2-Acetylthiazole

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    24295-03-2

    Molecular formula
    C5H5NOS

    SMILES
    CC(=O)C1=NC=CS1

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1014.0
    • Carbowax: 1639.0

  • Odor profile

    Nutty 83.85%
    Roasted 64.94%
    Popcorn 60.1%
    Meaty 45.78%
    Coffee 40.96%
    Hazelnut 39.92%
    Burnt 39.32%
    Sulfurous 34.56%
    Musty 32.3%
    Caramellic 31.29%

    Scent© AI

  • Properties

    XLogP3-AA
    1.0

    Molecular weight
    127.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Melting point expt.

    • 64.5 - 65.5 °C

    Boiling point

    • 89.00 to 91.00 °C. @ 12.00 mm Hg

    Flash point est.
    85.23 ˚C

    Solubility expt.

    • Insoluble in water; Soluble in fats, oils, most organic solvents
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 2-Acetylthiazole
    • 24295-03-2
    • 1-(1,3-Thiazol-2-yl)ethan-1-one
    • 1-(1,3-Thiazol-2-yl)ethanone
    • Ethanone, 1-(2-thiazolyl)-
    • 1-thiazol-2-yl-ethanone
    • 2-ACETYL THIAZOLE
    • Methyl 2-thiazolyl ketone
    • 1-(Thiazol-2-yl)ethan-1-one
    • Ketone, methyl 2-thiazolyl
    • Thiazole, 2-acetyl
    • 2-acetylthiazol
    • 1-(2-Thiazolyl)ethanone
    • 2-Thiazolyl methyl ketone
    • MFCD00005324
    • FEMA No. 3328
    • Methyl 5-thiazolyl ketone
    • 1-(2-thiazolyl)-ethanone
    • 1-(thiazol-2-yl)ethanone
    • UNII-16IGS5268I
    • DTXSID0030162
    • 16IGS5268I
    • EINECS 246-134-5
    • 3,3'-DICARBOXYDIPHENYLMETHANE
    • 2-ACETYLTHIAZOLE [FHFI]
    • DTXCID8010162
    • 1-(2-Thiazolyl)ethanone, 9CI
    • FEMA 3328
    • Methyl 2-thiazolyl ketone, 8CI
    • 2-ACETYL THIAZOLE [FCC]
    • CAS-24295-03-2
    • 2-acetyl-1,3-thiazole
    • acetylthiazole
    • 2-acetyl
    • 2-acetyl-
    • 2-Acetylthiazole, 99%
    • MLS002415692
    • SCHEMBL247631
    • CHEMBL1589555
    • 2-Acetylthiazole, >=99%, FG
    • CHEBI:173474
    • HMS3039C05
    • BCP27129
    • HY-Y0045
    • STR03999
    • Tox21_202054
    • Tox21_303515
    • AKOS005259005
    • AC-3209
    • CS-W008970
    • FA15955
    • PB42359
    • PS-5288
    • NCGC00091718-01
    • NCGC00091718-02
    • NCGC00257353-01
    • NCGC00259603-01
    • SMR001370882
    • SY004958
    • DB-020350
    • A1265
    • NS00012995
    • EN300-67228
    • F11223
    • T80017
    • Q27251815
    • F0001-0826
    • Z1069877574

  • Applications

    2-Acetylthiazole (CAS 24295-03-2) is a heteroaromatic molecule with a characteristic popcorn and roasted-nut odor that makes it a prized trace-level flavoring for bakery goods, breakfast cereals, coffee, chocolate, soy sauces, meat analogues, tobacco and e-liquid formulations; beyond food, it provides a warm gourmand facet in fine fragrances, serves as a GC-MS reference in Maillard-reaction and aroma-release studies, and acts as a versatile building block for synthesizing thiazole-based pharmaceuticals, agrochemicals and metal-complex ligands, while also being investigated for odor migration, toxicological profiling and controlled-release packaging applications.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 90.22
    methanol 157.3
    isopropanol 60.36
    water 10.69
    ethyl acetate 130.55
    n-propanol 71.64
    acetone 262.91
    n-butanol 63.72
    acetonitrile 185.99
    DMF 638.08
    toluene 75.85
    isobutanol 51.65
    1,4-dioxane 243.39
    methyl acetate 157.3
    THF 290.53
    2-butanone 157.23
    n-pentanol 59.58
    sec-butanol 50.99
    n-hexane 10.23
    ethylene glycol 67.95
    NMP 584.83
    cyclohexane 13.0
    DMSO 517.65
    n-butyl acetate 73.29
    n-octanol 33.9
    chloroform 231.61
    n-propyl acetate 86.18
    acetic acid 159.85
    dichloromethane 278.92
    cyclohexanone 213.05
    propylene glycol 40.26
    isopropyl acetate 79.45
    DMAc 475.27
    2-ethoxyethanol 181.79
    isopentanol 58.63
    n-heptane 10.17
    ethyl formate 115.0
    1,2-dichloroethane 177.54
    n-hexanol 46.76
    2-methoxyethanol 267.75
    isobutyl acetate 56.06
    tetrachloromethane 42.76
    n-pentyl acetate 57.85
    transcutol 408.52
    n-heptanol 27.26
    ethylbenzene 40.66
    MIBK 84.17
    2-propoxyethanol 137.25
    tert-butanol 80.97
    MTBE 76.77
    2-butoxyethanol 74.27
    propionic acid 82.95
    o-xylene 56.73
    formic acid 143.07
    diethyl ether 100.45
    m-xylene 59.14
    p-xylene 57.14
    chlorobenzene 127.01
    dimethyl carbonate 104.55
    n-octane 4.51
    formamide 220.28
    cyclopentanone 274.13
    2-pentanone 129.96
    anisole 136.27
    cyclopentyl methyl ether 135.98
    gamma-butyrolactone 330.33
    1-methoxy-2-propanol 173.3
    pyridine 209.95
    3-pentanone 119.45
    furfural 399.65
    n-dodecane 4.73
    diethylene glycol 159.02
    diisopropyl ether 35.01
    tert-amyl alcohol 62.82
    acetylacetone 215.6
    n-hexadecane 5.47
    acetophenone 132.78
    methyl propionate 133.92
    isopentyl acetate 64.44
    trichloroethylene 338.95
    n-nonanol 32.03
    cyclohexanol 66.9
    benzyl alcohol 99.96
    2-ethylhexanol 36.5
    isooctanol 25.38
    dipropyl ether 58.36
    1,2-dichlorobenzene 123.29
    ethyl lactate 60.77
    propylene carbonate 149.63
    n-methylformamide 254.22
    2-pentanol 43.39
    n-pentane 10.57
    1-propoxy-2-propanol 87.96
    1-methoxy-2-propyl acetate 105.23
    2-(2-methoxypropoxy) propanol 108.87
    mesitylene 41.28
    ε-caprolactone 175.89
    p-cymene 30.11
    epichlorohydrin 316.72
    1,1,1-trichloroethane 146.87
    2-aminoethanol 83.0
    morpholine-4-carbaldehyde 554.02
    sulfolane 404.86
    2,2,4-trimethylpentane 7.6
    2-methyltetrahydrofuran 179.16
    n-hexyl acetate 75.11
    isooctane 5.54
    2-(2-butoxyethoxy)ethanol 133.53
    sec-butyl acetate 60.61
    tert-butyl acetate 91.48
    decalin 11.92
    glycerin 106.15
    diglyme 258.66
    acrylic acid 103.18
    isopropyl myristate 40.26
    n-butyric acid 89.57
    acetyl acetate 100.93
    di(2-ethylhexyl) phthalate 46.48
    ethyl propionate 87.33
    nitromethane 459.15
    1,2-diethoxyethane 122.57
    benzonitrile 141.32
    trioctyl phosphate 31.08
    1-bromopropane 70.95
    gamma-valerolactone 420.23
    n-decanol 25.87
    triethyl phosphate 53.96
    4-methyl-2-pentanol 31.99
    propionitrile 112.21
    vinylene carbonate 164.99
    1,1,2-trichlorotrifluoroethane 219.67
    DMS 106.32
    cumene 32.72
    2-octanol 22.82
    2-hexanone 93.18
    octyl acetate 47.79
    limonene 42.85
    1,2-dimethoxyethane 272.95
    ethyl orthosilicate 49.71
    tributyl phosphate 43.04
    diacetone alcohol 109.96
    N,N-dimethylaniline 101.28
    acrylonitrile 171.58
    aniline 100.09
    1,3-propanediol 99.35
    bromobenzene 116.58
    dibromomethane 144.15
    1,1,2,2-tetrachloroethane 211.04
    2-methyl-cyclohexyl acetate 67.33
    tetrabutyl urea 64.82
    diisobutyl methanol 28.48
    2-phenylethanol 69.09
    styrene 59.65
    dioctyl adipate 65.2
    dimethyl sulfate 198.92
    ethyl butyrate 72.28
    methyl lactate 91.88
    butyl lactate 52.17
    diethyl carbonate 59.63
    propanediol butyl ether 76.4
    triethyl orthoformate 60.34
    p-tert-butyltoluene 29.29
    methyl 4-tert-butylbenzoate 101.75
    morpholine 231.97
    tert-butylamine 51.27
    n-dodecanol 22.07
    dimethoxymethane 291.09
    ethylene carbonate 124.46
    cyrene 146.71
    2-ethoxyethyl acetate 102.93
    2-ethylhexyl acetate 55.08
    1,2,4-trichlorobenzene 140.11
    4-methylpyridine 222.96
    dibutyl ether 51.0
    2,6-dimethyl-4-heptanol 28.48
    DEF 204.42
    dimethyl isosorbide 201.19
    tetrachloroethylene 142.04
    eugenol 108.49
    triacetin 108.65
    span 80 83.95
    1,4-butanediol 58.14
    1,1-dichloroethane 137.15
    2-methyl-1-pentanol 56.7
    methyl formate 227.28
    2-methyl-1-butanol 53.01
    n-decane 6.86
    butyronitrile 99.12
    3,7-dimethyl-1-octanol 37.23
    1-chlorooctane 25.56
    1-chlorotetradecane 14.37
    n-nonane 6.26
    undecane 5.57
    tert-butylcyclohexane 11.06
    cyclooctane 5.98
    cyclopentanol 81.12
    tetrahydropyran 133.29
    tert-amyl methyl ether 71.2
    2,5,8-trioxanonane 204.19
    1-hexene 31.1
    2-isopropoxyethanol 113.67
    2,2,2-trifluoroethanol 103.23
    methyl butyrate 106.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Colocasia esculenta (Taro) Colocasia esculenta (L.) Schott, fam. Araceae 0.3%
Rocket leaf 2 headspace Eruca sativa L., fam. Brassicaceae 1.3%