Calcium disodium (ethylenedinitrilo)tetraacetate dihydrate

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  • Identifiers

    CAS number
    6766-87-6

    Molecular formula
    C10H16CaN2Na2O10

    SMILES
    C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].O.O.[Na+].[Na+].[Ca+2]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 65.17%
    Sweet 38.53%
    Savory 25.02%
    Fishy 20.26%
    Alcoholic 17.69%
    Oily 14.69%
    Clean 14.2%
    Meaty 13.8%
    Milky 13.63%
    Cooling 13.55%

     

    Flavor
    Odorless 58.79%
    Bitter 39.77%
    Bland 30.93%
    Mild 28.59%
    Very mild 23.2%
    Sweet-like 21.29%
    Yeast 20.44%
    Nitrile 18.93%
    Bread crust 18.92%
    Roasted peanuts 18.58%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    -2.51 (strong acid)

    Molecular weight
    410.3 g/mol

    Flash point

    • 261.68 ˚C est.

  • Synonyms

    • 6766-87-6
    • 23411-34-9
    • edetate calcium disodium dihydrate
    • Calcium disodium (ethylenedinitrilo)tetraacetate dihydrate
    • Edetate calcium disodium
    • Calcium disodium EDTA [FCC]
    • Calcium disodium EDTA dihydrate
    • Calcium disodium versenate
    • Edetate Calcium Disodium [USAN]
    • 25IH6R4SGF
    • Calcium disodium ethylenediaminetetraacetate dihydrate
    • Edetate calcium disodium [ORANGE BOOK]
    • Versene CA
    • calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;dihydrate
    • Edetate calcium disodium [USP]
    • Ethylenediaminetetraacetic acid calcium Disodium salt hydrate
    • Ethylenediamine-N,N,N',N'-tetraacetic Acid Calcium Disodium Hydrate
    • Calciate(2-),[[N,N'-1,2-ethanediylbis[N-[(carboxy-kO)methyl]glycinato-kN,kO]](4-)]-,disodium, dihydrate, (OC-6-21)-
    • Disodium((ethylenedinitrilo)tetraacetato)calciate(2-) hydrate
    • CALCIUM DISODIUM EDETATE DIHYDRATE
    • Calcium disodium edetate hydrate
    • UNII-25IH6R4SGF
    • Disodium[(ethylenedinitrilo)tetraacetato]calciate(2-) hydrate
    • MFCD00149454
    • Calcium disodium edetate hydrate [JAN]
    • JCQNARRMQCMKAN-UHFFFAOYSA-J
    • Ethylenediaminetetraacetic acid calcium disodium salt dihydrate
    • EDETATE CALCIUM DISODIUM [II]
    • SODIUM CALCIUM EDETATE HYDRATE
    • AKOS025294960
    • SODIUM-CALCIUM EDETATE DIHYDRATE
    • EDETATE CALCIUM DISODIUM [VANDF]
    • SODIUM CALCIUM EDETATE [WHO-IP]
    • Calciate (2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',O(Sup n),O(Sup n)'-, disodium, hydrate, (oc-6-21)-
    • EDETATE CALCIUM DISODIUM [USP-RS]
    • FE157146
    • NATRII CALCII EDETAS [WHO-IP LATIN]
    • CALCIUM SODIUM EDETATE HYDRATE [JAN]
    • CALCIUM DISODIUM ION(4-) EDTA DIHYDRATE
    • EDETATE CALCIUM DISODIUM [USP MONOGRAPH]
    • Q27253964
    • Ethylenediaminetetraaceticacidcalciumdisodiumsaltdihydrate
    • CALCIUM DISODIUM- ETHYLENEDIAMINETETRAACETATE DIHYDRATE
    • CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY-.KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, SODIUM, HYDRATE (1:2:2), (OC-6-21)-
    • EDTA calcium disodium salt dihydrate 98%, meets the analytical specifications of Ph. Eur., USP

  • Applications

    Calcium disodium (ethylenedinitrilo)tetraacetate dihydrate (CAS 6766-87-6) is widely used as a metal chelating (sequestering) agent to bind trace metal ions and reduce their catalytic impact on formulation stability. In cosmetics and personal care, it helps stabilize products by chelating metal contaminants. In household and industrial cleaning products, it enhances detergent performance and color stability by sequestering metal ions. In food processing, it functions as a sequestrant to preserve color, flavor, and clarity by binding metal ions. In polymers and coatings, it acts as a stabilizer/processing aid to minimize metal-catalyzed oxidation during manufacture and use. In pharmaceuticals, it serves as an excipient/stabilizer to improve formulation stability and compatibility with metal-containing ingredients.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.88
    methanol 4.29
    isopropanol 0.17
    water 1.22
    ethyl acetate 0.2
    n-propanol 0.39
    acetone 0.79
    n-butanol 0.17
    acetonitrile 0.27
    DMF 37.0
    toluene 0.1
    isobutanol 0.15
    1,4-dioxane 0.11
    methyl acetate 0.43
    THF 0.84
    2-butanone 0.66
    n-pentanol 0.06
    sec-butanol 0.16
    n-hexane 0.01
    ethylene glycol 1.41
    NMP 65.1
    cyclohexane 0.01
    DMSO 55.18
    n-butyl acetate 0.22
    n-octanol 0.04
    chloroform 0.36
    n-propyl acetate 0.12
    acetic acid 3.01
    dichloromethane 0.77
    cyclohexanone 0.9
    propylene glycol 1.16
    isopropyl acetate 0.09
    DMAc 30.83
    2-ethoxyethanol 0.71
    isopentanol 0.08
    n-heptane 0.01
    ethyl formate 0.67
    1,2-dichloroethane 0.49
    n-hexanol 0.07
    2-methoxyethanol 4.21
    isobutyl acetate 0.03
    tetrachloromethane 0.07
    n-pentyl acetate 0.07
    transcutol 1.49
    n-heptanol 0.05
    ethylbenzene 0.05
    MIBK 0.11
    2-propoxyethanol 0.89
    tert-butanol 0.13
    MTBE 0.06
    2-butoxyethanol 0.33
    propionic acid 1.39
    o-xylene 0.16
    formic acid 14.91
    diethyl ether 0.07
    m-xylene 0.08
    p-xylene 0.06
    chlorobenzene 0.1
    dimethyl carbonate 0.93
    n-octane 0.0
    formamide 20.93
    cyclopentanone 2.24
    2-pentanone 0.32
    anisole 0.12
    cyclopentyl methyl ether 0.24
    gamma-butyrolactone 4.17
    1-methoxy-2-propanol 1.76
    pyridine 0.84
    3-pentanone 0.44
    furfural 6.75
    n-dodecane 0.0
    diethylene glycol 1.42
    diisopropyl ether 0.01
    tert-amyl alcohol 0.17
    acetylacetone 0.56
    n-hexadecane 0.0
    acetophenone 0.48
    methyl propionate 0.81
    isopentyl acetate 0.13
    trichloroethylene 1.17
    n-nonanol 0.04
    cyclohexanol 0.1
    benzyl alcohol 0.24
    2-ethylhexanol 0.05
    isooctanol 0.03
    dipropyl ether 0.12
    1,2-dichlorobenzene 0.17
    ethyl lactate 0.5
    propylene carbonate 1.2
    n-methylformamide 13.44
    2-pentanol 0.06
    n-pentane 0.01
    1-propoxy-2-propanol 0.63
    1-methoxy-2-propyl acetate 0.62
    2-(2-methoxypropoxy) propanol 0.92
    mesitylene 0.05
    ε-caprolactone 0.92
    p-cymene 0.08
    epichlorohydrin 1.57
    1,1,1-trichloroethane 0.14
    2-aminoethanol 1.94
    morpholine-4-carbaldehyde 9.8
    sulfolane 27.29
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.23
    n-hexyl acetate 0.09
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.56
    sec-butyl acetate 0.05
    tert-butyl acetate 0.12
    decalin 0.01
    glycerin 4.55
    diglyme 1.37
    acrylic acid 2.93
    isopropyl myristate 0.03
    n-butyric acid 0.7
    acetyl acetate 0.14
    di(2-ethylhexyl) phthalate 0.13
    ethyl propionate 0.19
    nitromethane 6.37
    1,2-diethoxyethane 0.1
    benzonitrile 0.17
    trioctyl phosphate 0.08
    1-bromopropane 0.13
    gamma-valerolactone 4.9
    n-decanol 0.03
    triethyl phosphate 0.36
    4-methyl-2-pentanol 0.02
    propionitrile 0.23
    vinylene carbonate 1.41
    1,1,2-trichlorotrifluoroethane 6.51
    DMS 0.34
    cumene 0.04
    2-octanol 0.02
    2-hexanone 0.13
    octyl acetate 0.05
    limonene 0.11
    1,2-dimethoxyethane 0.91
    ethyl orthosilicate 0.23
    tributyl phosphate 0.13
    diacetone alcohol 0.54
    N,N-dimethylaniline 0.31
    acrylonitrile 0.83
    aniline 0.29
    1,3-propanediol 0.98
    bromobenzene 0.08
    dibromomethane 0.35
    1,1,2,2-tetrachloroethane 0.84
    2-methyl-cyclohexyl acetate 0.18
    tetrabutyl urea 0.36
    diisobutyl methanol 0.04
    2-phenylethanol 0.18
    styrene 0.06
    dioctyl adipate 0.11
    dimethyl sulfate 6.86
    ethyl butyrate 0.26
    methyl lactate 2.43
    butyl lactate 0.33
    diethyl carbonate 0.21
    propanediol butyl ether 0.43
    triethyl orthoformate 0.23
    p-tert-butyltoluene 0.07
    methyl 4-tert-butylbenzoate 0.56
    morpholine 0.45
    tert-butylamine 0.06
    n-dodecanol 0.02
    dimethoxymethane 2.3
    ethylene carbonate 0.57
    cyrene 1.89
    2-ethoxyethyl acetate 0.17
    2-ethylhexyl acetate 0.11
    1,2,4-trichlorobenzene 0.26
    4-methylpyridine 0.64
    dibutyl ether 0.03
    2,6-dimethyl-4-heptanol 0.04
    DEF 2.02
    dimethyl isosorbide 1.92
    tetrachloroethylene 0.71
    eugenol 0.56
    triacetin 0.34
    span 80 0.41
    1,4-butanediol 0.21
    1,1-dichloroethane 0.15
    2-methyl-1-pentanol 0.04
    methyl formate 5.99
    2-methyl-1-butanol 0.12
    n-decane 0.0
    butyronitrile 0.12
    3,7-dimethyl-1-octanol 0.04
    1-chlorooctane 0.02
    1-chlorotetradecane 0.01
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 0.21
    tetrahydropyran 0.09
    tert-amyl methyl ether 0.11
    2,5,8-trioxanonane 1.16
    1-hexene 0.03
    2-isopropoxyethanol 0.18
    2,2,2-trifluoroethanol 2.19
    methyl butyrate 0.34

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction