1,2,3,4-Tetrahydro-4-methylquinoline

Overview IFRA Request a quote

  • Identifiers

    CAS number
    19343-78-3

    Molecular formula
    C10H13N

    SMILES
    CC1CCNC2=CC=CC=C12

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Animal 58.22%
    Sweet 43.42%
    Phenolic 42.01%
    Earthy 37.94%
    Musty 35.9%
    Leathery 33.59%
    Burnt 30.09%
    Smoky 29.57%
    Nutty 28.7%
    Tobacco 28.65%

     

    Flavor
    Sweet 46.78%
    Floral 37.1%
    Animal 36.2%
    Bitter 31.17%
    Earthy 31.09%
    Woody 28.02%
    Musty 27.95%
    Fruity 27.5%
    Herbal 27.46%
    Spicy 23.92%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    6.13 (neutral)

    Molecular weight
    147.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    243°C

    Flash point

    • 110.17 ˚C est.

  • Synonyms

    • 4-Methyl-1,2,3,4-tetrahydroquinoline
    • 1,2,3,4-Tetrahydro-4-methylquinoline
    • Quinoline, 1,2,3,4-tetrahydro-4-methyl-
    • 1,2,3,4-Tetrahydrolepidine
    • PCF8IC3A94
    • AI3-22251
    • Lepidine, 1,2,3,4-tetrahydro-
    • EINECS 242-977-8
    • UNII-PCF8IC3A94
    • DTXSID40864885
    • RefChem:71308
    • DTXCID40813353
    • 242-977-8
    • OXNZWCYNCDWCJA-UHFFFAOYSA-N
    • 19343-78-3
    • MFCD00047565
    • 1,2,3,4-Tetrahydro-4-methylquinoline; 1,2,3,4-Tetrahydrolepidine; 4-Methyl-1,2,3,4-tetrahydroquinoline
    • tetrahydro-4-methylquinoline
    • 74459-14-6
    • SCHEMBL4433763
    • SCHEMBL6869987
    • SCHEMBL17969164
    • SCHEMBL29641546
    • UAA34378
    • AKOS004121067
    • AKOS016844137
    • AC-9369
    • DS-6584
    • SY270577
    • DB-005613
    • CS-0019301
    • NS00013213
    • EN300-57913
    • A10659
    • AB00999686-01
    • F320047
    • 19343-78-3

  • Applications

    1,2,3,4-Tetrahydro-4-methylquinoline (CAS 19343-78-3) is primarily used as an intermediate in organic synthesis, serving as a building block for nitrogen-containing heterocycles in pharmaceutical and agrochemical development. It is commonly evaluated as a precursor for quinoline- and piperidine-type scaffolds and can be incorporated into routes toward heterocyclic amines. The compound may be used in dye and pigment chemistry as a heterocyclic building block, and in polymer, coatings, and specialty chemical synthesis as a versatile amine intermediate for functionalized materials. In fragrance and flavor contexts, related tetrahydroquinoline derivatives are sometimes explored as odor-active components, and the material is frequently encountered in research as a template for catalysis and method development. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 264.02
    methanol 266.32
    isopropanol 186.15
    water 0.47
    ethyl acetate 491.57
    n-propanol 242.36
    acetone 751.73
    n-butanol 225.05
    acetonitrile 519.53
    DMF 636.09
    toluene 292.17
    isobutanol 164.71
    1,4-dioxane 1300.99
    methyl acetate 491.92
    THF 1332.84
    2-butanone 507.37
    n-pentanol 161.98
    sec-butanol 137.41
    n-hexane 41.31
    ethylene glycol 36.58
    NMP 617.6
    cyclohexane 67.82
    DMSO 922.07
    n-butyl acetate 588.77
    n-octanol 121.22
    chloroform 1239.58
    n-propyl acetate 339.77
    acetic acid 250.29
    dichloromethane 1237.6
    cyclohexanone 783.47
    propylene glycol 39.53
    isopropyl acetate 251.98
    DMAc 329.74
    2-ethoxyethanol 230.47
    isopentanol 175.55
    n-heptane 54.14
    ethyl formate 357.83
    1,2-dichloroethane 798.74
    n-hexanol 279.19
    2-methoxyethanol 352.12
    isobutyl acetate 205.81
    tetrachloromethane 227.54
    n-pentyl acetate 224.86
    transcutol 890.27
    n-heptanol 121.79
    ethylbenzene 101.23
    MIBK 238.69
    2-propoxyethanol 424.43
    tert-butanol 211.05
    MTBE 301.1
    2-butoxyethanol 208.29
    propionic acid 221.67
    o-xylene 129.32
    formic acid 62.9
    diethyl ether 488.68
    m-xylene 170.04
    p-xylene 127.94
    chlorobenzene 452.04
    dimethyl carbonate 178.74
    n-octane 25.03
    formamide 114.24
    cyclopentanone 1043.43
    2-pentanone 431.86
    anisole 214.65
    cyclopentyl methyl ether 528.53
    gamma-butyrolactone 1086.37
    1-methoxy-2-propanol 268.42
    pyridine 725.98
    3-pentanone 350.84
    furfural 653.81
    n-dodecane 21.08
    diethylene glycol 236.2
    diisopropyl ether 125.23
    tert-amyl alcohol 140.73
    acetylacetone 474.2
    n-hexadecane 24.59
    acetophenone 187.09
    methyl propionate 356.65
    isopentyl acetate 369.98
    trichloroethylene 1183.47
    n-nonanol 106.58
    cyclohexanol 209.91
    benzyl alcohol 136.86
    2-ethylhexanol 168.61
    isooctanol 102.81
    dipropyl ether 292.21
    1,2-dichlorobenzene 311.3
    ethyl lactate 99.98
    propylene carbonate 472.64
    n-methylformamide 353.93
    2-pentanol 134.12
    n-pentane 39.38
    1-propoxy-2-propanol 288.34
    1-methoxy-2-propyl acetate 336.19
    2-(2-methoxypropoxy) propanol 169.19
    mesitylene 110.67
    ε-caprolactone 586.42
    p-cymene 88.17
    epichlorohydrin 1115.11
    1,1,1-trichloroethane 657.94
    2-aminoethanol 73.92
    morpholine-4-carbaldehyde 647.23
    sulfolane 992.07
    2,2,4-trimethylpentane 25.81
    2-methyltetrahydrofuran 810.21
    n-hexyl acetate 279.7
    isooctane 26.22
    2-(2-butoxyethoxy)ethanol 267.05
    sec-butyl acetate 172.33
    tert-butyl acetate 268.8
    decalin 35.68
    glycerin 69.98
    diglyme 560.35
    acrylic acid 184.45
    isopropyl myristate 111.62
    n-butyric acid 343.87
    acetyl acetate 291.85
    di(2-ethylhexyl) phthalate 90.14
    ethyl propionate 237.88
    nitromethane 750.43
    1,2-diethoxyethane 471.33
    benzonitrile 287.31
    trioctyl phosphate 76.21
    1-bromopropane 426.7
    gamma-valerolactone 1032.94
    n-decanol 85.58
    triethyl phosphate 104.86
    4-methyl-2-pentanol 94.36
    propionitrile 357.48
    vinylene carbonate 443.91
    1,1,2-trichlorotrifluoroethane 354.89
    DMS 220.64
    cumene 72.61
    2-octanol 83.76
    2-hexanone 313.34
    octyl acetate 139.06
    limonene 136.99
    1,2-dimethoxyethane 535.36
    ethyl orthosilicate 104.12
    tributyl phosphate 101.47
    diacetone alcohol 221.41
    N,N-dimethylaniline 120.76
    acrylonitrile 437.41
    aniline 270.89
    1,3-propanediol 150.1
    bromobenzene 506.3
    dibromomethane 793.07
    1,1,2,2-tetrachloroethane 732.64
    2-methyl-cyclohexyl acetate 176.53
    tetrabutyl urea 120.64
    diisobutyl methanol 101.67
    2-phenylethanol 188.95
    styrene 139.34
    dioctyl adipate 127.65
    dimethyl sulfate 262.33
    ethyl butyrate 305.49
    methyl lactate 114.76
    butyl lactate 129.17
    diethyl carbonate 176.82
    propanediol butyl ether 151.45
    triethyl orthoformate 179.01
    p-tert-butyltoluene 85.56
    methyl 4-tert-butylbenzoate 160.2
    morpholine 951.93
    tert-butylamine 136.03
    n-dodecanol 70.07
    dimethoxymethane 544.99
    ethylene carbonate 410.22
    cyrene 161.87
    2-ethoxyethyl acetate 310.84
    2-ethylhexyl acetate 304.45
    1,2,4-trichlorobenzene 330.7
    4-methylpyridine 606.17
    dibutyl ether 238.61
    2,6-dimethyl-4-heptanol 101.67
    DEF 402.9
    dimethyl isosorbide 344.57
    tetrachloroethylene 507.48
    eugenol 149.79
    triacetin 203.83
    span 80 150.24
    1,4-butanediol 63.12
    1,1-dichloroethane 697.02
    2-methyl-1-pentanol 132.71
    methyl formate 354.86
    2-methyl-1-butanol 153.41
    n-decane 33.79
    butyronitrile 370.42
    3,7-dimethyl-1-octanol 114.61
    1-chlorooctane 120.41
    1-chlorotetradecane 52.73
    n-nonane 33.88
    undecane 26.01
    tert-butylcyclohexane 38.52
    cyclooctane 30.73
    cyclopentanol 251.14
    tetrahydropyran 902.49
    tert-amyl methyl ether 181.69
    2,5,8-trioxanonane 326.85
    1-hexene 145.86
    2-isopropoxyethanol 170.65
    2,2,2-trifluoroethanol 97.91
    methyl butyrate 327.5

    Scent© AI

1 4

IFRA standard 51

Recommendation
Specification
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 See notebox Category 7A
Rinse-off products applied to the hair with some hand contact
 See notebox
Category 2
Products applied to the axillae
 See notebox Category 7B
Leave-on products applied to the hair with some hand contact
 See notebox
Category 3
Products applied to the face/body using fingertips
 See notebox Category 8
Products with significant anogenital exposure
 See notebox
Category 4
Products related to fine fragrance
 See notebox Category 9
Products with body and hand exposure, primarily rinse off
 See notebox
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 See notebox Category 10A
Household care products with mostly hand contact
 See notebox
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 See notebox Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 See notebox
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 See notebox Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 See notebox
Category 5D
Baby Creams, baby Oils and baby talc
 See notebox Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 See notebox
Category 6
Products with oral and lip exposure
 See notebox Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 See notebox

Specification
The material has been identified for having the potential of forming nitrosamines in nitrosating systems. Downstream users therefore have to be notified of the presence of the material and its potential, to be able to consider adequate protective measures.