Bis(2-chloroethyl)sulfide

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  • Identifiers

    CAS number
    505-60-2

    Molecular formula
    C4H8Cl2S

    SMILES
    C(CCl)SCCCl

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Sulfurous 69.47%
    Meaty 60.72%
    Vegetable 46.06%
    Onion 45.86%
    Savory 45.54%
    Alliaceous 45.33%
    Garlic 43.98%
    Cooked 37.81%
    Roasted 37.5%
    Fatty 36.74%

     

    Flavor
    Sulfurous 57.98%
    Onion 52.76%
    Meaty 45.16%
    Garlic 43.56%
    Sulfury 40.83%
    Alliaceous 34.16%
    Cooked 28.28%
    Roasted 27.79%
    Metallic 26.08%
    Burnt 25.7%

     

    Odor impact est.
    Low

    Odor threshold

    • 1.30X10-3 mg/L (gas) (detection in air, chemically pure)
    • 2.30X10-3 ppm (detection in air, purity not specified)
    • Odor 0.0150 mg/cu m (low) odor 0.0150 mg/cu m (high).
    • It is colorless and odorless, but when mixed with other chemicals, it becomes brown and has a garlic-like smell.
    • Olfactory fatigue, resulting in discontinued ability to detect the sulfur mustard odor, occurred within 3 - 8 minutes of initial exposure in subjects participating in sulfur mustard chamber tests. Due to the delayed symptoms and difficulties associated with detection by smell, individuals may not know that they are being exposed, and consequently, appropriate actions may not be taken.

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    5.16 (weak acid)

    Molecular weight
    159.08 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Melting point expt.

    • 55 to 57 °F (EPA, 1998)
    • 13-14 °C
    • 13.5 °C
    • 55-57 °F

    Boiling point

    • 419 to 423 °F at 760 mmHg (EPA, 1998)
    • 215-217 °C at 760 mm Hg
    • 216 °C
    • 419-423 °F

    Flash point

    • 89.04 ˚C est.
    • 221 °F (EPA, 1998)
    • 104 °C
    • 105 °C
    • 221 °F

    Solubility expt.

    • In water, 609 mg/L at 25 °C
    • In water, 684 mg/L at 25 °C
    • In water, 920 mg/L at 22 °C
    • Soluble in fat solvents and other common organic solvents; high lipid solubility
    • For more Solubility (Complete) data for BIS(2-CHLOROETHYL)SULFIDE (7 total), please visit the HSDB record page.
    • Solubility in water, g/100ml at 25 °C: 0.0068 (very poor)

  • Synonyms

    • Mustard gas
    • Sulfur mustard
    • Yperite
    • Senfgas
    • Iprit
    • Bis(2-chloroethyl) sulfide
    • Lost
    • 505-60-2
    • Schwefel-lost
    • Yellow cross liquid
    • Mustard, sulfur
    • Distilled mustard
    • S-Lost
    • Gelbkreuz
    • Kampstoff lost
    • Mustard vapor
    • S-yperite
    • S Mustard
    • Yellow cross gas
    • Mustard HD
    • Sulfur mustard gas
    • Sulphur mustard
    • Agent hd
    • Bis(2-chloroethyl)sulphide
    • 1,1'-Thiobis(2-chloroethane)
    • Dichlorodiethyl sulfide
    • Agent THD
    • Di-2-chloroethyl sulfide
    • Gelbkreuz [Czech]
    • Sulphur mustard gas
    • 2,2'-Dichloroethyl sulfide
    • Sulfide, bis(2-chloroethyl)
    • 2,2'-Dichlorodiethyl sulfide
    • Di-2-chloroethyl sulphide
    • BIS(2-CHLOROETHYL)SULFIDE
    • dichlorodiethylsulfide
    • Bis(beta-chloroethyl)sulfide
    • Bis(2-chloroethyl) sulphide
    • 2,2'-Dichloroethyl sulphide
    • Bis(beta-chloroethyl)sulphide
    • Bis(beta-chloroethyl) sulfide
    • CCRIS 570
    • 2,2'-Dichlorodiethyl sulphide
    • HSDB 336
    • beta,beta'-Dichloroethyl sulfide
    • beta,beta-Dichlor-ethyl-sulphide
    • Diethyl sulfide, 2,2'-dichloro
    • beta,beta'-Dichloroethyl sulphide
    • UNII-T8KEC9FH9P
    • bis(2-chloroethyl)sulfane
    • 1-chloro-2-(2-chloroethylsulfanyl)ethane
    • T8KEC9FH9P
    • Ethane, 1,1'-thiobis(2-chloro-
    • bis-(2-chloroethyl)sulfide
    • Dichloroethyl sulfide
    • BRN 1733595
    • 1-Chloro-2-(beta-chloroethylthio)ethane
    • Dichlorodiethylsulphide
    • CHEBI:25434
    • 1-Chloro-2-[(2-chloroethyl)sulfanyl]ethane
    • Ethane, 1,1'-thiobis[2-chloro-
    • MUSTARD GAS [MI]
    • 1-chloro-2-[(2-chloroethyl)thio]ethane
    • MUSTARD GAS [WHO-DD]
    • SULFUR MUSTARD [HSDB]
    • SULFUR MUSTARD [IARC]
    • Mustardgas
    • DTXSID0037100
    • beta,beta'-dichlorodiethyl sulfide
    • Gelbkreuz (Czech)
    • DICHLORODIETHYLSULFIDE [MART.]
    • Psoriasin
    • Bis-(2-chloroethyl) Sulfide
    • SULFUR MUSTARD (IARC)
    • DICHLORODIETHYLSULFIDE (MART.)
    • Gas, Mustard
    • 1-chloro-2-((2-chloroethyl)thio)ethane
    • 1-chloro-2-((2-chloroethyl)sulfanyl)ethane
    • Sulfide, Dichlorodiethyl
    • Di 2 chloroethyl Sulfide
    • Ethane, 1,1'-thiobis(2-chloro)-
    • Sulfide, Di-2-chloroethyl
    • HD (chemical warfare agent)
    • Schwefellost
    • SYperite
    • SLost
    • Kampstoff "Lost
    • beta, beta'-dichloroethyl sulfide
    • Dichloroethyl sulfide [Forbidden]
    • S Lost
    • 2-chloroethylsulphide
    • 1-chloro-2-(2-chloroethylthio)ethane
    • Di2chloroethyl sulfide
    • Kampfstoff ''lost''
    • Di2chloroethyl sulphide
    • KAMPFSTOFF "LOST
    • Dichloro-diethyl-sulphide
    • SULFUR MUSTARD HD
    • Bis(2chloroethyl)sulphide
    • bis(2chloroethyl) sulfide
    • Bis(betachloroethyl)sulfide
    • 2,2'Dichloroethyl sulfide
    • Di(2-chloroethyl) sulfide
    • bis(betachloroethyl)sulphide
    • 2,2'Dichloroethyl sulphide
    • Sulfide, bis(2chloroethyl)
    • 2-2-dichlorodiethyl-sulfide
    • beta,betaDichlorethylsulphide
    • 2,2'Dichlorodiethyl sulfide
    • SCHEMBL43809
    • 1,1'Thiobis(2chloroethane)
    • 2,2'Dichlorodiethyl sulphide
    • bis-(2-chloro-ethyl)-sulfane
    • beta,beta'Dichloroethyl sulfide
    • Ethane, 1,1'thiobis(2chloro
    • CHEMBL455341
    • Diethyl sulfide, 2,2'dichloro
    • beta,beta'Dichloroethyl sulphide
    • DTXCID8017100
    • Bis(.beta.-chloroethyl) sulfide
    • .beta.-Chloroethylisobutyl sulfide
    • 1Chloro2(betachloroethylthio)ethane
    • .beta.,.beta.-Dichloroethyl sulfide
    • BIS(BETA-CHLOROETHYL) SULPHIDE
    • .beta.,.beta.'-Dichloroethyl sulfide
    • AKOS006275641
    • BETA-CHLOROETHYLISOBUTYL SULFIDE
    • Ethane, 1,1'-thiobis(2-chloroethane)

  • Applications

    Bis(2-chloroethyl)sulfide, CAS 505-60-2, is a highly regulated chemical warfare agent with no routine civilian or industrial use. In controlled settings, its applications are limited to chemical defense research and development, assessment of personal protective equipment and decontamination procedures, and the development of analytical methods and reference materials for detection and regulatory compliance. Handling, storage and disposal are subject to strict international and national regulations, including arms-control treaties. Outside these regulated contexts, there are no standard applications in typical consumer or industrial sectors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 85.17
    methanol 70.23
    isopropanol 72.5
    water 0.73
    ethyl acetate 159.94
    n-propanol 90.63
    acetone 337.54
    n-butanol 94.71
    acetonitrile 136.75
    DMF 332.77
    toluene 240.75
    isobutanol 73.17
    1,4-dioxane 424.95
    methyl acetate 146.95
    THF 715.91
    2-butanone 209.42
    n-pentanol 72.01
    sec-butanol 74.65
    n-hexane 46.7
    ethylene glycol 30.31
    NMP 496.14
    cyclohexane 220.98
    DMSO 530.22
    n-butyl acetate 271.41
    n-octanol 91.16
    chloroform 769.25
    n-propyl acetate 155.14
    acetic acid 215.19
    dichloromethane 616.47
    cyclohexanone 660.38
    propylene glycol 36.47
    isopropyl acetate 110.52
    DMAc 223.64
    2-ethoxyethanol 117.32
    isopentanol 71.92
    n-heptane 134.67
    ethyl formate 128.32
    1,2-dichloroethane 398.94
    n-hexanol 123.89
    2-methoxyethanol 169.64
    isobutyl acetate 111.19
    tetrachloromethane 212.98
    n-pentyl acetate 174.38
    transcutol 484.87
    n-heptanol 81.0
    ethylbenzene 99.91
    MIBK 112.26
    2-propoxyethanol 175.85
    tert-butanol 100.2
    MTBE 98.53
    2-butoxyethanol 134.78
    propionic acid 127.08
    o-xylene 144.15
    formic acid 54.13
    diethyl ether 147.71
    m-xylene 133.38
    p-xylene 138.95
    chlorobenzene 332.11
    dimethyl carbonate 71.45
    n-octane 43.34
    formamide 84.99
    cyclopentanone 680.03
    2-pentanone 190.46
    anisole 163.15
    cyclopentyl methyl ether 375.15
    gamma-butyrolactone 572.87
    1-methoxy-2-propanol 123.04
    pyridine 502.24
    3-pentanone 167.54
    furfural 577.58
    n-dodecane 25.18
    diethylene glycol 122.57
    diisopropyl ether 58.67
    tert-amyl alcohol 81.49
    acetylacetone 253.92
    n-hexadecane 29.6
    acetophenone 194.06
    methyl propionate 131.84
    isopentyl acetate 210.63
    trichloroethylene 851.92
    n-nonanol 83.41
    cyclohexanol 228.86
    benzyl alcohol 137.22
    2-ethylhexanol 128.52
    isooctanol 70.31
    dipropyl ether 254.83
    1,2-dichlorobenzene 309.27
    ethyl lactate 74.1
    propylene carbonate 294.75
    n-methylformamide 134.62
    2-pentanol 71.09
    n-pentane 51.33
    1-propoxy-2-propanol 198.66
    1-methoxy-2-propyl acetate 200.62
    2-(2-methoxypropoxy) propanol 137.43
    mesitylene 94.65
    ε-caprolactone 417.61
    p-cymene 132.4
    epichlorohydrin 479.49
    1,1,1-trichloroethane 447.24
    2-aminoethanol 49.84
    morpholine-4-carbaldehyde 433.53
    sulfolane 713.33
    2,2,4-trimethylpentane 23.03
    2-methyltetrahydrofuran 448.01
    n-hexyl acetate 184.6
    isooctane 17.52
    2-(2-butoxyethoxy)ethanol 182.18
    sec-butyl acetate 102.45
    tert-butyl acetate 134.83
    decalin 59.89
    glycerin 62.1
    diglyme 388.12
    acrylic acid 140.39
    isopropyl myristate 95.42
    n-butyric acid 184.63
    acetyl acetate 142.41
    di(2-ethylhexyl) phthalate 86.4
    ethyl propionate 119.44
    nitromethane 301.99
    1,2-diethoxyethane 262.49
    benzonitrile 242.97
    trioctyl phosphate 68.49
    1-bromopropane 226.39
    gamma-valerolactone 621.63
    n-decanol 65.35
    triethyl phosphate 116.01
    4-methyl-2-pentanol 43.03
    propionitrile 120.3
    vinylene carbonate 296.4
    1,1,2-trichlorotrifluoroethane 404.12
    DMS 140.5
    cumene 71.88
    2-octanol 66.69
    2-hexanone 165.45
    octyl acetate 110.19
    limonene 217.3
    1,2-dimethoxyethane 270.53
    ethyl orthosilicate 116.26
    tributyl phosphate 87.85
    diacetone alcohol 138.76
    N,N-dimethylaniline 131.6
    acrylonitrile 163.99
    aniline 215.51
    1,3-propanediol 75.88
    bromobenzene 376.98
    dibromomethane 470.34
    1,1,2,2-tetrachloroethane 649.47
    2-methyl-cyclohexyl acetate 179.84
    tetrabutyl urea 129.68
    diisobutyl methanol 102.02
    2-phenylethanol 160.85
    styrene 135.4
    dioctyl adipate 148.73
    dimethyl sulfate 146.61
    ethyl butyrate 224.39
    methyl lactate 75.24
    butyl lactate 124.25
    diethyl carbonate 136.84
    propanediol butyl ether 121.14
    triethyl orthoformate 187.3
    p-tert-butyltoluene 125.82
    methyl 4-tert-butylbenzoate 173.62
    morpholine 412.33
    tert-butylamine 74.22
    n-dodecanol 54.99
    dimethoxymethane 175.45
    ethylene carbonate 240.9
    cyrene 175.58
    2-ethoxyethyl acetate 186.12
    2-ethylhexyl acetate 196.56
    1,2,4-trichlorobenzene 363.41
    4-methylpyridine 383.85
    dibutyl ether 185.06
    2,6-dimethyl-4-heptanol 102.02
    DEF 210.41
    dimethyl isosorbide 315.09
    tetrachloroethylene 524.31
    eugenol 162.74
    triacetin 194.69
    span 80 171.28
    1,4-butanediol 39.44
    1,1-dichloroethane 315.93
    2-methyl-1-pentanol 62.12
    methyl formate 134.44
    2-methyl-1-butanol 70.48
    n-decane 45.32
    butyronitrile 137.97
    3,7-dimethyl-1-octanol 92.38
    1-chlorooctane 118.73
    1-chlorotetradecane 54.51
    n-nonane 49.89
    undecane 31.85
    tert-butylcyclohexane 42.81
    cyclooctane 76.35
    cyclopentanol 238.88
    tetrahydropyran 513.9
    tert-amyl methyl ether 99.13
    2,5,8-trioxanonane 285.37
    1-hexene 94.33
    2-isopropoxyethanol 96.88
    2,2,2-trifluoroethanol 101.45
    methyl butyrate 163.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction