Bromoform

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  • Identifiers

    CAS number
    75-25-2

    Molecular formula
    CHBr3

    SMILES
    C(Br)(Br)Br

    Safety labels

    Acute Toxic
    Acute Toxic

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 40.62%
    Fishy 38.51%
    Meaty 32.93%
    Sulfurous 29.88%
    Cheesy 28.39%
    Green 24.92%
    Ripe 24.68%
    Savory 24.49%
    Roasted 21.07%
    Cooked 20.84%

     

    Flavor
    Odorless 31.64%
    Sulfurous 28.03%
    Fishy 25.97%
    Meaty 25.15%
    Sulfury 24.69%
    Ammoniacal 23.75%
    Onion 19.06%
    Glue 19.03%
    Bloody 18.77%
    Rotten 18.39%

     

    Odor impact est.
    High

    Odor threshold

    • Odor Threshold Low: 0.19 [mmHg]. Odor Threshold High: 15.0 [mmHg]. Odor threshold from AIHA
    • In water: detection: 0.3 mg/kg
    • In air: 4.80X10+8 molecules/cu cm

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    0.47 (strong acid)

    Molecular weight
    252.73 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • 48 °F (NTP, 1992)
    • 8.69 °C
    • 8.3 °C
    • 47 °F

    Boiling point

    • 301.1 °F at 760 mmHg (NTP, 1992)
    • 149.2 °C
    • 149.5 °C
    • 301 °F

    Flash point

    • 65.43 ˚C est.

    Solubility expt.

    • less than 0.1 mg/mL at 72.5 °F (NTP, 1992)
    • In water, 3,100 mg/L at 25 °C
    • Soluble in about 800 parts water
    • In water, 0.3 g/100 mL water at 30 °C
    • 0.1 g/100 g water at 20 °C
    • For more Solubility (Complete) data for Bromoform (8 total), please visit the HSDB record page.
    • Solubility in water, g/100ml at 20 °C: 0.1 (poor)
    • 0.1%

  • Synonyms

    • Bromoform
    • tribromomethane
    • 75-25-2
    • Methane, tribromo-
    • Tribrommethan
    • Methenyl tribromide
    • Methyl tribromide
    • Bromoforme
    • Bromoformio
    • Tribrommethaan
    • Tribromometan
    • CHBr3
    • Bromoforme [French]
    • Bromoformio [Italian]
    • NCI-C55130
    • Tribrommethaan [Dutch]
    • Tribrommethan [German]
    • Tribromometan [Italian]
    • RCRA waste number U225
    • TUT9J99IMU
    • NSC 8019
    • DTXSID1021374
    • CHEBI:38682
    • BROMOFORM [MI]
    • NSC-8019
    • BROMOFORM [HSDB]
    • BROMOFORM [IARC]
    • MFCD00000128
    • BROMOFORM [WHO-DD]
    • DTXCID401374
    • 4471-18-5
    • NSC8019
    • Bromoform - Stabilized with ethanol
    • UN 2515
    • Tribrommethan (German)
    • BROMOFORM (IARC)
    • BROMOFORME (FRENCH)
    • BROMOFORMIO (ITALIAN)
    • TRIBROMMETHAAN (DUTCH)
    • TRIBROMOMETAN (ITALIAN)
    • CCRIS 98
    • Bromoform [USP]
    • MBR
    • HSDB 2517
    • EINECS 200-854-6
    • UNII-TUT9J99IMU
    • UN2515
    • RCRA waste no. U225
    • BROMOFORM (13C)
    • BRN 1731048
    • Tribromomethane; Bromoform; Methenyl tribromide; NSC 8019
    • bromo form
    • AI3-28587
    • methane, tribromo
    • Tri bromo methane
    • Tribromomethane; methyl tribromide
    • methylene tribromide
    • TRIBROM METHAN
    • FORMYL TRIBROMIDE
    • WLN: EYEE
    • Bromoform, technical grade
    • Bromoform (ACGIH:OSHA)
    • SCHEMBL18691
    • 4-01-00-00082 (Beilstein Handbook Reference)
    • BIDD:ER0622
    • Bromoform, puriss., 97.0%
    • CHEMBL345248
    • TRIBROM METHAN (GERMAN)
    • Bromoform [UN2515] [Poison]
    • BCP10566
    • Bromoform (stabilized with Ethanol)
    • Tox21_200189
    • R-20B3
    • Bromoform 100 microg/mL in Methanol
    • Bromoform, 96%, stab. with ethanol
    • AKOS009031540
    • AT27291
    • Bromoform 5000 microg/mL in Methanol
    • DB03054
    • CAS-75-25-2
    • Bromoform, puriss., >=99.0% (GC)
    • MSK000954-1000M
    • NCGC00091318-01
    • NCGC00091318-02
    • NCGC00257743-01
    • BP-21414
    • FB163767
    • Tribromomethane (stabilized with Ethanol)
    • Tribromomethane 100 microg/mL in Methanol
    • Bromoform Solution in Methanol, 1000ug/mL
    • B0806
    • NS00002299
    • S0653
    • T0348
    • EN300-19388
    • Bromoform, amylene stabilized, analytical standard
    • Q409799
    • Bromoform, contains 1-3% ethanol as stabilizer, 96%
    • F0001-1896
    • Bromoform - contains 60-120ppm 2-Methyl-2-butene as stabilizer
    • BROMOFORM (CONTAINS 60-120PPM 2-METHYL-2-BUTENE AS STABILIZER)
    • Bromoform, contains 60-120 ppm 2-methyl-2-butene as stabilizer, 99%
    • 200-854-6

  • Applications

    Bromoform (CAS 75-25-2) is primarily used as an intermediate in organic synthesis to introduce the tribromomethyl group into target molecules. It also serves as a nonpolar solvent or reaction medium in certain industrial processes and as a feedstock for the manufacture of brominated specialty chemicals. In addition, it is employed as a high-density solvent for separations or extractions of nonpolar materials, and may be used as a reagent in bromination steps in polymer or pharmaceutical manufacturing when handled under appropriate controls and regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 29.78
    methanol 21.36
    isopropanol 31.67
    water 0.84
    ethyl acetate 76.13
    n-propanol 33.7
    acetone 98.05
    n-butanol 40.62
    acetonitrile 40.07
    DMF 124.76
    toluene 115.97
    isobutanol 32.31
    1,4-dioxane 177.06
    methyl acetate 66.87
    THF 303.05
    2-butanone 84.04
    n-pentanol 42.25
    sec-butanol 38.53
    n-hexane 38.59
    ethylene glycol 11.74
    NMP 241.81
    cyclohexane 83.49
    DMSO 159.89
    n-butyl acetate 102.22
    n-octanol 61.44
    chloroform 183.31
    n-propyl acetate 73.77
    acetic acid 48.66
    dichloromethane 150.88
    cyclohexanone 174.28
    propylene glycol 14.74
    isopropyl acetate 76.0
    DMAc 142.03
    2-ethoxyethanol 64.4
    isopentanol 43.79
    n-heptane 63.5
    ethyl formate 47.9
    1,2-dichloroethane 115.58
    n-hexanol 62.2
    2-methoxyethanol 76.86
    isobutyl acetate 65.29
    tetrachloromethane 76.36
    n-pentyl acetate 90.57
    transcutol 194.11
    n-heptanol 53.52
    ethylbenzene 75.3
    MIBK 87.48
    2-propoxyethanol 93.59
    tert-butanol 52.19
    MTBE 82.42
    2-butoxyethanol 77.72
    propionic acid 34.55
    o-xylene 103.83
    formic acid 14.82
    diethyl ether 88.9
    m-xylene 99.31
    p-xylene 89.87
    chlorobenzene 118.55
    dimethyl carbonate 51.95
    n-octane 34.65
    formamide 27.5
    cyclopentanone 209.24
    2-pentanone 94.96
    anisole 117.18
    cyclopentyl methyl ether 182.72
    gamma-butyrolactone 173.99
    1-methoxy-2-propanol 72.07
    pyridine 147.72
    3-pentanone 88.73
    furfural 181.56
    n-dodecane 27.91
    diethylene glycol 62.31
    diisopropyl ether 68.8
    tert-amyl alcohol 54.9
    acetylacetone 137.77
    n-hexadecane 30.94
    acetophenone 123.06
    methyl propionate 68.1
    isopentyl acetate 98.0
    trichloroethylene 194.15
    n-nonanol 62.08
    cyclohexanol 81.56
    benzyl alcohol 76.67
    2-ethylhexanol 68.62
    isooctanol 51.11
    dipropyl ether 112.31
    1,2-dichlorobenzene 120.38
    ethyl lactate 44.27
    propylene carbonate 112.71
    n-methylformamide 42.47
    2-pentanol 42.77
    n-pentane 38.66
    1-propoxy-2-propanol 95.31
    1-methoxy-2-propyl acetate 111.88
    2-(2-methoxypropoxy) propanol 96.52
    mesitylene 86.72
    ε-caprolactone 142.2
    p-cymene 87.39
    epichlorohydrin 185.15
    1,1,1-trichloroethane 146.28
    2-aminoethanol 19.39
    morpholine-4-carbaldehyde 189.73
    sulfolane 254.1
    2,2,4-trimethylpentane 32.84
    2-methyltetrahydrofuran 205.0
    n-hexyl acetate 100.72
    isooctane 29.62
    2-(2-butoxyethoxy)ethanol 107.42
    sec-butyl acetate 68.26
    tert-butyl acetate 106.45
    decalin 50.01
    glycerin 24.14
    diglyme 189.42
    acrylic acid 36.81
    isopropyl myristate 75.95
    n-butyric acid 53.27
    acetyl acetate 76.23
    di(2-ethylhexyl) phthalate 63.8
    ethyl propionate 71.3
    nitromethane 74.76
    1,2-diethoxyethane 122.69
    benzonitrile 91.71
    trioctyl phosphate 51.96
    1-bromopropane 88.62
    gamma-valerolactone 200.85
    n-decanol 54.21
    triethyl phosphate 69.06
    4-methyl-2-pentanol 41.78
    propionitrile 40.28
    vinylene carbonate 94.71
    1,1,2-trichlorotrifluoroethane 131.36
    DMS 80.93
    cumene 65.17
    2-octanol 50.77
    2-hexanone 87.33
    octyl acetate 80.0
    limonene 117.34
    1,2-dimethoxyethane 134.59
    ethyl orthosilicate 72.36
    tributyl phosphate 58.95
    diacetone alcohol 97.44
    N,N-dimethylaniline 115.05
    acrylonitrile 44.83
    aniline 92.07
    1,3-propanediol 29.32
    bromobenzene 135.51
    dibromomethane 129.76
    1,1,2,2-tetrachloroethane 174.23
    2-methyl-cyclohexyl acetate 100.96
    tetrabutyl urea 89.18
    diisobutyl methanol 67.38
    2-phenylethanol 89.61
    styrene 88.37
    dioctyl adipate 94.9
    dimethyl sulfate 91.93
    ethyl butyrate 96.53
    methyl lactate 45.72
    butyl lactate 64.87
    diethyl carbonate 66.27
    propanediol butyl ether 63.04
    triethyl orthoformate 87.19
    p-tert-butyltoluene 89.07
    methyl 4-tert-butylbenzoate 127.84
    morpholine 144.62
    tert-butylamine 47.41
    n-dodecanol 49.9
    dimethoxymethane 115.22
    ethylene carbonate 80.78
    cyrene 122.58
    2-ethoxyethyl acetate 101.14
    2-ethylhexyl acetate 98.05
    1,2,4-trichlorobenzene 142.91
    4-methylpyridine 146.11
    dibutyl ether 92.17
    2,6-dimethyl-4-heptanol 67.38
    DEF 110.32
    dimethyl isosorbide 205.11
    tetrachloroethylene 129.97
    eugenol 103.84
    triacetin 105.12
    span 80 100.54
    1,4-butanediol 20.83
    1,1-dichloroethane 100.13
    2-methyl-1-pentanol 48.35
    methyl formate 43.29
    2-methyl-1-butanol 40.85
    n-decane 38.45
    butyronitrile 49.89
    3,7-dimethyl-1-octanol 67.13
    1-chlorooctane 72.74
    1-chlorotetradecane 46.48
    n-nonane 38.67
    undecane 31.85
    tert-butylcyclohexane 44.89
    cyclooctane 50.97
    cyclopentanol 87.48
    tetrahydropyran 169.0
    tert-amyl methyl ether 91.23
    2,5,8-trioxanonane 162.43
    1-hexene 60.37
    2-isopropoxyethanol 66.61
    2,2,2-trifluoroethanol 32.48
    methyl butyrate 80.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction