alpha-Cedrene

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  • Identifiers

    CAS number
    469-61-4

    Molecular formula
    C15H24

    SMILES
    C[C@@H]1CC[C@@H]2[C@]13CC=C([C@H](C3)C2(C)C)C

    Safety labels

    Flammable
    Flammable

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Woody 89.4%
    Sweet 59.72%
    Dry 52.46%
    Amber 46.69%
    Spicy 43.73%
    Cedar 42.43%
    Fresh 39.9%
    Balsamic 36.3%
    Pine 36.08%
    Sandalwood 35.87%

    Scent© AI

  • Properties

    XLogP3-AA
    4.6

    Molecular weight
    204.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    261°C

    Flash point est.
    109.38 ˚C

  • Synonyms

    • ALPHA-CEDRENE
    • (-)-alpha-cedrene
    • 469-61-4
    • Cedr-8-ene
    • (-)-cedrene
    • Cedrene
    • .alpha.-Cedrene
    • Levo-alpha-cedrene
    • Laevo-alpha-cedrene
    • (-)-.alpha.-Cedrene
    • 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-,(3R,3aS,7S,8aS)-
    • DTXSID0047032
    • 50D4A81G8T
    • EINECS 207-418-4
    • BRN 3196861
    • LEVO-.ALPHA.-CEDRENE
    • [3R-(3alpha,3abeta,7beta,8aalpha)]-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene
    • CHEBI:10216
    • DTXCID801022504
    • 3-05-00-01095 (Beilstein Handbook Reference)
    • (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.0(1,5)]undec-8-ene
    • J5.927G
    • 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, [3R-(3.alpha.,3a.beta.,7.beta.,8a.alpha.)]-
    • 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, (3R,3aS,7S,8aS)-
    • (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undec-8-ene
    • (3R,3aS,7S,8aS)-3,6,8,8-Tetramethyl-2,3,4,7,8,8a-hexahydro-1H-3a,7-methanoazulene
    • (3R,3AS,7S,8AS)-2,3,4,7,8,8A-HEXAHYDRO-3,6,8,8-TETRAMETHYL-1H-3A,7-METHANOAZULENE
    • (3R-(3.ALPHA.,3A.BETA.,7.BETA.,8A.ALPHA.))-2,3,4,7,8,8A-HEXAHYDRO-3,6,8,8-TETRAMETHYL-1H-3A,7-METHANOAZULENE
    • (3R-(3alpha,3Abeta,7beta,8aalpha))-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene
    • (?)-|A-Cedrene
    • (-)-a-Cedrene (major, contains (+)-b-cedrene)
    • DTXSID00859378
    • UNII-50D4A81G8T
    • (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo(5.3.1.0(1,5))undec-8-ene
    • (1S,2R,5S,7S)-2,6,6,8-tetramethyltricyclo(5.3.1.01,5)undec-8-ene
    • MFCD00063003
    • (-)--Cedrene
    • (-)- alpha -Cedrene
    • ?-Cedrene, sum of isomers
    • DTXCID80210180
    • Tox21_302305
    • (1S,2R,5S)-2,6,6,8-Tetramethyltricyclo[5.3.1.01.5]undec-8-ene
    • a-Cedrene 100 microg/mL in Methanol
    • AKOS030503768
    • LMPR0103690006
    • NCGC00256204-01
    • 1H-3a,7-Methanoazulene, 2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-, (3R-(3alpha,3abeta,7beta,8aalpha))-
    • BS-42448
    • CAS-469-61-4
    • FC172232
    • HY-135190
    • CS-0109773
    • C22909
    • Q27108601
    • (-)-alpha-Cedrene, >=95.0% (sum of enantiomers, GC)
    • 207-418-4

  • Applications

    Alpha-cedrene (CAS 469-61-4) is a major sesquiterpene hydrocarbon of cedarwood oil with warm, dry, resinous woody tonality, widely used as a fragrance ingredient in fine perfumery, cosmetics, personal care, soaps, detergents, air-care (candles, wax melts, reed diffusers), and automotive fresheners to add depth, substantivity, and to build woody–amber–chypre–leather accords; it is also employed at very low levels as a flavor modifier to impart cedar/woody nuances within regulatory limits; serves as an active scent component in cedarwood-based insect-repellent formulations for pet care, closets, treated textiles, and sachets; used in research and industry as a scaffold/intermediate for terpenoid synthesis, a GC/GC‑MS reference and retention-index marker for quality control, provenance verification, and adulteration detection of essential oils; applicable in fragrance microencapsulation, scent masterbatches for polymers, and wood-care polishes to deliver cedar notes and mild pest deterrence; generally safe when used per IFRA and applicable regulations, with assessment needed for sensitization, flammability, and oxidative stability; reported bioactivities (e.g., antimicrobial, insect-repellent) are mainly from in vitro/limited in vivo studies and are not medicinal claims.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 98.53
    methanol 67.18
    isopropanol 103.77
    water 0.7
    ethyl acetate 278.54
    n-propanol 117.97
    acetone 268.61
    n-butanol 141.39
    acetonitrile 204.81
    DMF 241.07
    toluene 536.34
    isobutanol 106.53
    1,4-dioxane 554.12
    methyl acetate 224.23
    THF 1017.02
    2-butanone 259.53
    n-pentanol 71.07
    sec-butanol 85.3
    n-hexane 59.71
    ethylene glycol 14.65
    NMP 279.71
    cyclohexane 173.08
    DMSO 115.12
    n-butyl acetate 357.76
    n-octanol 118.65
    chloroform 618.91
    n-propyl acetate 161.39
    acetic acid 68.19
    dichloromethane 544.51
    cyclohexanone 504.5
    propylene glycol 22.4
    isopropyl acetate 251.48
    DMAc 210.65
    2-ethoxyethanol 90.9
    isopentanol 131.37
    n-heptane 112.7
    ethyl formate 142.32
    1,2-dichloroethane 328.8
    n-hexanol 211.08
    2-methoxyethanol 147.34
    isobutyl acetate 160.26
    tetrachloromethane 186.02
    n-pentyl acetate 207.27
    transcutol 309.78
    n-heptanol 130.31
    ethylbenzene 216.18
    MIBK 238.83
    2-propoxyethanol 263.61
    tert-butanol 131.98
    MTBE 229.94
    2-butoxyethanol 166.26
    propionic acid 83.55
    o-xylene 287.25
    formic acid 16.7
    diethyl ether 279.07
    m-xylene 390.09
    p-xylene 265.82
    chlorobenzene 375.3
    dimethyl carbonate 128.63
    n-octane 43.67
    formamide 36.11
    cyclopentanone 592.54
    2-pentanone 277.0
    anisole 276.17
    cyclopentyl methyl ether 492.36
    gamma-butyrolactone 506.29
    1-methoxy-2-propanol 153.54
    pyridine 491.4
    3-pentanone 238.31
    furfural 332.34
    n-dodecane 31.52
    diethylene glycol 114.09
    diisopropyl ether 163.95
    tert-amyl alcohol 94.95
    acetylacetone 328.85
    n-hexadecane 37.96
    acetophenone 224.76
    methyl propionate 219.85
    isopentyl acetate 339.38
    trichloroethylene 529.98
    n-nonanol 116.75
    cyclohexanol 189.67
    benzyl alcohol 144.44
    2-ethylhexanol 167.77
    isooctanol 114.15
    dipropyl ether 309.23
    1,2-dichlorobenzene 333.07
    ethyl lactate 71.36
    propylene carbonate 277.46
    n-methylformamide 106.11
    2-pentanol 105.87
    n-pentane 75.34
    1-propoxy-2-propanol 217.59
    1-methoxy-2-propyl acetate 333.1
    2-(2-methoxypropoxy) propanol 157.54
    mesitylene 269.89
    ε-caprolactone 390.31
    p-cymene 212.4
    epichlorohydrin 454.07
    1,1,1-trichloroethane 391.45
    2-aminoethanol 36.0
    morpholine-4-carbaldehyde 341.71
    sulfolane 347.04
    2,2,4-trimethylpentane 40.93
    2-methyltetrahydrofuran 531.09
    n-hexyl acetate 265.41
    isooctane 50.01
    2-(2-butoxyethoxy)ethanol 188.8
    sec-butyl acetate 152.04
    tert-butyl acetate 275.4
    decalin 82.54
    glycerin 34.39
    diglyme 371.16
    acrylic acid 66.86
    isopropyl myristate 146.08
    n-butyric acid 167.21
    acetyl acetate 219.56
    di(2-ethylhexyl) phthalate 114.0
    ethyl propionate 179.11
    nitromethane 150.74
    1,2-diethoxyethane 251.35
    benzonitrile 264.66
    trioctyl phosphate 96.38
    1-bromopropane 293.38
    gamma-valerolactone 525.26
    n-decanol 88.79
    triethyl phosphate 126.95
    4-methyl-2-pentanol 96.93
    propionitrile 239.5
    vinylene carbonate 266.8
    1,1,2-trichlorotrifluoroethane 170.74
    DMS 223.55
    cumene 151.53
    2-octanol 92.08
    2-hexanone 175.33
    octyl acetate 156.33
    limonene 250.25
    1,2-dimethoxyethane 249.66
    ethyl orthosilicate 132.27
    tributyl phosphate 106.56
    diacetone alcohol 179.01
    N,N-dimethylaniline 190.11
    acrylonitrile 222.28
    aniline 275.85
    1,3-propanediol 75.95
    bromobenzene 483.19
    dibromomethane 400.55
    1,1,2,2-tetrachloroethane 362.52
    2-methyl-cyclohexyl acetate 224.16
    tetrabutyl urea 131.42
    diisobutyl methanol 128.23
    2-phenylethanol 236.17
    styrene 237.43
    dioctyl adipate 159.31
    dimethyl sulfate 142.92
    ethyl butyrate 256.66
    methyl lactate 79.87
    butyl lactate 125.6
    diethyl carbonate 164.08
    propanediol butyl ether 102.47
    triethyl orthoformate 195.33
    p-tert-butyltoluene 217.34
    methyl 4-tert-butylbenzoate 241.69
    morpholine 454.23
    tert-butylamine 122.6
    n-dodecanol 71.01
    dimethoxymethane 330.03
    ethylene carbonate 244.91
    cyrene 146.5
    2-ethoxyethyl acetate 244.64
    2-ethylhexyl acetate 299.69
    1,2,4-trichlorobenzene 335.74
    4-methylpyridine 492.57
    dibutyl ether 189.23
    2,6-dimethyl-4-heptanol 128.23
    DEF 233.17
    dimethyl isosorbide 354.88
    tetrachloroethylene 271.39
    eugenol 181.15
    triacetin 205.97
    span 80 151.56
    1,4-butanediol 27.76
    1,1-dichloroethane 327.95
    2-methyl-1-pentanol 79.03
    methyl formate 99.0
    2-methyl-1-butanol 110.75
    n-decane 53.74
    butyronitrile 253.67
    3,7-dimethyl-1-octanol 125.78
    1-chlorooctane 132.89
    1-chlorotetradecane 63.69
    n-nonane 51.78
    undecane 40.14
    tert-butylcyclohexane 70.93
    cyclooctane 95.76
    cyclopentanol 182.47
    tetrahydropyran 575.61
    tert-amyl methyl ether 169.95
    2,5,8-trioxanonane 246.49
    1-hexene 125.66
    2-isopropoxyethanol 87.76
    2,2,2-trifluoroethanol 44.63
    methyl butyrate 192.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
Restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0.27 % Category 7A
Rinse-off products applied to the hair with some hand contact
 3.1 %
Category 2
Products applied to the axillae
 0.08 % Category 7B
Leave-on products applied to the hair with some hand contact
 3.1 %
Category 3
Products applied to the face/body using fingertips
 1.6 % Category 8
Products with significant anogenital exposure
 0.16 %
Category 4
Products related to fine fragrance
 1.5 % Category 9
Products with body and hand exposure, primarily rinse off
 2.9 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0.38 % Category 10A
Household care products with mostly hand contact
 11 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0.38 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 11 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0.38 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 5.8 %
Category 5D
Baby Creams, baby Oils and baby talc
 0.38 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 5.8 %
Category 6
Products with oral and lip exposure
 0.88 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Cupressus funebris Cupressus funebris Endl., fam. Cupressaceae 31.99%
Phlomis fruticosa (Yugoslavia) Phlomis fruticosa L., fam. Lamiaceae (Labiatae) 0.6%