744619
    • Gluconate (Calcium)
    • 2,3,4,5,6-Pentahydroxycaproic Acid hemicalcium salt
    • CALCIUM GLUCONATE (USP IMPURITY)
    • CALCIUM GLUCONATE [USP IMPURITY]
    • CALCIUM GLUCONATE (USP MONOGRAPH)
    • CALCIUM GLUCONATE [USP MONOGRAPH]
    • Gluconate, Calcium
    • Calcium D-gluconate (1:2)
    • Gluconate de calcium [French]
    • Gluconato di calcio [Italian]
    • Calcium Gluconate [USAN:JAN]
    • CALCIUM GLUCONATE ANHYDROUS (USP-RS)
    • CALCIUM GLUCONATE ANHYDROUS [USP-RS]
    • CALCIUM GLUCONATE, ANHYDROUS (EP MONOGRAPH)
    • CALCIUM GLUCONATE, ANHYDROUS [EP MONOGRAPH]
    • Gluconic acid, calcium salt
    • Gluconic acid, calcium salt (2:1), D-
    • Calcio gluconato
    • Gluconic acid, calcium salt, D-
    • CALCIUM GLYCONATE
    • 23% Calcium Gluconate
    • Calcium D-gluconate;Gluconic acid hemicalcium salt
    • calcium di(D-gluconate)
    • Calcium gluconate hydrate
    • calcium bis(D-gluconate)
    • Calcium gluconate (USP)
    • SCHEMBL24132
    • Sykes Calcium Gluconate 23%
    • CALCIUM GLUCONATE [MI]
    • Calgonate Calcium Gluconate Gel
    • DTXCID609618
    • CALCIUM GLUCONATE [FCC]
    • CALCIUM GLUCONATE [HSDB]
    • Calcium Gluconate 23% Solution
    • CHEMBL2106119
    • CALCIUM GLUCONATE [VANDF]
    • CALCIUM GLUCONATE [WHO-DD]
    • CALCIUM GLUCONATE [WHO-IP]
    • Calgonate Calcium Gluconate Gel2.5%
    • AKOS015895893
    • CALCII GLUCONAS [WHO-IP LATIN]
    • CALCIUM GLUCONATE [ORANGE BOOK]
    • DB11126
    • MG07602
    • AS-80559
    • G0037
    • NS00078671
    • C08133
    • D00935
    • F85235
    • Q413739
    • Z2768168188
    • calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
    • Calcium D-gluconate;2,3,4,5,6-Pentahydroxycaproic acid hemicalcium salt
    • 206-075-8

  • Applications

    Calcium Gluconate (CAS 299-28-5) is used across several industries as a calcium source and functional additive. In food processing, it serves as a calcium fortificant and dietary supplement ingredient for fortified foods and beverages. In pharmaceutical formulations, it provides calcium content in various dosage forms, including oral and injectable preparations, without implying therapeutic claims. In agriculture, it is applied as a calcium source to correct plant calcium deficiencies through foliar sprays or soil applications. In cosmetics and personal care, it is used as a mineral fortifier and buffering/stabilizing agent in certain formulations. In cleaning and household products, it can act as a chelating/stabilizing agent to sequester metal ions and improve formulation stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.11
    methanol 40.94
    isopropanol 2.81
    water 1208.44
    ethyl acetate 0.9
    n-propanol 3.53
    acetone 3.72
    n-butanol 1.65
    acetonitrile 0.94
    DMF 145.44
    toluene 0.29
    isobutanol 1.55
    1,4-dioxane 4.15
    methyl acetate 0.96
    THF 3.76
    2-butanone 1.46
    n-pentanol 0.66
    sec-butanol 2.23
    n-hexane 0.07
    ethylene glycol 250.97
    NMP 142.13
    cyclohexane 0.54
    DMSO 701.99
    n-butyl acetate 0.47
    n-octanol 0.65
    chloroform 0.07
    n-propyl acetate 0.31
    acetic acid 22.2
    dichloromethane 0.18
    cyclohexanone 2.5
    propylene glycol 72.85
    isopropyl acetate 0.62
    DMAc 73.62
    2-ethoxyethanol 16.13
    isopentanol 1.2
    n-heptane 0.4
    ethyl formate 1.26
    1,2-dichloroethane 0.39
    n-hexanol 1.38
    2-methoxyethanol 72.59
    isobutyl acetate 0.08
    tetrachloromethane 0.15
    n-pentyl acetate 0.32
    transcutol 13.34
    n-heptanol 1.09
    ethylbenzene 0.16
    MIBK 0.94
    2-propoxyethanol 10.44
    tert-butanol 4.66
    MTBE 0.8
    2-butoxyethanol 4.42
    propionic acid 7.46
    o-xylene 0.7
    formic acid 404.26
    diethyl ether 0.75
    m-xylene 0.46
    p-xylene 0.15
    chlorobenzene 0.07
    dimethyl carbonate 4.25
    n-octane 0.13
    formamide 311.53
    cyclopentanone 4.13
    2-pentanone 1.56
    anisole 0.46
    cyclopentyl methyl ether 2.72
    gamma-butyrolactone 6.45
    1-methoxy-2-propanol 30.47
    pyridine 1.19
    3-pentanone 1.45
    furfural 7.69
    n-dodecane 0.07
    diethylene glycol 49.83
    diisopropyl ether 0.39
    tert-amyl alcohol 3.79
    acetylacetone 4.08
    n-hexadecane 0.07
    acetophenone 0.83
    methyl propionate 2.68
    isopentyl acetate 0.34
    trichloroethylene 0.34
    n-nonanol 0.61
    cyclohexanol 2.93
    benzyl alcohol 1.14
    2-ethylhexanol 0.72
    isooctanol 0.67
    dipropyl ether 0.98
    1,2-dichlorobenzene 0.12
    ethyl lactate 2.4
    propylene carbonate 1.75
    n-methylformamide 58.1
    2-pentanol 1.32
    n-pentane 0.17
    1-propoxy-2-propanol 6.06
    1-methoxy-2-propyl acetate 2.29
    2-(2-methoxypropoxy) propanol 4.38
    mesitylene 0.49
    ε-caprolactone 2.63
    p-cymene 0.38
    epichlorohydrin 1.94
    1,1,1-trichloroethane 0.09
    2-aminoethanol 99.1
    morpholine-4-carbaldehyde 67.42
    sulfolane 60.31
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 1.81
    n-hexyl acetate 0.41
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 5.82
    sec-butyl acetate 0.19
    tert-butyl acetate 1.13
    decalin 0.12
    glycerin 297.71
    diglyme 12.18
    acrylic acid 15.25
    isopropyl myristate 0.2
    n-butyric acid 2.89
    acetyl acetate 0.82
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.54
    nitromethane 20.57
    1,2-diethoxyethane 0.87
    benzonitrile 0.22
    trioctyl phosphate 0.4
    1-bromopropane 0.11
    gamma-valerolactone 12.22
    n-decanol 0.48
    triethyl phosphate 0.78
    4-methyl-2-pentanol 0.73
    propionitrile 0.44
    vinylene carbonate 1.35
    1,1,2-trichlorotrifluoroethane 17.2
    DMS 0.93
    cumene 0.15
    2-octanol 0.52
    2-hexanone 0.35
    octyl acetate 0.31
    limonene 0.7
    1,2-dimethoxyethane 6.74
    ethyl orthosilicate 0.66
    tributyl phosphate 0.31
    diacetone alcohol 8.52
    N,N-dimethylaniline 1.0
    acrylonitrile 1.13
    aniline 1.07
    1,3-propanediol 44.97
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.5
    2-methyl-cyclohexyl acetate 0.46
    tetrabutyl urea 0.91
    diisobutyl methanol 0.64
    2-phenylethanol 1.11
    styrene 0.12
    dioctyl adipate 0.37
    dimethyl sulfate 22.21
    ethyl butyrate 0.58
    methyl lactate 18.02
    butyl lactate 1.19
    diethyl carbonate 0.36
    propanediol butyl ether 5.97
    triethyl orthoformate 0.72
    p-tert-butyltoluene 0.45
    methyl 4-tert-butylbenzoate 2.03
    morpholine 8.1
    tert-butylamine 1.51
    n-dodecanol 0.38
    dimethoxymethane 20.21
    ethylene carbonate 1.03
    cyrene 12.22
    2-ethoxyethyl acetate 0.7
    2-ethylhexyl acetate 0.26
    1,2,4-trichlorobenzene 0.17
    4-methylpyridine 0.79
    dibutyl ether 0.26
    2,6-dimethyl-4-heptanol 0.64
    DEF 9.24
    dimethyl isosorbide 6.43
    tetrachloroethylene 0.73
    eugenol 2.17
    triacetin 1.06
    span 80 3.77
    1,4-butanediol 12.22
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.5
    methyl formate 21.33
    2-methyl-1-butanol 1.41
    n-decane 0.11
    butyronitrile 0.26
    3,7-dimethyl-1-octanol 0.41
    1-chlorooctane 0.15
    1-chlorotetradecane 0.08
    n-nonane 0.11
    undecane 0.08
    tert-butylcyclohexane 0.06
    cyclooctane 0.38
    cyclopentanol 4.18
    tetrahydropyran 1.16
    tert-amyl methyl ether 1.24
    2,5,8-trioxanonane 10.11
    1-hexene 0.08
    2-isopropoxyethanol 4.76
    2,2,2-trifluoroethanol 24.9
    methyl butyrate 0.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction