4-Hydroxyacetophenone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    99-93-4

    Molecular formula
    C8H8O2

    SMILES
    CC(=O)C1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • Carbowax: 1790.0

  • Odor profile

    Sweet 89.03%
    Floral 66.65%
    Phenolic 64.39%
    Hawthorn 60.84%
    Cherry 56.22%
    Hay 55.32%
    Vanilla 54.76%
    Balsamic 54.21%
    Woody 53.37%
    Herbal 52.94%

    Scent© AI

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    8.85 (weak base)

    Molecular weight
    136.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    290°C

    Flash point est.
    128.79 ˚C

    Solubility expt.

    • Practically insoluble or insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • 4'-Hydroxyacetophenone
    • 99-93-4
    • 4-Hydroxyacetophenone
    • 1-(4-Hydroxyphenyl)ethanone
    • P-HYDROXYACETOPHENONE
    • 4-Acetylphenol
    • Piceol
    • Ethanone, 1-(4-hydroxyphenyl)-
    • p-Acetylphenol
    • p-Hydroxyphenyl methyl ketone
    • para-Hydroxyacetophenone
    • p-Oxyacetophenone
    • Methyl p-hydroxyphenyl ketone
    • 4-hydroxy acetophenone
    • Acetophenone, 4'-hydroxy-
    • Phenol, p-acetyl-
    • Acetophenone, p-hydroxy-
    • 1-(4-Hydroxyphenyl)Ethan-1-One
    • (4-Hydroxyphenyl)ethan-1-one
    • USAF KF-15
    • 4-Hydroksyacetofenol
    • HYDROXYACETOPHENONE, PARA
    • 4-Acetophenol
    • 4'-hydroxy acetophenone
    • NSC 3698
    • Methyl-p-hydroxyphenyl ketone
    • MFCD00002359
    • 4-Hydroksyacetofenol [Polish]
    • 1-(4-Hydroxy-phenyl)-ethanone
    • HYDROXYACETOPHENONE
    • G1L3HT4CMH
    • EINECS 202-802-8
    • DTXSID0029133
    • CHEBI:28032
    • Paracetamol Impurity E
    • AI3-12133
    • NSC-3698
    • 4-Hydroxyphenyl Methyl Ketone
    • CHEMBL201083
    • DTXCID209133
    • FEMA NO. 4330
    • EC 202-802-8
    • 4-HYDROXYACETOPHENONE [FHFI]
    • c0694
    • PARACETAMOL IMPURITY E [EP IMPURITY]
    • AC6
    • 1-(4-Hydroxyphenyl)ethanone (4-Hydroxyacetophenone)
    • CAS-99-93-4
    • PARACETAMOL IMPURITY E (EP IMPURITY)
    • UNII-G1L3HT4CMH
    • pAcetylphenol
    • pOxyacetophenone
    • 4Acetylphenol
    • Phenol, pacetyl
    • 4Hydroksyacetofenol
    • hydroxyacetophenones
    • pHydroxyacetophenone
    • 1-(4-Hydroxyphenyl)ethanone; Paracetamol Imp. E (EP); 4-Hydroxyacetophenone; Paracetamol Impurity E
    • p-Hydroxacetophenone
    • 4'hydroxyacetophenone
    • parahydroxyacetophenone
    • 4'-hyroxyacetophenone
    • p-hydroxy acetophenone
    • p-hydroxy-acetophenone
    • rho-hydroxyacetophenone
    • Acetophenone, phydroxy
    • 4?-Hydroxyacetophenone
    • 4''-hydroxyacetophenone
    • Acetaminophen Impurity E
    • Acetophenone, 4'hydroxy
    • 4\'-Hydroxypropiophenone
    • (4-hydroxyphenyl)ethanone
    • acetophenone, 4-hydroxy-
    • 1(4Hydroxyphenyl)ethanone
    • Methylphydroxyphenyl ketone
    • bmse000593
    • bmse000670
    • bmse010030
    • Methyl phydroxyphenyl ketone
    • pHydroxyphenyl methyl ketone
    • WLN: QR DV1
    • 4-HAP
    • SCHEMBL40866
    • Ethanone, 1(4hydroxyphenyl)
    • BIDD:ER0242
    • 1-(4-hydroxyphenyl) ethanone
    • 1-(4-hydroxyphenyl)-ethanone
    • 4'-Hydroxyacetophenone, 99%
    • 278564_ALDRICH
    • CHEBI:24668
    • HY-Y0073R
    • 1-(4-hydroxyphenyl)-1-ethanone
    • 4-Hydroxyacetophenone (Standard)
    • HYDROXYACETOPHENONE [INCI]
    • NSC3698
    • 2o48
    • Acetophenone, 4'-hydroxy-(8CI)
    • CS-D1120
    • HY-Y0073
    • STR01114
    • Tox21_200228
    • Tox21_303602
    • BDBM50177409
    • LT0047
    • STK397448
    • ZINC00330136
    • AKOS000118915
    • AC-6123
    • FH24301
    • NCGC00248570-01
    • NCGC00248570-02
    • NCGC00257375-01
    • NCGC00257782-01
    • 261172-42-3
    • DA-49721
    • SY009665
    • 4'-Hydroxyacetophenone, analytical standard
    • DB-269493
    • H0193
    • NS00003966
    • EN300-17800
    • 4 inverted exclamation mark -Hydroxyacetophenone
    • AB00443569-03
    • AB-131/40179700
    • Q7190613
    • Z57040434
    • F0001-2341
    • 1-(4-Hydroxyphenyl)ethanone;4-Acetophenol;4-Acetylphenol

  • Applications

    4-Hydroxyacetophenone, also known as p-hydroxyacetophenone, is an important intermediate in pharmaceuticals and the flavor-fragrance industry because its activated para-hydroxyl group can readily form bridges or undergo esterification; consequently the compound is employed to synthesize flavonoid derivatives, antioxidant ingredients in cosmetics, anti-inflammatory excipients, sweet-vanilla-like flavor enhancers in food, precursors to analgesic and antispasmodic drugs, thermal stabilizers for PVC polymers, ligands in coordination chemistry, intermediates for pesticides, as well as UV absorbers and luminophores for electronic materials; its natural occurrence in licorice further makes it valuable for standardizing herbal extracts and for biological research.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 292.87
    methanol 409.41
    isopropanol 195.89
    water 8.12
    ethyl acetate 265.47
    n-propanol 189.28
    acetone 563.56
    n-butanol 158.64
    acetonitrile 335.66
    DMF 753.34
    toluene 16.06
    isobutanol 124.55
    1,4-dioxane 1114.86
    methyl acetate 345.14
    THF 938.03
    2-butanone 283.79
    n-pentanol 107.89
    sec-butanol 133.71
    n-hexane 3.94
    ethylene glycol 89.67
    NMP 575.58
    cyclohexane 5.74
    DMSO 624.18
    n-butyl acetate 103.04
    n-octanol 106.01
    chloroform 97.77
    n-propyl acetate 140.84
    acetic acid 309.23
    dichloromethane 222.93
    cyclohexanone 302.39
    propylene glycol 93.21
    isopropyl acetate 123.09
    DMAc 477.93
    2-ethoxyethanol 260.21
    isopentanol 120.26
    n-heptane 8.8
    ethyl formate 221.63
    1,2-dichloroethane 144.9
    n-hexanol 96.74
    2-methoxyethanol 458.74
    isobutyl acetate 68.52
    tetrachloromethane 14.22
    n-pentyl acetate 92.34
    transcutol 991.93
    n-heptanol 70.38
    ethylbenzene 16.9
    MIBK 106.49
    2-propoxyethanol 226.85
    tert-butanol 235.73
    MTBE 155.12
    2-butoxyethanol 156.98
    propionic acid 181.88
    o-xylene 22.56
    formic acid 186.09
    diethyl ether 221.65
    m-xylene 18.83
    p-xylene 27.28
    chlorobenzene 42.2
    dimethyl carbonate 135.31
    n-octane 5.03
    formamide 441.24
    cyclopentanone 516.19
    2-pentanone 195.06
    anisole 116.03
    cyclopentyl methyl ether 207.58
    gamma-butyrolactone 697.11
    1-methoxy-2-propanol 265.26
    pyridine 182.69
    3-pentanone 136.79
    furfural 413.39
    n-dodecane 6.92
    diethylene glycol 208.22
    diisopropyl ether 42.93
    tert-amyl alcohol 148.29
    acetylacetone 285.75
    n-hexadecane 7.62
    acetophenone 102.64
    methyl propionate 202.77
    isopentyl acetate 87.62
    trichloroethylene 194.81
    n-nonanol 94.33
    cyclohexanol 105.0
    benzyl alcohol 81.29
    2-ethylhexanol 58.05
    isooctanol 52.79
    dipropyl ether 94.0
    1,2-dichlorobenzene 45.85
    ethyl lactate 72.62
    propylene carbonate 260.68
    n-methylformamide 416.41
    2-pentanol 89.91
    n-pentane 4.74
    1-propoxy-2-propanol 136.0
    1-methoxy-2-propyl acetate 143.44
    2-(2-methoxypropoxy) propanol 181.57
    mesitylene 15.0
    ε-caprolactone 291.66
    p-cymene 22.4
    epichlorohydrin 631.79
    1,1,1-trichloroethane 78.81
    2-aminoethanol 150.85
    morpholine-4-carbaldehyde 711.77
    sulfolane 554.43
    2,2,4-trimethylpentane 4.92
    2-methyltetrahydrofuran 441.88
    n-hexyl acetate 166.9
    isooctane 3.84
    2-(2-butoxyethoxy)ethanol 290.75
    sec-butyl acetate 78.4
    tert-butyl acetate 135.67
    decalin 5.92
    glycerin 146.5
    diglyme 532.71
    acrylic acid 163.19
    isopropyl myristate 65.57
    n-butyric acid 190.02
    acetyl acetate 168.59
    di(2-ethylhexyl) phthalate 55.69
    ethyl propionate 117.06
    nitromethane 766.6
    1,2-diethoxyethane 269.78
    benzonitrile 97.32
    trioctyl phosphate 47.12
    1-bromopropane 51.5
    gamma-valerolactone 674.4
    n-decanol 71.09
    triethyl phosphate 55.0
    4-methyl-2-pentanol 51.88
    propionitrile 169.2
    vinylene carbonate 218.54
    1,1,2-trichlorotrifluoroethane 212.79
    DMS 142.0
    cumene 16.98
    2-octanol 51.8
    2-hexanone 128.16
    octyl acetate 89.03
    limonene 35.1
    1,2-dimethoxyethane 512.64
    ethyl orthosilicate 51.78
    tributyl phosphate 58.1
    diacetone alcohol 174.2
    N,N-dimethylaniline 65.79
    acrylonitrile 212.65
    aniline 64.89
    1,3-propanediol 218.93
    bromobenzene 29.79
    dibromomethane 78.3
    1,1,2,2-tetrachloroethane 127.69
    2-methyl-cyclohexyl acetate 79.77
    tetrabutyl urea 75.34
    diisobutyl methanol 38.6
    2-phenylethanol 75.82
    styrene 21.09
    dioctyl adipate 98.65
    dimethyl sulfate 182.72
    ethyl butyrate 99.36
    methyl lactate 105.48
    butyl lactate 75.26
    diethyl carbonate 74.31
    propanediol butyl ether 164.87
    triethyl orthoformate 73.72
    p-tert-butyltoluene 21.63
    methyl 4-tert-butylbenzoate 108.86
    morpholine 837.14
    tert-butylamine 105.18
    n-dodecanol 52.86
    dimethoxymethane 452.27
    ethylene carbonate 197.38
    cyrene 162.85
    2-ethoxyethyl acetate 176.59
    2-ethylhexyl acetate 67.8
    1,2,4-trichlorobenzene 64.01
    4-methylpyridine 139.63
    dibutyl ether 116.68
    2,6-dimethyl-4-heptanol 38.6
    DEF 239.47
    dimethyl isosorbide 284.07
    tetrachloroethylene 67.34
    eugenol 108.31
    triacetin 182.27
    span 80 131.01
    1,4-butanediol 81.13
    1,1-dichloroethane 103.65
    2-methyl-1-pentanol 86.27
    methyl formate 379.84
    2-methyl-1-butanol 105.91
    n-decane 10.99
    butyronitrile 142.1
    3,7-dimethyl-1-octanol 75.75
    1-chlorooctane 46.54
    1-chlorotetradecane 20.27
    n-nonane 9.57
    undecane 8.57
    tert-butylcyclohexane 6.04
    cyclooctane 2.73
    cyclopentanol 177.68
    tetrahydropyran 429.41
    tert-amyl methyl ether 101.72
    2,5,8-trioxanonane 361.32
    1-hexene 20.19
    2-isopropoxyethanol 157.96
    2,2,2-trifluoroethanol 135.83
    methyl butyrate 149.57

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Styrax (Honduras) 8024-01-9 Liquidambar styraciflua L., fam. Hamamelidaceae 0.1%