Bronopol

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  • Identifiers

    CAS number
    52-51-7

    Molecular formula
    C3H6BrNO4

    SMILES
    C(C(CO)([N+](=O)[O-])Br)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 61.63%
    Sweet 47.86%
    Buttery 20.3%
    Savory 20.15%
    Cooling 18.88%
    Milky 18.48%
    Bitter 17.93%
    Alcoholic 17.89%
    Mint 16.4%
    Caramellic 15.74%

     

    Flavor
    Odorless 63.97%
    Bitter 36.79%
    Bland 30.5%
    Mild 26.5%
    Sweet-like 24.93%
    Very mild 22.86%
    Yeast 20.0%
    Nitrile 18.57%
    Very slight 18.42%
    Bouillon 18.32%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    5.47 (weak acid)

    Molecular weight
    199.99 g/mol

    Melting point expt.

    • 266 to 271 °F (NTP, 1992)
    • 123-130
    • 131.5 °C
    • 120-122 °C

    Boiling point

    • 305.1 °F at 760 mmHg (NTP, 1992)
    • 130 undefined

    Flash point

    • 152.44 ˚C est.
    • 167 °C

    Solubility expt.

    • greater than or equal to 100 mg/mL at 63 °F (NTP, 1992)
    • 25-25g/100mL at 22°C
    • In water, 2.5X10+5 mg/L at 22 °C
    • Soluble in alcohol, ethyl acetate. Slightly soluble in chloroform, acetone, ether, benzene. Insoluble in ligroin.
    • Solubility in water, g/100ml at 23 °C: 28 (freely soluble)

  • Synonyms

    • bronopol
    • 52-51-7
    • 2-Bromo-2-nitro-1,3-propanediol
    • 2-Bromo-2-nitropropane-1,3-diol
    • Bronosol
    • Bronocot
    • Bronidiol
    • Bronopolu
    • Bronotak
    • Lexgard bronopol
    • Onyxide 500
    • Bronopolum
    • 1,3-Propanediol, 2-bromo-2-nitro-
    • 2-Nitro-2-bromo-1,3-propanediol
    • Caswell No. 116A
    • MFCD00007390
    • beta-Bromo-beta-nitrotrimethyleneglycol
    • NSC 141021
    • Bronopolum [INN-Latin]
    • HSDB 7195
    • EINECS 200-143-0
    • UNII-6PU1E16C9W
    • EPA Pesticide Chemical Code 216400
    • NSC-141021
    • BRN 1705868
    • 6PU1E16C9W
    • DTXSID8024652
    • CHEBI:31306
    • AI3-61639
    • 2-Bromo-2-nitropropan-1,3-diol
    • DTXCID904652
    • EC 200-143-0
    • C3H6BrNO4
    • NCGC00164057-01
    • Bronopolum (INN-Latin)
    • BRONOPOL (MART.)
    • BRONOPOL [MART.]
    • Bronopolu [Polish]
    • Bioban
    • Myacide AS
    • Myacide AS plus
    • Myacide BT
    • CAS-52-51-7
    • Bronopol [INN:BAN:JAN]
    • Myacide Pharma BP
    • Canguard 409
    • BNPD
    • Nalco 92RU093
    • UN3241
    • Remain Silver
    • Remain Gold
    • Bronopol solution
    • Gold-Bloc
    • Soft Tuch
    • 2-Bronopol
    • Gil Sani-Guard
    • Bronopol Teat Dip
    • QM Gold
    • Ultra-Soft Barrier
    • 2-bromo-2-nitro-propane-1,3-diol
    • Bronopol (Standard)
    • 1,2-Bromo-2-nitropropane-1,3-diol
    • Medic Booster Barrier
    • Bronopol (JAN/INN)
    • BRONOPOL [HSDB]
    • BRONOPOL [INN]
    • BRONOPOL [JAN]
    • BRONOPOL [MI]
    • BRONOPOL [VANDF]
    • WLN: WNXE1Q1Q
    • 1, 2-bromo-2-nitro-
    • 2-Bromo-2-nitropropane-1,3-diol (Bronopol)
    • BRONOPOL [WHO-DD]
    • SCHEMBL23260
    • TDX-84
    • Bioban BNPD-40 (Salt/Mix)
    • CHEMBL1408862
    • SCHEMBL16556987
    • HY-B1217R
    • LVDKZNITIUWNER-UHFFFAOYSA-
    • 2-Bromo-2-nitropropane-1,3-diol [UN3241] [Flammable Solid]
    • ALBB-031641
    • HY-B1217
    • Tox21_112079
    • Tox21_300126
    • BDBM50248122
    • NSC141021
    • s4553
    • 2-bromanyl-2-nitro-propane-1,3-diol
    • AKOS003606838
    • CCG-213823
    • CS-4699
    • DB13960
    • FB01194
    • AST Inc. PRO-4 BARRIER TEAT DIP
    • USEPA/OPP Pesticide Code: 216400
    • NCGC00164057-02
    • NCGC00164057-03
    • NCGC00253984-01
    • AS-11889
    • 2-Bromo-2-nitro-1,3-propanediol, 98%
    • AST Inc. PRO-4 SANITIZING TEAT DIP
    • .beta.-Bromo-.beta.-nitrotrimethyleneglycol
    • DB-027831
    • B1247
    • Bronopol, PESTANAL(R), analytical standard
    • NS00003792
    • SFP INC. TD-44 SANITIZING TEAT DIP
    • D01577
    • E85247
    • EN300-141420
    • SBI-0653499.0001
    • AB01563195_01
    • A829125
    • SR-01000944249
    • Q2462902
    • SR-01000944249-1
    • BRD-K33457401-001-01-1
    • SFP INC. TD-44 BARRIER SANITIZING POST TEAT DIP
    • InChI=1/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2
    • 200-143-0

  • Applications

    Bronopol (CAS 52-51-7) is used primarily as a bactericidal preservative in cosmetics and personal care products, such as shampoos, creams, and gels, to control microbial growth; it is also employed as a preservative/biocide in household cleaning products to extend shelf life and prevent spoilage. In industry, bronopol serves as a biocide in process water systems, including cooling towers and metalworking fluids. In coatings, paints, inks, and adhesives, it is used to inhibit microbial growth during storage and use. It is also used as an antimicrobial agent in polymer emulsions and latex coatings to enhance product stability. In papermaking and water treatment, bronopol is employed as a microbial control additive to manage microbial growth in process waters.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 19.78
    methanol 39.65
    isopropanol 13.12
    water 31.87
    ethyl acetate 3.28
    n-propanol 13.8
    acetone 27.28
    n-butanol 10.31
    acetonitrile 6.58
    DMF 229.27
    toluene 0.62
    isobutanol 9.13
    1,4-dioxane 9.23
    methyl acetate 5.91
    THF 28.8
    2-butanone 14.73
    n-pentanol 7.56
    sec-butanol 10.05
    n-hexane 0.23
    ethylene glycol 30.5
    NMP 178.62
    cyclohexane 0.38
    DMSO 199.75
    n-butyl acetate 3.25
    n-octanol 4.97
    chloroform 1.45
    n-propyl acetate 4.27
    acetic acid 24.37
    dichloromethane 2.21
    cyclohexanone 16.07
    propylene glycol 24.71
    isopropyl acetate 3.37
    DMAc 139.13
    2-ethoxyethanol 40.74
    isopentanol 8.13
    n-heptane 0.76
    ethyl formate 7.12
    1,2-dichloroethane 2.45
    n-hexanol 5.44
    2-methoxyethanol 66.62
    isobutyl acetate 2.53
    tetrachloromethane 0.44
    n-pentyl acetate 4.15
    transcutol 50.04
    n-heptanol 5.43
    ethylbenzene 0.53
    MIBK 9.03
    2-propoxyethanol 24.11
    tert-butanol 14.84
    MTBE 5.11
    2-butoxyethanol 17.39
    propionic acid 11.54
    o-xylene 1.21
    formic acid 58.42
    diethyl ether 3.51
    m-xylene 1.02
    p-xylene 0.87
    chlorobenzene 0.55
    dimethyl carbonate 7.2
    n-octane 0.34
    formamide 82.21
    cyclopentanone 29.77
    2-pentanone 11.68
    anisole 3.15
    cyclopentyl methyl ether 8.2
    gamma-butyrolactone 28.1
    1-methoxy-2-propanol 48.47
    pyridine 4.94
    3-pentanone 8.31
    furfural 29.99
    n-dodecane 0.25
    diethylene glycol 33.65
    diisopropyl ether 1.65
    tert-amyl alcohol 13.02
    acetylacetone 15.2
    n-hexadecane 0.27
    acetophenone 7.47
    methyl propionate 7.54
    isopentyl acetate 3.27
    trichloroethylene 3.54
    n-nonanol 4.87
    cyclohexanol 6.67
    benzyl alcohol 6.02
    2-ethylhexanol 3.53
    isooctanol 4.54
    dipropyl ether 4.01
    1,2-dichlorobenzene 0.88
    ethyl lactate 12.09
    propylene carbonate 11.37
    n-methylformamide 65.97
    2-pentanol 6.59
    n-pentane 0.4
    1-propoxy-2-propanol 17.93
    1-methoxy-2-propyl acetate 9.06
    2-(2-methoxypropoxy) propanol 25.07
    mesitylene 1.1
    ε-caprolactone 13.29
    p-cymene 1.45
    epichlorohydrin 16.31
    1,1,1-trichloroethane 1.14
    2-aminoethanol 33.82
    morpholine-4-carbaldehyde 86.39
    sulfolane 86.15
    2,2,4-trimethylpentane 0.39
    2-methyltetrahydrofuran 10.82
    n-hexyl acetate 5.04
    isooctane 0.31
    2-(2-butoxyethoxy)ethanol 26.17
    sec-butyl acetate 2.71
    tert-butyl acetate 6.54
    decalin 0.27
    glycerin 53.02
    diglyme 42.0
    acrylic acid 15.9
    isopropyl myristate 2.81
    n-butyric acid 10.09
    acetyl acetate 2.6
    di(2-ethylhexyl) phthalate 4.97
    ethyl propionate 3.91
    nitromethane 46.57
    1,2-diethoxyethane 6.8
    benzonitrile 2.63
    trioctyl phosphate 4.14
    1-bromopropane 1.1
    gamma-valerolactone 50.33
    n-decanol 3.63
    triethyl phosphate 4.22
    4-methyl-2-pentanol 4.8
    propionitrile 4.07
    vinylene carbonate 8.49
    1,1,2-trichlorotrifluoroethane 31.26
    DMS 4.02
    cumene 0.74
    2-octanol 3.63
    2-hexanone 7.66
    octyl acetate 3.93
    limonene 2.7
    1,2-dimethoxyethane 33.18
    ethyl orthosilicate 3.67
    tributyl phosphate 3.96
    diacetone alcohol 24.29
    N,N-dimethylaniline 5.92
    acrylonitrile 7.06
    aniline 2.62
    1,3-propanediol 29.25
    bromobenzene 0.34
    dibromomethane 1.29
    1,1,2,2-tetrachloroethane 3.87
    2-methyl-cyclohexyl acetate 5.31
    tetrabutyl urea 9.59
    diisobutyl methanol 3.34
    2-phenylethanol 4.73
    styrene 0.53
    dioctyl adipate 6.35
    dimethyl sulfate 26.25
    ethyl butyrate 4.23
    methyl lactate 22.65
    butyl lactate 9.58
    diethyl carbonate 2.68
    propanediol butyl ether 21.97
    triethyl orthoformate 4.32
    p-tert-butyltoluene 1.69
    methyl 4-tert-butylbenzoate 14.24
    morpholine 19.47
    tert-butylamine 6.24
    n-dodecanol 2.65
    dimethoxymethane 41.76
    ethylene carbonate 5.66
    cyrene 46.39
    2-ethoxyethyl acetate 6.48
    2-ethylhexyl acetate 2.43
    1,2,4-trichlorobenzene 1.43
    4-methylpyridine 5.04
    dibutyl ether 2.61
    2,6-dimethyl-4-heptanol 3.34
    DEF 26.83
    dimethyl isosorbide 36.44
    tetrachloroethylene 2.42
    eugenol 16.31
    triacetin 10.61
    span 80 17.79
    1,4-butanediol 17.87
    1,1-dichloroethane 1.28
    2-methyl-1-pentanol 5.92
    methyl formate 35.2
    2-methyl-1-butanol 8.02
    n-decane 0.39
    butyronitrile 3.85
    3,7-dimethyl-1-octanol 4.38
    1-chlorooctane 1.21
    1-chlorotetradecane 0.59
    n-nonane 0.37
    undecane 0.3
    tert-butylcyclohexane 0.32
    cyclooctane 0.23
    cyclopentanol 12.36
    tetrahydropyran 4.96
    tert-amyl methyl ether 5.84
    2,5,8-trioxanonane 37.54
    1-hexene 0.62
    2-isopropoxyethanol 21.31
    2,2,2-trifluoroethanol 22.74
    methyl butyrate 7.1

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction