Cacodylic Acid

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  • Identifiers

    CAS number
    75-60-5

    Molecular formula
    C2H7AsO2

    SMILES
    C[As](=O)(C)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 41.48%
    Fruity 38.38%
    Pungent 36.51%
    Sharp 35.68%
    Ethereal 32.65%
    Sour 28.95%
    Cheesy 26.81%
    Odorless 26.42%
    Dairy 25.62%
    Fresh 25.61%

     

  • Properties

    pKa est.
    9.47 (weak base)

    Molecular weight
    138.0 g/mol

    Melting point expt.

    • 383 to 385 °F (NTP, 1992)
    • 140 °F 140 °F for trihydrate. Liquifies in water of hydration at 140 °F and becomes anhydrous at 284 °F (EPA, 1998)
    • 195 °C
    • 200 °C
    • MP: APPROX 60 °C; 200 G/100 CC OF WATER @ 15-20 °C; 40 G/100 CC OF ALCOHOL@ 25 °C; 100 G/100 CC OF 90% ALCOHOL @ 15-20 °C /SODIUM CACODYLATE TRIHYDRATE/

    Boiling point

    • greater than 392 °F at 760 mmHg (NTP, 1992)
    • >200 °C

    Flash point

    • 106.75 ˚C est.

    Solubility expt.

    • Very soluble (NTP, 1992)
    • Soluble in acetic acid
    • Soluble in ethanol; insoluble in diethyl ether
    • In water, 2X10+6 mg/l @ 25 °C.
    • Soluble in short chain alcohols; insoluble in diethyl ether.
    • In water, 2X10+6 mg/l @ 25 °C.

  • Synonyms

    • cacodylic acid
    • Dimethylarsinic acid
    • 75-60-5
    • Hydroxydimethylarsine oxide
    • Chexmate
    • Silvisar
    • Arsan
    • Phytar
    • Erase
    • DIMETHYLARSENIC ACID
    • Arsinic acid, dimethyl-
    • Phytar 560
    • Moncide
    • Cacodylate
    • Silvisar 510
    • Agent Blue
    • Rad-e-cate 35
    • Ansar 138
    • Sylvicor
    • Dilic
    • Acide cacodylique
    • Arsine oxide, dimethylhydroxy-
    • RCRA waste number U136
    • Ansar
    • Phytar 138
    • Acide dimethylarsinique
    • Caswell No. 133
    • Arsine oxide, hydroxydimethyl-
    • Kyselina kakodylova
    • CCRIS 5893
    • HSDB 360
    • NSC 103115
    • Dimethylarsonic Acid
    • UNII-AJ2HL7EU8K
    • EINECS 200-883-4
    • UN1572
    • EPA Pesticide Chemical Code 012501
    • BRN 1736965
    • Arsinic acid, As,As-dimethyl-
    • rad-e-cat 25
    • Bolls-eye
    • DTXSID7020508
    • Acid, Cacodylic
    • AI3-25369
    • Bolls-eye (Salt/Mix)
    • MFCD00002095
    • AJ2HL7EU8K
    • NSC-103115
    • UN 1572
    • CACODYLIC ACID [MI]
    • cacodylic-acid
    • DTXCID90508
    • CACODYLIC ACID [WHO-DD]
    • CHEBI:48765
    • OGGXGZAMXPVRFZ-UHFFFAOYSA-
    • DIMETHYLARSENIC ACID [HSDB]
    • DIMETHYLARSINIC ACID [IARC]
    • 4-04-00-03681 (Beilstein Handbook Reference)
    • Bolate
    • Bolls
    • Lithium cacodylate
    • Alkargen
    • Cotton aide HC
    • Phytar 600
    • DIMETHYLARSINIC ACID (IARC)
    • Acide cacodylique [French]
    • Kyselina kakodylova [Czech]
    • 917-76-0
    • Acid, Dimethylarsinic
    • Acide dimethylarsenique
    • Acide dimethylarsenique [French]
    • Acide dimethylarsinique [French]
    • As,As-Dimethylarsinic acid
    • RCRA waste no. U136
    • Kakodylsaeure
    • RadECate 35
    • Arsinic acid, dimethyl
    • Spectrum_001957
    • Me2As(=O)OH
    • CAC
    • Spectrum2_001170
    • Spectrum4_000235
    • Spectrum5_001683
    • Dimethylhydroxyarsine Oxide
    • Arsine oxide, lithium salt
    • Arsinic acid, lithium salt
    • bmse000786
    • bmse000822
    • Cacodylic acid, >=98%
    • Pesticide Code 012501
    • Dimethylarsinic acid (9CI)
    • NCIOpen2_000362
    • NCIOpen2_000410
    • NCIOpen2_001868
    • SCHEMBL15351
    • KBioGR_000929
    • KBioSS_002511
    • MLS002207238
    • Cacodylic acid, >=99.0%
    • DivK1c_000708
    • SPECTRUM1503947
    • SPBio_001159
    • [As(CH3)2O(OH)]
    • CHEMBL1231644
    • WLN: Q-AS-O&1&1
    • Cacodylic acid, SAJ first grade
    • HMS502D10
    • KBio1_000708
    • KBio2_002503
    • KBio2_005071
    • KBio2_007639
    • NINDS_000708
    • HMS1922O04
    • Cacodylic acid, analytical standard
    • HYDROXYDIMETHYL ARSINE OXIDE
    • NSC71159
    • Tox21_300767
    • CCG-39551
    • Lithium, [(dimethyloxoarsenio)oxy]-
    • NSC-71159
    • NSC103115
    • AKOS005267136
    • Cacodylic acid [UN1572] [Poison]
    • DB02994
    • FC47033
    • CAS-75-60-5
    • IDI1_000708
    • Dimethylarsinic acid, analytical standard

  • Applications

    Chemical name: Cacodylic Acid (CAS 75-60-5) is used in biochemical laboratories as a source of cacodylate buffers for pH control in tissue fixation and electron microscopy sample preparation; it serves as a key intermediate in the synthesis of organoarsenic compounds, enabling access to cacodylate esters and related derivatives in research; historically it has been used in arsenic-containing herbicides (cacodylate-based formulations) in agricultural chemistry; and it may be used as a reagent for preparative organoarsenic chemistry and as a reference material or calibrant in analytical methods for arsenic speciation.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 352.64
    methanol 657.27
    isopropanol 225.11
    water 477.77
    ethyl acetate 55.22
    n-propanol 210.93
    acetone 263.13
    n-butanol 150.96
    acetonitrile 152.14
    DMF 415.31
    toluene 27.15
    isobutanol 128.5
    1,4-dioxane 177.59
    methyl acetate 80.19
    THF 290.41
    2-butanone 121.63
    n-pentanol 96.04
    sec-butanol 137.81
    n-hexane 25.15
    ethylene glycol 299.42
    NMP 251.84
    cyclohexane 34.59
    DMSO 338.89
    n-butyl acetate 49.69
    n-octanol 69.11
    chloroform 78.85
    n-propyl acetate 50.91
    acetic acid 233.49
    dichloromethane 71.71
    cyclohexanone 130.19
    propylene glycol 218.38
    isopropyl acetate 36.95
    DMAc 255.51
    2-ethoxyethanol 207.89
    isopentanol 88.82
    n-heptane 29.31
    ethyl formate 75.02
    1,2-dichloroethane 60.88
    n-hexanol 104.5
    2-methoxyethanol 379.3
    isobutyl acetate 34.12
    tetrachloromethane 28.23
    n-pentyl acetate 42.73
    transcutol 218.0
    n-heptanol 74.42
    ethylbenzene 16.47
    MIBK 47.84
    2-propoxyethanol 204.43
    tert-butanol 163.21
    MTBE 59.28
    2-butoxyethanol 126.03
    propionic acid 142.45
    o-xylene 26.23
    formic acid 304.71
    diethyl ether 97.53
    m-xylene 26.04
    p-xylene 22.25
    chlorobenzene 25.06
    dimethyl carbonate 51.47
    n-octane 11.83
    formamide 330.0
    cyclopentanone 179.52
    2-pentanone 84.8
    anisole 44.98
    cyclopentyl methyl ether 108.3
    gamma-butyrolactone 150.47
    1-methoxy-2-propanol 239.93
    pyridine 92.86
    3-pentanone 73.31
    furfural 138.34
    n-dodecane 8.47
    diethylene glycol 231.65
    diisopropyl ether 27.95
    tert-amyl alcohol 97.13
    acetylacetone 77.79
    n-hexadecane 8.64
    acetophenone 49.78
    methyl propionate 71.68
    isopentyl acetate 38.1
    trichloroethylene 68.09
    n-nonanol 60.16
    cyclohexanol 114.46
    benzyl alcohol 59.38
    2-ethylhexanol 50.47
    isooctanol 48.05
    dipropyl ether 69.79
    1,2-dichlorobenzene 23.5
    ethyl lactate 56.8
    propylene carbonate 69.06
    n-methylformamide 243.84
    2-pentanol 94.59
    n-pentane 36.71
    1-propoxy-2-propanol 134.83
    1-methoxy-2-propyl acetate 58.76
    2-(2-methoxypropoxy) propanol 86.25
    mesitylene 19.63
    ε-caprolactone 87.13
    p-cymene 22.15
    epichlorohydrin 116.98
    1,1,1-trichloroethane 39.54
    2-aminoethanol 306.98
    morpholine-4-carbaldehyde 235.94
    sulfolane 181.96
    2,2,4-trimethylpentane 10.26
    2-methyltetrahydrofuran 130.34
    n-hexyl acetate 53.56
    isooctane 8.83
    2-(2-butoxyethoxy)ethanol 124.01
    sec-butyl acetate 29.12
    tert-butyl acetate 40.53
    decalin 11.04
    glycerin 301.38
    diglyme 193.26
    acrylic acid 141.55
    isopropyl myristate 27.79
    n-butyric acid 104.68
    acetyl acetate 37.48
    di(2-ethylhexyl) phthalate 34.64
    ethyl propionate 44.86
    nitromethane 217.17
    1,2-diethoxyethane 68.31
    benzonitrile 43.86
    trioctyl phosphate 30.53
    1-bromopropane 43.03
    gamma-valerolactone 190.85
    n-decanol 45.79
    triethyl phosphate 30.64
    4-methyl-2-pentanol 47.49
    propionitrile 88.63
    vinylene carbonate 63.85
    1,1,2-trichlorotrifluoroethane 137.93
    DMS 41.67
    cumene 16.11
    2-octanol 47.29
    2-hexanone 64.51
    octyl acetate 38.46
    limonene 32.84
    1,2-dimethoxyethane 219.75
    ethyl orthosilicate 31.23
    tributyl phosphate 30.27
    diacetone alcohol 81.11
    N,N-dimethylaniline 51.68
    acrylonitrile 106.63
    aniline 65.18
    1,3-propanediol 236.4
    bromobenzene 17.21
    dibromomethane 57.97
    1,1,2,2-tetrachloroethane 68.81
    2-methyl-cyclohexyl acetate 41.31
    tetrabutyl urea 49.16
    diisobutyl methanol 31.18
    2-phenylethanol 62.23
    styrene 18.65
    dioctyl adipate 40.79
    dimethyl sulfate 74.98
    ethyl butyrate 42.85
    methyl lactate 90.9
    butyl lactate 54.53
    diethyl carbonate 30.54
    propanediol butyl ether 123.8
    triethyl orthoformate 39.85
    p-tert-butyltoluene 23.34
    methyl 4-tert-butylbenzoate 62.01
    morpholine 213.37
    tert-butylamine 115.58
    n-dodecanol 36.49
    dimethoxymethane 214.64
    ethylene carbonate 57.23
    cyrene 93.58
    2-ethoxyethyl acetate 50.96
    2-ethylhexyl acetate 32.44
    1,2,4-trichlorobenzene 29.14
    4-methylpyridine 69.53
    dibutyl ether 39.68
    2,6-dimethyl-4-heptanol 31.18
    DEF 104.21
    dimethyl isosorbide 114.69
    tetrachloroethylene 59.62
    eugenol 81.35
    triacetin 56.12
    span 80 92.28
    1,4-butanediol 122.53
    1,1-dichloroethane 52.48
    2-methyl-1-pentanol 55.74
    methyl formate 165.62
    2-methyl-1-butanol 91.16
    n-decane 12.81
    butyronitrile 75.31
    3,7-dimethyl-1-octanol 45.78
    1-chlorooctane 26.83
    1-chlorotetradecane 14.01
    n-nonane 13.0
    undecane 9.89
    tert-butylcyclohexane 10.1
    cyclooctane 14.37
    cyclopentanol 155.46
    tetrahydropyran 133.58
    tert-amyl methyl ether 50.78
    2,5,8-trioxanonane 152.57
    1-hexene 41.02
    2-isopropoxyethanol 117.46
    2,2,2-trifluoroethanol 133.6
    methyl butyrate 56.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction