Calcium Diglutamate

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  • Identifiers

    CAS number
    5996-22-5

    Molecular formula
    C10H16CaN2O8

    SMILES
    C(CC(=O)O)[C@@H](C(=O)[O-])N.C(CC(=O)O)[C@@H](C(=O)[O-])N.[Ca+2]

  • Odor profile

    Fragrance
    Odorless 75.0%
    Sweet 32.65%
    Savory 32.6%
    Meaty 23.22%
    Milky 19.3%
    Sour 18.0%
    Buttery 17.33%
    Cooked 17.21%
    Cocoa 15.21%
    Clean 14.82%

     

    Flavor
    Odorless 72.96%
    Mild 36.16%
    Very mild 30.31%
    Bland 27.0%
    Yeast 24.7%
    Sour 24.51%
    Faint 24.1%
    Sweet-like 22.33%
    Urine 19.56%
    Mousy 19.53%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    4.08 (weak acid)

    Molecular weight
    332.32 g/mol

    Flash point

    • 168.27 ˚C est.

    Solubility expt.

    • Freely soluble in water; practically insoluble in ethanol or ether

  • Synonyms

    • Calcium diglutamate
    • Calcium di-L-glutamate
    • UNII-9FA5OTO85L
    • 5996-22-5
    • EINECS 227-838-1
    • 9FA5OTO85L
    • Calcium L-glutamate (1:2)
    • Glutamic acid, calcium salt (2:1), L-
    • L-Glutamic acid, calcium salt (2:1)
    • DTXSID00894986
    • calcium;(2S)-2-amino-5-hydroxy-5-oxopentanoate
    • CALCIUM GLUTAMATE
    • INS NO.623
    • INS-623
    • MONOCALCIUM DI-L-GLUTAMATE
    • CALCIUM GLUTAMATE [WHO-DD]
    • CALCIUM DIGLUTAMATE ANHYDROUS
    • E-623
    • SCHEMBL587122
    • DTXSID20904298
    • DTXCID901324543
    • Glutamic acid, calcium salt (1:1)
    • 227-838-1

  • Applications

    Calcium Diglutamate (CAS 5996-22-5) is primarily used in the food industry as a flavor enhancer, delivering umami and savory notes while also acting as a calcium fortificant in fortified products. It is applied in processed foods, soups, sauces, seasonings, and snack formulations where taste enhancement and mineral enrichment are desired. In animal nutrition, it may be added to feed formulations to improve palatability and provide a calcium source. In nutraceutical or functional food applications, it can serve as a calcium-containing flavoring ingredient that supports mineral intake while contributing to taste.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2.5
    methanol 6.41
    isopropanol 1.34
    water 51.37
    ethyl acetate 1.34
    n-propanol 1.13
    acetone 5.34
    n-butanol 1.02
    acetonitrile 1.3
    DMF 105.23
    toluene 0.82
    isobutanol 0.87
    1,4-dioxane 6.21
    methyl acetate 1.16
    THF 5.51
    2-butanone 1.91
    n-pentanol 0.74
    sec-butanol 0.95
    n-hexane 0.34
    ethylene glycol 22.12
    NMP 119.68
    cyclohexane 0.35
    DMSO 153.35
    n-butyl acetate 1.28
    n-octanol 1.16
    chloroform 0.17
    n-propyl acetate 0.75
    acetic acid 13.45
    dichloromethane 0.48
    cyclohexanone 5.2
    propylene glycol 10.15
    isopropyl acetate 1.21
    DMAc 77.44
    2-ethoxyethanol 9.34
    isopentanol 1.33
    n-heptane 0.45
    ethyl formate 2.76
    1,2-dichloroethane 0.78
    n-hexanol 1.39
    2-methoxyethanol 24.17
    isobutyl acetate 0.31
    tetrachloromethane 0.13
    n-pentyl acetate 1.18
    transcutol 23.84
    n-heptanol 1.51
    ethylbenzene 0.6
    MIBK 1.77
    2-propoxyethanol 9.5
    tert-butanol 3.23
    MTBE 1.21
    2-butoxyethanol 6.84
    propionic acid 4.13
    o-xylene 1.7
    formic acid 74.25
    diethyl ether 0.89
    m-xylene 1.18
    p-xylene 0.77
    chlorobenzene 0.35
    dimethyl carbonate 3.64
    n-octane 0.22
    formamide 54.61
    cyclopentanone 7.58
    2-pentanone 2.37
    anisole 1.4
    cyclopentyl methyl ether 3.12
    gamma-butyrolactone 12.25
    1-methoxy-2-propanol 13.93
    pyridine 2.87
    3-pentanone 1.91
    furfural 22.54
    n-dodecane 0.12
    diethylene glycol 25.8
    diisopropyl ether 0.59
    tert-amyl alcohol 2.48
    acetylacetone 6.84
    n-hexadecane 0.13
    acetophenone 2.9
    methyl propionate 2.31
    isopentyl acetate 1.13
    trichloroethylene 0.86
    n-nonanol 1.22
    cyclohexanol 1.9
    benzyl alcohol 2.32
    2-ethylhexanol 1.05
    isooctanol 1.21
    dipropyl ether 1.3
    1,2-dichlorobenzene 0.59
    ethyl lactate 2.88
    propylene carbonate 5.42
    n-methylformamide 21.84
    2-pentanol 0.93
    n-pentane 0.22
    1-propoxy-2-propanol 5.82
    1-methoxy-2-propyl acetate 3.96
    2-(2-methoxypropoxy) propanol 11.52
    mesitylene 1.09
    ε-caprolactone 6.11
    p-cymene 0.85
    epichlorohydrin 4.59
    1,1,1-trichloroethane 0.21
    2-aminoethanol 14.11
    morpholine-4-carbaldehyde 69.16
    sulfolane 50.93
    2,2,4-trimethylpentane 0.15
    2-methyltetrahydrofuran 2.78
    n-hexyl acetate 1.52
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 14.73
    sec-butyl acetate 0.52
    tert-butyl acetate 1.96
    decalin 0.21
    glycerin 44.81
    diglyme 20.77
    acrylic acid 9.52
    isopropyl myristate 0.8
    n-butyric acid 3.32
    acetyl acetate 1.62
    di(2-ethylhexyl) phthalate 2.19
    ethyl propionate 1.12
    nitromethane 18.72
    1,2-diethoxyethane 2.37
    benzonitrile 1.21
    trioctyl phosphate 1.5
    1-bromopropane 0.23
    gamma-valerolactone 27.38
    n-decanol 1.02
    triethyl phosphate 1.51
    4-methyl-2-pentanol 0.83
    propionitrile 0.58
    vinylene carbonate 5.21
    1,1,2-trichlorotrifluoroethane 12.96
    DMS 2.74
    cumene 0.62
    2-octanol 0.88
    2-hexanone 0.98
    octyl acetate 1.23
    limonene 1.07
    1,2-dimethoxyethane 10.91
    ethyl orthosilicate 1.27
    tributyl phosphate 1.37
    diacetone alcohol 7.87
    N,N-dimethylaniline 2.82
    acrylonitrile 1.65
    aniline 1.6
    1,3-propanediol 9.8
    bromobenzene 0.28
    dibromomethane 0.27
    1,1,2,2-tetrachloroethane 0.99
    2-methyl-cyclohexyl acetate 1.35
    tetrabutyl urea 3.56
    diisobutyl methanol 0.96
    2-phenylethanol 2.26
    styrene 0.49
    dioctyl adipate 1.7
    dimethyl sulfate 16.99
    ethyl butyrate 1.27
    methyl lactate 10.02
    butyl lactate 3.18
    diethyl carbonate 0.87
    propanediol butyl ether 9.91
    triethyl orthoformate 1.41
    p-tert-butyltoluene 0.82
    methyl 4-tert-butylbenzoate 6.13
    morpholine 7.07
    tert-butylamine 1.17
    n-dodecanol 0.81
    dimethoxymethane 15.12
    ethylene carbonate 3.08
    cyrene 18.1
    2-ethoxyethyl acetate 2.76
    2-ethylhexyl acetate 0.86
    1,2,4-trichlorobenzene 0.83
    4-methylpyridine 3.17
    dibutyl ether 0.74
    2,6-dimethyl-4-heptanol 0.96
    DEF 10.49
    dimethyl isosorbide 14.1
    tetrachloroethylene 1.01
    eugenol 7.32
    triacetin 4.14
    span 80 9.25
    1,4-butanediol 4.32
    1,1-dichloroethane 0.23
    2-methyl-1-pentanol 0.86
    methyl formate 16.25
    2-methyl-1-butanol 1.17
    n-decane 0.19
    butyronitrile 0.68
    3,7-dimethyl-1-octanol 0.97
    1-chlorooctane 0.35
    1-chlorotetradecane 0.21
    n-nonane 0.2
    undecane 0.15
    tert-butylcyclohexane 0.15
    cyclooctane 0.29
    cyclopentanol 2.19
    tetrahydropyran 1.32
    tert-amyl methyl ether 1.56
    2,5,8-trioxanonane 20.47
    1-hexene 0.4
    2-isopropoxyethanol 4.25
    2,2,2-trifluoroethanol 9.07
    methyl butyrate 1.64

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction